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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21287 results · page 297 of 710

Negative / Null Result ReportMedicine

Evaluation of Hypermobility in Rhinoplasty: A Case-Control and Cross-Sectional Study.

Kocak OF, Alpayci M, Demir CY et al. · 2025 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To determine the frequency and severity of joint hypermobility (JH) in rhinoplasty patients and to assess rhinoplasty satisfaction in rhinoplasty cases with JH. Study design Comparative cross-sectional study. Place and Duration…

View details →DOI: 10.29271/jcpsp.2025.12.1603
Negative / Null Result ReportMedicine

Paired analysis of meconium and neonatal hair reveals distinct biomarker profiles of prenatal exposure to trace metal elements.

Alsayegh MMA, Sallom BA, Fadel EA et al. · 2026 · Scientific reports

Prenatal exposure to trace metal elements remains a significant public health concern, particularly because these elements can cross the placental barrier and accumulate in fetal tissues. Meconium and neonatal hair are commonly used as…

View details →DOI: 10.1038/s41598-026-54043-9
Negative / Null Result Report

Hallucination Mitigation in Large Language Model-Based Tool Recommendation: A Cross-Provider Architectural Ablation Study Across Two Model Generations

Menxhiqi L, Marinova G · 2026 · Preprint

In a closed-inventory Large Language Model (LLM) system such as Online-CADCOM, which recommends engineering tools from a verified inventory, mention-level hallucination occurs when the model recommends tools not present in the inventory.…

View details →DOI: 10.20944/preprints202606.0008.v1
Negative / Null Result ReportMedicine

PNEUMOCOCCAL SEROLOGICAL EVALUATION IN VACCINATED CHILDREN DIAGNOSED WITH TRANSIENT HYPOGAMMAGLOBULINEMIA OF INFANCY AND UNCLASSIFIED HYPOGAMMAGLOBULINEMIA.

Öztürk G, Orhon F, Bayrakoğlu D et al. · 2026 · International archives of allergy and immunology

The severity and incidence of invasive pneumococcal infections increase in inborn errors of immunities. However, there are limited number of studies in the literature evaluating pneumococcal antibody levels in patients with a prediagnosis…

View details →DOI: 10.1159/000552296
Negative / Null Result Report

Tenofovir intracellular concentration as Tenofovir alafenamide in Bictegravir-including versus Dolutegravir-including antiretroviral regimens

Ferrara M, Maccario V, Fantino S et al. · 2026 · Preprint

This study investigates intracellular (IC) exposure to tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either…

View details →DOI: 10.22541/au.177547173.39036280/v1
Negative / Null Result ReportOpen accessMedicine

Exploring the significance of fatty acid-binding protein 4 levels as a biomarker for autism spectrum disorder: a cross-sectional study.

Abdelaziz AW, Alkherkhisy MM, El-Sheikh HR et al. · 2026 · BMC psychiatry

Background Lipid metabolism and its regulatory molecules, especially adipokines, have gained significant attention in recent pathogenesis research of autism spectrum disorder (ASD). Aims To evaluate serum fatty acid-binding protein 4…

View details →DOI: 10.1186/s12888-026-08295-4
Negative / Null Result ReportMedicine

What is the Rate of Occult Vessel Abnormalities in High-Energy Tibial Plateau Fractures (OTA/AO 41)?

Zhang D, Eurich J, Pitz-Goncalves L et al. · 2026 · Journal of orthopaedic trauma

Objectives To determine the rate of occult vascular abnormalities in high-energy tibial plateau fractures using Computed Tomography Angiography (CTA). Methods Design Prospective Cohort Study. Setting Single Academic Level I Trauma Center.…

View details →DOI: 10.1097/bot.0000000000003215
Negative / Null Result ReportMedicine

Smell and taste dysfunction after total laryngectomy: A cross-sectional study comparing patient and physician perspectives.

Bilen YE, Sinanoğlu N, Külekci Ç · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Total laryngectomy disrupts nasal airflow, often resulting in significant olfactory and gustatory dysfunction. While these sensory losses may adversely affect patients' quality of life and psychological well-being, they typically…

View details →DOI: 10.1007/s00405-025-09855-2
Negative / Null Result ReportMedicine

Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.

Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…

View details →DOI: 10.5152/tjg.2026.25774
Negative / Null Result ReportMedicine

The Effect of EMG biofeedback in female patients with stress urinary incontinence: a randomized sham controlled blinded clinical study.

Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science

AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…

View details →DOI: 10.1007/s11845-026-04374-3
Negative / Null Result ReportMedicine

Compression Garments and Adaptations to Plyometric Training in Soccer Players: A Randomized-Controlled Study.

Gosset M, Coquart A, Delaval B et al. · 2026 · Journal of strength and conditioning research

Abstract Gosset, M, Coquart, A, Delaval, B, Catalano, J, Huou, G, Boufflers, M, Bozok, D, Bellanger, L, Douchet, T, Viroux, P, Jaffré, C, and Abaïdia, A-E. Compression garments and adaptations to plyometric training in soccer players: A…

View details →DOI: 10.1519/jsc.0000000000005489
Negative / Null Result ReportMedicine

Impact of peptide receptor radionuclide therapy (PRRT) on the quality of life in patients with neuroendocrine tumours.

Fernando H, Vito I, Santillan N et al. · 2026 · Journal of neuroendocrinology

As peptide receptor radionuclide therapy (PRRT) maintains a key role in the treatment of neuroendocrine tumours (NETs), there is growing recognition of the importance of evaluating patient-reported health related quality of life (HRQoL).…

View details →DOI: 10.1111/jne.70201
Negative / Null Result ReportMedicine

Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.

Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama

We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…

View details →DOI: 10.18926/amo/70454
Negative / Null Result ReportOpen accessMedicine

Evaluation of 980nm diode laser as adjunct to flap surgery.

Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation

The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…

View details →DOI: 10.6026/973206300221689
Negative / Null Result ReportMedicine

Maintenance of occupational therapy for individuals with dementia: Findings from a pragmatic randomized controlled trial.

Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…

View details →DOI: 10.1177/13872877261442233
Negative / Null Result ReportMedicine

Motivational interviewing and air cleaners for smokers with COPD (MOVE): a randomized, double-blind, placebo-controlled trial.

Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…

View details →DOI: 10.1093/ajrccm/aamag016
Negative / Null Result ReportOpen accessMedicine

Effectiveness of a Telemedicine Exercise Program to Improve Lung Function in Young Adults After COVID-19: A Pilot Study.

Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)

Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…

View details →DOI: 10.3390/healthcare14060718
Negative / Null Result Report

Enhancing Student Engagement and Teamwork: Evidence from a Randomized Controlled Trial of the BOPPPS Model in College Volleyball Courses

Xie E, He Y, Cao T et al. · 2026 · Preprint

Abstract Background BOPPPS, which comprises six components—Bridge-in, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary—is a student-centered structured teaching model widely applied in theoretical courses.…

View details →DOI: 10.21203/rs.3.rs-8477294/v1
Negative / Null Result ReportMedicine

Adolescents Who Underwent Revision Hip Arthroscopy Showed Comparable Magnitude of Improvement but Had Lower Clinical Benefit Rates and Higher Risk of Subsequent Surgeries Compared to a Propensity-Matched Primary Group at 2-Year Follow-Up.

Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…

View details →DOI: 10.1002/arj.70139
Negative / Null Result ReportMedicine

Outcomes of Maximal Conventional Therapy Before Biological Treatment in Recurrent Chronic Rhinosinusitis With Nasal Polyps.

Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery

Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…

View details →DOI: 10.1097/scs.0000000000012616
Negative / Null Result ReportMedicine

[C-Quant scattered light measurement and corneal densitometry in Fuchs endothelial dystrophy before and after DMEK].

Da Costa M, Seitz B, Munteanu C et al. · 2026 · Die Ophthalmologie

Background In Germany, each surgical corneal center defines individual criteria for the indications for Descemet membrane endothelial keratoplasty (DMEK). Clinical experience shows a clear discrepancy between best corrected visual activity…

View details →DOI: 10.1007/s00347-026-02422-y
Negative / Null Result ReportMedicine

Meme-Based Learning in Neuroanatomy: A Comparative Study on Effectiveness, Gender, and Student Performance Levels.

Eldesoqui M, Al-Batati A, Erfan OS et al. · 2026 · Clinical anatomy (New York, N.Y.)

Generation Z has different requirements, problems, expectations, and attitudes that they bring into the educational environment. Teachers have unprecedented challenges in addressing their needs and aspirations. Gamification involves…

View details →DOI: 10.1002/ca.70122
Negative / Null Result ReportMedicine

Comparative Outcomes of the Modified Woodward Procedure Versus Conservative Management in Sprengel Deformity: A Retrospective Cohort Study.

Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics

Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…

View details →DOI: 10.1097/bpo.0000000000003387
Negative / Null Result ReportMedicine

Fortitude as a Key to Reducing Burnout: Its Critical Role in Influencing the Relationship Between Organizational Support and Burnout.

Weinzimmer LG, Hippler SE · 2026 · Journal of healthcare management / American College of Healthcare Executives

Goal Burnout in healthcare remains a significant problem, with implications not only for physicians and advanced practice providers but also for the entire US healthcare system, including patients and payers. Significant work has been done…

View details →DOI: 10.1097/jhm-d-24-00244
Negative / Null Result ReportOpen accessMedicine

Effect of temporomandibular joint exercises on mechanical low back pain: a preliminary randomized controlled study.

Rathi M, Mali N, Gazbare P et al. · 2026 · BMC musculoskeletal disorders

BACKGROUND: Low back pain and temporomandibular Dysfunction (TMD) have a coexistence in clinical practice. To find the effect of temporomandibular exercises (TME) along with conventional physiotherapy in patients with mechanical low back…

View details →DOI: 10.1186/s12891-026-09657-5
Negative / Null Result ReportMedicine

Editorial Commentary: Lumbar Pathology Likely Negatively Affects Surgical Outcomes in Patients With Femoroacetabular Impingement Syndrome, Though the Strength of the Relationship is Unclear.

Kaplan DJ · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

A complex interplay exists between the hip joint and the lumbosacralpelvis. As a patient moves from a standing to seated position, the lower back, pelvis, and hips must move in concert to properly function. Conceptually, any deviation from…

View details →DOI: 10.1002/arj.70202