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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 307 of 710

Negative / Null Result ReportMedicine

Industry Interactions at Medical Conferences: Representatives' Credentials and the Disclosure of Data Limitations Influence Clinician Perceptions.

O'Donoghue AC, Aikin KJ, Amoozegar JB et al. · 2025 · Journal of the American Board of Family Medicine : JABFM

Purpose Exhibit hall booths at medical conferences are a key avenue for promoting prescription drugs to health care providers (HCPs). Because HCPs spend considerable time interacting with industry representatives at conferences, we…

View details →DOI: 10.3122/jabfm.2024.240368r1
Negative / Null Result ReportMedicine

Should Communication Campaigns Promoting Vaccination Address Misinformation Beliefs? Implications from a Nationally Representative Longitudinal Survey Study among U.S. Adults.

Clark D, Kikut-Stein A, Jesch E et al. · 2024 · Journal of health communication

Public health communication campaign planners must carefully consider whether misinformation beliefs are important to target and, ideally, correct. Guided by the reasoned action approach, we hypothesized that behavior-specific beliefs…

View details →DOI: 10.1080/10810730.2024.2331488
Negative / Null Result ReportOpen accessMedicine

Social working memory in adolescence.

Grunewald K, Andrews JL, Schweizer S · 2026 · Child development

Little is known about how social network associations are tracked in cognition during adolescence, when social networks change in size and complexity. In 2023, 123 ethnically diverse adolescents and emerging adults (13-24 years; 52.9%…

View details →DOI: 10.1093/chidev/aacaf039
Negative / Null Result ReportOpen accessMedicine

Environmental Supports, Expectations, and Barriers to Leisure-Time Physical Activity During Pregnancy: A Rural-Urban Comparison.

Rogers CW, Crisp A, Wilhite K et al. · 2026 · The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association

Background Physical activity (PA) during pregnancy has well-documented benefits, yet pregnant rural residents may face additional barriers to PA. Objective To examine whether leisure-time physical activity (LTPA) and correlates of LTPA,…

View details →DOI: 10.1111/jrh.70166
Negative / Null Result ReportMedicine

Cardiac autonomic function in young, healthy adults: Influence of race and sex.

Taherzadeh Z, Kissell CE, Young BE et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Non-Hispanic Black (BL) adults living in the United States are more likely to develop cardiovascular disease (CVD) compared with their non-Hispanic White (WH) counterparts. Although measures of cardiac autonomic function [i.e., spontaneous…

View details →DOI: 10.1152/ajpregu.00288.2024
Negative / Null Result ReportOpen accessMedicine

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder.

Iwabuchi T, Hirai T, Umeda N et al. · 2025 · Autism research : official journal of the International Society for Autism Research

Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some…

View details →DOI: 10.1002/aur.70134
Negative / Null Result ReportOpen accessMedicine

Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication Across Two Cohorts.

Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Human brain mapping

Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…

View details →DOI: 10.1002/hbm.70414
Negative / Null Result ReportMedicine

Outcomes and performance following posteromedial elbow débridement in Major League Baseball players.

Wollenman CC, Davis PJ, Lane GC et al. · 2024 · Journal of shoulder and elbow surgery

Background Overhead athletes are particularly susceptible to elbow valgus extension overload syndrome and development of pathologic changes in the posteromedial elbow. Though arthroscopic débridement/osteophyte resection is frequently…

View details →DOI: 10.1016/j.jse.2024.05.035
Negative / Null Result ReportMedicine

An acute social stressor decreases reinforcing value of both high and low energy-dense food in college students in a randomized controlled trial.

McKay NJ, Horvatits EJ, Jean M et al. · 2024 · Physiology & behavior

It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge…

View details →DOI: 10.1016/j.physbeh.2024.114531
Negative / Null Result ReportOpen accessMedicine

Oxytocin administration during labor does not affect maternal serum oxytocin levels, early postpartum breastfeeding attitude and maternal attachment.

Özdemir M, Çeber Turfan E, Keskin HL · 2025 · PloS one

The goal was to investigate the effects of synthetic oxytocin administration during labor on maternal and neonatal serum oxytocin levels, early breastfeeding attitudes, and postpartum maternal attachment immediately after birth. This…

View details →DOI: 10.1371/journal.pone.0337762
Negative / Null Result ReportOpen accessMedicine

Contribution of sympathetic nervous system activation to endothelial ischemia reperfusion injury in healthy adults.

Rosenberg AJ, Young BE, Fernandez A et al. · 2025 · Physiological reports

Ischemia-reperfusion injury (IRI) describes the phenomenon through which the restoration of blood flow following prolonged ischemia exacerbates tissue damage during reperfusion. IRI can be modeled by inducing 20-min arm ischemia followed…

View details →DOI: 10.14814/phy2.70502
Negative / Null Result ReportMedicine

Greater Emotional and Psychological Well-being Are Associated With Reduced Employee Self-report Illness-Related Absenteeism: A Multi-Industry, Cross-sectional Study Conducted During COVID-19 Pandemic.

Fannin A, Hooley C, Nelson EJ · 2024 · Journal of occupational and environmental medicine

Objective The purpose of this study is to determine the relationship that emotional, psychological, and social well-being has with self-reported illness-related absenteeism. Methods This study examines the relationship between three…

View details →DOI: 10.1097/jom.0000000000003042
Negative / Null Result ReportOpen accessMedicine

A conditional process analysis of general self-esteem in student-athletes in lower secondary sport schools.

Gjesdal S, Kristensen JÅ, Saarinen M et al. · 2026 · Frontiers in psychology

Objective Specialised sport schools at the lower secondary level aim to support the holistic development of young athletes. Consequently, understanding how to influence student-athletes' self-perceptions both inside and outside of the…

View details →DOI: 10.3389/fpsyg.2026.1771557
Negative / Null Result ReportOpen accessMedicine

Effects of mindful breathing meditation on stereotype expression in two randomized controlled double-blinded trials.

Vieth E, von Stockhausen L · 2026 · PloS one

Models of stereotypes and discrimination propose the involvement of attentional control and executive functioning in successfully suppressing discriminatory behavior. A practice that has been shown to improve cognitive control, potentially…

View details →DOI: 10.1371/journal.pone.0347871
Negative / Null Result ReportOpen accessMedicine

Impact of Blood Group on Contralateral Suppression of Otoacoustic Emissions, Speech Perception in Noise, and Binaural Integration.

Ponnana S A P, Tauro JP, S NP et al. · 2026 · International archives of otorhinolaryngology

Introduction Understanding the relationship between blood groups (A, B, AB, and O) and auditory functioning can provide valuable insights into individual differences in hearing ability and potential risks for hearing loss. Objective To…

View details →DOI: 10.1055/s-0046-1819712
Negative / Null Result ReportOpen accessMedicine

Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

Lindman BR, Pibarot P, Schwartz A et al. · 2025 · Circulation

Background The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinical…

View details →DOI: 10.1161/circulationaha.125.074425
Negative / Null Result ReportMedicine

Neurocognitive Profile of Avoidant/Restrictive Food Intake Disorder: Cognitive Flexibility, Delay Discounting, and Detail Orientation.

McPherson IK, Dalton AG, Armstrong K et al. · 2026 · The International journal of eating disorders

Objective Neurocognitive deficits are well-documented across psychiatric disorders and may indicate novel treatment targets. However, empirical data on the neurocognitive profile of avoidant/restrictive food intake disorder (ARFID) are…

View details →DOI: 10.1002/eat.70077
Negative / Null Result ReportMedicine

A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats.

Sal-Sarria S, López-Taboada I, González-Pardo H et al. · 2024 · Behavioural brain research

Prolonged consumption of diets high in saturated fat and sugar has been related to obesity and overweight, which in turn are linked to cognitive impairment in both humans and rodents. This has become a current issue, especially in children…

View details →DOI: 10.1016/j.bbr.2024.115020
Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

View details →DOI: 10.1152/ajpregu.00113.2024
Negative / Null Result ReportOpen accessMedicine

Clinical Features Associated With Fatigue in People With Fibrotic Interstitial Lung Disease: Cross-Sectional Study.

Kawachi S, Hoffman M, Holland AE · 2025 · Respirology (Carlton, Vic.)

Background and objective Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been…

View details →DOI: 10.1111/resp.70091
Negative / Null Result ReportOpen accessMedicine

Impact of cognitive behavioral therapy on attention in patients with fibromyalgia: a randomized controlled trial.

Kazemipour S, Yamin JB, Moore D et al. · 2026 · Pain reports

Introduction More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is…

View details →DOI: 10.1097/pr9.0000000000001378
Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

View details →DOI: 10.1016/j.ajcnut.2024.08.024
Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

View details →DOI: 10.1002/jts.22991