Negative / Null Result ReportOpen accessMedicine
Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…
View details →DOI: 10.1212/nxi.0000000000200615 Negative / Null Result ReportMedicine
Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…
View details →DOI: 10.1111/psyg.70179 Negative / Null Result ReportOpen accessMedicine
Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research
Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…
View details →DOI: 10.1177/03000605261457776 Negative / Null Result Report
Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint
ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…
View details →DOI: 10.64898/2026.06.04.26354935 Negative / Null Result ReportMedicine
Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients
Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…
View details →DOI: 10.3390/nu18122022 Negative / Null Result ReportMedicine
Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy
Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…
View details →DOI: 10.1016/j.bjpt.2026.101593 Negative / Null Result ReportMedicine
Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…
View details →DOI: 10.3390/diagnostics16121841 Replication FailureOpen accessMedicine
Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
View details →DOI: 10.1136/bmjment-2026-302515 Negative / Null Result ReportMedicine
Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…
View details →DOI: 10.1016/j.ejvs.2026.06.019 Failed Experiment ReportMedicine
Ganesh A, Smith EE, Mostert J et al. · 2026 · Neurology
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
View details →DOI: 10.1212/wnl.0000000000218227 Replication FailureMedicine
Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
View details →DOI: 10.3390/ani16121854 Negative / Null Result ReportMedicine
Huang B, Mao C, Xu T et al. · 2026 · Animals : an open access journal from MDPI
Early-life microbial community assembly is important for gastrointestinal development, immune maturation, and feed utilization in young ruminants, but the maternal reservoirs associated with neonatal lamb gut microbial profiles remain…
View details →DOI: 10.3390/ani16121862 Negative / Null Result ReportMedicine
Choi JS, Kim KM · 2026 · Healthcare (Basel, Switzerland)
Background The number of long-term care hospitals (LTCHs) in Korea has been increasing. Because LTCHs primarily care for older adults who are vulnerable to infection, strict infection control (IC) practices are essential. This study aimed…
View details →DOI: 10.3390/healthcare14121709 Negative / Null Result ReportMedicine
Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research
ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…
View details →DOI: 10.1177/03000605261457301 Negative / Null Result ReportMedicine
Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…
View details →DOI: 10.1016/j.jneuroim.2026.579013 Negative / Null Result ReportMedicine
Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…
View details →DOI: 10.1007/s00467-026-07431-2 Negative / Null Result ReportOpen accessMedicine
Rinaldi V, Ridolfi F, Finotello R et al. · 2026 · Veterinary medicine and science
Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains…
View details →DOI: 10.1002/vms3.71021 Negative / Null Result ReportMedicine
Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →DOI: 10.1007/s10439-026-04203-9 Negative / Null Result ReportOpen accessMedicine
Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education
This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…
View details →DOI: 10.3390/ejihpe16060079 Replication Failure
Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint
Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…
View details →DOI: 10.21203/rs.3.rs-10086880/v1 Negative / Null Result ReportMedicine
Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)
Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…
View details →DOI: 10.1016/j.envpol.2026.128638 Negative / Null Result ReportMedicine
Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics
Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…
View details →DOI: 10.1007/s00264-026-06884-2 Negative / Null Result ReportMedicine
Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…
View details →DOI: 10.3390/healthcare14121624 Negative / Null Result ReportMedicine
Turgut H, Özdemir R, Memişoğlu F · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose This study aimed to characterize pathogen distribution and antimicrobial resistance patterns of gram-negative bloodstream infections in a tertiary neonatal intensive care unit and to determine which factors were associated with…
View details →DOI: 10.1007/s10096-026-05565-7 Negative / Null Result ReportMedicine
Hsu LI, Chen JW, Hsu HW et al. · 2026 · Anesthesiology
Background Tranexamic acid (TXA) reduces perioperative blood loss, but comparative effectiveness and safety across administration routes remain uncertain. The authors evaluated topical, IV, and oral TXA in unilateral total hip and knee…
View details →DOI: 10.1097/aln.0000000000006114 Negative / Null Result ReportMedicine
Miyake H, Onishi A, Tsuji H et al. · 2026 · Modern rheumatology
To identify factors associated with flare after glucocorticoid (GC) reduction in systemic lupus erythematosus (SLE) and determine whether belimumab influences this risk. Using the ANSWER-SLE cohort, this retrospective multicentre study…
View details →DOI: 10.1093/mr/roag053 Negative / Null Result ReportMedicine
Deconne TM, Suerken CK, Lipford ME et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundArterial stiffness is an emerging risk factor for Alzheimer's disease (AD) and related dementias (ADRD) and is assessed by measuring pulse wave velocity (PWV). Recent mathematical modeling has allowed for the delineation of…
View details →DOI: 10.1177/13872877261458779 Negative / Null Result ReportMedicine
Grębska P, Fedorczak A, Pytrus T et al. · 2026 · Nutrients
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication, restricted and repetitive behaviors, and sensory processing abnormalities, including food…
View details →DOI: 10.3390/nu18122008 Replication FailureMedicine
Alija B, Bolas T, Vithiananthan S · 2026 · The Journal of surgical research
Introduction Over one million hernia repairs are performed annually in the United States, with more than 20 million worldwide. Although randomized trials support watchful waiting in select cases, delayed repair can lead to strangulation,…
View details →DOI: 10.1016/j.jss.2026.05.020 Negative / Null Result ReportMedicine
Tuddenham S, Brotman RM, Handa VL · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Approximately 60% of adult women experience at least 1 urinary tract infection, and more than 25% experience multiple recurrences. If persistent bacterial reservoirs in the urinary tract contribute to the high incidence of…
View details →DOI: 10.1097/spv.0000000000001740 