Failed Experiment ReportOpen accessMedicine
Harbi E, Byrne YY, Bozbey HU et al. · 2026 · Apoptosis : an international journal on programmed cell death
Glioblastoma is the most aggressive and most common grade 4 tumor of the central nervous system (CNS). Despite standard treatments such as surgical resection and chemoradiotherapy, overall survival (OS) usually does not exceed 14-16 months…
View details →DOI: 10.1007/s10495-026-02275-5 Negative / Null Result ReportMedicine
Byrne RA, Hahn JY, O'Kane P et al. · 2025 · JACC. Cardiovascular interventions
Background In recent years, drug-coated balloon (DCB) angioplasty has become an established treatment option for the treatment of coronary in-stent restenosis (ISR). Objectives The aim of this study was to compare the angiographic and…
View details →DOI: 10.1016/j.jcin.2024.11.026 Negative / Null Result ReportMedicine
Morgenthaler J, Trommer M, Khor R et al. · 2024 · Oral oncology
Oropharyngeal carcinomas linked to high-risk types of human papillomavirus (HPV + OPC) as a distinct tumor entity, have a better prognosis than HPV - OPC. Current treatment approaches do not differentiate between HPV-positive and negative…
View details →DOI: 10.1016/j.oraloncology.2024.107089 Negative / Null Result ReportMedicine
Šostakaitė G, Jauniškytė M, Budrys D et al. · 2025 · Nutrition (Burbank, Los Angeles County, Calif.)
Background and aims Muscle wasting is a prevalent issue among long-term critically ill patients and is associated with adverse clinical outcomes. Evaluating muscle mass in the ICU presents challenges due to the lack of a consistent…
View details →DOI: 10.1016/j.nut.2024.112607 Negative / Null Result ReportOpen accessMedicine
Jaffee S, Kusyk DM, Onyiah C et al. · 2026 · Surgical neurology international
Background Neuropsychological assessment is crucial in the presurgical evaluation of patients with Parkinson's disease (PD) who are contemplating deep-brain stimulation (DBS). No standardized screening test battery currently exists. Our…
View details →DOI: 10.25259/sni_689_2025 Negative / Null Result ReportOpen accessMedicine
Adam AS, Marcélis L, Fage D et al. · 2026 · JIMD reports
Hereditary tyrosinemia type I (HT-1) is a rare metabolic disorder treated by NTBC, requiring careful therapeutic and nutritional monitoring. While follow-up traditionally relies on urinary succinylacetone, plasma NTBC and plasma amino…
View details →DOI: 10.1002/jmd2.70062 Negative / Null Result ReportOpen accessMedicine
Chen Y, Ma Y, Yuan H et al. · 2025 · BMC cancer
OBJECTIVES: To investigate clinicopathological predictors and evaluate the impact of adjuvant therapy on survival outcomes in patients with early-stage (FIGO 2023 Stage I-II) endometrial clear cell carcinoma (ECCC). METHODS: This…
View details →DOI: 10.1186/s12885-025-14965-5 Negative / Null Result ReportOpen accessMedicine
GamalEl Din SF, Nabil NI, Khalil MA et al. · 2025 · Urology research & practice
Objective The present study examined the impact of measuring penile girth and length in the erect state on reassuring individuals with small penis anxiety (SPA) in the flaccid state. Methods This study included 200 potent men aged 25-40…
View details →DOI: 10.5152/tud.2025.24133 Negative / Null Result ReportOpen accessMedicine
Sköld C, Hailer NP, Mallmin H · 2026 · Acta orthopaedica
Background and purpose Denosumab may preserve periprosthetic bone mineral density (pBMD) around uncemented total hip arthroplasty (THA) components. This exploratory analysis of a previously published randomized controlled trial (RCT) aimed…
View details →DOI: 10.2340/17453674.2026.45695 Negative / Null Result ReportOpen accessMedicine
Lin YH, Tsai IJ, Chang YA et al. · 2026 · Therapeutics and clinical risk management
Background Traumatic brain injury (TBI) is a major risk factor for subsequent neurodegenerative disorders. Emerging evidence suggests that statins may mitigate neuroinflammation and lipid dysregulation after TBI. This study aimed to…
View details →DOI: 10.2147/tcrm.s591742 Negative / Null Result ReportOpen accessMedicine
Dos Santos LC, da Cunha VB, Ribeiro JM et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Cocaine use disorder (CUD) remains a major public health challenge with limited effective therapeutic options. Cannabidiol (CBD) has been proposed as a potential treatment due to its neuroprotective and anti-craving properties. This…
View details →DOI: 10.1007/s00210-026-05037-x Failed Experiment ReportOpen accessMedicine
Zamalloa N, Rose J, Lap CJ et al. · 2026 · Current oncology (Toronto, Ont.)
Human epidermal growth factor receptor 2 (HER2) is a molecular target of interest in prostate cancer due to its association with poor prognosis and its potential role in androgen receptor signaling. However, earlier clinical trials…
View details →DOI: 10.3390/curroncol33020091 Negative / Null Result ReportOpen accessMedicine
Samson T, Aali M, McBride D et al. · 2026 · Current oncology (Toronto, Ont.)
Surgical resection combined with chemotherapy offers the best chance of survival in pancreatic ductal adenocarcinoma (PDAC), but many will experience recurrence and early mortality. We examined soluble AXL (sAXL), a blood protein, for its…
View details →DOI: 10.3390/curroncol33020088 Negative / Null Result ReportOpen accessMedicine
Ghiringhelli F, Rébé C · 2026 · Frontiers in immunology
Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non-small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor…
View details →DOI: 10.3389/fimmu.2026.1773253 Negative / Null Result ReportOpen accessMedicine
Schweiger L, Raggam RB, Toth-Gayor G et al. · 2025 · PloS one
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk…
View details →DOI: 10.1371/journal.pone.0321491 Negative / Null Result ReportOpen accessMedicine
Bespalov A, Swartz J, Knowles N et al. · 2025 · Alzheimer's research & therapy
Agitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer's disease (AD) dementia. It is associated with poor outcomes, including reduced functional ability, reduced…
View details →DOI: 10.1186/s13195-025-01780-0 Negative / Null Result ReportOpen accessMedicine
Kim JH, Song M, Lee KW et al. · 2026 · Life (Basel, Switzerland)
Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to…
View details →DOI: 10.3390/life16050712 Negative / Null Result ReportMedicine
Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology
Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…
View details →DOI: 10.1097/dad.0000000000002771 Negative / Null Result ReportOpen accessMedicine
Misawa A, Kimura E, Inoue M et al. · 2025 · Journal of surgical case reports
Tension-free vaginal mesh repair surgery (TVM) has decreased due to complications related to mesh use and the lack of superiority compared to native tissue repair (NTR). In japan it is still performed as a treatment for pelvic organ…
View details →DOI: 10.1093/jscr/rjaf537 Negative / Null Result ReportMedicine
Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines
Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…
View details →DOI: 10.3390/biomedicines12061201 Negative / Null Result ReportOpen accessMedicine
Samatoshenkov I, Zakirova E, Samatoshenkova J et al. · 2026 · Cells
Peripheral arterial disease and critical limb-threatening ischemia remain major clinical challenges, particularly in patients who are not candidates for surgical or endovascular revascularization. These limitations have stimulated…
View details →DOI: 10.3390/cells15121104 Negative / Null Result ReportOpen accessMedicine
Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus
Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…
View details →DOI: 10.7759/cureus.104675 Replication FailureMedicine
Sonnick MA, Laothamatas K, Furfaro D et al. · 2024 · Transplantation proceedings
Background In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is…
View details →DOI: 10.1016/j.transproceed.2024.08.025 Replication FailureMedicine
Pradhan A, Bhandari M, Vishwakarma P et al. · 2024 · European review for medical and pharmacological sciences
Heart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the…
View details →DOI: 10.26355/eurrev_202404_35929 Replication FailureOpen accessMedicine
Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal
Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…
View details →DOI: 10.1093/esj/aakag014 Negative / Null Result ReportOpen accessMedicine
Massardier E, Manchec O, Bérard E et al. · 2025 · Journal of experimental orthopaedics
Purpose Numerous studies have been published on the optimal management of the patella during total knee arthroplasty (TKA), but controversy remains. The aim of this study was to compare survivorship and functional outcomes with or without…
View details →DOI: 10.1002/jeo2.70448 Negative / Null Result ReportMedicine
Jung JC, Ju JW, Chang HW et al. · 2024 · Journal of cardiothoracic and vascular anesthesia
Objectives This study evaluated the performances of the age, creatinine, and ejection fraction (ACEF) I and II scores and compare them with that of the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II score in patients…
View details →DOI: 10.1053/j.jvca.2024.08.011 Negative / Null Result ReportOpen accessMedicine
Tambaro FP, Fabozzi F, Masetti R et al. · 2026 · Frontiers in oncology
Deterioration of nutritional status in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is associated with increased morbidity. Enteral nutrition (EN) has been associated with more favorable outcomes than total…
View details →DOI: 10.3389/fonc.2026.1778224 Negative / Null Result ReportOpen accessMedicine
Higuchi T, Igarashi K, Miwa S et al. · 2025 · Medicine
The clinical utility of P-glycoprotein (P-gp) in osteosarcoma remains controversial. This retrospective cohort study aimed to investigate the association between P-gp expression and clinicopathological factors, chemotherapy (CTx) response,…
View details →DOI: 10.1097/md.0000000000043472 Negative / Null Result ReportOpen accessMedicine
Kim GH, Fass R · 2025 · Journal of neurogastroenterology and motility
Extraesophageal symptoms and signs of gastroesophageal reflux disease (GERD), such as throat clearing, globus sensation, hoarseness, cough, asthma, pulmonary fibrosis, otitis, sinusitis, and dental erosions, are common and pose diagnostic…
View details →DOI: 10.5056/jnm24159 