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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21294 results · page 323 of 710

Negative / Null Result ReportOpen accessMedicine

Lifelong cognitive and motor outcomes after being born small for gestational age or with fetal growth restriction.

Ventura GC, Ryan H, Yu HN et al. · 2026 · World journal of clinical pediatrics

Children born with fetal growth restriction (FGR) or small for gestational age (SGA) face an increased risk of motor and cognitive impairments, although prevalence and severity vary across studies due to differences in definitions,…

View details →DOI: 10.5409/wjcp.v15.i2.115027
Negative / Null Result ReportMedicine

Lack of Effect of Propranolol on the Reconsolidation of Conditioned Fear Memory due to a Failure to Engage Memory Destabilisation.

Rotondo F, Biddle K, Chen J et al. · 2022 · Neuroscience

The prospect of exploiting memory reconsolidation to treat mental health disorders has received great research interest, particularly following demonstrations that the β-adrenergic receptor antagonist propranolol, which is safe for use in…

View details →DOI: 10.1016/j.neuroscience.2021.11.008
Negative / Null Result ReportOpen accessMedicine

Assessing Large Language Models for Early Article Identification in Otolaryngology-Head and Neck Surgery Systematic Reviews.

Bakare AB, Lee Y, Hong J et al. · 2026 · Health care science

Background Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology-Head and Neck Surgery systematic literature reviews. Methods Three PRISMA-based systematic reviews (Jabbour et al. 2017, Wong…

View details →DOI: 10.1002/hcs2.70048
Negative / Null Result ReportOpen accessMedicine

Human keratinocytes exhibit limited potential for SARS-CoV-2 infection despite ACE2 and mature cathepsin L expression.

Hertereau L, Barthe M, Lamghari N et al. · 2026 · JID innovations : skin science from molecules to population health

The distribution of receptors and cellular factors across tissues determines differential susceptibility of cells to viral infection. For severe acute respiratory syndrome coronavirus 2, viral spike and nucleocapsid proteins have been…

View details →DOI: 10.1016/j.xjidi.2025.100447
Negative / Null Result ReportMedicine

Evaluation of molecular and serological diagnostics for dengue during the 2023 outbreak in Jember, East Java, indonesia.

Sani LM, Senjarini K, Steinke S et al. · 2025 · Diagnostic microbiology and infectious disease

Background Dengue virus (DENV) is a major public health concern in Indonesia, with all four serotypes contributing to recurrent outbreaks. This study evaluated molecular diagnostic tests for DENV and identified circulating serotypes…

View details →DOI: 10.1016/j.diagmicrobio.2025.117050
Negative / Null Result ReportOpen accessMedicine

Identity by descent and local ancestry mapping of HCV spontaneous clearance in populations of diverse ancestries.

Yu Z, Abdel-Azim S, Duggal P et al. · 2025 · BMC genomics

Background Acute infection with hepatitis C virus (HCV) affects millions of individuals worldwide. Host genetics plays a role in spontaneous clearance of the acute infection which occurs in approximately 30% of the individuals. Common…

View details →DOI: 10.1186/s12864-024-11076-6
Failed Experiment ReportMedicine

High-fidelity detection and quantification of acoustic startle response in freely moving mice in an open field.

Shivashankar P, Agee LA, Wilson N et al. · 2025 · Journal of neuroscience methods

Background Acoustic startle response (ASR) is an involuntary reflex to an intense acoustic stimulus, characterized by rapid muscle contractions. Traditional ASR testing requires animals to be placed in spatially confining chambers to…

View details →DOI: 10.1016/j.jneumeth.2025.110497
Failed Experiment ReportOpen accessMedicine

Preliminary Results on How Longer Facial Hair Lengths May Interfere With N95 Respirator Efficacy: A Brief Report.

da Eira Silva V, Abele M, Bercovitz I et al. · 2025 · Workplace health & safety

Background The use of the N95 respirator outside work environments calls for a deeper understanding of the factors that interfere with its fitting, thus effectiveness. Here we determined how beard length influences N95 effectiveness. This…

View details →DOI: 10.1177/21650799241230039
Negative / Null Result ReportOpen accessMedicine

Individual and combined effects of ischemic conditioning strategies on infarct size after myocardial ischemia reperfusion.

Elmahdy A, Krasnikova M, Jha A et al. · 2025 · Scientific reports

Ischemic preconditioning (PreC), remote perconditioning (PerC), and postconditioning (PostC) are known to reduce myocardial infarct size, but their relative efficacy and potential additive effects remain unclear. This study compared the…

View details →DOI: 10.1038/s41598-025-17442-y
Negative / Null Result ReportMedicine

Dosimetric Parameters Related to Local Control and Rate of Distant Metastases in NSCLC SBRT Patients.

Lalonde RJ, Keller A, Huq S · 2021 · International journal of radiation oncology, biology, physics

Purpose/objective(s) Previous studies have suggested that the dose immediately outside the PTV may impact the incidence of distant metastases after stereotactic body radiation therapy (SBRT) for patients with early-stage non-small cell…

View details →DOI: 10.1016/j.ijrobp.2021.07.1251
Negative / Null Result ReportOpen accessMedicine

Re-evaluating transcranial static magnetic stimulation (tSMS): No inhibitory effects on motor cortex across hemispheres.

Lorenz S, Bartusch L, Heusler C et al. · 2026 · Clinical neurophysiology practice

Objective To investigate whether transcranial static magnetic stimulation (tSMS) exerts inhibitory effects on the human motor cortex and whether these effects differ between dominant and non-dominant hemispheres. Methods Participants…

View details →DOI: 10.1016/j.cnp.2026.02.008
Negative / Null Result ReportOpen accessMedicine

Feasibility of non-invasive neuromonitoring using BIS and NIRS during endovascular treatment of acute ischemic stroke.

Batra D, Chen M, Meis J et al. · 2025 · Neurological research and practice

Background Endovascular thrombectomy (EVT)-often combined with intravenous thrombolysis-is the standard of care for acute ischemic stroke (AIS) secondary to large vessel occlusions (LVO). While indications keep expanding, the feasibility…

View details →DOI: 10.1186/s42466-025-00420-0
Negative / Null Result ReportOpen accessMedicine

Impact of Father Involvement and Positive Parenting on Child Mental Health: Insights From a Survey of Ugandan Households.

Asiimwe R, Welch T, Dwanyen L et al. · 2026 · Family process

The influence of father positive parenting and involvement on children's mental health outcomes is underexplored in many sub-Saharan African countries, such as Uganda, despite research showing that fathers play a critical role in shaping…

View details →DOI: 10.1111/famp.70144
Negative / Null Result ReportOpen accessMedicine

The serotonin transporter and the serotonin 1B receptor in relation to social cognition in healthy adults.

Griffioen G, Tangen Ä, Veldman E et al. · 2026 · EJNMMI research

BACKGROUND: Social cognition is impaired across multiple psychiatric disorders and varies dimensionally in the general population. Studying healthy adults can therefore inform mechanisms relevant for social cognition. This study aimed to…

View details →DOI: 10.1186/s13550-026-01435-7
Negative / Null Result ReportOpen accessMedicine

Dyslexia Polygenic Index and Socio-Economic Status Interaction Effects on Reading Skills in Australia and the United Kingdom.

Bicona D, Mountford HS, Bridges EC et al. · 2025 · Behavior genetics

Literacy is a significant predictor of important life outcomes, such as attained education and income (Ritchie and Bates in Psychol Sci 24(7):1301-1308, 2013. 10.1177/0956797612466268) yet difficulties in reading and spelling are common.…

View details →DOI: 10.1007/s10519-025-10230-4
Negative / Null Result ReportOpen accessMedicine

The Impact of Baseline Anxiety on Drug Placebo Separation and Drug/Placebo Response in an Acute Schizophrenia Clinical Trial-A Post-hoc Analysis.

Kott A, Brannan S, Wang X et al. · 2023 · Schizophrenia bulletin open

Objectives We sought to evaluate the impact of baseline anxiety levels on drug placebo separation and drug and placebo response in acutely psychotic schizophrenic subjects. Methods In this post-hoc analysis, modified intent-to-treat…

View details →DOI: 10.1093/schizbullopen/sgad003
Negative / Null Result ReportOpen accessMedicine

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense.

Jhelum H, Schäfer R, Kaufer BB et al. · 2025 · Viruses

Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from…

View details →DOI: 10.3390/v18010021
Negative / Null Result ReportOpen accessMedicine

Anodal transcranial direct current stimulation does not alter GABA concentration or functional connectivity in the normal visual cortex.

Abuleil D, Gorbet D, McCulloch DL et al. · 2025 · Frontiers in neuroscience

Introduction Anodal direct current stimulation (a-tDCS) of the visual cortex is a potential rehabilitation tool for vision disorders such as amblyopia and macular degeneration. However, the underlying neural mechanisms are currently…

View details →DOI: 10.3389/fnins.2025.1639838
Negative / Null Result ReportOpen accessMedicine

Role of Zinc and Magnesium in Glycemic Status Among the Saudi Population.

Almajed N, Al-Musharaf S, Aldhwayan MM et al. · 2025 · International journal of general medicine

Purpose Certain trace minerals, such as zinc (Zn) and magnesium (Mg), may play a role in glucose regulation and insulin signaling pathways. However, population data from the Middle East are scarce and may differ in terms of dietary and…

View details →DOI: 10.2147/ijgm.s565497
Negative / Null Result ReportOpen accessMedicine

Large-sided games do not replicate the positional worst-case scenarios of official matches in professional football.

Herzig L, Stöckert J, Lochmann M et al. · 2026 · Frontiers in sports and active living

The aim of this study was to determine if positional Worst-Case-Scenarios (WCS) during official games (OG) are replicated in Large-Sided Games (LSG) with a similar Area per Player (ApP) as OG. Twenty-one football players from the second…

View details →DOI: 10.3389/fspor.2026.1797322
Replication FailureOpen accessMedicine

Awake targeted memory reactivation doesn't work.

Hoffman LJ, Foley JM, Tanrıverdi B et al. · 2025 · Memory & cognition

Memories are pliable and can be biased by post-encoding information. In targeted memory reactivation (TMR) studies, participants encode information then sleep, during which time sounds or scents that were previously associated with the…

View details →DOI: 10.3758/s13421-024-01576-x