A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21283 results · page 276 of 710
Sangermani M, Desiati I, Quattrini N et al. · 2026 · Scientific reports
Reanalysing previously collected samples to address new research questions offers a time-efficient alternative to initiating new cohort studies. However, concerns remain regarding the stability of the faecal microbiome following repeated…
Karahan M, Uluçam E · 2026 · Work (Reading, Mass.)
BackgroundSleep deprivation, common among physicians working long shifts, affects sensory integration, motor coordination, and cognitive performance. While its impact on cognitive and motor skills is well-documented, its effect on gait…
Perović A, Juričić G, Bratičević MN et al. · 2026 · Medicine and science in sports and exercise
Purpose During scuba diving, breathing under elevated pressure leads to hyperoxia, which may induce oxidative stress and erythrocyte damage. Hyperoxia may also influence erythropoietin (EPO) production, a phenomenon referred to as the…
Dobariya A, Patel R, Patel M · 2026 · European journal of hospital pharmacy : science and practice
Objective The study aimed to analyse the physicochemical stability and compatibility of ceftriaxone sodium (CEF) (2mg/mL) with pantoprazole sodium (PAN) (0.08mg/mL) and ondansetron hydrochloride (OND) (0.008mg/mL) in different infusion…
Amiri D, Hellmann PH, Thyssen JP et al. · 2026 · JAMA dermatology
Importance Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.…
Nechemya Y, Shames J · 2026 · Harefuah
Introduction Background: Chronic pain syndrome is a common disease with major economic costs. The aim of this study is to examine the effect of outpatient multidisciplinary pain rehabilitation on the utilization of medical services in…
Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine
Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…
Ozden H · 2026 · Open life sciences
Perfluorooctanoic acid (PFOA) is widely utilized perfluoroalkyl substance (PFAS) in various industrial and household applications, known for its persistence in the environment. Due to the limited toxicity data for PFOA in edible vegetable…
Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Objective Finding indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary coherence…
Putos J, Atkinson HF, Walton DM · 2026 · Osteoarthritis and cartilage open
Objectives The acute response of lumbar intervertebral discs (IVD) to spinal rotation mobilization (SRM) is poorly understood. We evaluated sustained morphological changes in lumbar IVDs following a rotation mobilization commonly used to…
Ajiki H, Tanaka M · 2026 · Journal of imaging
Even when an object's color is accurately reproduced in a colorimetrically reproduced image (CRI), the perceived material appearance does not necessarily match that of the original object. This mismatch remains a challenge for faithfully…
Uysal A, Soslu R, Soslu R · 2026 · Journal of strength and conditioning research
Abstract Uysal, A and Soslu, R. Acute and long-term effects of spinning-based high-intensity interval training on inducible nitric oxide synthase: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2026-This study…
Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Preprint
ABSTRACT Objective Finding: indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary…
Ravenda S, Gerra MC, Barbetti M et al. · 2026 · Psychoneuroendocrinology
MicroRNAs (miRNAs) have attracted great interest as potential biomarkers in several research domains, including acute and chronic stress conditions. While most of these studies focused on circulating blood miRNA levels, the investigation…
Lojek NM, Bostanci N, Henrique Borges P et al. · 2026 · Radiation research
Proton radiation is known to have detrimental neurological effects, but there is limited scientific understanding of these effects at the cellular and tissue levels. We leveraged our 3D in vitro cortical tissue model alongside 2D cortical…
Hu JC, Kapadia SN, Zhang H et al. · 2026 · JAMA health forum
Importance Buprenorphine is the most commonly prescribed medication for opioid use disorder, but rates of retention in treatment remain low. Prior authorization (PA) has been identified as a barrier to the administration of buprenorphine,…
Saud MA, Khamees Abed S, Shahooth MA et al. · 2026 · F1000Research
Background While ivermectin is a common antiparasitic drug used in veterinary medicine, the effects of repeated administration at therapeutic doses have not been well studied. Of particular interest is the impact of ivermectin on…
Zainuddin MS, Pamidi N, Azman AS et al. · 2026 · Redox report : communications in free radical research
Alzheimer's disease (AD) is a major global neurodegenerative disorder associated with high morbidity and mortality, yet current treatments remain largely symptomatic and ineffective in halting neurodegeneration. Growing evidence links…
Fukui S, Sumiyoshi R, Koga T et al. · 2026 · Drug discoveries & therapeutics
Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disease characterized by systemic inflammation. Although IL-6 receptor blockade with tocilizumab is an established treatment, Janus kinase (JAK) inhibition may…
Garabet W, Beckamp KH, Shabes P et al. · 2026 · VASA. Zeitschrift fur Gefasskrankheiten
Background: Supervised Exercise Therapy (SET) improves walking performance in patients with peripheral arterial disease (PAD) and intermittent claudication, yet implementation and adherence remain inconsistent. This study evaluated…
Mobasseri M, Vahabie AH, Jafari G et al. · 2026 · Brain imaging and behavior
Behavioral contagion is defined as the tendency of individuals to conform with others' behavior after observing them. Despite the important role that behavioral contagion plays in societies, its brain mechanism is still not fully…
Ptak A, Stefańska M · 2026 · Journal of clinical medicine
Background: The objective of this study was to assess the tension of selected postural muscles during the jaw-sucking movement in four body positions (standing position, all-fours position, lying on front, lying on the side). Material and…
Harding M, Case J, Knighton K et al. · 2026 · Preprint
Abstract Medical school has long been thought to have a potentially detrimental effect on the health of its students. We sought to understand if students experienced a decline in their cardiorespiratory physical fitness during their first…
Guo C, Geng A, Wang Q et al. · 2026 · Journal of integrative neuroscience
Background The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This…
Salimi Y, Namdarzadeh B, Aarani FD et al. · 2026 · Behavioural brain research
The gut-brain axis plays a key role in the bidirectional communication between the gastrointestinal system and the brain, with gut microbiota significantly influencing cognitive function. While synbiotic and probiotic interventions have…
Sudhakar S, Mishra VK, Harikrishna S et al. · 2026 · Physical chemistry chemical physics : PCCP
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
Sanmartino F, Rashid-López R, López-Sosa F et al. · 2026 · International journal of neural systems
Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes…
Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health
BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…
Koper M, Jaworska K, Kopacz W et al. · 2026 · Kidney & blood pressure research
Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of…
Wiel É, Menu H, Roger F et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Endotracheal Intubation (ETI) inserts an endotracheal tube (ETT) inside the human trachea to allow a proper mechanical ventilation of the lungs. Practitioners insert the ETT through the human vocal cords following a…