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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21294 results · page 325 of 710

Abandoned HypothesisOpen accessMedicine

Use Treadmills with Caution: Walking Energy Expenditure and Metabolic Cost Are Elevated Compared to Overground Across Multiple Speeds in Healthy Young Adults.

Das Gupta S, Kamishita K, Kondo M et al. · 2026 · Journal of functional morphology and kinesiology

Objectives : Treadmill walking is often employed for tightly controlled gait and energetics research, but growing evidence suggests that treadmill-based metabolic and biomechanical measurements may not directly reflect the ecologically…

View details →DOI: 10.3390/jfmk11020220
Negative / Null Result ReportMedicine

Integrating ankle weights into Nordic walking to improve muscle strength and functional outcomes in community-dwelling older adults: A randomized controlled trial.

Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion

Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…

View details →DOI: 10.1016/j.rh.2026.100998
Negative / Null Result ReportOpen accessMedicine

Cerebral glycerol during haemorrhagic shock in normal and raised intracranial pressure resuscitated with total REBOA: an experimental porcine study.

Bader S, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Background Haemorrhagic shock (HS) is frequently associated with secondary cerebral injury due to compromised cerebral perfusion. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective haemorrhage control…

View details →DOI: 10.1007/s00068-026-03236-y
Negative / Null Result ReportOpen accessMedicine

Evaluation of the Potential Effects of Carnosine on Intestinal Ischemia/Reperfusion Injury in a Rat Model: A Lack of Significant Protective Effect.

Iyiol AR · 2026 · Cureus

Background Intestinal ischemia-reperfusion (I/R) injury represents a critical clinical condition characterized by oxidative stress, inflammatory activation, and impairment of intestinal mucosal integrity. Although restoration of blood flow…

View details →DOI: 10.7759/cureus.107891
Negative / Null Result ReportOpen accessMedicine

Changes in Maternal Care and Infant Health After Noneconomic Damage Cap Repeals.

Mizushima Y, Whaley C, Kaimal A et al. · 2026 · JAMA network open

Importance Noneconomic damage caps, a form of medical malpractice law, remain controversial, as several states have enacted such laws since 2010, whereas others have repealed them. The clinical consequences of repealing these caps are…

View details →DOI: 10.1001/jamanetworkopen.2026.16654
Negative / Null Result ReportMedicine

2019 Marathon of Rome: Relationship Between Resilience and Coping Strategies in 682 Runners.

Longo UG, Mazzola A, Stelitano G et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objective The aim of this study was to evaluate, in runners participating in the 2019 Rome Marathon, the interaction between resilience and coping and how they are influenced by sex, age, body weight, height, number of weekly training…

View details →DOI: 10.1097/jsm.0000000000001492
Negative / Null Result ReportOpen accessMedicine

Simultaneous bispectral index and near-infrared spectroscopy monitoring to evaluate two induction protocols in elective cardiovascular surgery.

Eke H, Toprak B, Bozkurt ED · 2026 · Journal of cardiothoracic surgery

BACKGROUND: Laryngoscopy and intubation provoke strong sympathetic activation and may cause hemodynamic instability in cardiovascular surgery patients. Maintaining adequate hypnotic depth and cerebral oxygenation during induction is…

View details →DOI: 10.1186/s13019-026-04171-0
Negative / Null Result ReportMedicine

Decreased evertor strength following peroneus longus tendon harvest for anterior cruciate ligament reconstruction : an isokinetic muscle strength testing study.

Kotian RN, Ajoy SM, Panduranga R et al. · 2026 · The bone & joint journal

Aims There are conflicting results in the literature regarding the safety of the peroneus longus tendon (PLT) as a potential graft for anterior cruciate ligament (ACL) reconstruction, and no long-term studies with objective assessment…

View details →DOI: 10.1302/0301-620x.108b6.bjj-2025-0274.r1
Negative / Null Result ReportMedicine

Investigation of enamel surface changes in teeth with artificially produced white spot lesions after debonding: an in vitro study.

Tankuş M, Memikoğlu TUT · 2026 · BMC oral health

Background This study aimed to investigate enamel surface changes after debonding of teeth with metal and ceramic brackets exhibiting varying severities of white spot lesions (WSLs). Methods Forty healthy premolars were divided into two…

View details →DOI: 10.1186/s12903-026-08860-z
Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Functional Prognosis in Patients with Rhegmatogenous Retinal Detachment Treated by Pars Plana Vitrectomy-A Retrospective Study.

Chereji G, Chelaru VF, Nicoară SD · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Rhegmatogenous retinal detachment (RRD) is a surgical emergency that causes vision loss if not properly treated. Pars plana vitrectomy (PPV) is the preferred procedure for most complex RRD cases, with a high success…

View details →DOI: 10.3390/diagnostics16111696
Negative / Null Result ReportOpen accessMedicine

Changes in iron metabolism after primary PCI in patients with STEMI and ischemia-reperfusion injury.

Wang Z, Zhang Y, Zhang K et al. · 2026 · Experimental and therapeutic medicine

Within the present study, the aim was to investigate the dynamic changes in iron metabolism parameters in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) and to…

View details →DOI: 10.3892/etm.2026.13173
Negative / Null Result ReportOpen accessMedicine

Genetically predicted TTK inhibition and its association with reduced breast cancer risk: a two-step Mendelian randomization study of potential gut microbiome mediation.

Liu J, Liu M, Xu Y et al. · 2026 · Clinics (Sao Paulo, Brazil)

Background BOS172722, a selective TTK inhibitor, shows promise for Breast Cancer (BC) treatment. The role of gut microbiota as a potential mediator in this process has not been established. This Mendelian Randomization (MR) study…

View details →DOI: 10.1016/j.clinsp.2026.100961
Negative / Null Result ReportMedicine

Effects of different hyrax maxillary expansion protocols compared with novel magnetic expansion on the pharyngeal airway and maxillary sinus spaces: A retrospective CBCT-based observational study.

Algahefi AL, Alhammadi MS, Li Z et al. · 2026 · American journal of otolaryngology

Purpose To evaluate three-dimensional changes in the maxillary sinus (MS) and pharyngeal airway space (PAS) following rapid (RME), slow (SME), and magnetic maxillary expansion (MME) using cone-beam computed tomography (CBCT). Methods This…

View details →DOI: 10.1016/j.amjoto.2026.104844
Negative / Null Result ReportOpen accessMedicine

Only a partial shield: local vancomycin postpones but does not prevent hip and knee prosthetic infections.

Darup A, Ettinger M, Savov P et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Periprosthetic joint infection (PJI) represents a severe complication following total hip arthroplasty (THA) and total knee arthroplasty (TKA). The intraarticular application of vancomycin powder is increasingly integrated…

View details →DOI: 10.1007/s00402-026-06289-1
Negative / Null Result ReportOpen accessMedicine

Surface and fracture properties of lithium disilicate and resin-Matrix CAD/CAM ceramics.

G Montaser A, Tamimi S, A El Saeed S et al. · 2026 · The Saudi dental journal

Purpose To characterize hardness and fracture toughness of ceramic CAD/CAM materials with different composition (IPS e.max CAD and MAZIC Duro) and thicknesses (1mm and 1.5mm). Materials and methods Blocks of CAD/CAM esthetic restorative…

View details →DOI: 10.1007/s44445-026-00145-z
Negative / Null Result ReportOpen accessMedicine

Clinical Investigation of Periodontal Health in Smoker and Nonsmoker Individuals.

Oweis YG, Bdour SAA, Abd-Raheam IM et al. · 2026 · International journal of dentistry

Background Vaping, argileh, and electronic cigarette (e-cigarette) smoking are becoming popular among adolescents and conventional smokers. While the impact of conventional smoking on oral tissues is well-established, the impact of other…

View details →DOI: 10.1155/ijod/7805251
Negative / Null Result ReportOpen accessMedicine

Comparison of Lower Limb Muscle Strength Imbalances and Gait Performance in Postmenopausal Women with Healthy and Low Bone Mineral Density.

Svobodová L, Kasović M, Vodicka T et al. · 2026 · International journal of women's health

Introduction Osteoporosis and osteopenia increase the risk of fractures, impair physical function, and may lead to loss of independence in postmenopausal women. This study examined differences in muscle strength imbalances and gait…

View details →DOI: 10.2147/ijwh.s597264
Negative / Null Result ReportOpen accessMedicine

Effect of Two Post-Curing Units on the Physico-Mechanical Properties of 3D-Printed Resins for Permanent Crown Fabrication.

Mujayridi M, Matinlinna J, Silikas N · 2026 · Materials (Basel, Switzerland)

Three-dimensional (3D) printing is increasingly used for the fabrication of definitive crowns; however, whether specific post-curing hardware is mandatory for clinical success remains a practical concern. This study provided a practical…

View details →DOI: 10.3390/ma19091886
Negative / Null Result ReportOpen accessMedicine

Thyroid hormones and energy metabolism in amyotrophic lateral sclerosis.

Novikova L, Lang C, Tumani H et al. · 2026 · Brain communications

Weight loss, partially caused by hypermetabolism, represents a well-documented and therapeutically relevant feature of the amyotrophic lateral sclerosis phenotype worldwide. In this study, we retrospectively analysed the association…

View details →DOI: 10.1093/braincomms/fcag198
Negative / Null Result ReportMedicine

Evaluation of the shoulder complex in individuals with type 2 diabetes: A cross-sectional study.

Türk B, Metin G, Fencki SM et al. · 2026 · Journal of bodywork and movement therapies

Background Type 2 diabetes mellitus (T2DM) can impair musculoskeletal function, affecting the shoulder's mobility, proprioception, and functional stability. Despite its growing prevalence, shoulder involvement in T2DM remains largely…

View details →DOI: 10.1016/j.jbmt.2026.05.011
Negative / Null Result ReportMedicine

Effect of oral health education by audio aids, braille, tactile models on the oral health status of visually impaired adults: a 6-month follow-up study.

Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health

Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…

View details →DOI: 10.1186/s12903-026-08692-x
Negative / Null Result ReportOpen accessMedicine

Osteosynthesis versus arthroplasty in the management of radial head fractures: a retrospective cohort study.

Sousa MM, Vieira LP, Pinho AR et al. · 2026 · JSES reviews, reports, and techniques

Background Radial head fractures are among the most common elbow injuries in adults. The choice between osteosynthesis and radial head arthroplasty (RHA) remains controversial, particularly in comminuted or unstable fracture patterns. This…

View details →DOI: 10.1016/j.xrrt.2026.100780
Negative / Null Result ReportOpen accessMedicine

Focus on comfort: the effect of focus language on postoperative hospital stay compared to the Numeric Rating Scale in children receiving postoperative care-a pre-post study.

Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics

This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…

View details →DOI: 10.1007/s00431-026-06932-4
Negative / Null Result ReportOpen accessMedicine

Early outcomes of transverse perineal support in obstructed defecation syndrome with pathological perineal descent; a prospective cohort study.

Azmy Basiouny HM, Shafik AA, Elbarmelgi MY et al. · 2026 · BMC surgery

Background While current surgical approaches for obstructed defecation syndrome (ODS) primarily target rectocele and rectal intussusception, excessive perineal descent (PD) may contribute to persistent symptoms and suboptimal surgical…

View details →DOI: 10.1186/s12893-026-03888-y
Negative / Null Result ReportOpen accessMedicine

The effect of gastrojejunostomy on carbohydrate metabolism in patients with pancreatic cancer.

Grząsiak-Kraj O, Majos A, Durczyński A et al. · 2026 · Przeglad gastroenterologiczny

Introduction Impaired glucose metabolism and diabetes frequently accompany pancreatic cancer. In patients with unresectable disease, palliative gastrojejunostomy is commonly performed to relieve gastrointestinal obstruction; however, its…

View details →DOI: 10.5114/pg.2026.160484
Negative / Null Result ReportOpen accessMedicine

Assessment of changes in selected parameters of Arnett's soft tissue cephalometric analysis (STCA) in patients undergoing SARME/SARPE.

Nowak R, Olejnik A, Zawiślak E et al. · 2026 · Head & face medicine

Background Maxillary constriction in adults often requires surgically assisted maxillary expansion. While skeletal and dental changes are well described, soft-tissue effects remain less clear. This study evaluated soft-tissue changes using…

View details →DOI: 10.1186/s13005-026-00616-y