A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21287 results · page 282 of 710
Pagano R, Kruashvili L, Puchalska M et al. · 2026 · Preprint
ABSTRACT Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of…
Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
Dantas MCDS, Moreira SDNT, Pinto Júnior FEL · 2026 · Journal of cancer education : the official journal of the American Association for Cancer Education
Background Communication of difficult news is a core competency in oncology education. How accurately medical students self-assess their communication performance shapes formative learning and curriculum design. Purpose To examine…
Butzlaff R, Christoph C, Puhl L et al. · 2026 · Journal of psychosomatic research
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising non-pharmacological approach for postoperative pain management, but its interaction with childhood trauma (CT) remains unclear. This three-armed randomized…
Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayón F · 2026 · Preprint
Abstract Rationale: Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive…
Barris CT, Kress TC, Antonova G et al. · 2025 · American journal of physiology. Heart and circulatory physiology
The global rise in obesity parallels the increasing rates of hypertension and cardiovascular disease (CVD). These trends, and recent clinical and experimental data, have revealed that obesity abolishes the protection from CVD typically…
Giri S, Wang X · 2026 · American journal of physiology. Heart and circulatory physiology
Neointimal hyperplasia (NH) is a prominent pathological consequence following vascular injury and is driven in part by aberrant vascular smooth muscle cell (VSMC) proliferation. COP9 signalosome (CSN) subunit 5 (CSN5/JAB1/COPS5) is the…
de Sousa Fernandes MS, Kanashiro A, da Silva Fidélis DE et al. · 2026 · Scientific reports
Environmental enrichment (EE), an experimental paradigm promoting cognitive, sensory, social, and motor stimulation, has been associated with neuroprotective effects. Although EE modulates immune function, its influence on the basal redox…
Malpica G, Joaquim M, Machado RS et al. · 2026 · Preprint
Mitochondrial dynamics are critical for T cell activation, differentiation, and survival. The inner mitochondrial membrane ATP-dependent metalloprotease YME1L1 regulates proteostasis and the processing of optic atrophy protein 1 (OPA1),…
Ling L, Ali T, Li X et al. · 2026 · Neurochemistry international
Diabetic neuropathy (DN) is driven by neuroinflammation and oxidative stress, with c-Jun N-terminal kinase (JNK) as a key mediator; however, the effects of JNK inhibition on neuropathic pain remain unclear. Therefore, we investigated the…
Wu Z, Menezes ES, Silva NMLE et al. · 2026 · Genes
Background/Objectives : MicroRNAs (miRNAs) are key regulators of skeletal muscle adaptation; however, the extent to which exercise modulates the miRNA biogenesis pathway remains poorly understood. To investigate the impact of acute and…
Butcko AJ, Adeshina KA, Kamali P et al. · 2026 · Scientific reports
PNPLA3-I148M, the greatest genetic determinant for metabolic dysfunction-associated steatotic liver disease (MASLD), paradoxically associates with reduced cardiovascular disease (CVD); however, the mechanisms are poorly understood. To…
Chatzivasileiou K, Kamalakidis SN, Pissiotis AL et al. · 2026 · The International journal of prosthodontics
Purpose To evaluate the combined effect of different polishing protocols and different denture cleansers on the surface roughness of three heat-polymerized polymethyl methacrylate (PMMA) denture base materials. Materials and methods The…
Gu R, Qin FY, Sun Z et al. · 2026 · Toxicological sciences : an official journal of the Society of Toxicology
Deficiency of ferrochelatase (FECH) in erythropoietic protoporphyria (EPP) leads to accumulation of its substrate, protoporphyrin IX (PPIX), the final intermediate in the heme biosynthesis pathway. PPIX is produced primarily in the bone…
Gasper K, Haynes E · 2026 · Cognition & emotion
Positive feelings may diminish. It is unclear whether this decrease stems from people feeling less positive, more negative, more neutral, or some combination. Using an evaluative conditioning (EC) paradigm, we investigated how pre-existing…
Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry
Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…
Both A, Chevalier C, Connor MG et al. · 2026 · Preprint
Crosstalk between respiratory bacteria and human airway epithelial cells initiates cellular immunity, yet the molecular determinants of asymptomatic carriage versus inflammation remain incompletely understood. A key regulator of airway…
Souza VKB, Ferreira DA, Arantes APR et al. · 2026 · Cell biochemistry and biophysics
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of…
Litif C, Libster AM, Desfor S et al. · 2026 · Preprint
The Reln gene encodes the extracellular glycoprotein Reelin that regulates synaptic plasticity and activity-dependent gene expression with implications in several neuropsychiatric disorders, including substance use disorder. While reduced…
Anwar S, Ebrahimi-Iranpour S, Huq S et al. · 2025 · Preprint
Lysosomes are organelles responsible for degrading unwanted extracellular material that cells internalize, or intracellular material targeted for disposal. Typically, lysosomes are globular in morphology. However, in activated macrophages…