e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 322 of 724

Negative / Null Result ReportMedicine

Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.

Lao J, Wei Y, Liu F et al. · 2025 · European journal of nutrition

Purpose Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort. Methods Women participating…

View details →DOI: 10.1007/s00394-025-03650-9
Negative / Null Result Report

Dynamic risk and protective factors in mentally disordered offenders: forensic psychiatry treatment monitoring, prison release and length of stay

Weber K, Magnenat L, Morier S et al. · 2024 · Preprint

Abstract Background The reduction of violence risk and crime recidivism is the core marker of progress in forensic psychiatry treatment for mentally disordered offenders, and commonly used to decide prison release. While dynamic risk is…

View details →DOI: 10.21203/rs.3.rs-5296154/v1
Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

View details →DOI: 10.1089/lap.2024.0280
Negative / Null Result ReportOpen accessMedicine

Inflammation in atherosclerosis: a Big Idea that has underperformed so far.

Williams KJ · 2025 · Current opinion in lipidology

Purpose of review For many years, inflammation has been a major concept in basic research on atherosclerosis and in the development of potential diagnostic tools and treatments. The purpose of this review is to assess the performance of…

View details →DOI: 10.1097/mol.0000000000000973
Negative / Null Result Report

The Ability to Predict the Progression of the Change in Oct Angiography Values in the Visional Field and Retina Nerve Layer Tomography in Patients With Glaucoma Progress

Demir S, KÖYLÜ MT · 2023 · Preprint

INTRODUCTION To examine the ability of changes in optical coherence tomography angiography (OCTA) values to predict progression in the visual field (GA) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. METHODS…

View details →DOI: 10.21203/rs.3.rs-3778080/v1
Negative / Null Result ReportOpen accessMedicine

Evaluating the risk of atrial fibrillation in patients with chronic recurrent pericarditis prescribed colchicine: Observations using TriNetX global federated research network.

Kaşkal M, Bucci T, Alobaida M et al. · 2025 · European journal of clinical pharmacology

BACKGROUND: Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory…

View details →DOI: 10.1007/s00228-025-03925-4
Negative / Null Result ReportOpen accessMedicine

Surveillance after treatment for head and neck cancer.

Koivunen P · 2026 · Current opinion in otolaryngology & head and neck surgery

Purpose of review Systematic follow-up protocols, often including regular imaging, are an essential component of posttreatment care for head and neck cancer, aimed at the early detection of disease relapse and mitigating treatment-related…

View details →DOI: 10.1097/moo.0000000000001102
Negative / Null Result ReportOpen accessMedicine

Hyperthermic intraperitoneal chemotherapy plus SOX chemotherapy versus SOX chemotherapy alone in patients with gastric cancer and peritoneal metastasis: a phase II randomized clinical trial.

Luo L, Zhang Z, Zeng H et al. · 2025 · Journal of gastrointestinal oncology

Background The prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with…

View details →DOI: 10.21037/jgo-24-807
Negative / Null Result ReportOpen accessMedicine

Absence of lipopolysaccharide (LPS) expression in breast cancer cells.

de Miranda NFCC, Smit VTHBM, van der Ploeg M et al. · 2025 · Cellular oncology (Dordrecht, Netherlands)

The relationship between bacterial activity and tumorigenesis has gained attention in recent years, complementing the well-established association between viruses and cancer. A recent study employed immunodetection of lipopolysaccharide…

View details →DOI: 10.1007/s13402-025-01071-8
Negative / Null Result ReportOpen accessMedicine

Use of baloxavir as adjunctive antiviral therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with influenza.

Vetter P, Cabecinhas ARG, Schibler M et al. · 2026 · Antimicrobial agents and chemotherapy

Immunocompromised patients are at risk of developing severe influenza, with protracted viral shedding and development of resistance-associated mutations under antiviral treatment. We report a case series of severely immunocompromised…

View details →DOI: 10.1128/aac.01659-25
Negative / Null Result ReportMedicine

Leukocyte-Poor Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy A Multicenter, Randomized Controlled Trial.

Herrero C, Wasterlain A, Bloom DA et al. · 2024 · Bulletin of the Hospital for Joint Disease (2013)

Purpose The purpose of this study was to compare regimens of eccentric exercise and dry-needling, with and without an ultrasound-guided leukocyte-poor platelet-rich plasma (LP-PRP) injection, in patients with patellar tendinopathy. Methods…

Negative / Null Result ReportOpen accessMedicine

An analytical observational study for diagnostic accuracy of volume, conductivity & scatter (VCS) indices of neutrophils for diagnosis of sepsis in an emergency hospital setting.

Bharti A, Palta A, Bedi RK et al. · 2024 · The Indian journal of medical research

Background & objectives The newer technique using an innovative volume conductivity scatter (VCS) technology is emerging as a surrogate for sepsis diagnosis. The VCS technology offers a more objective method to measure cell volume (V),…

View details →DOI: 10.25259/ijmr_1898_23
Negative / Null Result ReportOpen accessMedicine

In Vitro Assessment of the Potential Effect of Vertical Peri-Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods.

Rahner A, Eickholz P, Gueth JF et al. · 2025 · Clinical oral implants research

Objectives In vitro analysis of the influence of vertical peri-implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and methods A total of 360 implants were dipped in indelible…

View details →DOI: 10.1111/clr.14415
Negative / Null Result ReportMedicine

Comparison of computed tomography findings between perianal tumors originating from the anal sacs and perianal glands in dogs.

Jeong J, Goh J, Nam C et al. · 2025 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

Tumors originating from the anal sacs and perianal glands are common tumors of the perianal region. However, differentiation of perianal tumors based on CT findings remains challenging because perianal tumors can show overlapping CT…

View details →DOI: 10.1111/vru.13453
Failed Experiment ReportMedicine

Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.

Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…

View details →DOI: 10.1093/cid/ciaf038
Negative / Null Result ReportOpen accessMedicine

A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice.

Sewell KM, Oriakhi K, Ngo Tenlep SY et al. · 2026 · Ecotoxicology and environmental safety

Organophosphate flame retardants (OPFRs) are used in many consumer products, and their presence in our environment raises concerns about potential health dangers. In humans, exposure to OPFRs, such as tris(1,3-dichloro-2-propyl) phosphate…

View details →DOI: 10.1016/j.ecoenv.2026.119827
Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

View details →DOI: 10.31138/mjr.300924.ioe
Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

View details →DOI: 10.1186/s41927-025-00505-y
Negative / Null Result ReportMedicine

Robotic carotid artery stenting: a multicenter, propensity score-matched analysis of clinical outcomes and cost-effectiveness.

Patel SA, Roy JM, Musmar B et al. · 2024 · Neurosurgical focus

Objective Preclinical studies suggest that robotic carotid artery stenting (CAS) could be superior to manual CAS. However, very limited comparative data exist for patients who have undergone robotic versus manual CAS. In addition, no data…

View details →DOI: 10.3171/2024.9.focus24479
Negative / Null Result ReportMedicine

The level of agreement between the numerical rating scale and visual analogue scale for assessing pain intensity in adults with chronic pain.

Goudman L, Pilitsis JG, Billet B et al. · 2024 · Anaesthesia

The numerical rating scale and visual analogue scale are used to quantify pain intensity. However, it has not yet been explored whether these scores are interchangeable in adults with chronic pain. Data from the prospective multicentre…

View details →DOI: 10.1111/anae.16151
Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

View details →DOI: 10.5489/cuaj.9121