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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 301 of 724

Negative / Null Result ReportMedicine

Effect of Basal Septal Hypertrophy on TAVR Outcomes: Evidence From a Large Cohort Study.

Arow Z, Oliva O, Iwata J et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Basal septal hypertrophy (BSH) is commonly encountered in elderly patients undergoing transcatheter aortic valve replacement (TAVR). However, its impact on periprocedural and procedural outcomes remains unclear. Aims The aim of…

View details →DOI: 10.1002/ccd.70462
Negative / Null Result ReportMedicine

Improving Medication Adherence in Kidney Transplant Recipients Through Educational Intervention and Monitoring: A Randomized Clinical Trial.

Heinrich de Oliveira C, Schweig A, Gonçalves BP et al. · 2026 · Transplantation proceedings

Background Kidney graft survival after transplantation is highly dependent on continuous adherence to immunosuppressive therapy. Poor adherence is a significant cause of graft loss, and educational interventions to optimize care have been…

View details →DOI: 10.1016/j.transproceed.2026.05.011
Negative / Null Result ReportOpen accessMedicine

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

Hu L, Zhao C, Wang T et al. · 2026 · BMC oral health

BACKGROUND: Pain is the common complication after tooth extraction, while the reasons behind it still remains. Insomnia, another prevalent issue, negatively affects physical, mental health, and quality of life. The relations between…

View details →DOI: 10.1186/s12903-026-08214-9
Negative / Null Result ReportMedicine

Network based statistics associates increased connectivity to REM sleep disorder and hallucinations in early DLB.

Carini L, Sommariva S, Famà F et al. · 2026 · NPJ Parkinson's disease

Dementia with Lewy Bodies (DLB) is a heterogeneous disease characterized by four core clinical features: visual hallucinations, REM sleep behaviour disorder (RBD), cognitive fluctuations and Parkinsonism. We study the relationship between…

View details →DOI: 10.1038/s41531-026-01412-w
Negative / Null Result ReportOpen accessMedicine

Dose and clinical impact of delineation variability in brain metastases treated with stereotactic radiotherapy.

Perrot A, Dissaux B, Roux AC et al. · 2026 · Clinical and translational radiation oncology

Introduction Accurate delineation is critical for stereotactic radiotherapy (SRT) of brain metastases. We evaluated how inter-reader delineation variability affects target dose coverage and local relapse-free survival (LRFS). Methods and…

View details →DOI: 10.1016/j.ctro.2026.101177
Negative / Null Result ReportMedicine

Impact of Scarring Disorders and Surgical Techniques on the Development of Capsular Contracture in Breast Augmentation.

Hall JA, Huttinger AL, Potturi N et al. · 2026 · Annals of plastic surgery

Background Capsular contracture is a common complication following breast augmentation and a major indication for reoperation. While pocket contamination and aberrant inflammatory processes are suspected causes, a definitive etiology has…

View details →DOI: 10.1097/sap.0000000000004706
Negative / Null Result ReportMedicine

Outcomes of a penicillin allergy de-labelling implementation intervention in a UK hospital: a prospective, single centre, type 2 hybrid effectiveness-implementation study evaluated using mixed methods.

Powell N, Hearsey D, West R et al. · 2026 · Implementation science communications

Background Non-allergy specialist healthcare workers removing low-risk penicillin allergy (penA) records, enabling patients to receive penicillin antibiotics, is safe but not common practice. We developed a behavioural change…

View details →DOI: 10.1186/s43058-026-01008-8
Negative / Null Result Report

Migration gains but not fertility change. An impact evaluation of a municipal family policy in Trentino via Synthetic Difference-in-Differences

Gorodetskaya O, Marzani P, Podesta' F · 2026 · Preprint

Abstract This study started from the assumption that family policies, although primarily implemented to improve the well-being of family members in a given territory, can exercise indirect effects on certain demographic outcomes, such as…

View details →DOI: 10.21203/rs.3.rs-8116068/v1
Failed Experiment ReportMedicine

The Impact of the Geriatric Emergency Department Initiative on Older Community Dwelling Adults Presenting to the Emergency Department With a Completed Delirium Screen.

Williams K, Craswell A, Tsao H et al. · 2026 · Emergency medicine Australasia : EMA

Objective Australia's ageing population resulted in increasing Emergency Department (ED) presentations among older adults, particularly frail and those at risk of adverse outcomes. Delirium contributes significantly to morbidity in this…

View details →DOI: 10.1111/1742-6723.70266
Negative / Null Result ReportMedicine

The impact of short-term ambient air pollution on CPAP therapy outcomes in obstructive sleep apnea.

Karkala A, Kalkanis A, Vangelder H et al. · 2026 · Sleep & breathing = Schlaf & Atmung

Purpose To determine whether short-term exposure to ambient air pollution adversely impacts the effectiveness of CPAP therapy in patients with diagnosed Obstructive Sleep Apnea (OSA). Methods In a retrospective cohort study of 185 patients…

View details →DOI: 10.1007/s11325-026-03730-y
Negative / Null Result ReportMedicine

Pre-processing and thermal treatment modulate structure, solubility and digestibility of faba bean protein isolates: A structure–function perspective

Sharma N, Gwala S, Owens RA et al. · 2026 · Food Hydrocolloids.

Despite growing interest in faba bean (Vicia faba L.) as a sustainable plant protein source, limited studies address process-induced structural mechanisms linking functionality with gastro-intestinal (GI) digestion. This study elucidates…

Negative / Null Result ReportMedicine

Do steroids improve outcomes of idiopathic sixth nerve palsy in children?

Sternfeld A, Goren L, Ehrenberg M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To analyze the effect of systemic steroid treatment in children with benign acquired isolated sixth nerve palsy (BAISNP) regarding healing, recurrence risk and late sequelae. Methods A retrospective cohort design was used. The…

View details →DOI: 10.1007/s00417-026-07286-1
Negative / Null Result ReportMedicine

Haemodynamic effects of low versus high dialysate temperature in haemodialysis patients: a single-blinded, randomised, cross-over study.

Jørgensen IEH, Jensen JSK, Buus NH et al. · 2026 · BMC nephrology

Background Cooling of the dialysate may improve intradialytic haemodynamics. This study compared low dialysate temperature (LDT) of 35 °C with high dialysate temperature (HDT) of 37 °C (standard) in terms of blood pressure (BP),…

View details →DOI: 10.1186/s12882-026-04990-2
Negative / Null Result Report

Fiscal Rule Stretching in the European Union: The Impact of Elections, Financial Stress, and Excessive Deficit Procedures on Government Debt Revisions

Bhuekar A · 2026 · Preprint

This paper examines the strategic manipulationof government debt data—referred to as ”fiscal rule stretch-ing”—among European Union member states, particularly inresponse to electoral incentives, financial market stress, and theconstraints…

View details →DOI: 10.20944/preprints202603.0301.v1
Negative / Null Result ReportMedicine

Data accuracy of prescriptions reported to the Arkansas prescription drug monitoring program.

Embry K, Cima L, Turpin J et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Prescription Drug Monitoring Programs (PDMPs) are databases for controlled substances dispensed from retail pharmacies. Although all 50 states operate their own PDMP, only a few have assessed the accuracy of the data being…

View details →DOI: 10.1016/j.japh.2026.103138
Negative / Null Result ReportMedicine

Climatic impact on ram lamb reproductive development: the effect of solar radiation.

Gómez-Vargas JC, Parra-Bracamonte GM, Muñoz-García C et al. · 2026 · Animal : an international journal of animal bioscience

Climate change has a significant impact on global animal production. The objective was to evaluate the long-term effects of direct solar radiation on reproductive development in Pelibuey ram lambs under heat stress. Eighteen ram lambs (6.9…

View details →DOI: 10.1016/j.animal.2026.101868
Negative / Null Result ReportMedicine

Interhospital transfer dynamics in foreign body aspiration: Age-stratified nationwide retrospective cohort study.

Deniz MS, Çiflik KB, Özdemir Çiflik B et al. · 2026 · Turk gogus kalp damar cerrahisi dergisi

Background Foreign body aspiration (FBA) is an acute clinical emergency that is particularly common in the pediatric population and, if not managed promptly, can lead to serious morbidity and mortality across all age groups. The need for…

View details →DOI: 10.4274/tjtcs.2026.2026-4-11
Negative / Null Result ReportMedicine

Evaluating the predictive utility of European-based and transethnic polygenic risk scores for kidney function in older Black adults: insights from the Health and Retirement Study.

Cobb RJ, Thorpe RJ Jr, Norris KC · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences

Background Black populations in the U.S. experience a disproportionately faster progression of chronic kidney disease than the general population. Polygenic risk scores (PRS) are a promising tool for risk stratification, yet their utility…

View details →DOI: 10.1093/gerona/glag122
Negative / Null Result ReportMedicine

[Exploration of the value of VAS score in the diagnosis and treatment of patients with vestibular diseases during caloric test].

Tian L, Liu X, Yu J et al. · 2026 · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery

Objective: To identify the factors influencing the visual analogue scale(VAS) scores for distress experienced by patients with vestibular diseases during caloric tests, and to explore the value of VAS scores in disease diagnosis and…

View details →DOI: 10.13201/j.issn.2096-7993.2026.06.002
Negative / Null Result ReportMedicine

Echolocating free-tailed bats use vision and hearing but not magnetoreception when navigating a maze.

Lemus K, Meyers R, Ellis S et al. · 2026 · Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

Insectivorous bats navigate mainly by echolocation, but may also use visual, olfactory, and magnetic cues when travelling long distances. Parsing the relative contributions of different senses for navigation is difficult in wild bats. In…

View details →DOI: 10.1007/s00359-026-01813-5
Negative / Null Result ReportMedicine

Effects of Psychosocial Interventions on Measures of Stress Among Breast Cancer Survivors: A Scoping Review.

Cousin L, Guillen S, Behar-Horenstein LS et al. · 2026 · Cancer nursing

Background With 4 million breast cancer survivors (BCSs) in the United States, researchers are interested in mitigating the effects of stress after cancer diagnosis. This stress can affect immune and endocrine systems, elevating cancer…

View details →DOI: 10.1097/ncc.0000000000001550
Negative / Null Result ReportMedicine

Health behaviors of young adults in the context of preventing cardiovascular diseases caused by atherosclerosis.

Kawalec-Kajstura E, Kopeć M, Sułkowska J et al. · 2025 · Folia medica Cracoviensia

Introduction Cardiovascular diseases caused by atherosclerosis are one of the leading causes of death in Poland and worldwide. Atherosclerosis develops from the earliest years of life and is influenced by modifiable risk factors resulting…

View details →DOI: 10.24425/fmc.2025.156703
Negative / Null Result ReportMedicine

Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure and clinical severity in children: a prospective observational study.

Naseem M, Anand V, Das R et al. · 2026 · European journal of pediatrics

Elevated intracranial pressure (ICP) can complicate various neurological conditions in children and may result in fatal brainstem herniation. Early detection and management can prevent this fatal complication. This prospective…

View details →DOI: 10.1007/s00431-026-07053-8