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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21287 results · page 285 of 710

Negative / Null Result ReportOpen accessMedicine

Object relations are processed with, but not without, awareness.

Palgi S, Bester-Arest T, Faivre N et al. · 2025 · Neuroscience of consciousness

The scope of unconscious integration is widely debated. Here, we examined this question, focusing specifically on deciphering the relations between two associatively related objects, in a set of five behavioral and electrophysiological…

View details →DOI: 10.1093/nc/niaf010
Negative / Null Result ReportOpen accessMedicine

Association of reproductive and menstrual factors with the risk of breast cancer in women: a population-based study.

Song Z, Ding M, Zang Q et al. · 2025 · BMC cancer

Background Reproductive factors significantly impact the incidence of breast cancer (BC), a concerning trend. This study aims to reassess this association and provide recommendations for fertility policies to delay the onset of BC. Methods…

View details →DOI: 10.1186/s12885-025-15048-1
Negative / Null Result ReportOpen accessMedicine

Epileptic High-Frequency Oscillations in Intracranial EEG Are Not Confounded by Cognitive Tasks.

Boran E, Stieglitz L, Sarnthein J · 2021 · Frontiers in human neuroscience

Rationale : High-frequency oscillations (HFOs) in intracranial EEG (iEEG) are used to delineate the epileptogenic zone during presurgical diagnostic assessment in patients with epilepsy. HFOs are historically divided into ripples (80-250…

View details →DOI: 10.3389/fnhum.2021.613125
Negative / Null Result ReportOpen accessMedicine

Impact of Facility Criteria Revision for Rotational Atherectomy on Outcomes After PCI: A Quasi-Experimental Difference-in-Differences Study.

Aikawa T, Mori Y, Kuno T et al. · 2026 · JACC. Advances

Background In April 2020, the facility criteria for using rotational atherectomy (RA) during percutaneous coronary intervention (PCI) were updated in Japan. Board-certified PCI operators are now permitted to perform RA during PCI in…

View details →DOI: 10.1016/j.jacadv.2026.102672
Negative / Null Result ReportMedicine

Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning.

Lupien SJ, Roy DC, Raymond C et al. · 2020 · Development and psychopathology

Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with…

View details →DOI: 10.1017/s0954579420001431
Negative / Null Result ReportOpen accessMedicine

Risk of infectious mononucleosis is not associated with prior infection morbidity.

Rostgaard K, Kristjánsson R, Davidsson O et al. · 2025 · Frontiers in epidemiology

Background The probability of presenting with infectious mononucleosis (IM) upon primary Epstein-Barr virus infection increases dramatically at the start of puberty. Aiming to understand why that is, we assessed whether the number of…

View details →DOI: 10.3389/fepid.2025.1518559
Negative / Null Result ReportOpen accessMedicine

The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.

Jackson E, Riley T, Overton PG · 2026 · PloS one

Background Although several effective therapies exist for Attention Deficit Hyperactivity Disorder (ADHD), current pharmaceutical treatment carries a high risk of misuse and high levels of discontinuation, evidencing a need for…

View details →DOI: 10.1371/journal.pone.0349512
Negative / Null Result ReportOpen accessMedicine

Resting state EEG reveals no reliable biomarkers of tinnitus laterality.

Kim SJ, Shin SH, Byun SW et al. · 2025 · Scientific reports

This study assessed whether resting-state quantitative EEG (qEEG) can differentiate tinnitus laterality under rigorous multiple-comparison control and nested, cross-validated machine learning (ML). We analyzed 210 pre-specified qEEG…

View details →DOI: 10.1038/s41598-025-19789-8
Negative / Null Result ReportOpen accessMedicine

Acceptance of mixed gambles is sensitive to the range of gains and losses experienced, and estimates of lambda (λ) are not a reliable measure of loss aversion: Reply to André and de Langhe (2020).

Walasek L, Mullett TL, Stewart N · 2021 · Journal of experimental psychology. General

Walasek and Stewart (2015) demonstrated that loss aversion estimated from fitting accept-reject choice data from a set of 50-50 gambles can be made to disappear or even reverse by manipulating the range of gains and losses experienced in…

View details →DOI: 10.1037/xge0001054
Negative / Null Result ReportOpen accessMedicine

A Matched Design for Causal Inference With Survey Data: Evaluation of Medical Marijuana Legalization in Kentucky and Tennessee.

Benedetti MH, Lu B, Zhu M · 2024 · Biometrical journal. Biometrische Zeitschrift

A concern surrounding marijuana legalization is that driving after marijuana use may become more prevalent. Survey data are valuable for estimating policy effects, however their observational nature and unequal sampling probabilities…

View details →DOI: 10.1002/bimj.70012
Negative / Null Result ReportOpen accessMedicine

Excited State Dynamics of CO<sub>2</sub> Reduction Catalyst under Vibrational Strong Coupling.

Jin T, Gebre ST, Miller CJ et al. · 2025 · Journal of the American Chemical Society

Molecular polaritons, formed by coupling molecular electronic or vibrational transitions to photonic modes in microcavities, have gained interest for their potential to influence chemical dynamics. Here, we investigate the effects of…

View details →DOI: 10.1021/jacs.5c11060
Negative / Null Result ReportOpen accessMedicine

Precocial Weaning Influences Anxiety, Social and Maternal Care but Not Cognition in African Striped Mice, Rhabdomys dilectus chakae.

Oosthuizen MK, Pillay N · 2026 · Developmental psychobiology

Weaning is a stressful stage in the lives of young mammals. Early weaning, in particular, can lead to long-lasting physiological and psychological changes. We investigated the effects of precocial weaning on anxiety, social behavior,…

View details →DOI: 10.1002/dev.70124
Negative / Null Result ReportOpen accessMedicine

Do Expectant Mothers Exhibit Different Autonomic Responses to the Infant Cry Stimuli at Home Versus in the Laboratory?

Denherder S, Neff D, Speck B et al. · 2025 · Developmental psychobiology

The COVID-19 pandemic introduced challenges for keeping participants and research assistants safe during laboratory visits. One solution was administering research assessments in the participant's home via an online platform, despite…

View details →DOI: 10.1002/dev.70032
Negative / Null Result ReportOpen accessMedicine

Peer collaborative learning and academic engagement in university libraries: a moderated mediation model and latent profile analysis.

Tang H, Shen L · 2025 · Frontiers in psychology

Objective As university libraries transform into "Learning Commons," peer collaborative learning has become increasingly common. However, the complexity of its effectiveness and its underlying mechanisms remain underexplored. This study…

View details →DOI: 10.3389/fpsyg.2025.1759026
Negative / Null Result ReportOpen accessMedicine

Does Conflictual Dialogue Improve a Story?

Berks JW, Williams MN · 2026 · Europe's journal of psychology

According to creative writing experts, adding conflict to dialogue improves story quality and audience reaction to that story. This idea draws from the widely held theory that conflict is vital for dramatic stories. Yet despite conflict's…

View details →DOI: 10.5964/ejop.17499
Replication FailureOpen accessMedicine

Liposomal Bupivacaine versus Ropivacaine with Dexamethasone in Rectus Sheath Block for Laparoscopic Gastrectomy: A Randomized Controlled Trial.

Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy

Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…

View details →DOI: 10.2147/dddt.s574724
Negative / Null Result ReportOpen access

A realist approach to implementation fidelity in a mixed-method evaluation of electronic decision support systems to improve the quality of antenatal care in Nepal

Radovich E, Karki S, Das S et al. · 2024 · Preprint

Background Understanding implementation fidelity, or adherence to the intervention-as-intended, is essential to interpreting the results of evaluations. In this paper, we propose a longitudinal, explanatory approach to implementation…

View details →DOI: 10.1101/2024.05.07.24306757
Negative / Null Result ReportOpen accessMedicine

Time-varying trends from Arctic ozonesonde time series in the years 1994-2022.

Nilsen K, Kivi R, Laine M et al. · 2024 · Scientific reports

Although evidence of recovery in Antarctic stratospheric ozone has been found, evidence of recovery in Arctic ozone is still elusive, even though 25 years have passed since the peak in ozone depleting substances. Here we have used a…

View details →DOI: 10.1038/s41598-024-75364-7
Negative / Null Result ReportOpen accessMedicine

Independent associations of physical activity and depression with open-angle glaucoma in a population-based analysis.

Lee SY, Shin SJ, Lee J et al. · 2025 · Scientific reports

Patients with open-angle glaucoma (OAG), a chronic visual impairment, are at elevated risk of developing depression. Physical activity (PA) has been associated with benefits for mental health, but evidence is limited regarding its impact…

View details →DOI: 10.1038/s41598-025-28364-0
Negative / Null Result ReportMedicine

Does additional education affect memory consistently? An analysis of compulsory schooling reforms across Europe and U.S.

Perez-Arce F, Knapp D, Lobo R et al. · 2026 · Social science & medicine (1982)

Background A growing literature suggests that education positively influences cognitive function in later life. However, the magnitude and consistency of this effect across study designs and populations remain open questions. Methods This…

View details →DOI: 10.1016/j.socscimed.2026.119377
Negative / Null Result ReportOpen accessMedicine

Preschoolers' Early Sentence Comprehension: Comparing Bilingual and Monolingual Children and the Role of Executive Function and Vocabulary Development.

Rodenhurst N, Messenger K · 2026 · Developmental science

Previous research into children's comprehension of syntactic structures has investigated early awareness of transitive and intransitive structures amongst monolingual children but research into bilingual children's understanding of the…

View details →DOI: 10.1111/desc.70232
Negative / Null Result ReportOpen accessMedicine

Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making.

Robins PL, Gilbert JR, Luber B et al. · 2026 · Human brain mapping

A core function of episodic memory is to distinguish between overlapping experiences by converting similar inputs into distinct, non-overlapping representations, a process termed pattern separation. While anatomical models emphasize the…

View details →DOI: 10.1002/hbm.70529
Negative / Null Result Report

No evidence of differences between hierarchical versus distinction relations in self-based ACT exercises: A critical reanalysis of Foody et al. (2013) and Foody et al. (2015)

Hussey I · 2026 · Preprint

The evidential link between Relational Frame Theory (RFT) and Acceptance and Commitment Therapy (ACT) is a matter of on-going debate. Foody et al. (2013) is frequently cited as evidence for ACT’s concept of Self-as-Context and as evidence…

View details →DOI: 10.31234/osf.io/ab7de_v5
Negative / Null Result ReportOpen accessMedicine

Mortality risks associated with short-term exposure to ultrafine particles in London and the West Midlands.

Nenon D, Fuller G, Masselot P et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)

Background Some research has suggested that ultrafine particles (UFP), with an aerodynamic diameter less than 100 nm, might be the most harmful component of ambient particulate matter air pollution on human health. In the United Kingdom,…

View details →DOI: 10.1097/ee9.0000000000000449