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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 311 of 724

Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

View details →DOI: 10.1007/s00259-025-07632-1
Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

View details →DOI: 10.1139/cjpp-2023-0109
Negative / Null Result ReportOpen accessMedicine

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis.

Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…

View details →DOI: 10.1038/s41598-026-51510-1
Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

View details →DOI: 10.3171/case25247
Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

View details →DOI: 10.1089/trgh.2023.0159
Negative / Null Result ReportMedicine

A true reflection of executive functioning or a representation of task-specific variance? Re-evaluating the unity/diversity framework.

Sambol S, Suleyman E, Scarfo J et al. · 2023 · Acta psychologica

The unity/diversity framework, originally published by Miyake et al. (2000) has become the most cited model of executive functioning. Consequently, when researchers operationalise executive function (EF) they often exclusively assess the…

View details →DOI: 10.1016/j.actpsy.2023.103934
Negative / Null Result ReportOpen accessMedicine

Derived hematological indices during peripheral blood stem cell mobilization in the plerixafor era: insightful dynamics but limited predictive value.

Murugesan M, Niveditha LP, Sindhu ER et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Derived hematological indices reflect immune activation, but their dynamics during the plerixafor era and their predictive value for stem cell yield remain unclear. Objectives To assess changes in derived hematological…

View details →DOI: 10.1016/j.htct.2026.106474
Negative / Null Result ReportOpen accessMedicine

Impact of Introduction of Code Blue Response System in a Cardiorespiratory Center: Before-After Study.

Kumar S, Kumar A, Ameta N et al. · 2026 · Annals of cardiac anaesthesia

Background In-hospital cardiac arrest demands immediate response to improve survival outcomes. The Code Blue Response System (CBRS) was designed to streamline emergency interventions by reducing response times. This study aimed to evaluate…

View details →DOI: 10.4103/aca.aca_102_25
Negative / Null Result ReportMedicine

Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Rebel HG, de Gruijl FR · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

We reported earlier that adult FabplCre;Apc 15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that…

View details →DOI: 10.1007/s43630-026-00935-8
Negative / Null Result ReportMedicine

Effects of Ultrasound-Mediated Treatments on Dental Biofilm Attachment and Viability.

De Grandi D, LuTheryn G, Stoffels M et al. · 2026 · Ultrasound in medicine & biology

Objective Dental biofilms are responsible for the majority of oral cavity diseases (e.g., caries, periodontitis and gingivitis). In this work, we evaluate the effects of therapeutic ultrasound on a Streptococcus mutans biofilm model. The…

View details →DOI: 10.1016/j.ultrasmedbio.2026.05.008
Negative / Null Result ReportMedicine

Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.

Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition

Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…

View details →DOI: 10.1016/j.tjnut.2025.101280
Negative / Null Result ReportMedicine

Ultrasound-Guided Superficial Parasternal Intercostal Plane Block for Early Pain Management in Patients Undergoing Cardiac Surgery-A Randomized Controlled Trial.

Kalli AJ, Mäkelä P, Huhtala H et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Sternotomy causes substantial postoperative pain. Recently, several less invasive nerve blocks have been described that are safer to use even on anticoagulated patients. This study aims to evaluate early pain management using…

View details →DOI: 10.1111/aas.70253
Negative / Null Result ReportMedicine

Thoracic duct ligation during esophagectomy fails to prevent chylothorax or improve survival: a propensity score matched cohort study.

Quan S, Xie H, Zhang D et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Postoperative chylothorax is a serious complication following esophagectomy. The efficacy of thoracic duct ligation (TDL) for chylothorax prevention is controversial. This study aimed to evaluate the impact of TDL on chylothorax…

View details →DOI: 10.1007/s10388-026-01219-x
Negative / Null Result ReportMedicine

The Effect of Bariatric Surgery on Complication Risk Following Total Hip Arthroplasty in Patients with Morbid Obesity.

Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…

View details →DOI: 10.2106/jbjs.25.01658
Negative / Null Result ReportMedicine

Intraoperative PEEP Strategy and Postoperative Pulmonary Complications in Obese Patients: A Randomized Trial with Exploratory Analysis of Smoking Status.

Giaccari LG, Brunetti S, Coppolino F et al. · 2026 · Medical sciences (Basel, Switzerland)

Background : Obesity increases the risk of postoperative pulmonary complications (PPCs), and active smoking may further amplify this risk. Whether smoking status identifies a subgroup of obese surgical patients with differential PPC risk…

View details →DOI: 10.3390/medsci14020284
Negative / Null Result ReportMedicine

Repeated whole-body cryostimulation promotes a blood pressure reduction at rest in healthy adult men.

Jdidi H, de Bisschop C, Dugué B et al. · 2026 · European journal of applied physiology

Purpose Whole-body cryostimulation (WBC) has recently been shown to improve autonomic nervous control of the cardiovascular system. This study aimed to investigate the acute and repeated effects of WBC on baroreflex sensitivity (BRS),…

View details →DOI: 10.1007/s00421-026-06261-2
Failed Experiment ReportMedicine

Embryo developmental and morphokinetic patterns in the domestic cat (Felis catus): associations with maternal age and SRT1720 supplementation during oocyte in vitro maturation.

Meco M, Carreira RP, Ochota M et al. · 2026 · Theriogenology

This study describes embryo developmental progression and morphokinetic patterns in embryos derived from oocytes of young and aged domestic cats, a model for endangered felids, using a time-lapse monitoring system. Because maternal aging…

View details →DOI: 10.1016/j.theriogenology.2026.118026
Negative / Null Result ReportMedicine

Professionalism on camera: results of a telehealth etiquette pilot curriculum on health profession students' competency.

Pittmann R, Herring E, Pennington S et al. · 2026 · Frontiers in health services

Introduction Telehealth etiquette refers to professional behaviors that support effective virtual communication between patients and providers. While telehealth has become a lasting part of healthcare delivery, most health professions…

View details →DOI: 10.3389/frhs.2026.1840148
Negative / Null Result ReportMedicine

Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial.

Glenthøj LB, Vernal DL, Mariegaard LS et al. · 2026 · Schizophrenia (Heidelberg, Germany)

Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these…

View details →DOI: 10.1038/s41537-026-00779-2
Negative / Null Result ReportOpen accessMedicine

Fertility and mode of delivery after ileal pouch-anal anastomosis for ulcerative colitis: A population-based study.

Brar MS, Park JJ, de Buck van Overstraeten A · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Background and aims Fertility and mode of delivery are major concerns for women with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA). Although infertility after IPAA has been attributed to pelvic adhesions, the…

View details →DOI: 10.1111/codi.70437
Negative / Null Result ReportMedicine

Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.

Caunca M, Gutierrez S, Wheeler K et al. · 2026 · Neurology

Background and objectives The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the…

View details →DOI: 10.1212/wnl.0000000000218164
Negative / Null Result ReportMedicine

Evaluation of microleakage and remineralization potential of a fissure sealant containing microcapsules on artificial enamel lesions: with and without adhesive application.

Parlak Insel B, Guven Y, Sepet E et al. · 2026 · BMC oral health

Within the concept of minimal invasive dentistry, the progression of initial caries lesions can be inhibited with preventive measures. This study evaluated the microleakage and remineralization potential of a bioactive fissure sealant (FS)…

View details →DOI: 10.1186/s12903-026-08761-1
Negative / Null Result ReportMedicine

Overcoming doramectin failure: field efficacy of pour-on 5% fluralaner and an experimental 1% oral formulation for the prevention of Cochliomyia hominivorax-associated umbilical myiasis in newborn calves.

de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors

Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…

View details →DOI: 10.1186/s13071-026-07455-5