e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21287 results · page 300 of 710

Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

View details →DOI: 10.1016/j.jocn.2025.111754
Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

View details →DOI: 10.1016/j.ijgc.2025.102838
Negative / Null Result Report

Sleep Benefits to Spatial Source Memory in Older Adults

Kuhlmann BG, Shakoor S, Schicker LA et al. · 2025 · Preprint

While it is well-established that sleep benefits episodic memory, most evidence is on younger adults. The current study examined sleep benefits in older adults and chose spatial source memory as a target measure for which a recent study in…

View details →DOI: 10.31234/osf.io/jfswh_v1
Negative / Null Result ReportMedicine

Postoperative Outcomes in Body Contouring Procedures Following Glucagon-Like Peptide-1 Receptor Agonist Use: A 10-Year Analysis.

Liang J, Pillai T, Chopra S et al. · 2025 · Aesthetic surgery journal

Background Utilization of glucagon-like peptide-1 receptor agonists (GLP-1ras) has increased dramatically in recent years. Although GLP-1ras appear safe to use overall, it remains unclear whether preoperative GLP-1ra use impacts body…

View details →DOI: 10.1093/asj/sjaf029
Negative / Null Result ReportMedicine

Cranioplasty after surgical site infection in brain tumor patients: insights from a 15-year Swedish multicenter study.

Holmgren K, Fletcher-Sandersjöö A, Sæmundsson B et al. · 2026 · Journal of neurosurgery

Objective Postoperative surgical site infections (SSIs) following brain tumor surgery frequently necessitate wound revision and bone flap removal. However, data on subsequent cranial reconstruction in this context remain limited. The aim…

View details →DOI: 10.3171/2025.7.jns251301
Negative / Null Result ReportMedicine

When the Lights Go Out: Studying Sex Differences in Sleep Latency, Sleep Quality, and Social Behavior in Captive Rhesus Macaques (Macaca mulatta) Over a 24-h Period.

Roach A, Furman S, Hadeed J et al. · 2025 · American journal of primatology

Assessments of nonhuman primate (NHP) affiliation are typically restricted to daytime behavior. There is, however, a growing interest in understanding NHP behavior and welfare over the 24-h period. To assess the sleep quality and sociality…

View details →DOI: 10.1002/ajp.70098
Negative / Null Result ReportMedicine

The MEniscal TeaR Outcome (METRO) study : a prospective cohort study exploring the factors that affect outcomes in patients undergoing treatment for a meniscal tear.

Ahmed I, Dhaif F, Bowes MA et al. · 2025 · The bone & joint journal

Aims The aim of this study was to describe the baseline characteristics of patients with a meniscal tear and explore associations with 12-month outcomes. Methods This prospective, national multicentre cohort study recruited patients aged…

View details →DOI: 10.1302/0301-620x.107b11.bjj-2024-1429.r1
Negative / Null Result ReportMedicine

Longitudinal associations between maternal depression, problematic media use, and parenting efficacy as a time-varying mediator.

Holmgren HG, Densley RL, Coyne SM et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Prior research suggests a link between maternal depression and mothers' problematic media use (PMU), defined as compulsive or dysregulated media use that interferes with daily functioning. This study examined whether parenting…

View details →DOI: 10.1037/fam0001474
Negative / Null Result ReportMedicine

Associations between physical literacy and physical activity in adults. A cross-sectional study with self-report and device-based physical activity assessments.

Naylor A, Keegan R, Martin K et al. · 2025 · Journal of sports sciences

Physical literacy has been shown to relate to children's engagement in physical activity. However, it is unclear whether this relationship extends to adults. A two-phase cross-sectional study was conducted to examine whether physical…

View details →DOI: 10.1080/02640414.2025.2468593
Negative / Null Result ReportMedicine

Affective predictors of day-level impaired control over alcohol use.

Waddell JT, DeFalco A, Emery NE · 2026 · Addictive behaviors

Rationale Impaired control over alcohol use is a core aspect of Alcohol Use Disorder symptomatology. However, research regarding how impaired control manifests at the day-level, and what temporally proceeds it in daily life, remains…

View details →DOI: 10.1016/j.addbeh.2025.108506
Negative / Null Result ReportOpen accessMedicine

The effect of using intra-oral camera as an educational aid for oral health promotion in children.

Pratyusha K, Chaitanya P, Vinay C et al. · 2025 · European oral research

Purpose The aim of this study was to evaluate the effect of using an intraoral camera (IOC) as an educational aid for promoting oral health among 7-10-year-old children in India. Materials and methods A randomized trial was conducted…

View details →DOI: 10.26650/eor.20241534830
Negative / Null Result ReportMedicine

Impaired Goal-Directed Planning in Transdiagnostic Compulsivity Is Explained by Uncertainty About Learned Task Structure.

Sookud S, Martin I, Gillan CM et al. · 2026 · Biological psychiatry. Cognitive neuroscience and neuroimaging

Background Diminished use of goal-directed (model-based) decision making is a hallmark of transdiagnostic compulsivity, promoting an overreliance on inflexible and habitual behaviors. However, the origin of this impairment remains unclear.…

View details →DOI: 10.1016/j.bpsc.2025.10.005
Negative / Null Result Report

State but not trait measures of vividness relate to memory accuracy

Duckett W, Simons J · 2025 · Preprint

Vivid mental imagery is often assumed to relate to memory accuracy, but recent empirical findings from studies of aphantasia have found conflicting results regarding this association. The present study investigates the relationship between…

View details →DOI: 10.31234/osf.io/sqydt_v1
Negative / Null Result Report

Consolidating Climate Anxiety Scales Using Rasch Modelling

Gago T, Sargisson RJ, Milfont TL · 2025 · Preprint

Despite being an important mental health consequence of climate change, climate anxiety assessment has been fragmented. Reviews of measures of climate anxiety raise concerns about content and convergent validity. We aimed to select the…

View details →DOI: 10.31234/osf.io/fx3a5_v1
Negative / Null Result ReportMedicine

Predictors and Outcomes Associated with Clinically Significant Improvements in Anxiety and Depression Symptoms Following Cardiac Rehabilitation.

Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology

Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…

View details →DOI: 10.1016/j.cjca.2025.10.009
Negative / Null Result ReportMedicine

Water deficit induced by polyethylene glycol leads to the depletion of phenolic compounds but did not alter lignification in roots of Scots pine (Pinus sylvestris).

Ivanov YV, Kartashov AV, Ivanova AI et al. · 2026 · Functional plant biology : FPB

Global climate change is accompanied by an increase in the frequency and severity of droughts, which negatively impact plant growth. One of the protective mechanisms that allows plants to withstand the negative drought effects is the…

View details →DOI: 10.1071/fp26003
Negative / Null Result Report

Cereal grafting in rice and pearl millet preserves photosynthetic performance and stomatal dynamics, establishing a platform for root-shoot communication studies

Mbaluto CM, Martinez-Goni XS, Tripathi A et al. · 2026 · Preprint

Cereal grafting using embryonic tissues has recently become technically feasible; however, the physiological consequences of cereal grafting remain uncharacterized. We systematically evaluate photosynthetic performance and stomatal…

View details →DOI: 10.64898/2026.06.25.734459
Negative / Null Result ReportMedicine

Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.

Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology

Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…

View details →DOI: 10.1007/s00213-026-07115-7
Negative / Null Result ReportMedicine

Temporal dynamics of nutrient elements in biochar and biochar-amended soils over three years: a comparative micro-XRF and SEM-EDX study.

Aumtong S, Soongsoongnoen P, Wanwinit D · 2026 · Scientific reports

Biochar reshapes soil composition for years, yet most evidence comes from short-term, single-element laboratory incubations, leaving multi-element dynamics in tropical soils poorly resolved. We tracked 11 elements in longan-wood biochar…

View details →DOI: 10.1038/s41598-026-59314-z
Negative / Null Result ReportMedicine

Cognitive flexibility subtypes and anorexia nervosa symptom severity: Evaluating the contribution of perfectionism.

Heled E, Himai Y, Papelbaum M et al. · 2026 · Journal of psychiatric research

Impaired cognitive flexibility (CF) and elevated perfectionism are well-documented in anorexia nervosa (AN), yet their contribution to symptom severity remains unclear. The current study aimed to examine whether CF predicts symptom…

View details →DOI: 10.1016/j.jpsychires.2026.06.014
Negative / Null Result ReportMedicine

Saccharomyces cerevisiae and Bacillus subtilis show modest, node-dependent effects on insulin sensitivity in periparturient cows.

Pirbornatan A, Chalmeh A, Pourjafar M et al. · 2026 · Veterinary journal (London, England : 1997)

Periparturient immunometabolic adaptations yield small, node-dependent shifts in endotoxin proxies and insulin-sensitivity indices. Direct-fed microbials (DFM) are mechanistically plausible but often produce modest metabolic readouts. Test…

View details →DOI: 10.1016/j.tvjl.2026.106746
Negative / Null Result Report

Higher Renal Mineralocorticoid Receptor and 11β-hydroxysteroid Dehydrogenase Type 2 Levels Promote Potassium Retention in Female Spontaneously Hypertensive Rats Under MR Blockade

Baranovskaya I, Bilous I, Alexander S et al. · 2026 · Preprint

Mineralocorticoid receptor (MR) blockade exerts sex-specific effects in hypertension and cardiovascular disease; however, its role in blood pressure regulation in spontaneously hypertensive rats (SHR) remains unclear. We assessed the…

View details →DOI: 10.20944/preprints202606.0922.v1