e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

750 results in Failed Experiment Report · page 3 of 25

Failed Experiment ReportOpen accessMedicine

Electrophysiological profile of vernakalant in an experimental whole-heart model: the absence of proarrhythmia despite significant effect on myocardial repolarization

Gerrit Frommeyer, Peter Milberg, C. Clauss et al. · 2014 · EP Europace

AIM: The most recent European Society of Cardiology (ESC) update on atrial fibrillation has introduced vernakalant (VER) for pharmacological cardioversion of atrial fibrillation. The aim of the present study was to investigate the safety…

View details →DOI: 10.1093/europace/euu014Cited by 18
Failed Experiment ReportPsychology

An investigation of self‐efficacy crossover between mentors and protégés within mentoring dyads

Lebena Varghese, Lisa M. Finkelstein · 2020 · Annals of the New York Academy of Sciences

Our current research investigated how mentors enhance protégé self-efficacy. Drawing from social comparison theory, we propose that the shared experience between mentors and protégés facilitates the ability of protégés to adopt the…

View details →DOI: 10.1111/nyas.14324Cited by 18
Failed Experiment ReportMedicine

A phase II study of GDC-0032 (taselisib) for previously treated PI3K positive patients with stage IV squamous cell lung cancer (SqNSCLC): LUNG-MAP sub-study SWOG S1400B.

James L. Wade, Corey J. Langer, Mary W. Redman et al. · 2017 · Journal of Clinical Oncology

9054 Background: Lung-MAP (S1400) is a National Clinical Trials Network “umbrella” trial for previously-treated SqNSCLC. Sub-study S1400B included patients (pts) with tumors harboring PI3K mutations.Taselisib (GDC-0032), a potent, small…

View details →DOI: 10.1200/jco.2017.35.15_suppl.9054Cited by 16
Failed Experiment ReportOpen accessMedicine

IFN-γ and PPARδ Influence the Efficacy and Retention of Multipotent Adult Progenitor Cells in Graft vs Host Disease

Fiona Carty, Hazel Dunbar, Ian J. Hawthorne et al. · 2021 · Stem Cells Translational Medicine

Cell-based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry-sponsored…

View details →DOI: 10.1002/sctm.21-0008Cited by 15
Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genetic improvement of indigenous Greek sheep and goat breeds

Angeliki Argyriadou, Athanasios Ι. Gelasakis, Georgios Banos et al. · 2020 · Journal of the Hellenic Veterinary Medical Society

The objective of the study was twofold: (i) to review the genetics of production and resilience traits of indigenous Greek small ruminant breeds as well as the evolution of national breeding programs, and (ii) explore innovative and…

View details →DOI: 10.12681/jhvms.22967Cited by 15
Failed Experiment ReportOpen accessMedicine

Profiling tofersen as a treatment of superoxide dismutase 1 amyotrophic lateral sclerosis

Miguel Oliveira Santos, Mamede de Carvalho · 2024 · Expert Review of Neurotherapeutics

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive motor neuron disorder with a fatal outcome 3-5 years after disease onset due to respiratory complications. Superoxide dismutase 1 (SOD1) mutations are found in…

View details →DOI: 10.1080/14737175.2024.2355983Cited by 15
Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology

A Francisella tularensis Live Vaccine Strain That Improves Stimulation of Antigen-Presenting Cells Does Not Enhance Vaccine Efficacy

Deanna Schmitt, Dawn M. O’Dee, Joseph Horzempa et al. · 2012 · PLoS ONE

Vaccination is a proven strategy to mitigate morbidity and mortality of infectious diseases. The methodology of identifying and testing new vaccine candidates could be improved with rational design and in vitro testing prior to animal experimentation. The tularemia vaccine, Francisella tularensis live vaccine strain (LVS), does not elicit complete protection against lethal challenge with a virulent type A Francisella strain. One factor that may contribute to this poor performance is limited stimulation of antigen-presenting cells. In this study, we examined whether the interaction of genetical

View details →DOI: 10.1371/journal.pone.0031172Cited by 14
Failed Experiment ReportOpen accessMedicine

Clearance of HBeAg and HBsAg of HBV in mice model by a recombinant HBV vaccine combined with GM-CSF and IFN-α as an effective therapeutic vaccine adjuvant

Weidong Zhao, Gan Zhao, Shuren Zhang et al. · 2018 · Oncotarget

// Weidong Zhao 1 , Gan Zhao 1 , Shuren Zhang 1 , Xianzheng Wang 1 , Xueping Yu 2 and Bin Wang 1 1 Key Laboratory of Medical Molecular Virology of The Ministry of Health and Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China 2 Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China Correspondence to: Bin Wang, email: bwang3@fudan.edu.cn Keywords: GM-CSF; IFN-α; therapeutic vaccine; HBV; Ly6C hi monocyte Received: April 14, 2017      Accepted: October 30, 2017      Epub

View details →DOI: 10.18632/oncotarget.25789Cited by 14
Failed Experiment ReportPhysics and Astronomy

Factorial Correlators and Oscillatory Multiplicity Moments at the CERN SPS Energy for Ring-Like and Jet-Like Events

Prabir Kumar Haldar, Sanjib Kumar Manna · 2011 · Chinese Physics Letters

We present an analysis of ring-like and jet-like events in terms of factorial correlations and oscillatory multiplicity moments of 32S-Ag/Br interactions at 200 A GeV. The investigation reveals that the correlated moments increase with…

View details →DOI: 10.1088/0256-307x/28/1/012502Cited by 13
Failed Experiment Report

Multiple subtraction using statistically estimated inverse wavelets

Yike Liu, Degang Jin, Xu Chang et al. · 2010 · Geophysics

Abstract Surface-related multiple elimination (SRME) typically consists of two steps: The first step is prediction and the second step is subtraction. In subtraction, it is important to effectively attenuate multiple events and preserve…

View details →DOI: 10.1190/1.3494082Cited by 13
Failed Experiment Report

A note on Nakano generalized difference sequence space

Awad A. Bakery, Afaf R. Abou Elmatty · 2020 · Advances in Difference Equations

Abstract In this paper, we investigate the necessary conditions on any s -type sequence space to form an operator ideal. As a result, we show that the s -type Nakano generalized difference sequence space X fails to generate an operator…

View details →DOI: 10.1186/s13662-020-03082-1Cited by 13
Failed Experiment Report

On statistically-secure quantum homomorphic encryption

Ching-Yi Lai, Kai-Min Chung · 2018 · Quantum Information and Computation

Homomorphic encryption is an encryption scheme that allows computations to be evaluated on encrypted inputs without knowledge of their raw messages. Recently Ouyang et al. constructed a quantum homomorphic encryption (QHE) scheme for…

View details →DOI: 10.26421/qic18.9-10-4Cited by 11
Failed Experiment ReportOpen accessPhysics and Astronomy

Physics basis for the reference flat-top plasma scenario in the ST–E1 fusion power plant

Steven McNamara, S. Abouelazayem, А. И. Алиева et al. · 2026 · Nuclear Fusion

Abstract As part of the U.S. Department of Energy’s Milestone-Based Fusion Energy Development Program, Tokamak Energy has completed the pre-concept design of the ST–E1 fusion power plant. ST–E1 is envisaged to operate in two phases: a pilot plant phase, targeting sustained net power production of 300 − 500 MWe for a duration > 1 hr , followed by a commercial power plant phase targeting steady-state operations and a normalised overnight capital cost of ⩽ 12 000 $ / kWe . The design process adopted was highly iterative, integrating all major plant systems and progressing i

View details →DOI: 10.1088/1741-4326/ae5f33Cited by 11
Failed Experiment ReportOpen accessMedicine

Detection of Two Highly Diverse Peribunyaviruses in Mosquitoes from Palenque, Mexico

Anne Kopp, Alexandra Hübner, Florian Zirkel et al. · 2019 · Viruses

. Orthobunyaviruses and pacuviruses are mainly transmitted by blood-feeding insects and infect a variety of vertebrates whereas herbeviruses and shangaviruses have a host range restricted to insects. Here, we tested mosquitoes from a tropical rainforest in Mexico for infections with peribunyaviruses. We identified and characterized two previously unknown viruses, designated Baakal virus (BKAV) and Lakamha virus (LAKV). Sequencing and de novo assembly of the entire BKAV and LAKV genomes revealed that BKAV is an orthobunyavirus and LAKV is likely to belong to a new genus. LAKV was almost equidis

View details →DOI: 10.3390/v11090832Cited by 11
Failed Experiment ReportOpen accessEconomics, Econometrics and Finance

Optimal Markowitz portfolio using returns forecasted with time series and machine learning models

Damian Ślusarczyk, Robert Ślepaczuk · 2025 · Journal Of Big Data

We aim to answer whether using forecasted stock returns based on machine learning and time series models in a mean-variance portfolio framework yields better results than relying on historical returns. Nevertheless, the problem of…

View details →DOI: 10.1186/s40537-025-01164-zCited by 11
Failed Experiment ReportOpen accessNeuroscience

Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer’s disease therapy

Min Li, Min Li, Shuang Chen et al. · 2025 · Signal Transduction and Targeted Therapy

Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preceding β-amyloid accumulation and driving disease progression. However, therapeutic autophagy modulation is severely restricted by the blood-brain barrier (BBB). To overcome this, we developed Microglia-Liposome Fusion Extrusion (MiLi-FE), a method to engineer microglia-derived nanovesicles (AR@ENV) for the codelivery of AR7 (a CMA inducer) and rapamycin (a mac

View details →DOI: 10.1038/s41392-025-02453-yCited by 11
Failed Experiment ReportOpen accessMedicine

AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis

Sahar Motamedi, Nina Ravoet, Jonas Dehairs et al. · 2025 · Nature Communications

Ferroptosis, a regulated form of cell death driven by lipid peroxidation, holds promise for targeting treatment-resistant cancer cells. Using a panel of melanoma cell lines, we uncover variability in the timing of ferroptosis onset upon…

View details →DOI: 10.1038/s41467-025-66113-zCited by 9
Failed Experiment ReportOpen accessPhysics and Astronomy

Neutrino heating in 1D, 2D, and 3D core-collapse supernovae: characterizing the explosion of high-compactness stars

Luca Boccioli, David Vartanyan, Evan O’Connor et al. · 2025 · Monthly Notices of the Royal Astronomical Society

ABSTRACT Massive stars can end their lives with a successful supernova explosion (leaving behind a neutron star or, more rarely, a black hole), or a failed explosion that leaves behind a black hole. The density structure of the pre-collapse progenitor star already encodes much of the information regarding the outcome and properties of the explosion. However, the complexity of the collapse and subsequent shock expansion phases prevents drawing a straightforward connection between the pre-collapse and post-explosion properties. In order to derive such a connection several explodability studies h

View details →DOI: 10.1093/mnras/staf963Cited by 9
Failed Experiment Report

Classical stabilities of multiplicative inverse difference and adjoint functional equations

B. V. Senthil Kumar, Khalifa Al-Shaqsi, Hemen Dutta · 2020 · Advances in Difference Equations

Abstract The aim of this present article is to investigate various classical stability results of the multiplicative inverse difference and adjoint functional equations $$ m_{d} \biggl(\frac{rs}{r+s} \biggr)-m_{d} \biggl( \frac{2rs}{r+s}…

View details →DOI: 10.1186/s13662-020-02680-3Cited by 6
Failed Experiment Report

Replicate ice-coring system testing

Jay A. Johnson, Nicolai B. Mortensen, Christopher J. Gibson et al. · 2014 · Annals of Glaciology

Abstract Drilling the WDC06A borehole at the West Antarctic Ice Sheet (WAIS) Divide with the Deep Ice Sheet Coring (DISC) drill began in December 2007 and was successfully completed in December 2011 to a depth of 3405 m. The design and…

View details →DOI: 10.3189/2014aog68a034Cited by 5
Failed Experiment Report

Anterior Open‐Wedge Osteotomy to Correct Sagittal and Coronal Malalignment in a Case of Failed High Tibial Osteotomy and Failed Posterior Cruciate Ligament Reconstruction

K. Raghuveer Reddy, N. Somasekhara Reddy, N. Prakash · 2024 · Arthroscopy Techniques

Abstract Anterior open‐wedge high tibial osteotomy of the proximal tibia is a reliable surgical procedure to treat genu recurvatum secondary to decreased posterior tibial slope. It is also useful in cases of posterior cruciate ligament…

View details →DOI: 10.1016/j.eats.2024.103032Cited by 3
Failed Experiment Report

Significant Enhancement of Electrocaloric Effect in Ferroelectric Polymer via Nanopores Interfacial Engineering

Youhao Xiong, Zilong Xie, Sen Xue et al. · 2025 · Advanced Functional Materials

Abstract Ferroelectric polymer‐based electrocaloric (EC) materials are promising for next‐generation solid‐state refrigeration due to their high entropy change, eco‐friendliness, lightweight, and flexibility. The practical application of…

View details →DOI: 10.1002/adfm.202507417Cited by 2
Failed Experiment Report

Four Reasons Why Heterodox Academy Failed

Nathan Cofnas · 2022 · Academic Questions

Seven years ago, under the leadership of Jonathan Haidt, Heterodox Academy set out to organize a meaningful resistance to the reigning social justice orthodoxy on campus. “Seven years later,” writes Nathan Cofnas, “you can count HxA’s…

View details →DOI: 10.51845/35.4.4Cited by 2
Failed Experiment Report

‘In what orbit we shall find ourselves, no one could predict’: institutional reform, the university merger and ecclesiastical influence on Irish higher education in the 1960s

Ann Nolan, John Walsh · 2017 · Irish Historical Studies

Abstract This paper explores the persistence of ecclesiastical influence on higher education in Ireland during an era of far-reaching policy change in the 1960s. The extensive interaction between political and official elites and the…

View details →DOI: 10.1017/ihs.2017.7Cited by 2
Failed Experiment Report

Hybrid of Least Significant Bits and most Significant Bits for Improving Security and Quality of Digital Image Steganography

Abubakar Aminu Mu’azu, Kauthar Kabir · 2023 · WSEAS TRANSACTIONS ON COMPUTERS

The Security of confidential communication is protected using the most popular type of carrier to hold information known as Image steganography. The Least Significant Bit (LSB) algorithm and the Most Significant Bit (MSB) algorithm are…

View details →DOI: 10.37394/23205.2023.22.29Cited by 1
Failed Experiment Report

Impedance Based Fixture Neutralization (FINE) Method to Replicate Field Environments in Laboratory Settings

T. Skousen, J. Reyes-Blanco, P. Avitabile · 2026 · Experimental Techniques

Abstract Test article vibration test responses will vary from one test laboratory to another due to differences in shaker and fixture dynamic characteristics. This is also seen between the field and laboratory due to the differing dynamic…

View details →DOI: 10.1007/s40799-025-00830-4Cited by 1