A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20233 results in Negative / Null Result Report · page 311 of 675
Gil CB, Paz D, Pinales BE et al. · 2025 · Preprint
Mutations in the transcriptional cofactor HCFC1 cause methylmalonic aciduria and homocystinemia, cblX type ( cblX ) (MIM#309541), non-syndromic X-linked intellectual disability (XLID), and focal epilepsy. Zebrafish studies have revealed…
Hochstenbach LMJ, Verbeek JGE, Brokken-Peters MBJ et al. · 2026 · Rheumatology (Oxford, England)
Objectives To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness. Methods MyRA was co-developed with patients and used at their own discretion during a 4-month…
Song M, Mao M, Zhao H et al. · 2025 · Infectious agents and cancer
Objective To investigate the oncogenic risks of distinct high-risk human papillomavirus (HR-HPV) genotypes and whether multiple infections exacerbate pathogenicity, with analysis of age stratification and viral load impact. Methods…
Grummon AH, Zeitlin AB, Lee CJY et al. · 2026 · American journal of preventive medicine
Introduction As of 2025, 9 states have adopted Universal Free School Meal programs. The success of these programs depends in part on high participation. This study tested whether a social media campaign promoting school meal participation…
Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology
Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…
Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…
Busse A, Müller J, Benbow ME et al. · 2025 · Journal of Applied Entomology
Understanding the dispersal ability of insects is critical for conservation efforts, as well as for preventing economic and health risks, such as the spread of bluetongue disease or African swine fever (ASF). However, knowledge of the…
de Faria OAC, Kussano NR, de Faria LC et al. · 2026 · Reproduction in domestic animals = Zuchthygiene
This study aimed to evaluate whether the quality of injection and number of oocytes injected during Intrafollicular Transfer of Immature Oocytes (IFIOT) affect ovulation timing, follicle dynamics, oocyte recovery, nuclear maturation and in…
Ng PH, St-Hilaire S · 2025 · Diseases of aquatic organisms
Microcystis spp. blooms in fish ponds can lead to fluctuations in water parameters, and the microcystin-LR (MC-LR) toxin they produce may pose health risks for fish, as well as consumers. Hydrogen peroxide (H2O2) treatment has been…
Vavricka SR, Zeitz J, Madanchi M et al. · 2025 · The American journal of gastroenterology
Introduction Retrospective data suggest association of high-altitude exposure and inflammatory bowel disease flares. Knowledge about underlying pathogenesis remains limited. Methods This prospective interventional trial evaluated the…
Hammett JF, Kirwan M, Chen W · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
Objective Intimate partner violence (IPV) is a major public health concern. Heavy episodic drinking (HED; i.e., drinking 5+ drinks for men or 4+ drinks for women in a 2-hr period) is a contributing cause of IPV, yet HED does not elicit IPV…
Savran F, Bayram F, Küçük F · 2026 · The Journal of craniofacial surgery
Objective This study aimed to evaluate the effects of intravenous dexamethasone and tranexamic acid (TXA), used alone and in combination, on perioperative bleeding and postoperative edema and ecchymosis in rhinoplasty. Methods In this…
Lipps KM, Samuel AM, Patel D et al. · 2025 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality
Background Hypertension (HTN) is common in the inpatient setting, with many patients receiving as-needed (PRN) antihypertensive medications (anti-HTN) despite lack of benefit and risk of adverse events. We aimed to decrease PRN anti-HTN…
Shishimi G, Akaishi R, Matsukami M · 2025 · Preprint
Mirror self-recognition (MSR) is a key indicator of self-awareness, primarily studied in vertebrates. Investigating MSR in invertebrates such as the western honeybee ( Apis mellifera ), an insect with advanced cognition, is essential to…
Kato K, Honda Y, Kamatani T et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Objective Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in NLRP3. Although somatic NLRP3 mosaicism is increasingly recognized, it remains unclear how variant allele…
Demeckova V, Demcakova V, Sedlakova-Kadukova J · 2025 · IEEE transactions on nanobioscience
Silver nanoparticles (AgNPs) are widely used for their antimicrobial properties but pose risks like environmental contamination and potential harm to human health. Nanoparticles' small size facilitates translocation within the body, often…
Shaik NF, Denison L, Venezia GMA et al. · 2026 · Journal of hospital medicine
Background Hospitalized patients often experience poor sleep, which is associated with worse health outcomes, increased rates of delirium, and readmissions. Objective To improve overnight sleep for clinically stable general neurology…
Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research
Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…
Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research
The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…
Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition
Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…
Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest
Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…
Dumlu B, Bölükbaşi ŞC, Bayir A · 2026 · Lipids
We investigated molecular characteristics and tissue distribution of elongation of very long chain fatty acids (ELOVL) genes in the chicken (Gallus gallus) genome. The research specifically examines the expression levels of these genes in…
Barretto R, Sonnenfeld MM, da Silva RCM et al. · 2026 · Journal of robotic surgery
Objective To evaluate whether the use of intraoperative indocyanine green (ICG) fluorescence impacts anastomotic safety and surgical outcomes in patients undergoing bowel endometriosis resection. Methods Retrospective, multicenter…
Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…
Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…
Jones RW · 2025 · Potato Res..
Interest in phytomelatonin biosynthesis and activity has increased due to apparent effects on enhancing resistance to biotic and abiotic stress. Activity related to biotic stress has been associated with increased salicylic acid production…
Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal
Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…
Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one
Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…
Ceja G, Spencer J, Crawford S et al. · 2026 · Journal of dairy science
The objective of this study was to quantify state-level differences in milk yield, milk component yields, and lactation curve characteristics across 8 major US dairy states, and to determine whether temperature-humidity index (THI)…
Shaw JR, Gray H, Xu Y et al. · 2026 · Blood advances
Prothrombin complex concentrates (PCC) are used off-label to treat direct factor Xa inhibitor (FXaI)-associated bleeding or before urgent surgery. GAUGE was a prospective observational cohort study of the effects of PCC on thrombin…