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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 313 of 724

Negative / Null Result ReportOpen accessMedicine

Safety of flexible bronchoscopy in elderly patients.

Spiegel S, Hübner RH, Schürmann D et al. · 2026 · BMC pulmonary medicine

Background Flexible bronchoscopy is an indispensable tool in respiratory medicine. In the context of an aging society and increasing life expectancy, the number of elderly, often multimorbid patients is growing. This raises important…

View details →DOI: 10.1186/s12890-026-04326-8
Negative / Null Result ReportMedicine

Preclinical and clinical evaluation of a new flexible high pressure injection knife for endoscopic submucosal dissection.

Olivier R, Albouys J, Juglard C et al. · 2026 · Scientific reports

We studied a newly developed high-pressure injection flexible knife, to offer potential procedural simplification in colorectal Endoscopic Submucosal Dissection (ESD). Animal study: open randomized controlled study using an anesthetized…

View details →DOI: 10.1038/s41598-026-37018-8
Negative / Null Result ReportOpen accessMedicine

Effect of conventional warm-up versus stretching warm-up on physical performance in children soccer players: a randomized crossover trial.

Hernandez-Martínez J, Cid-Calfucura I, Perez-Carcamo J et al. · 2026 · Frontiers in physiology

Introduction To evaluate the effects of the conventional warm-up (CC) compared to warm-ups that included static (SSC), dynamic (DSC), or ballistic (BSC) stretching on jump performance (CMJ, SJ, DJ), curve sprint speed, agility (ICODT), and…

View details →DOI: 10.3389/fphys.2026.1827385
Negative / Null Result ReportOpen accessMedicine

Assessment of pain and post-injection induration in children: A comparative study of cold application, manual pressure, and shot blocker techniques.

Sasireka V, Bhuvaneswari G, Babu S · 2026 · Journal of education and health promotion

Background Intramuscular (IM) injections are widely used in pediatric care but often cause pain and distress. Effective management is essential to improve children's healthcare experiences. Non-pharmacological methods, including Cold…

View details →DOI: 10.4103/jehp.jehp_1383_25
Negative / Null Result ReportOpen accessMedicine

Critical care ultrasound evaluation of snuffbox artery vascular tension: a prospective observational study between healthy volunteers and intensive care unit patients.

Qin Y, Zhu Y, Dai X et al. · 2026 · Frontiers in medicine

Background Systemic vascular resistance is conventionally assessed using invasive methods; the snuffbox artery resistance index (RI) is a superior non-invasive predictor of lactate clearance in septic shock patients to the perfusion index.…

View details →DOI: 10.3389/fmed.2026.1722497
Negative / Null Result ReportMedicine

Comparing video-assisted and verbal explanations in Japanese hospital dentistry: patient evaluations in third molar extraction and medical-dental collaborative care.

Matsumoto K, Mitani I, Tsutsui T et al. · 2026 · BMC medical informatics and decision making

Background Video-assisted explanations may support standardized patient information delivery, but their role in hospital dentistry remains insufficiently evaluated. This study aimed to compare patient evaluations of video-assisted and…

View details →DOI: 10.1186/s12911-026-03643-6
Negative / Null Result ReportOpen accessMedicine

Retinal microvascular alterations in children with amblyopia.

Al-Haddad C, Ibrahim H, Salameh N et al. · 2026 · PloS one

Purpose To investigate and compare retinal vascular changes, including superficial macular vessel density, foveal avascular zone, and the macular perfusion densities, in amblyopic, fellow, and control eyes using optical coherence…

View details →DOI: 10.1371/journal.pone.0351232
Negative / Null Result ReportMedicine

Validity of optical coherence tomography angiography in the differential diagnosis of papilledema and pseudopapilledema.

Cerdan-Hernandez E, Palencia-Herranz MJ, Barón M et al. · 2026 · Journal of optometry

Purpose To assess the value of optical coherence tomography angiography (OCTA) peripapillary retinal vascularization in differentiating papilledema from pseudopapilledema. Methods A cross-sectional study, prospective recruitment patients…

View details →DOI: 10.1016/j.optom.2026.100617
Negative / Null Result ReportMedicine

Influence of X-ray beam angulation on the radiographic detection of implant-abutment interface misfits: A quantitative in vitro analysis.

Terzioglu H, Efeoglu S, Sarikaya CH et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose This study evaluated the effect of periapical X-ray angulation on the diagnostic accuracy of detecting vertical misfits at the implant-abutment interface using Medentika Microcone dental implants (4.0 mm diameter, 11 mm length;…

View details →DOI: 10.1111/jopr.70178
Negative / Null Result Report

Study on the Role of Intraoperative Dexamethasone and Furosemide in Preventing SIRS After Endourological Lithotripsy for Upper Urinary Tract Calculi

Tu X, Zhuang X, Zhao T et al. · 2026 · Preprint

Abstract Objective: To investigate the effects of intraoperative dexamethasone, furosemide, and their combination on systemic inflammatory response syndrome (SIRS) after endourological lithotripsy for upper urinary tract calculi, and…

View details →DOI: 10.21203/rs.3.rs-9201287/v1
Negative / Null Result ReportOpen accessMedicine

Effects of dietary chitin supplementation on body weight, haematology and serum biochemistry, fecal scores and gut microbiota of captive pangolins.

Wang X, Xie C, Zheng R et al. · 2026 · Animal microbiome

Termites are a natural component of the diet of Malayan pangolins, whereas artificial diets used under captive conditions may differ substantially from wild prey in structure and composition, particularly in chitin content. This study…

View details →DOI: 10.1186/s42523-026-00576-3
Negative / Null Result ReportOpen accessMedicine

Transspinal direct current stimulation as targeted therapy to increase motor neuron output and restore inhibition in human spinal cord injury.

Sayed Ahmad AM, Knikou M · 2026 · Frontiers in neurology

Introduction In this clinical trial, we evaluated changes in the output of motoneurons and spinal inhibitory mechanisms across multiple spinal segments before and after a series of transspinal direct current stimulation (tsDCS) sessions in…

View details →DOI: 10.3389/fneur.2026.1773679
Negative / Null Result ReportOpen accessMedicine

Preclinical Analysis of Sex-Specific Differences in the Angiogenic and Inflammatory Tissue Response to Surgical Sutures.

Wrublewsky S, Weigl J, Bickelmann C et al. · 2026 · Journal of functional biomaterials

Surgical sutures are widely used biomaterials in clinical practice. Like all other biomaterials, they induce a foreign body response after implantation that involves inflammation and angiogenesis. Although it is well known that these…

View details →DOI: 10.3390/jfb17050233
Negative / Null Result ReportOpen accessMedicine

N95 filtering facepiece respirator fit assessment outcomes by gender, age, race, and facial hair in a community population sample.

Bagheri Hosseinabadi M, Yu M, Petersen A et al. · 2026 · Annals of work exposures and health

The necessity for respiratory protection has increased due to global threats such as pandemics, industrial accidents, and extreme weather events. The effectiveness of N95 filtering facepiece respirators depends on how well they fit the…

View details →DOI: 10.1093/annweh/wxag050
Negative / Null Result ReportMedicine

Comparable survival over an extended follow-up after on-pump versus off-pump coronary artery bypass grafting: a propensity score-matched cohort.

Pikkujämsä A, Rinne P, Wistbacka JO et al. · 2026 · BMC cardiovascular disorders

Background Long-term survival following off-pump coronary artery bypass grafting (OPCAB) compared with conventional on-pump coronary artery bypass grafting (ONCAB) remains uncertain. Randomised trials and meta-analyses up to 5-10 years…

View details →DOI: 10.1186/s12872-026-06117-9
Negative / Null Result ReportMedicine

Impact of music intervention on endoscopic retrograde cholangiopancreatography patients' pain, anxiety, and vital signs: a randomized controlled trial.

Çakır E, Ciğerci Y, Yılmaz S · 2026 · Scientific reports

This study aimed to evaluate the effects of a music intervention on anxiety, pain, and vital signs in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). This randomized controlled trial included 70 patients who…

View details →DOI: 10.1038/s41598-026-50809-3
Negative / Null Result ReportMedicine

Automated Rigo Classification: An Innovative Artificial Intelligence System.

Schmidt N, Johnson G, Nencka A et al. · 2026 · Studies in health technology and informatics

Although there is variation in clinicians' application of the Rigo classification system (RCS) to adolescent idiopathic scoliosis, no artificial intelligence (AI) models have been developed to standardize the RCS specifically. This study…

View details →DOI: 10.3233/shti260751
Negative / Null Result ReportOpen accessMedicine

Effects of Combined Extreme Warming and Drought on the Physiology and Growth of <i>Quercus variabilis</i> Blume Seedlings.

Lee SH, Jang JW, Han SH et al. · 2026 · Plants (Basel, Switzerland)

Climate change is intensifying extreme climatic events such as warming and drought. This study investigated the physiological and growth responses of Quercus variabilis , a major broadleaf plantation species in South Korea, to warming and…

View details →DOI: 10.3390/plants15091354
Abandoned HypothesisOpen accessMedicine

Emotion regulation skills training for adolescents and parents in a clinical setting: a randomised controlled trial.

Holmqvist Larsson K, Falkenström F, Andersson G et al. · 2026 · Child and adolescent psychiatry and mental health

Background Emotion dysregulation is a transdiagnostic construct associated with psychiatric symptomatology. Improving strategies to regulate emotions is an important focus in several psychological treatments. In the current study we…

View details →DOI: 10.1186/s13034-026-01098-1
Negative / Null Result ReportMedicine

Three-year retinal and visual outcomes after ultraviolet- and blue light-filtering intraocular lenses.

Ceylan FA, Tatar Kartaloğlu O, Yılmaz İE · 2026 · Clinical & experimental optometry

Clinical relevance Intraocular lens selection following cataract surgery has implications beyond refractive correction, with different lens chromophore compositions potentially affecting retinal light exposure and downstream visual and…

View details →DOI: 10.1080/08164622.2026.2688367
Abandoned HypothesisOpen accessMedicine

Implantation of a Continuous-Flow Left Ventricular Assist Device During Cardiopulmonary Bypass Is Associated with a Significant and Transient Acute Thromboinflammatory Response.

Gerogianni A, Sørensen G, Hoel TN et al. · 2026 · International journal of molecular sciences

Left ventricular assist device (LVAD) implantation is a life-saving therapy for end-stage heart failure but may compromise immune integrity. Mechanical shear stress and surface-induced innate immune activation can trigger bleeding and…

View details →DOI: 10.3390/ijms27104594
Negative / Null Result ReportMedicine

Mid-term clinical outcomes of mobile-bearing UKA: a retrospective study on the influence of patellofemoral joint disease, lower limb alignment, and implant positioning.

Chen M, Zhang C, Fan Z et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) has become an effective treatment for medial compartment osteoarthritis of the knee. However, its use in patients who also have patellofemoral joint osteoarthritis (PFOA) before surgery…

View details →DOI: 10.1186/s12891-026-10086-7
Negative / Null Result ReportOpen accessMedicine

Deficit irrigation and grafting effects on soil attributes, vegetative growth, yield components, and quality of 'Crimson Seedless' grapevines under a semiarid region.

Salama AM, Al-Obeed RS, Helmy A et al. · 2026 · Frontiers in plant science

This study evaluated the combined effects of grafting and deficit irrigation (DI) on soil attributes, vegetative growth, yield components, fruit quality, and water productivity of 'Crimson Seedless' grapevines under semiarid conditions. It…

View details →DOI: 10.3389/fpls.2026.1785340
Negative / Null Result ReportOpen accessMedicine

Fiber-to-stone distance and fragment size with holmium laser lithotripsy.

Glienke L, Hall TL, Ghani KR et al. · 2026 · Urolithiasis

Control of fragment size during laser lithotripsy has taken on increasing importance with adoption of ureteroscopic aspiration technologies. The objective of this study was to characterize the relationship between laser-fiber-to-stone…

View details →DOI: 10.1007/s00240-026-01970-x
Negative / Null Result ReportMedicine

Effect of ulnar positive variance on outcomes after arthroscopic transosseous repair of palmer 1B TFCC foveal tears.

Won JH, Shin JW, Kwon J et al. · 2026 · Journal of orthopaedic surgery and research

Purpose To determine whether ulnar positive variance (UPV) and relative ulnar positive variance (RUPV) affect clinical outcomes following arthroscopic transosseous repair of triangular fibrocartilage complex (TFCC) foveal tears. Methods…

View details →DOI: 10.1186/s13018-026-07010-z