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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 313 of 710

Negative / Null Result ReportMedicine

The Role of Corticosteroids in the Management of Orbital Cellulitis: A Report by the American Academy of Ophthalmology.

Wladis EJ, Aakalu VK, Dagi Glass LR et al. · 2026 · Ophthalmology

Objective To review the literature on the benefits and risks of systemic corticosteroids in the setting of orbital cellulitis. Methods A literature search was last performed in the PubMed database in August 2025. Articles were limited to…

View details →DOI: 10.1016/j.ophtha.2026.03.015
Negative / Null Result ReportMedicine

Do MRI radiomic models truly generalize? External validation of three studies in parotid lesion characterization.

Benyoucef R, Goubet M, Barrat A et al. · 2026 · European radiology

Objectives External validation of six radiomic models published in three studies: two distinguishing benign from malignant lesions (study 1) and four distinguishing pleomorphic adenomas from Warthin's tumors (studies 2 and 3). Materials…

View details →DOI: 10.1007/s00330-026-12512-9
Negative / Null Result ReportMedicine

Registered Report: A Replication Examining Occupational Experience and Performance on the Water-Level Task.

Tenney ER, Rochford K, Stillwell A et al. · 2026 · Psychological science

This is a registered report to directly replicate the primary finding in Hecht and Proffitt (1995). Hecht and Proffitt found that those with occupational experience handling liquid in containers performed worse at solving a water-level…

View details →DOI: 10.1177/09567976251412721
Negative / Null Result ReportMedicine

A Replication and Extension of Three Studies Investigating Escalation of Commitment and Regret Aversion.

Dhanda N, Ziano I, Ching KH et al. · 2025 · Personality & social psychology bulletin

This article presents preregistered replications of three influential studies in the field of escalation of commitment and regret aversion. In Study 1, we found partial support for Staw's (1976) article on the effects of personal…

View details →DOI: 10.1177/01461672251345021
Negative / Null Result Report

Re-examining the effect of inoculation messages on anti-vaccine conspiracy attitudes: A conceptual replication of Banas et al (2023)

Adinugroho I, Bentall R, Stafford T · 2025 · Preprint

This is the first study to attempt replication of Banas et al (2023) on inoculation messages. The original experiment demonstrated that inoculation messages could stimulate resistance to anti-vaccine conspiracy theories. However, a gap was…

View details →DOI: 10.31234/osf.io/d3x9p_v4
Negative / Null Result Report

Re-examining the effect of inoculation messages on anti-vaccine conspiracy attitudes: A conceptual replication of Banas et al (2023)

Adinugroho I, Bentall R, Stafford T · 2025 · Preprint

This is the first study to attempt replication of Banas et al (2023) on inoculation messages. The original experiment demonstrated that inoculation messages could stimulate resistance to anti-vaccine conspiracy theories. However, a gap was…

View details →DOI: 10.31234/osf.io/d3x9p_v2
Negative / Null Result Report

Ranschburg Unrepeated

Remouchamps R, Majerus S, Kowialiewski B · 2025 · Preprint

In verbal working memory (WM), the second occurrence of an item in a memory list generally leads to impaired recall performance, a phenomenon called the “Ranschburg effect”. One explanation for this effect is response suppression, by which…

View details →DOI: 10.31234/osf.io/3zmje_v1
Negative / Null Result ReportMedicine

Newborn Auditory Brainstem Response and Sudden Infant Death Syndrome.

Maylott SE, Zeng G, Leung TS et al. · 2025 · Journal of neuroscience research

Sudden infant death syndrome (SIDS)-the sudden and unexplained death of a seemingly healthy infant, < 1 year old-may be associated with abnormalities in the brain regions that underlie breathing and arousal during sleep. While post-mortem…

View details →DOI: 10.1002/jnr.70083
Negative / Null Result ReportOpen accessMedicine

Shedding light on public perceptions of scientists who engage in wrongness admission amidst a failed replication.

Evans ND, Fetterman AK · 2026 · Public understanding of science (Bristol, England)

Admitting that one's research findings are wrong involves admitting a potential instance of incompetence, which can keep scientists from engaging in wrongness admission. However, wrongness admission can yield favorable perceptions. In five…

View details →DOI: 10.1177/09636625251372820
Negative / Null Result ReportMedicine

Towards distinguishing intra-canal and paraspinal cavitation activity during focused ultrasound exposures in the spine.

Frizado AP, O'Reilly MA · 2025 · Physics in medicine and biology

Objective. Although less established than transcranial focused ultrasound (FUS), transvertebral FUS is being developed to treat spinal cord pathologies. Transvertebral sonication of the spinal cord for microbubble-mediated drug delivery…

View details →DOI: 10.1088/1361-6560/ae0f36
Negative / Null Result Report

Ptbp1 is not required for retinal neurogenesis and cell fate specification

Appel H, Carmen-Orozco RP, Santiago CP et al. · 2025 · Preprint

The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that…

View details →DOI: 10.1101/2025.07.02.662808
Negative / Null Result Report

Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification

Van der Snickt T, Ailliet S, Bassini S et al. · 2025 · Preprint

Enzyme-free isothermal amplification methods offer a promising alternative to enzymatic assays for nucleic acid detection, particularly in low-resource settings. The nonenzymatic isothermal strand displacement and amplification (NISDA)…

View details →DOI: 10.1101/2025.05.19.654176
Negative / Null Result Report

Metascientific replication project with the advanced meta-experimental protocol of the transparent psi project procedures for testing the precognitive effect claimed by Bem

Walleczek J, von Stillfried N, Schmidt S et al. · 2025 · Preprint

This metascientific project studied the replicability of Bem Experiment 1, which had claimed a precognitive effect, i.e., the ability to successfully guess the outcome of future random events (Bem. J Pers Soc Psychol. 2011;100: 407-25).…

View details →DOI: 10.31234/osf.io/53ckh_v1
Negative / Null Result ReportMedicine

Exploring a novel method for inoculation to experimentally induce digital dermatitis in dairy calves.

Petersen Dias A, Orsel K, Gammariello CS et al. · 2025 · Research in veterinary science

Digital dermatitis (DD) is a polymicrobial, multifactorial hoof disorder with an undefined etiology, and existing animal models fail to induce a fast, standardized infection in bovine skin. This study explored bacterial inoculation methods…

View details →DOI: 10.1016/j.rvsc.2025.105794
Negative / Null Result ReportMedicine

Preregistered Direct Replication and Extension of "The Wisdom to Know the Difference: Strategy-Situation Fit in Emotion Regulation in Daily Life Is Associated With Well-Being".

Willroth EC, Young G, Ford BQ et al. · 2025 · Psychological science

Certain emotion-regulation strategies (e.g., reappraisal) are associated with better well-being and are therefore seen as adaptive (health-promoting) strategies. However, it is unlikely that any strategy is adaptive regardless of context.…

View details →DOI: 10.1177/09567976251335567
Negative / Null Result ReportMedicine

A Multidimensional Preclinical Investigation of the Biogenic Amine Depletion and Subchronic Swim Models of Fibromyalgia.

Argenbright CM, Scully IF, Flores D et al. · 2025 · The journal of pain

Pain is a multidimensional phenomenon, encompassing affective-motivational, cognitive-evaluative, and sensory-discriminative domains. Understanding these components is crucial for effective diagnosis and management, particularly in…

View details →DOI: 10.1016/j.jpain.2025.105486
Negative / Null Result ReportMedicine

Multimodal assessments of therapist characteristics are largely unrelated to patient outcomes: A preregistered analysis.

Goldberg SB, Baldwin SA, Flynn AWP et al. · 2026 · Clinical psychological science : a journal of the Association for Psychological Science

While it is known that therapists vary in effectiveness, it is unclear what therapist-level characteristics predict this variation. We conducted a large-scale, preregistered study ( n = 97 therapists from the United States and Canada, n =…

View details →DOI: 10.1177/21677026261424222
Negative / Null Result Report

Re-examining the effect of inoculation messages on anti-vaccine conspiracy attitudes: A conceptual replication of Banas et al (2023)

Adinugroho I, Bentall R, Stafford T · 2025 · Preprint

This is the first study to attempt replication of Banas et al (2023) on inoculation messages. The original experiment demonstrated that inoculation messages could stimulate resistance to anti-vaccine conspiracy theories. However, a gap was…

View details →DOI: 10.31234/osf.io/d3x9p_v1
Negative / Null Result Report

From “Bob/Kirk” to “Błażej/Piotrek” Effect – Replication of Social Bias Effect Towards People Whose Names Match Their Faces

Stawiany K, Kozak K, Sokołowska Z · 2025 · Preprint

The study explores the hypothesis that individuals show greater sympathy towards coherent name-face pairs compared to incoherent pairs, replicating the effect observed by Barton and Halberstadt. A structured questionnaire was designed…

View details →DOI: 10.20944/preprints202501.0057.v1