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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 295 of 724

Negative / Null Result ReportOpen accessMedicine

Corneal Biomechanics Before and After Descemet Membrane Endothelial Keratoplasty in Patients with Fuchs Endothelial Corneal Dystrophy.

Reinprayoon U, Yaisawang S, Israsena N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose Descemet Membrane Endothelial Keratoplasty (DMEK) is a surgical intervention for restoring endothelial function in Fuchs endothelial corneal dystrophy (FECD). However, changes in corneal biomechanical properties assessed using…

View details →DOI: 10.2147/opth.s598840
Negative / Null Result ReportMedicine

Effects of an 8-Week Time-Restricted Eating and Walking Exercise on Regional Fat Distribution and Lean Mass in Women with Hidden Obesity: A Randomized Controlled Trial.

Chen S, Kortas J, Ren Y et al. · 2026 · Healthcare (Basel, Switzerland)

Objectives : Explore and compare the effects of 8-week time-restricted eating (TRE), walking exercise, and their combination on fat and lean muscle distribution in female college students with hidden obesity. Methods : A total of 68…

View details →DOI: 10.3390/healthcare14121768
Negative / Null Result ReportOpen accessMedicine

Short-term physiological effects of pressure rise time modulation during volume-guaranteed neonatal ventilation.

Aliyev F, Yigit S, Yucel E et al. · 2026 · Scientific reports

Pressure rise time (PRT) is an adjustable ventilator parameter that regulates the rate of inspiratory flow delivery and may influence ventilator mechanics and tissue oxygenation. However, its short-term physiological effects in neonates…

View details →DOI: 10.1038/s41598-026-44486-5
Negative / Null Result ReportMedicine

The effect of harmonica-based breathing and airway clearance exercises on pulmonary function in children with cystic fibrosis: A randomized controlled trial.

Tavasoli H, Rajabi MM, Sadat Hoseini AS · 2026 · Journal of pediatric nursing

Purpose To determine the effect of harmonica-based breathing and airway clearance exercises on pulmonary function in children with cystic fibrosis (CF). Methods This randomized controlled trial included 70 children with CF aged 8-18 years.…

View details →DOI: 10.1016/j.pedn.2026.05.012
Methods Dead-EndMedicine

Exploratory Analysis of the Convergence Between Acoustic Measures and Qualitative Spectrographic Analysis Following Expressiveness Training in Journalism Students.

Batista DJ, da Conceição AS · 2026 · Journal of voice : official journal of the Voice Foundation

Objectives This study aims to explore the convergence between objective acoustic measures and qualitative spectrographic analysis in the evaluation of the effects of an expressiveness-oriented training program in journalism students.…

View details →DOI: 10.1016/j.jvoice.2026.04.023
Negative / Null Result ReportMedicine

Effect of Thermal Processing on the Nutritional Composition and Bioactive Compounds of 'Largueta' Almonds (<i>Prunus dulcis</i>).

Fernández-León MF, Flórez Acosta LR, Fernández-León AM · 2026 · Foods (Basel, Switzerland)

Almond ( Prunus dulcis ) is a highly nutritious nut, rich in unsaturated fatty acids, fibre, and bioactive compounds such as tocopherols, phenolic compounds, and carotenoids. Processing methods commonly applied in the almond industry,…

View details →DOI: 10.3390/foods15122059
Negative / Null Result ReportMedicine

Two-year prospective natural history study of EYS-associated retinitis pigmentosa using adaptive optics: the KEYS study.

Masakazu H, Akiko M, Midori Y et al. · 2026 · Scientific reports

This study was conducted to evaluate the longitudinal morphological changes in cone density (CD) in patients with the eyes shut homolog (EYS)-associated retinitis pigmentosa (RP) using adaptive optics (AO) fundus imaging and to assess its…

View details →DOI: 10.1038/s41598-026-56837-3
Negative / Null Result ReportMedicine

Silencing LsAtg8 reduces female fecundity and elevates Wolbachia density in embryos of the rice planthopper Laodelphax striatellus.

Wang MK, Wang MR, Niu YD et al. · 2026 · Pest management science

Background Autophagy is essential for insect reproduction and endosymbiont homeostasis, with Atg8 serving as a key autophagy-related gene. However, the specific role of LsAtg8 in reproduction and endosymbiont regulation in Laodelphax…

View details →DOI: 10.1002/ps.70934
Negative / Null Result ReportMedicine

Evaluation of the first edition of the 'Spirituality in medicine' programme implemented for medical students at the Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland. Pre- and post-test research.

Fopka-Kowalczyk M, Krajnik M · 2026 · BMC medical education

Background This article presents an evaluation of the first obligatory programme on 'Spirituality in Medicine' for medical students in Poland, implemented at the Collegium Medicum in Bydgoszcz of the Nicolaus Copernicus University in…

View details →DOI: 10.1186/s12909-026-09439-6
Negative / Null Result Report

Interleukin-15 enhances expansion and CD 16 expression of natural killer cells in cynomolgus macaque peripheral blood mononuclear cells

Hyeon J, Kwon J, Cho H et al. · 2026 · Preprint

Abstract 1) Background Natural killer (NK) cells play a critical role in innate immunity and are widely used in immunological studies and cell-based therapies. Efficient in vitro expansion of NK cells is essential for both basic research…

View details →DOI: 10.21203/rs.3.rs-9547356/v1
Negative / Null Result ReportMedicine

Effects of stimulation frequency and pulse width in transcutaneous auricular vagus nerve stimulation on finger somatosensory function.

Tanabe K, Kojima S, Saito K et al. · 2026 · Scientific reports

Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive electrical stimulation technique applied to the left cymba concha that may improve somatosensory impairment in stroke. Although previous studies have investigated…

View details →DOI: 10.1038/s41598-026-51309-0
Negative / Null Result Report

Understanding the Effectiveness of Foreign Assistance to Prevent Food Insecurity in Palestine: A Temporal Analysis of Targeting Mechanisms and Treatment Effects (2018–2020)

Morrar R, Ferrière N · 2026 · Preprint

Abstract This research examines the efficiency of foreign aid in alleviating food insecurity among Palestinian households, emphasizing heterogeneous outcomes of food security groups and heterogeneous population groups. This analysis…

View details →DOI: 10.21203/rs.3.rs-8920370/v1
Failed Experiment ReportMedicine

Effects of a 15-week recreational football programme on insulin resistance and glycaemic control in inactive premenopausal women with mild arterial hypertension: A randomised controlled trial.

Póvoas S, Castagna C, Connolly LJ et al. · 2026 · Journal of sports sciences

This study aimed to investigate the impact of a 15-week recreational football intervention on insulin resistance and glycaemic control in inactive premenopausal women with mild hypertension. A total of 41 women, aged 35-50 years, were…

View details →DOI: 10.1080/02640414.2025.2609442
Failed Experiment ReportOpen accessMedicine

A comparison of student evaluations of teaching and learning in the inverted classroom model versus traditional lectures in dental education.

Reuter AK, Deschner J, Schütz L et al. · 2026 · BMC medical education

Introduction The inverted classroom model (ICM) is a learner-centred approach that aims to promote engagement, independence and deeper understanding by shifting knowledge acquisition to self-directed learning before class and using class…

View details →DOI: 10.1186/s12909-026-09733-3
Failed Experiment ReportMedicine

Reflectance confocal microscopy for monitoring treatment response in superficial basal cell carcinoma: diagnostic challenges due to scar formation.

Clark M, Wuennenberg J, Maghfour J et al. · 2026 · Clinical and experimental dermatology

Background Reflectance confocal microscopy (RCM) criteria for the in vivo diagnosis of superficial basal cell carcinoma (sBCC) lesions have been validated, with studies indicating a high level of diagnostic sensitivity. However, there…

View details →DOI: 10.1093/ced/llaf407
Negative / Null Result ReportMedicine

Evaluating the value and risks of DNA evidence in Japanese criminal trials: Changes before and after the lay judge system.

Akanuma S, Sugano Y, Shimmura S et al. · 2026 · Legal medicine (Tokyo, Japan)

DNA evidence can be used to link perpetrators to crime scenes or victims. We examined all Japanese criminal court cases included in a commercially available LEX/DB Internet (LEX database) from 1989, the year DNA analysis was first used as…

View details →DOI: 10.1016/j.legalmed.2026.102861
Negative / Null Result ReportMedicine

Hepatic inflammation after exposure to a mixture of low-dose arsenic and cadmium in a murine model of fatty liver disease.

Subramaniam NK, Gagnon N, Guilbert C et al. · 2026 · Toxicological sciences : an official journal of the Society of Toxicology

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden and major contributor to chronic liver disease. Evidence suggests arsenic (As) and/or cadmium (Cd) exposure may influence MASLD development,…

View details →DOI: 10.1093/toxsci/kfag073
Negative / Null Result ReportMedicine

Test-Retest reliability of performance, knee functionality and movement quality biomechanics in agility T-test using markerless motion capture.

Wen Z, Claeys K, García JG et al. · 2026 · Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

The purpose of this study was to assess reliability of performance, knee functionality and movement quality parameters in agility T-test using markerless motion capture. Seventeen healthy participants performed two sessions of agility…

View details →DOI: 10.1016/j.jelekin.2026.103165