A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21707 results · page 284 of 724
Gasper K, Haynes E · 2026 · Cognition & emotion
Positive feelings may diminish. It is unclear whether this decrease stems from people feeling less positive, more negative, more neutral, or some combination. Using an evaluative conditioning (EC) paradigm, we investigated how pre-existing…
Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry
Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…
Kagota S, Maruyama-Fumoto K, Niki A et al. · 2026 · Metabolic syndrome and related disorders
Background Perivascular adipose tissue (PVAT), found outside blood vessels, enhances vasorelaxation when endothelium-mediated vasorelaxation fails, as observed in the mesenteric arteries of rats with metabolic syndrome (MetS) and…
Yadav P, Hamrahian AH, Salvatori R · 2026 · Pituitary
PURPOSE: Macimorelin, a ghrelin receptor agonist, is used for diagnosing adult GH deficiency (AGHD). The FDA-approved GH cut-off is 2.8 ng/mL, whereas post-hoc analyses proposed a cut-off of 5.1 ng/mL. The real-world performance of these…
Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.
Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…
Prasadan K, Saleh M, Thomas M et al. · 2026 · The Journal of biological chemistry
Several studies have analyzed the effect of glucagon on β-cells and glucose homeostasis, either by ablating α-cells or by globally deleting the glucagon/glucagon receptor gene. To investigate possible interactions between α-cells and…
Sedghi A, Kaiser DPO, Arndt M et al. · 2026 · Annals of clinical and translational neurology
Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a…
Elham Mahdavi, Ghorbani Yekta B, Fereshteh Atabi · 2026 · Cellular and molecular biology (Noisy-le-Grand, France)
Rapid-eye movement (REM) sleep is a critical stage of sleep that plays a pivotal role in memory formation, consolidation, and mood regulation. While REM sleep deprivation (REM SD) has been shown to impair cognitive and affective functions,…
Hsu G, Petticord DF, Slimon KF et al. · 2025 · Oikos
Prey capture by carnivorous plants is influenced by plant traits, environmental factors and interactions with animals. However, little is known about how interactions with heterospecific plant neighbors affect prey capture. Here, we…
Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…
Rodriguez AK, Taylor TL, Fawver B et al. · 2026 · Psychology of sport and exercise
Individuals experiencing anxiety exhibit attentional biases towards unpleasant stimuli. Exercise is an anxiolytic intervention, evidenced by changes in attentional bias following physical activity. Many individuals experience 'anxiety…
Amaravadi RK · 2022 · Autophagy
Macroautophagy/autophagy is a resistance mechanism to targeted therapy in BRAF mutant cancers. Preclinical evidence and clinical trial data demonstrate that hydroxychloroquine (HCQ) is an effective autophagy inhibitor at clinically…
Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…
Ghazali M, Sele V, Sahuquillo A et al. · 2026 · Journal of hazardous materials
The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the…
Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science
Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…
Noorman L, Bekebrede AF, de Vries S et al. · 2026 · Animal : an international journal of animal bioscience
In vitro and in situ experiments, primarily conducted using human cells, have demonstrated that metabolites produced during protein fermentation can negatively affect intestinal health. However, in vivo research on their impact on…
Nass N, Sprung S, Ignatov A et al. · 2026 · Cancer treatment and research communications
In cancer, aerobic glycolysis predominantly used to provide energy. This high glycolytic flow results in the formation of reactive aldehydes such as glyoxal and methylglyoxal forming advanced glycation end products (AGEs) by reacting with…
Willey CN, Bufi R, Takemon Y et al. · 2026 · American journal of physiology. Renal physiology
Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease (DKD) and IgA nephropathy. However, it is unclear whether NBL1 is a…
Claus L, Zhang X, Ocasio L et al. · 2026 · Clinical radiology
Aim Computed tomography angiography (CTA) is essential for preprocedural assessment in transcatheter aortic valve replacement (TAVR), particularly as TAVR becomes the preferred treatment for high-risk patients with severe aortic stenosis.…
Söröd M, Gyllencreutz E · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside…
Matiya DJ, Tutt K, Wakefield JG et al. · 2026 · Preprint
The greater wax moth, Galleria mellonella , is an increasingly important invertebrate model for infection biology, yet silk extrusion during handling complicates larval injections and hampers survival assessment. Here, we develop and…
Dai R, Wells CD · 2025 · Preprint
Climate change is driving the poleward expansion of many species, including the Atlantic blue crab ( Callinectes sapidus ), whose northern range now extends into the Gulf of Maine. As a recently arrived predator, the blue crab may pose a…
Böhm M, Stegemann A, Wolnicka-Głubisz A et al. · 2026 · Aging and disease
Alpha-melanocyte-stimulating hormone (α-MSH) is a key endocrine mediator of photoprotection in the ultraviolet (UV)B-induced skin response. Its effects are mediated by the melanocortin-1 (MC1R) receptor and include increased eumelanin…
Cabaret J, Guerrero Molina C, Martínez-Ortiz-de Montellano C et al. · 2026 · Pathogens (Basel, Switzerland)
Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of…
Santos de Oliveira N, Barbieri M, Moraes PA et al. · 2026 · Women & health
A prospective longitudinal study was conducted among 70 users of the etonogestrel contraceptive implant. World Health Organization Quality of Life (WHOQOL-BREF), Female Sexual Function Index (FSFI), and Birth Control Satisfaction…
Yaqub M, Bonde N, Maity T et al. · 2026 · Preprint
Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections, particularly ventilator-associated pneumonia, for which therapeutic options are increasingly limited. Colistin, a polymyxin antibiotic, is a drug of…
Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer
Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…
Bonilla AM, Garrido G, Consolini AE et al. · 2025 · Preprint
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties re-main unexplored. The behavioral effects, underlying mechanisms,…
Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…
Effinger D, Hirschberger S, Arntjen T et al. · 2026 · Nutrients
Background/Objectives : The ketogenic diet (KD) has been shown to exert beneficial effects on human immunity by enhancing cytotoxic T lymphocyte function through metabolic reprogramming. However, strict dietary restrictions limit adherence…