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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19743 results in Negative / Null Result Report · page 31 of 659

Negative / Null Result ReportOpen accessMathematics

A cautionary note on the use of the Analysis of Covariance (ANCOVA) in classification designs with and without within-subject factors

Bruce A. Schneider, Meital Avivi-Reich, Mindaugas Mozuraitis · 2015 · Frontiers in Psychology

A number of statistical textbooks recommend using an analysis of covariance (ANCOVA) to control for the effects of extraneous factors that might influence the dependent measure of interest. However, it is not generally recognized that serious problems of interpretation can arise when the design contains comparisons of participants sampled from different populations (classification designs). Designs that include a comparison of younger and older adults, or a comparison of musicians and non-musicians are examples of classification designs. In such cases, estimates of differences among groups can

View details →DOI: 10.3389/fpsyg.2015.00474Cited by 177
Negative / Null Result ReportOpen accessPsychology

A Randomized Controlled Trial Evaluating a Manualized TeleCoaching Protocol for Improving Adherence to a Web-Based Intervention for the Treatment of Depression

David C. Mohr, Jenna Duffecy, Joyce Ho et al. · 2013 · PLoS ONE

BACKGROUND: Web-based interventions for depression that are supported by coaching have generally produced larger effect-sizes, relative to standalone web-based interventions. This is likely due to the effect of coaching on adherence. We evaluated the efficacy of a manualized telephone coaching intervention (TeleCoach) aimed at improving adherence to a web-based intervention (moodManager), as well as the relationship between adherence and depressive symptom outcomes. METHODS: 101 patients with MDD, recruited from primary care, were randomized to 12 weeks moodManager+TeleCoach, 12 weeks of self-

View details →DOI: 10.1371/journal.pone.0070086Cited by 177
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

REGIONAL FINANCIAL MANAGEMENT SYSTEM OF REGENCY/CITY REGIONAL ORIGINAL INCOME IN ACEH PROVINCE PERIOD YEAR 2016-2020

Bustani Bustani, Muammar Khaddafi, Rico Nur Ilham · 2022 · International Journal of Educational Review Law And Social Sciences (IJERLAS)

This study aims to examine the effect of general allocation funds, special allocation funds and profit-sharing funds on local revenue in districts/cities in Aceh Province . This study uses secondary data, namely data obtained from the…

View details →DOI: 10.54443/ijerlas.v2i3.277Cited by 177
Negative / Null Result ReportOpen accessDentistry

Deep Learning for Automated Detection of Cyst and Tumors of the Jaw in Panoramic Radiographs

Hyunwoo Yang, Eun Jo, Hyung Jun Kim et al. · 2020 · Journal of Clinical Medicine

Patients with odontogenic cysts and tumors may have to undergo serious surgery unless the lesion is properly detected at the early stage. The purpose of this study is to evaluate the diagnostic performance of the real-time object detecting deep convolutional neural network You Only Look Once (YOLO) v2-a deep learning algorithm that can both detect and classify an object at the same time-on panoramic radiographs. In this study, 1602 lesions on panoramic radiographs taken from 2010 to 2019 at Yonsei University Dental Hospital were selected as a database. Images were classified and labeled into f

View details →DOI: 10.3390/jcm9061839Cited by 177
Negative / Null Result ReportOpen accessMedicine

Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study

Siaw Cheok Liew, Esha Dasgupta, Shew Fung Wong et al. · 2012 · Nutrition Journal

BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels. METHODS: This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fa

View details →DOI: 10.1186/1475-2891-11-1Cited by 177
Negative / Null Result ReportEconomics, Econometrics and Finance

Relaxing Occupational Licensing Requirements: Analyzing Wages and Prices for a Medical Service

Morris M. Kleiner, Allison Marier, Kyoung Won Park et al. · 2016 · The Journal of Law and Economics

Occupational licensing laws have been relaxed in a large number of US states to give nurse practitioners the ability to perform more tasks without the supervision of medical doctors. We investigate how these regulations affect wages, hours…

View details →DOI: 10.1086/688093Cited by 177
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Factors explaining inter-municipal cooperation in service delivery: a meta-regression analysis

Germà Bel, Mildred E. Warner · 2015 · Journal of Economic Policy Reform

Inter-municipal cooperation is an important public service delivery reform, whose drivers move beyond simple concerns with costs and economic efficiency, to policy issues related to governance structure and spatial context. We conduct a meta-regression analysis based on the existing multivariate empirical literature to explore what factors explain divergence in results in the existing empirical studies. We find strong evidence that fiscal constraints, spatial, and organizational factors are significant drivers of cooperation. Our meta-regressions do not yield results to explain divergence in r

View details →DOI: 10.1080/17487870.2015.1100084Cited by 177
Negative / Null Result ReportOpen accessEnvironmental Science

Impact of COVID-19 large scale restriction on environment and economy in Indonesia

Rezzy Eko Caraka, Youngjo Lee, Robert Kurniawan et al. · 2020 · Research Explorer (The University of Manchester)

COVID-19 has a severe and widespread impact, especially in Indonesia. COVID-19 was first reported in Indonesia on March 03, 2020 then rapidly spread to all 34 provinces by April 09, 2020. Since then, COVID-19 is declared a state of…

View details →DOI: 10.22034/gjesm.2019.06.si.07Cited by 177
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Regionally Specific and Genome-Wide Analyses Conclusively Demonstrate the Absence of CpG Methylation in Human Mitochondrial DNA

Elizabeth E. Hong, Cindy Yen Okitsu, Andrew D. Smith et al. · 2013 · Molecular and Cellular Biology

Although CpG methylation clearly distributes genome-wide in vertebrate nuclear DNA, the state of methylation in the vertebrate mitochondrial genome has been unclear. Several recent reports using immunoprecipitation, mass spectrometry, and…

View details →DOI: 10.1128/mcb.00220-13Cited by 176
Negative / Null Result ReportEarth and Planetary Sciences

The effect of kerogen on the elastic anisotropy of organic-rich shales

Colin M. Sayers · 2013 · Geophysics

ABSTRACT The elastic properties of reservoir rocks are important for geomechanics applications; the most important of which are: analysis of stress changes due to production, analysis of rock deformation and failure, wellbore trajectory…

View details →DOI: 10.1190/geo2012-0309.1Cited by 176
Negative / Null Result ReportBusiness, Management and Accounting

Factors influencing consumer loyalty: evidence from the Ghanaian retail banking industry

Osaretin Kayode Omoregie, John Agyekum Addae, Stanley Coffie et al. · 2019 · International Journal of Bank Marketing

Purpose The increasing number of banks in the Ghanaian banking industry has brought about intense competition in the industry. The purpose of this paper is, therefore, to examine the factors that influence retail banking customers’ loyalty…

View details →DOI: 10.1108/ijbm-04-2018-0099Cited by 175
Negative / Null Result ReportMedicine

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

Mengyue Niu, Yang Li, Gerald Li et al. · 2020 · European Journal of Neurology

BACKGROUND AND PURPOSE: The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exosomes as a…

View details →DOI: 10.1111/ene.14208Cited by 175
Negative / Null Result ReportOpen accessEnvironmental Science

Male fertility thermal limits predict vulnerability to climate warming

Belinda van Heerwaarden, Carla M. Sgrò · 2021 · Nature Communications

Forecasting which species/ecosystems are most vulnerable to climate warming is essential to guide conservation strategies to minimize extinction. Tropical/mid-latitude species are predicted to be most at risk as they live close to their upper critical thermal limits (CTLs). However, these assessments assume that upper CTL estimates, such as CTmax, are accurate predictors of vulnerability and ignore the potential for evolution to ameliorate temperature increases. Here, we use experimental evolution to assess extinction risk and adaptation in tropical and widespread Drosophila species. We find t

View details →DOI: 10.1038/s41467-021-22546-wCited by 175
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Relative roles of climatic suitability and anthropogenic influence in determining the pattern of spread in a global invader

Núria Roura‐Pascual, Cang Hui, Takayoshi Ikeda et al. · 2010 · Proceedings of the National Academy of Sciences

Because invasive species threaten the integrity of natural ecosystems, a major goal in ecology is to develop predictive models to determine which species may become widespread and where they may invade. Indeed, considerable progress has…

View details →DOI: 10.1073/pnas.1011723108Cited by 175
Negative / Null Result ReportOpen accessPhysics and Astronomy

Observation of ice-like water layers at an aqueous protein surface

Konrad Meister, Simona Strazdaitė, Arthur L. DeVries et al. · 2014 · Proceedings of the National Academy of Sciences

We study the properties of water at the surface of an antifreeze protein with femtosecond surface sum frequency generation spectroscopy. We find clear evidence for the presence of ice-like water layers at the ice-binding site of the…

View details →DOI: 10.1073/pnas.1414188111Cited by 175
Negative / Null Result ReportOpen accessMedicine

Behavioral Counseling to Prevent Skin Cancer

US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA

Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma,…

View details →DOI: 10.1001/jama.2018.1623Cited by 175
Negative / Null Result ReportMathematics

The Generalizability of Online Experiments Conducted During the COVID-19 Pandemic

Kyle Peyton, Gregory A. Huber, Alexander Coppock · 2021 · Journal of Experimental Political Science

Abstract The COVID-19 pandemic imposed new constraints on empirical research, and online data collection by social scientists increased. Generalizing from experiments conducted during this period of persistent crisis may be challenging due…

View details →DOI: 10.1017/xps.2021.17Cited by 174
Negative / Null Result ReportPsychology

Personality Trait Development During the Transition to Parenthood

Manon A. van Scheppingen, Joshua J. Jackson, Jule Specht et al. · 2016 · Social Psychological and Personality Science

Social investment theory (SIT) proposes that the transition to parenthood triggers positive personality trait change in early adulthood. Using data from a representative sample of first-time parents compared to nonparents, the results of…

View details →DOI: 10.1177/1948550616630032Cited by 174
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Structural transformation or elite land capture? The growth of “emergent” farmers in Zambia

Nicholas J. Sitko, Thomas S. Jayne · 2014 · Food Policy

Over the last decade, Zambia has witnessed a rapid increase in the number of medium-scale “emergent farms” cultivating 5–20 ha of land. This study analyzes the factors underpinning this growth. We find that the growth of emergent farmers…

View details →DOI: 10.1016/j.foodpol.2014.05.006Cited by 174
Negative / Null Result ReportOpen accessNeuroscience

Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain

Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford et al. · 2021 · Neurobiology of Aging

Loss of physiological microglial function may increase the propagation of neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we hypothesized age could be a cause of dystrophic microglia. Stereological counts were…

View details →DOI: 10.1016/j.neurobiolaging.2020.12.003Cited by 174
Negative / Null Result ReportMedicine

Prospective Audit of Parastomal Hernia: Prevalence and Associated Comorbidities

Charles Pilgrim, Richard McIntyre, Michael Bailey · 2010 · Diseases of the Colon & Rectum

PURPOSE: There is little evidence regarding the prevalence or incidence of parastomal hernia, but it is thought to be common. Repair of parastomal hernia can be troublesome, and methods of repair need to be validated based on reduced…

View details →DOI: 10.1007/dcr.0b013e3181bdee8cCited by 174
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood

Sarah J. Marzi, Karen Sugden, Louise Arseneault et al. · 2018 · American Journal of Psychiatry

OBJECTIVE: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether…

View details →DOI: 10.1176/appi.ajp.2017.17060693Cited by 173
Negative / Null Result ReportOpen accessSocial Sciences

An Examination Of The Museum Experience Based On Pine And Gilmore's Experience Economy Realms

Laetitia Radder, Xiliang Han · 2015 · Journal of Applied Business Research (JABR)

This study determined whether Pine and Gilmores four experience economy realms (education, entertainment, escapism and esthetics) were represented by visitors experiences of three South African heritage museums, evaluated whether their experience expectations associated with the experience realms had been met, and examined the relationship between the latter, satisfaction and behavioral intentions. In addition, the relationship between personal and trip-related factors and the experience realms was investigated. Exploratory and confirmatory factor analyses identified three experience realms -

View details →DOI: 10.19030/jabr.v31i2.9129Cited by 173
Negative / Null Result ReportOpen accessMedicine

Second Allograft for Hematologic Relapse of Acute Leukemia After First Allogeneic Stem-Cell Transplantation From Related and Unrelated Donors: The Role of Donor Change

Maximilian Christopeit, Oliver Kuß, Jürgen Finke et al. · 2013 · Journal of Clinical Oncology

PURPOSE: To evaluate the role of a second allogeneic hematopoietic stem-cell transplantation (HSCT2) given for relapsed acute leukemia (AL) after related or unrelated first hematopoietic stem-cell transplantation (HSCT1) and to analyze the…

View details →DOI: 10.1200/jco.2012.44.7961Cited by 173
Negative / Null Result ReportOpen accessNeuroscience

The Number and Quality of Representations in Working Memory

Weiwei Zhang, Steven J. Luck · 2011 · Psychological Science

Flexible-resource theories characterize working memory as a flexible resource that can store either a large number of low-quality representations or a small number of high-quality representations. In contrast, limited-item theories propose…

View details →DOI: 10.1177/0956797611417006Cited by 173
Negative / Null Result ReportOpen accessPsychology

Loot boxes are again linked to problem gambling: Results of a replication study

David Zendle, Paul Cairns · 2019 · PLoS ONE

Loot boxes are items in video games that contain randomised contents and can be purchased with real-world money. Similarities between loot boxes and forms of gambling have led to questions about their legal status, and whether they should be regulated as gambling. Previous research has suggested a link between the amount that gamers spend on loot boxes and their problem gambling: The more individuals spent on loot boxes, the more severe their problem gambling. However, the generalisability of prior work may be limited by both the self-selected nature of the sample under test, and the fact that

View details →DOI: 10.1371/journal.pone.0213194Cited by 173
Negative / Null Result ReportOpen accessMedicine

Non-adherence to self-care practices & medication and health related quality of life among patients with type 2 diabetes: a cross-sectional study

Farzana Saleh, Shirin Jahan Mumu, Ferdous Ara et al. · 2014 · BMC Public Health

BACKGROUND: Non-adherence to lifestyle modification among diabetic patients develops the short-term risks and the long-term complications as well as declines the quality of life. This study aimed to find out the association between non-adherence to self-care practices, medication and health related quality of life (HR-QoL) among type 2 diabetic patients. METHODS: At least 1 year diagnosed patients with type 2 diabetes (N = 500), age>25 years were conveniently selected from the Out-Patient Department of Bangladesh Institute of Health Sciences Hospital. Patients' self-care practices were assesse

View details →DOI: 10.1186/1471-2458-14-431Cited by 173
Negative / Null Result ReportOpen accessEngineering

Patellar shape can be a predisposing factor in patellar instability

Alfredo Schiavone Panni, Simone Cerciello, Nicola Maffulli et al. · 2010 · Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: Predisposing factors to objective patellar instability include trochlear dysplasia, patella alta, patellar tilt and elevated tibial tuberosity-femoral groove distance. The shape of the patella is classically not considered a predisposing factor. Anomalies of dynamic and static factors, including excessive patellar height, tibial tubercle lateralisation or trochlear dysplasia, may influence the development of the patella. METHODS: One hundred and five patients (140 knees) with objective patellar instability were retrospectively reviewed to identify a possible association between the ab

View details →DOI: 10.1007/s00167-010-1329-4Cited by 172
Negative / Null Result ReportOpen accessPsychology

Gender Stereotypes of Personality

Corinna E. Löckenhoff, Wayne Chan, Robert R. McCrae et al. · 2014 · Journal of Cross-Cultural Psychology

Numerous studies have documented subtle but consistent sex differences in self-reports and observer-ratings of five-factor personality traits, and such effects were found to show well-defined developmental trajectories and remarkable similarity across nations. In contrast, very little is known about perceived gender differences in five-factor traits in spite of their potential implications for gender biases at the interpersonal and societal level. In particular, it is not clear how perceived gender differences in five-factor personality vary across age groups and national contexts and to what

View details →DOI: 10.1177/0022022113520075Cited by 172