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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 311 of 662

Negative / Null Result ReportOpen accessMedicine

Blood pressure management after endovascular thrombectomy: Insights of recent randomized controlled trials.

Dong X, Liu Y, Chu X et al. · 2024 · CNS neuroscience & therapeutics

Background The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher…

View details →DOI: 10.1111/cns.14907
Negative / Null Result ReportMedicine

Real-world experience of transoesophageal echocardiography for detection of clinically significant persistent foramen ovale.

Wilmshurst P, Pearson M, Walsh K et al. · 2026 · Diving and hyperbaric medicine

Introduction Transoesophageal echocardiography (TOE) is claimed to be the investigation of choice for detecting a persistent foramen ovale (PFO) with almost 100% diagnostic accuracy. If true, TOE would detect all large/clinically…

View details →DOI: 10.28920/dhm56.2.148-153
Negative / Null Result ReportMedicine

Molecular dynamics simulations of beta-2-glycoprotein 1 (β2GPI) reveal that post-translational modifications facilitate novel structures.

Lalaurie CJ, Dalby PA, McDonnell T · 2026 · Scientific reports

Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS). β2GPI can adopt a number of structures; an extended J-shape, an O-shape and a transitional S-shape. It has also been shown previously that…

View details →DOI: 10.1038/s41598-026-52707-0
Negative / Null Result ReportMedicine

Outcomes of a Foundational Sciences Daily Engagement Game in Medical Education.

Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…

View details →DOI: 10.1002/bmb.70059
Negative / Null Result ReportMedicine

Spatial memory performance is associated with region-specific coordination of hippocampo-cortical sleep oscillations.

Caneo M, Espinosa N, Aguilera A et al. · 2026 · Scientific reports

Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo-cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional…

View details →DOI: 10.1038/s41598-026-52285-1
Negative / Null Result ReportMedicine

Efficacy of leukocyte-platelet-rich fibrin (L-PRF) and injectable platelet-rich fibrin (i-PRF) on the rate of canine retraction: a split mouth, randomized controlled trial.

Kamrani A, Khera AK, Raghav P et al. · 2026 · The Angle orthodontist

Objectives To evaluate and compare the effects of leukocyte-platelet-rich fibrin (L-PRF), injectable platelet-rich fibrin (i-PRF; submucosal), and i-PRF (intraligamental) on the rate of maxillary canine retraction. Materials and methods A…

View details →DOI: 10.2319/080325-664.1
Negative / Null Result ReportOpen accessMedicine

Clinicopathologic features and outcomes of patients with DNAJB9-positive fibrillary glomerulonephritis.

Hurdogan O, Mirioglu S, Cebeci E et al. · 2026 · Clinical kidney journal

Background Fibrillary glomerulonephritis (FGN) is a very rare glomerular disease characterized by non-branching fibril deposition and DNAJB9 positivity. We aimed to analyze our cohort to better elucidate clinicopathologic features and…

View details →DOI: 10.1093/ckj/sfag138
Negative / Null Result ReportMedicine

How hostile attribution bias affects attachment anxiety/avoidance and relationship satisfaction: a cross-cultural perspective during the COVID pandemic.

Li D, Carnelley KB, Crawford MT et al. · 2026 · The Journal of social psychology

This is the first cross-cultural study of the contribution of romantic hostile attribution bias to relationship satisfaction that takes into account the role of attachment orientation. In two studies conducted 1 year apart, data were…

View details →DOI: 10.1080/00224545.2026.2626036
Negative / Null Result ReportMedicine

<i>In vivo</i> and <i>in vitro</i> anthelmintic activity of quebracho-chestnut tannin extract against <i>Haemonchus contortus</i> in lambs.

Bruttomesso MF, Morici GE, Arias MR et al. · 2026 · Journal of helminthology

Haemonchus contortus is considered the most pathogenic gastrointestinal nematode of sheep and, due to the increasing resistance to synthetic anthelmintics, it poses a serious challenge to small ruminant production systems. The aim of this…

View details →DOI: 10.1017/s0022149x26101357
Negative / Null Result ReportMedicine

Immune checkpoint inhibitors in pediatric central nervous system tumors: biology, clinical experience, and translational pathways to precision immunotherapy.

Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology

Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…

View details →DOI: 10.1007/s11060-026-05491-w
Negative / Null Result ReportMedicine

Endovascular thrombectomy in addition to intravenous thrombolysis versus intravenous thrombolysis alone in medium distal vessel occlusions: Results from the SITS International Stroke Treatment Register.

Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society

Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…

View details →DOI: 10.1177/17474930261455992
Negative / Null Result ReportMedicine

Surgical nodal staging in rhabdomyosarcoma of the bladder and/or prostate with or without nodal or metastatic spread. A report from the European Paediatric Soft-Tissue Sarcoma Study Group (EpSSG).

Smeulders N, Gaze MN, Guérin F et al. · 2026 · Journal of pediatric surgery

Background Risk stratification of rhabdomyosarcoma (RMS) requires accurate staging, with histological nodal assessment being of critical importance for specific tumour sites. This report explores the value of surgical nodal staging in…

View details →DOI: 10.1016/j.jpedsurg.2026.163162
Negative / Null Result ReportMedicine

Emotional eating and metabolic dysfunction-associated steatotic liver disease (MASLD): a pre-registered study in a clinical population.

Vazquez M, Wilkinson LL, Pembroke T · 2026 · Physiology & behavior

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 38 % of adults globally and has been identified as a significant and increasing contributor to global health and economic burdens. Obesity is significantly associated…

View details →DOI: 10.1016/j.physbeh.2025.115186
Negative / Null Result ReportMedicine

Cross-reactivity of anti-human antibodies in canine tissues using immunohistochemistry.

Forehand A, Criswell S · 2025 · Biotechnic & histochemistry : official publication of the Biological Stain Commission

Dogs represent the most common domesticated animal outside of the research arena for whom tissue for pathological diagnosis is requested. Currently, there is a paucity of literature describing the cross-reactivity of anti-human antibodies…

View details →DOI: 10.1080/10520295.2025.2566683
Negative / Null Result ReportMedicine

Therapeutic Efficacy of Mesenchymal Stem Cells (MSCs) on Alzheimer's Disease: Review of Clinical Results.

Kim AL, Lee WK, Kwon S et al. · 2026 · Tissue engineering and regenerative medicine

Background Alzheimer's disease (AD) presents significant unmet medical needs with no effective therapeutic options. Current pharmacological treatments provide only symptomatic relief and do not prevent the ongoing neurodegeneration. Cell…

View details →DOI: 10.1007/s13770-025-00782-1
Negative / Null Result ReportOpen accessMedicine

Residual Wrist Pain and Cyst Recurrence Following Removal of Dorsal Ganglion With and Without Posterior Interosseous Nerve Neurectomy.

Furlong CT, Stanton HL, Yin R et al. · 2026 · Journal of hand surgery global online

Purpose Pain from dorsal wrist ganglion cysts may result from irritation of the terminal branch of the posterior interosseous nerve. Excision of this branch is often used to treat wrist pain from various etiologies, including recurrent…

View details →DOI: 10.1016/j.jhsg.2026.101051
Negative / Null Result ReportMedicine

A Fine Balance: Anticoagulation for Non-Valvular Atrial Fibrillation After Cerebral Amyloid Angiopathy-Related Intracranial Haemorrhage.

Turner D, Kamadasala K, McGarity B · 2025 · Heart, lung & circulation

The management of anticoagulation in patients with non-valvular atrial fibrillation at high risk of bleeding complications can be challenging. One such group is elderly patients with previous intracranial haemorrhage secondary to cerebral…

View details →DOI: 10.1016/j.hlc.2025.06.1027
Negative / Null Result ReportMedicine

Atrial shunt therapy for heart failure: an update review.

Giorgi J, Flores-Bravo Y, Dandamudi M et al. · 2025 · Heart failure reviews

Interatrial shunt devices (IASDs) and implant-free strategies have emerged as novel approaches for heart failure (HF) management by mechanically unloading the left atrium (LA) to reduce left atrial pressure (LAP), a key driver of pulmonary…

View details →DOI: 10.1007/s10741-025-10580-5
Negative / Null Result ReportMedicine

Renal Artery Stent Procedural Trends and Disparities in a National Cohort.

Gusdorf J, Earle WB, Li S et al. · 2026 · The American journal of cardiology

Atherosclerotic renal artery stenosis (RAS) affects nearly 7% of adults over age 65 and is associated with increased cardiovascular and renal morbidity. Although early observational studies suggested benefit from renal artery stenting,…

View details →DOI: 10.1016/j.amjcard.2025.12.011
Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

View details →DOI: 10.1016/j.ajog.2025.11.001