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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21287 results · page 295 of 710

Negative / Null Result ReportMedicine

Peer victimization and emotion regulation strategies in adolescents: A cross-lagged panel model.

Alexander KN, Turner MS, Salazar JP et al. · 2025 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Many adolescents experience peer victimization during this critical period for development. Emotion regulation strategies, including cognitive reappraisal and emotional suppression, can help adolescents cope with such experiences. Although…

View details →DOI: 10.1111/jora.70119
Negative / Null Result Report

Acute and chronic dosing of the GABA A alpha 2,3 selective agonist BAER-101 do not alter behavior but may impact auditory-evoked EEG responses in adults with fragile X syndrome

DeStefano L, Kim H, Erickson C et al. · 2025 · Preprint

Abstract Background: Fragile X syndrome (FXS) is characterized by sensory hypersensitivity and neural hyperexcitability linked to GABAergic dysfunction. BAER-101, formerly known as AZD7325, is a positive allosteric modulator of GABA A…

View details →DOI: 10.21203/rs.3.rs-8123031/v1
Negative / Null Result Report

Daily and Weekly Fluctuations in the Microbiome of the Urinary Tract of Postmenopausal Women with No History of Urinary Tract Infections

Hogins J, Mekala S, Resendiz J et al. · 2025 · Preprint

At least half of all women will experience a urinary tract infection (UTI) in their lifetime. Age, sexual activity, hormonal status, and the urinary tract microbiome (urobiome) contribute to the probability of infection. While studies have…

View details →DOI: 10.1101/2025.11.04.686513
Negative / Null Result ReportMedicine

Lion-Tiger-Stripes: Delimiting the Semantic Association Effect on Working Memory With Mediated Association.

Ishiguro S, Guitard D, Saint-Aubin J · 2025 · Quarterly journal of experimental psychology (2006)

Semantic relatedness of items improves working memory performance. We targeted one type of semantic relatedness, semantic association. The beneficial effect of association is often explained by the spreading-activation process:…

View details →DOI: 10.1177/17470218251392562
Negative / Null Result ReportMedicine

Age, Intersectional Discrimination, and Health in Black Transgender Women.

Grant S, Goldberg E, Gadipudi A et al. · 2025 · Journal of racial and ethnic health disparities

Black transgender women report high levels of discrimination, which is associated with poor health outcomes. Some evidence suggests that intersectional discrimination-that is, interacting forms of marginalization related to one's real or…

View details →DOI: 10.1007/s40615-025-02710-4
Negative / Null Result ReportMedicine

Does the Perth Alexithymia Questionnaire Offer a Multidimensional Measurement of the Alexithymia Construct?

Bagby RM, Mortezaei A, McIntyre C et al. · 2026 · Journal of personality assessment

The Perth Alexithymia Questionnaire (PAQ) was developed to assess alexithymia as a multidimensional construct consistent with the attention-appraisal model. This study evaluated the hierarchical structure of the PAQ using Goldberg's…

View details →DOI: 10.1080/00223891.2025.2559701
Negative / Null Result ReportMedicine

The psychometric properties of the working memory questionnaire in a South African young adult sample.

Ferreira-Correia A, Mnisi N, Harwood K et al. · 2025 · Applied neuropsychology. Adult

The Working Memory Questionnaire (WMQ) was developed to assess everyday difficulties associated with working memory (WM) impairments. This study evaluated the psychometric properties of the WMQ within a South African context. A…

View details →DOI: 10.1080/23279095.2025.2556922
Negative / Null Result ReportOpen accessMedicine

Understanding how a tap on/tap off system supports clinical work in an emergency department: a qualitative study.

Baysari M, Stanceski K, Bamgboje-Ayodele A et al. · 2026 · BMC medical informatics and decision making

Background Single sign-on (SSO), tap-on-tap-off (TOTO) and virtual desktops (VD) are increasingly being used in hospitals to reduce the burden and risks of password management, but we know little about how these systems are used in…

View details →DOI: 10.1186/s12911-026-03424-1
Negative / Null Result ReportMedicine

Serum ACE2 and Anti-MMR Antibody Profiles in Pediatric Patients with and without SARS-CoV-2 Infection.

Labbani-Motlagh Z, Nozarian Z, Haghi Ashtiani MT et al. · 2025 · Iranian journal of immunology : IJI

Background Coronavirus Disease 2019 (COVID-19) typically manifests with milder symptoms and lower mortality rates in children when compared to adults. Objective To investigate potential mechanisms underlying this age-related protection, we…

View details →DOI: 10.22034/iji.2025.104055.2879
Negative / Null Result ReportMedicine

A new species of hermit crab provisionally assigned to the genus Pagurus Fabricius, 1775 (Crustacea: Anomura: Paguridae) from the Ryukyu Islands, Japan.

Komai T · 2025 · Zootaxa

A new pagurid hermit crab species, Pagurus inflatus sp. nov., has been provisionally assigned to the heterogeneous genus Pagurus Fabricius, 1775. This new species is characteristic in its elongated right cheliped with a noticeably inflated…

View details →DOI: 10.11646/zootaxa.5647.1.3
Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

View details →DOI: 10.1007/s10493-025-01051-5
Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

View details →DOI: 10.4103/jpbs.jpbs_1240_25
Failed Experiment ReportMedicine

Pembrolizumab in recurrent or metastatic medullary thyroid cancer.

Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist

Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…

View details →DOI: 10.1093/oncolo/oyaf348
Failed Experiment ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor.

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

View details →DOI: 10.3168/jds.2025-26959
Abandoned HypothesisOpen accessMedicine

Engaging in the Life-planning in Early Alzheimer's and other Dementias advance care planning intervention is associated with perceived advance care planning concordance and interpersonal connectedness.

Bybee SG, Clayton JL, Aruscavage N et al. · 2025 · The Gerontologist

Background and objectives Persons living with dementia often rely upon a care partner as their surrogate medical decision maker, yet little is known about how dementia care dyads achieve advance care planning (ACP) concordance: when a care…

View details →DOI: 10.1093/geront/gnaf179
Negative / Null Result ReportMedicine

<i>N</i>-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport.

Achilles S, Tomczak JN, Baumann FS et al. · 2025 · American journal of physiology. Gastrointestinal and liver physiology

DRA (Downregulated in adenoma, SLC26A3) is a major apical intestinal Cl - /HCO 3 - exchanger, which is expressed in complex and hybrid N -glycosylated forms. Although the importance of N -glycosylation is evident from the significantly…

View details →DOI: 10.1152/ajpgi.00362.2024
Negative / Null Result ReportMedicine

Effects of a Secondary Cognitive Task on Psychological and Stretch Performance.

Kostrna J, Astudillo A, Perez E · 2025 · Research quarterly for exercise and sport

Extensive research supports the positive effects of stretching on joint flexibility. During stretching, an individual's perceptions of stretch-related discomfort and pain negatively influence affective response. This study examined the…

View details →DOI: 10.1080/02701367.2025.2496765
Negative / Null Result ReportOpen accessMedicine

Piperacillin-tazobactam-associated thrombocytopenia with negative antiplatelet antibody testing: a case report and literature review.

Tian P, Fan M, Huang C · 2026 · Frontiers in medicine

Background Piperacillin-tazobactam is a widely used antibiotic. Although rare, thrombocytopenia related to piperacillin-tazobactam can be clinically significant. Drug-induced immune thrombocytopenia (DIIT) is difficult to distinguish from…

View details →DOI: 10.3389/fmed.2026.1775491
Negative / Null Result ReportMedicine

Body temperature and time perception in morning and evening types.

Erdoğan Ş, Tavat BC · 2025 · Physiology & behavior

Previous studies have suggested that time perception fluctuates throughout the day in relation to daily fluctuations of body temperature, and that there is a negative relationship between body temperature and time perception. The aim of…

View details →DOI: 10.1016/j.physbeh.2025.114943
Negative / Null Result Report

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB

Necker-Brown A, Mostafa MM, Georgescu A et al. · 2025 · Preprint

Transcription factors of the interferon regulatory factor (IRF) family play key roles during viral and bacterial infections. However, IRF regulation by inflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor (TNF)…

View details →DOI: 10.1101/2025.07.24.665057
Negative / Null Result ReportMedicine

Effect of Radial Lengthening on the Stability of the Distal Radioulnar Joint: A Biomechanical Cadaveric Study.

Yin CY, Vilai P, Thoreson AR et al. · 2026 · The Journal of hand surgery

Purpose Radial lengthening has been clinically proposed as an alternative treatment for distal radioulnar joint (DRUJ) instability associated with distal radius fractures based on the hypothesis that it functions in a manner similar to…

View details →DOI: 10.1016/j.jhsa.2025.06.013
Negative / Null Result ReportMedicine

Three-dimensional Reservoir Modelling and Quantitative Microbial Risk Assessment of Recreational Access to a Drinking Water Reservoir.

Cinque K, Deere D, Veal C et al. · 2025 · Environmental management

The major drinking water reservoirs and catchments supplying many of Australia's capital cities have been protected from significant levels of public access since their construction (up to 140 years ago). In addition to the primary…

View details →DOI: 10.1007/s00267-025-02203-4
Negative / Null Result ReportMedicine

Comparison of Asynchronous Telepsychiatry vs Synchronous Telepsychiatry (CATELEST) in Skilled Nursing Facilities: A Randomized Controlled Noninferiority Clinical Trial.

Xiong GL, Iosif AM, Gonzalez AD et al. · 2025 · Journal of the American Medical Directors Association

Objective Comparison of asynchronous telepsychiatry (ATP) with traditional synchronous telepsychiatry (STP) in skilled nursing facilities (SNFs) in California, United States. Design Patient-level randomized, controlled noninferiority…

View details →DOI: 10.1016/j.jamda.2025.105753