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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 312 of 710

Negative / Null Result ReportMedicine

First-trimester nonsteroidal anti-inflammatory drugs exposure and risk of major congenital malformations: A retrospective register-based cohort study.

Hasidim, Ben Shitrit, Idan et al. · 2026 · PLoS medicine

Pain and fever are common in early pregnancy, yet their management poses a major clinical dilemma. Although not confirmed, recent studies have raised safety concerns regarding acetaminophen. Evidence on the use of nonsteroidal…

View details →DOI: 10.1371/journal.pmed.1005063
Negative / Null Result ReportMedicine

Ascending aortic dilation and aortic regurgitation - a neglected problem among single-ventricle patients after Fontan palliation.

Kowalczyk, Kowalik, Kowalski et al. · 2026 · Cardiology journal

The Fontan procedure revolutionized the management of univentricular heart physiology but is associated with long-term complications. Although pulmonary vascular disease, atrioventricular valve regurgitation, and ventricular dysfunction…

View details →DOI: 10.5603/cj.109556
Negative / Null Result ReportMedicine

Association Between the Time Elapsed Since the Last Dental Visit and Prevalent Diseases in Peruvian Older Adults.

Quiroz-Silva, Quispe-Hinostroza, Palacios-Cortez et al. · 2026 · Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

To assess the association between the time since the last dental visit and the prevalent systemic diseases among older Peruvian adults in 2023. A cross-sectional secondary analysis was conducted using data from the 2023 Demographic and…

View details →DOI: 10.1111/scd.70178
Negative / Null Result ReportMedicine

From Lungs to Vascular Health: Airflow Obstruction, Not Lung Function Decline, Predicts Atherosclerosis Progression Independent of Smoking Status.

Henríquez-Beltrán, Gracia-Lavedan, Sánchez-Cucó et al. · 2026 · Archivos de bronconeumologia

To prospectively evaluate the relationship between 4-year changes in lung function and the progression of subclinical atherosclerosis among 1623 middle-aged adults with at least one cardiovascular risk factor participating in ILERVAS, and…

View details →DOI: 10.1016/j.arbres.2026.04.012
Negative / Null Result ReportMedicine

Clinical significance of ventricular ectopy and development of dilated cardiomyopathy in Irish wolfhound dogs.

Post, Bell, Abrams et al. · 2026 · Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

Cardiac disease is the second leading cause of death in Irish wolfhound (IW) populations (15.27%). Dilated cardiomyopathy (DCM) is a common hereditary disease in IWs. No correlation between ventricular premature complexes (VPCs) and DCM…

View details →DOI: 10.1016/j.jvc.2026.04.003
Negative / Null Result ReportMedicine

Prevalence and associated factors of intestinal parasitic infections in the school children of Sarlahi, Nepal.

Lama, Subedi, Parajuli · 2026 · Parasite epidemiology and control

A large proportion of the global population is affected by intestinal parasitic infections (IPIs) caused by protozoa and helminths. These infections lead to intestinal inflammation, malabsorption, and nutritional deficiencies, ultimately…

View details →DOI: 10.1016/j.parepi.2026.e00508
Negative / Null Result ReportMedicine

Incidence, microbial profile and antimicrobial resistance trends of CLABSI in adult ICUs: a longitudinal prospective study.

Anand, Sarfraz, Thakuria et al. · 2026 · Iranian journal of microbiology

Central line-associated bloodstream infections (CLABSIs) remain a major cause of healthcare-associated mortality, prolonged hospitalization, and increased healthcare costs, especially in resource-poor settings where surveillance data are…

View details →DOI: 10.18502/ijm.v18i1.20905
Negative / Null Result ReportMedicine

Magnetic resonance imaging of dogs with cervical disease revealed a higher proportion of intervertebral disk disease in small dogs and neoplasia in large dogs.

Darrah, Spence · 2026 · American journal of veterinary research

To compare the proportion of lesions identified on cervical MRI in dogs based on weight. Medical records from a tertiary referral hospital were reviewed for dogs that underwent cervical MRI to investigate clinical signs consistent with…

View details →DOI: 10.2460/ajvr.25.12.0450
Negative / Null Result ReportMedicine

Associations Between Apparent Diffusion Coefficient Values and Histopathologic Prognostic Factors in Breast Cancer: A Retrospective Study.

Mahdavi Sabet, Zeinalkhani, Forghani et al. · 2026 · International journal of breast cancer

This study is aimed at investigating the correlation between apparent diffusion coefficient (ADC) values obtained from diffusion-weighted imaging (DWI) and prognostic factors in breast cancer. We hypothesized that lower ADC values would be…

View details →DOI: 10.1155/ijbc/5114852
Negative / Null Result ReportMedicine

Natural sugar-source associations of Culicoides biting midges (Diptera: Ceratopogonidae) in a Kansas tallgrass prairie.

Markwardt, Olds, Shults et al. · 2026 · Journal of medical entomology

Culicoides Latreille is a diverse genus of approximately 1,300 species of small biting flies found across the globe, containing numerous species of medical and veterinary importance. Many diseases associated with Culicoides have no…

View details →DOI: 10.1093/jme/tjag065
Negative / Null Result ReportMedicine

Closeness of Social Media Contacts and Loneliness Among US Adults: A Nationally Representative Study.

Primack, Kim, Koneru et al. · 2026 · Public health reports (Washington, D.C. : 1974)

Loneliness is strongly linked to morbidity and mortality. While social media use has been associated with increased loneliness among adolescents, little research has examined this association among adults. It is also not clear whether it…

View details →DOI: 10.1177/00333549261443288
Negative / Null Result ReportMedicine

Motor imagery and resistance training improve strength in older adults through distinct effects on agonist-antagonist coordination.

Yao, Mamone, Wu et al. · 2026 · Frontiers in psychology

Age-related declines in muscle strength are partly attributable to altered neural drive and agonist-antagonist coordination. This study aimed to evaluate the effects of motor imagery training (MIT) on maximal force production and…

View details →DOI: 10.3389/fpsyg.2026.1817866
Negative / Null Result ReportMedicine

Impact of intraoperative nonsteroidal anti-inflammatory drugs on acute kidney injury after major noncardiac surgery: a propensity score-matched analysis.

Zhang, Liao, Zhu et al. · 2026 · Renal failure

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as part of multimodal analgesia, but their association with acute kidney injury (AKI) in patients undergoing elective surgery remains uncertain. We conducted a retrospective,…

View details →DOI: 10.1080/0886022x.2026.2663247
Negative / Null Result ReportMedicine

Multifaceted Assessment of Nutritional Status and Gastrointestinal Health in Duchenne Muscular Dystrophy: Approaches Based on Skinfold Thickness and Mid-Upper Arm Circumference.

Çirkin, Güzin, Doğan et al. · 2026 · Journal of paediatrics and child health

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder characterized by prominent nutritional and gastrointestinal challenges. This study aimed to evaluate the nutritional status, gastrointestinal symptoms and…

View details →DOI: 10.1111/jpc.70413
Negative / Null Result ReportMedicine

Identification of Dietary Patterns Among Women Undergoing Assisted Reproduction and Its Association with Reproductive Outcomes.

Zhang, Cong, Zhao et al. · 2026 · International journal of women's health

This study aimed to identify dietary patterns among women undergoing assisted reproductive technology (ART) and to analyze the association between these patterns and reproductive outcomes. This study included 331 women who underwent…

View details →DOI: 10.2147/ijwh.s603264
Negative / Null Result ReportMedicine

Impact of environmental factors and climate conditions on the occurrence of Vibrio and Shewanella infections in Norway, 2014-2018.

Salamanca, King, Deininger et al. · 2026 · BMC public health

Vibrio and Shewanella spp. (VS) are climate-sensitive bacteria found in marine environments, which sometimes cause severe human infections. VS infections have risen globally, particularly in Northern Europe. In this study, we aimed to…

View details →DOI: 10.1186/s12889-026-27550-7
Negative / Null Result ReportMedicine

Association of moderate-to-vigorous leisure-time physical activity and sedentary behaviour with cardiovascular disease and the mediating role of white blood cells.

Liu, Huang, Hao et al. · 2026 · European journal of applied physiology

Physical activity and sedentary behaviour are major modifiable risk factors for cardiovascular disease. However, the effect of leisure-time physical activity, particularly moderate-to-vigorous leisure-time physical activity, on the…

View details →DOI: 10.1007/s00421-026-06253-2
Negative / Null Result ReportMedicine

Management and outcome of patients with traumatic brain injury treated in three major Nordic intensive care units: a comparative cohort study.

Lidström, Hutchens, Froese et al. · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine

Traumatic brain injury (TBI) is a major cause of death and disability, with large variations in management strategies and outcomes across countries. Nordic countries are similar in demographics, but differences in treatment strategies…

View details →DOI: 10.1186/s13049-026-01657-7
Negative / Null Result ReportMedicine

The Effect of the COVID-19 Pandemic on Diagnostic Testing Time Completion for African American End Stage Renal Disease (ESRD) Patients Being Evaluated for Kidney Transplantation.

Levesque, Mueller, Anderson et al. · 2026 · Journal of racial and ethnic health disparities

The COVID-19 pandemic was directly associated with fewer additions to the kidney transplant waiting list and likely contributed to delays in transplant rates, particularly for African Americans. It remains unclear if the pandemic…

View details →DOI: 10.1007/s40615-026-03088-7
Negative / Null Result ReportMedicine

Empirical evaluation of feature processing strategies in deep residual networks for short-term load forecasting: a Malaysian tropical power system case study.

Liu, Ahmad, Samsudin et al. · 2026 · Scientific reports

Short-term load forecasting (STLF) plays a critical role in ensuring the reliable and economical operation of power systems, particularly under complex and dynamic meteorological conditions. While Deep Residual Networks (DRNs) have…

View details →DOI: 10.1038/s41598-026-60033-8
Negative / Null Result ReportMedicine

Bile reinfusion is associated with shifts in host-microbiota metabolic profiles following cholangiocarcinoma-associated microbiota transplantation.

Saensupha, Jirahiranpat, Pratumwan et al. · 2026 · Scientific reports

Cholangiocarcinoma (CCA) is a heterogeneous group of malignant tumours originating along the biliary tract. Previous studies have demonstrated that CCA is characterised by altered gut microbial composition and disrupted bile acid…

View details →DOI: 10.1038/s41598-026-58698-2