Negative / Null Result ReportOpen accessMedicine
Loghin II, Vaţă A, Rusu ȘA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives. Mother-to-child transmission (MTCT) or vertical transmission of human immunodeficiency virus (HIV) is largely preventable in settings where prevention of MTCT (PVT) strategies are consistently implemented.…
View details →DOI: 10.3390/medicina62040632 Negative / Null Result Report
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
View details →DOI: 10.12688/openreseurope.21896.1 Negative / Null Result Report
Liang A, Veetil S, Groom K et al. · 2026 · Preprint
Abstract Laser Powder Bed Fusion (LPBF) is a widely adopted additive manufacturing technique for producing geometrically metal components. While this process yields fine microstructures beneficial for strength, the associated rapid thermal…
View details →DOI: 10.21203/rs.3.rs-9968290/v1 Negative / Null Result ReportMedicine
Ware A, LaMountain J, White RC et al. · 2026 · Nature communications
The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…
View details →DOI: 10.1038/s41467-026-74396-z Negative / Null Result ReportOpen accessMedicine
Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…
View details →DOI: 10.1093/cid/ciaf568 Negative / Null Result ReportOpen accessMedicine
· 2006
Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…
Negative / Null Result Report
Reid L, Ganapathiraju S, Mancinelli S et al. · 2026 · Preprint
Retinoid-related orphan receptor gamma (RORγ) is a lineage-defining transcription factor for T helper 17 (Th17) cells and has long been considered selectively expressed within the immune system. However, accumulating evidence has…
View details →DOI: 10.64898/2026.03.03.709291 Negative / Null Result ReportMedicine
Palenchar PM · 2026 · PloS one
Understanding how evolution shapes variability in gene expression is complicated by the interdependence of expression levels, expression variability, and evolutionary rates. Metrics that quantify variability independently of expression…
View details →DOI: 10.1371/journal.pone.0352202 Negative / Null Result ReportOpen accessMedicine
Senise G, Bodega F, Porta C et al. · 2026 · Cells
Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…
View details →DOI: 10.3390/cells15121112 Negative / Null Result ReportOpen accessMedicine
· 2006
Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…
Negative / Null Result Report
Li B · 2026 · Preprint
The Standard Model describes particle phenomena through continuous gauge structures, chiral assignments, color, generations, and Yukawa masses, but it does not derive these labels from a deeper structural principle. This paper proposes a…
View details →DOI: 10.20944/preprints202606.0775.v1 Negative / Null Result Report
Dai R · 2026 · Preprint
Abstract Recent IsoMemo / Pandora compilations now make it possible to pool archaeological human stable-isotope data across continents. We tested whether a simple latitudinal gradient is detectable in archaeological human δ³⁴S after…
View details →DOI: 10.21203/rs.3.rs-9736542/v1 Negative / Null Result Report
Cabooter Q, Bruyne JD, Casselman B et al. · 2026 · Preprint
Ultrasound mid-air haptics (UMAH) can create touch sensations without physical contact, but it remains unclear whether they evoke steady-state somatosensory evoked potentials (SSSEPs) that could serve as objective markers of user…
View details →DOI: 10.20944/preprints202606.0669.v1 Failed Experiment ReportOpen accessMedicine
Heinemann FM, Hallensleben M, Althaus K et al. · 2026 · HLA
Single antigen (SA) tests are indispensable for an accurate HLA antibody identification in sera of transplant patients. Three commercial tests using purified single antigens combined with microbead or microarray technology are currently…
View details →DOI: 10.1111/tan.70734 Failed Experiment ReportMedicine
Zheng J, Wu M, Wang X et al. · 2026 · Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications. However, its genome-wide off-target effects are not fully understood, raising…
View details →DOI: 10.3390/cells15050438 Negative / Null Result Report
Lindell H, Lehtilä K, Dinnétz P · 2026 · Preprint
Abstract Background Wild boar ( Sus scrofa ) have expanded in northern Europe, yet their role in the ecology of tick-borne pathogens remains poorly understood. This study investigated the occurrence of Anaplasma phagocytophilum and…
View details →DOI: 10.21203/rs.3.rs-9583918/v1 Negative / Null Result ReportOpen accessMedicine
Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology
Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…
View details →DOI: 10.1177/17588359251412729 Negative / Null Result ReportOpen accessPhysics
Atsushi Taruya, Takahiro Nishimichi, Donghui Jeong · 2021 · arXiv
Perturbation theory (PT) has been used to interpret the observed nonlinear large-scale structure statistics at the quasi-linear regime. To facilitate the PT-based analysis, we have presented the GridSPT algorithm, a grid-based method to compute the nonlinear density and velocity fields in standard perturbation theory (SPT) from a given linear power spectrum. Here, we further put forward the approach by taking the redshift-space distortions into account. With the new implementation, we have, for the first time, generated the redshift-space density field to the fifth order and computed the next-
Negative / Null Result ReportOpen accessComputer Science
Jin Zeng, Yang Liu, Gene Cheung et al. · 2022 · arXiv
A graph convolutional network (GCN) employs a graph filtering kernel tailored for data with irregular structures. However, simply stacking more GCN layers does not improve performance; instead, the output converges to an uninformative low-dimensional subspace, where the convergence rate is characterized by the graph spectrum -- this is the known over-smoothing problem in GCN. In this paper, we propose a sparse graph learning algorithm incorporating a new spectrum prior to compute a graph topology that circumvents over-smoothing while preserving pairwise correlations inherent in data. Specifica
Negative / Null Result ReportOpen accessComputer Science
Wentao Zhao, Dalin Zhou, Xinguo Qiu et al. · 2020 · arXiv
Graph neural networks (GNNs) have been investigated for potential applicability in multiple fields that employ graph data. However, there are no standard training settings to ensure fair comparisons among new methods, including different model architectures and data augmentation techniques. We introduce a standard, reproducible benchmark to which the same training settings can be applied for node classification. For this benchmark, we constructed 9 datasets, including both small- and medium-scale datasets from different fields, and 7 different models. We design a k-fold model assessment strate
Negative / Null Result ReportOpen accessComputer Science
Charles Jin, Melinda Sun, Martin Rinard · 2021 · arXiv
We propose a novel clustering mechanism based on an incompatibility property between subsets of data that emerges during model training. This mechanism partitions the dataset into subsets that generalize only to themselves, i.e., training on one subset does not improve performance on the other subsets. Leveraging the interaction between the dataset and the training process, our clustering mechanism partitions datasets into clusters that are defined by--and therefore meaningful to--the objective of the training process. We apply our clustering mechanism to defend against data poisoning attacks,
Negative / Null Result ReportOpen accessPhysics
Fabien Robineau, Frédéric Boy, Jean-Pierre Orliaguet et al. · 2006 · arXiv
Performing minimal-invasive surgical punctures require guiding a needle toward an intracorporeal clinically-defined target. As this technique does not involve cutting the body open, a visualization system is employed to provide the surgeon with indirect visual spatial information about the intracorporeal positions of the tool. One may consider that such systems reduce the ergonomics of the situation as they generate a decorrelation between the actual movement of the needle and the displayed information about this movement. The present study aims at assessing the guidance of an intracorporeal p
Negative / Null Result ReportOpen accessComputer Science
Alexia Jolicoeur-Martineau · 2019 · arXiv
This paper provides a more rigorous look at Relativistic Generative Adversarial Networks (RGANs). We prove that the objective function of the discriminator is a statistical divergence for any concave function $f$ with minimal properties ($f(0)=0$, $f'(0) \neq 0$, $\sup_x f(x)>0$). We also devise a few variants of relativistic $f$-divergences. Wasserstein GAN was originally justified by the idea that the Wasserstein distance (WD) is most sensible because it is weak (i.e., it induces a weak topology). We show that the WD is weaker than $f$-divergences which are weaker than relativistic $f$-diver
Negative / Null Result ReportOpen accessComputer Science
Paul Röttger, Janet B. Pierrehumbert · 2021 · arXiv
Language use differs between domains and even within a domain, language use changes over time. For pre-trained language models like BERT, domain adaptation through continued pre-training has been shown to improve performance on in-domain downstream tasks. In this article, we investigate whether temporal adaptation can bring additional benefits. For this purpose, we introduce a corpus of social media comments sampled over three years. It contains unlabelled data for adaptation and evaluation on an upstream masked language modelling task as well as labelled data for fine-tuning and evaluation on
Negative / Null Result ReportOpen accessComputer Science
Mireille El-Assal, Pierre Tirilly, Ioan Marius Bilasco · 2023 · arXiv
Video analysis is a computer vision task that is useful for many applications like surveillance, human-machine interaction, and autonomous vehicles. Deep Convolutional Neural Networks (CNNs) are currently the state-of-the-art methods for video analysis. However they have high computational costs, and need a large amount of labeled data for training. In this paper, we use Convolutional Spiking Neural Networks (CSNNs) trained with the unsupervised Spike Timing-Dependent Plasticity (STDP) learning rule for action classification. These networks represent the information using asynchronous low-ener
Negative / Null Result ReportOpen accessComputer Science
Óscar García-Sierra, Ana Fernández-Pampillón Cesteros, Miguel Ortega-Martín · 2024 · arXiv
Subword tokenization algorithms used by Large Language Models are significantly more efficient and can independently build the necessary vocabulary of words and subwords without human intervention. However, those subwords do not always align with real morphemes, potentially impacting the models' performance, though it remains uncertain when this might occur. In previous research, we proposed a method to assess the morphological quality of vocabularies, focusing on the overlap between these vocabularies and the morphemes of a given language. Our evaluation method was built on three quality meas
Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Kaijun Wang, Kaijun Wang, Jie Ma et al. · 2022 · Frontiers in Nutrition
Artemisia argyi leaf is a well-known species in traditional Chinese medicine, and its essential oil (AAEO) has been identified to exert various physiological activities. The aim of this study was to investigate the effects of AAEO on lipid metabolism and the potential microbial role in high-fat diet (HFD)-fed mice. A total of 50 male mice were assigned to five groups for feeding with a control diet (Con), a high-fat diet (HFD), and the HFD plus the low (LEO), medium (MEO), and high (HEO) doses of AAEO. The results demonstrated that dietary HFD markedly increased the body weight gain compared w
View details →DOI: 10.3389/fnut.2022.1024722 Negative / Null Result ReportOpen accessMedicine
Julie Labrosse, Marie Osdoit, Anne-Sophie Hamy et al. · 2020 · PLoS ONE
Although identified to be at a higher risk of relapse, no consensus exists on the treatment of breast cancer (BC) patients with no pathological complete response after neoadjuvant chemotherapy (NAC). The benefit of adjuvant chemotherapy (ADJ) in this context has scarcely been studied. We evaluated the benefit of administrating adjuvant chemotherapy in a real life cohort of BC patients with invasive residual disease after NAC. 1199 female BC patients with T1-3NxM0 invasive tumors receiving NAC at Institut Curie from 2002 to 2012 were included in the analysis. 1061 had been treated by NAC only,
View details →DOI: 10.1371/journal.pone.0234173 Negative / Null Result ReportOpen accessOrthopedic surgery
Yakup Ekinci, Mithat Oner, Ibrahim Karaman et al. · 2020 · Acta Orthopaedica et Traumatologica Turcica
Abstract Objective: The aim of this study was to compare simultaneous bilateral total knee arthroplasty (BTKA) and unilateral total knee arthroplasty (UTKA) in terms of morbidity, clinical and radiological findings and quality of life. Methods: The study included 48 simultaneous BTKAs (46 females, 2 males; mean age: 64.00±8.31 years) and 53 UTKAs (46 females, 7 males; mean age: 64.40±7.45 years) performed between November 2007 and June 2012. Groups were compared with respect to comorbidity, complications, blood transfusion, hospital stay, clinical and radiological (American Knee Society Score)
View details →DOI: 10.3944/aott.2014.3226 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
Yuelin Xiong, Huatang Luo, Hao Wang et al. · 2026 · PLoS Neglected Tropical Diseases
Background Schistosomiasis, a neglected tropical disease (NTD), remains a public health concern in China. Health education is a fundamental intervention for its control. Even in transmission-interrupted areas like Wuhan, sustained awareness is crucial. However, recent literature on school-based interventions evaluating knowledge, attitudes and practices (KAP) among children in such areas is limited. Objective This study aimed to evaluate and compare the effectiveness of peer-led education versus routine health education in improving schistosomiasis-related KAP among elementary students in an u
View details →DOI: 10.1371/journal.pntd.0013857 