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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 274 of 724

Negative / Null Result ReportOpen accessMedicine

Spinal Versus General Anesthesia for Lumbar Discectomy: Patient-Centered Analysis of Satisfaction with Anesthesia Service.

Rimaitis M, Bilskienė D, Rimaitis K et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Spinal (SA) and general anesthesia (GA) are both available for lumbar disc hernia (LDH) surgery. Patient satisfaction with anesthesia service is under-investigated and may help identify areas requiring…

View details →DOI: 10.3390/medicina62030524
Negative / Null Result ReportMedicine

Short Versus Extended Duration of Triple Antithrombotic Therapy After Percutaneous Coronary Intervention in Patients Requiring Oral Anticoagulation: A Retrospective Single-Center Study.

Kurpad KP, Vorla M, Bin-Farooq T et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Balancing ischemic and bleeding risks in patients undergoing percutaneous coronary intervention (PCI) who require anticoagulation remains a clinical challenge. While dual antithrombotic therapy (DAT) with a P2Y12 inhibitor and…

View details →DOI: 10.1002/ccd.70667
Negative / Null Result ReportMedicine

Pediatric Robotic Cochlear Implantation: Hearing Outcomes.

Marie A, Leclere JC, Fleming Y et al. · 2026 · Audiology & neuro-otology

Introduction Cochlear implantation is the standard of care for children with severe-to-profound sensorineural hearing loss, offering substantial improvements in speech intelligibility, tonal audiometry perception, language acquisition, and…

View details →DOI: 10.1159/000551887
Negative / Null Result ReportMedicine

Coronary artery calcium and multiparametric cardiovascular risk assessment in non-dialysis chronic kidney disease.

Đuran I, Komazec N, Ljubičić B et al. · 2026 · Biomolecules & biomedicine

Cardiovascular disease is a leading cause of mortality in chronic kidney disease (CKD), but whether impaired renal function independently increases coronary artery calcium (CAC) burden in patients with comparable cardiovascular referral…

View details →DOI: 10.17305/bb.2026.14105
Negative / Null Result ReportMedicine

Generativity in Physician Assistants: Insights Amid a Preceptor Shortage.

Chung K · 2026 · The journal of physician assistant education : the official journal of the Physician Assistant Education Association

Introduction Amid a preceptor shortage, this pilot study examined the relationship between generativity, a psychosocial construct reflecting concern for guiding the next generation, and demographic characteristics among physician…

View details →DOI: 10.1097/jpa.0000000000000751
Negative / Null Result ReportMedicine

Tigecycline Use in Pediatrics: A Comprehensive Analysis of Clinical, Laboratory, and Microbiological Factors.

Arga G, Öcal D, Özdemir H et al. · 2026 · Turkish archives of pediatrics

Objective This study aimed to evaluate the indications and clinical and microbiological outcomes of tigecycline use in pediatric patients and to analyze the factors associated with treatment success and mortality. Methods The patients…

View details →DOI: 10.65717/turkarchpediatr.2026.25440
Negative / Null Result ReportOpen accessMedicine

Effectiveness of dexmedetomidine versus fentanyl on postoperative pain and recovery after pediatric tonsillectomy: A retrospective cohort study.

Jallad M, AlAnazi B, Aloqbawi A et al. · 2026 · Saudi journal of anaesthesia

Background Pediatric tonsillectomy is commonly associated with significant postoperative pain. Opioids remain a mainstay for perioperative analgesia but carry risks of respiratory depression and prolonged recovery, especially in patients…

View details →DOI: 10.4103/sja.sja_788_25
Negative / Null Result ReportMedicine

Association Between Frailty and Short-Term Treatment-Related Adverse Events in Patients With Overactive Bladder.

Iwagami S, Yamamoto H, Miyai H et al. · 2026 · Lower urinary tract symptoms

Objectives To evaluate whether frailty at treatment initiation is associated with treatment-related adverse events in patients with newly diagnosed overactive bladder (OAB). Methods This retrospective, single-center cohort study included…

View details →DOI: 10.1111/luts.70060
Negative / Null Result ReportMedicine

The interplay of APOE genotype, plasma levels, and cognitive functions in middle-aged adults with a parental history of Alzheimer's disease.

Mattar YA, Refaat O, El-Makawi S et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Background Family history and APOE ε4 carriage represent the strongest non-modifiable Alzheimer's disease (AD) risk factors after advancing age. Early identification of cognitive markers in individuals at risk is essential for effective…

View details →DOI: 10.1080/15622975.2026.2666647
Negative / Null Result ReportMedicine

Axial Force Transmission Through Orthosis Straps in a Neonatal Hip Flexion-Abduction Orthosis: An Exploratory In Vivo Study in Infants with Developmental Dysplasia of the Hip.

Schwanitz von Keitz P, Liebau KH, Mittelmeier W et al. · 2026 · Children (Basel, Switzerland)

Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion-abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load…

View details →DOI: 10.3390/children13060777
Negative / Null Result Report

Longitudinal Interaction Between Frailty and Postoperative Symptom Burden in Elderly Patients Undergoing Colorectal Cancer Surgery: A Random Intercept Cross-Lagged Panel Model Study

Li P, Ge L, Liu Y et al. · 2026 · Preprint

Background: /Objectives: Frailty and postoperative symptom burden are prevalent in older adults undergoing colorectal cancer (CRC) surgery, but their temporal, within-person interplay remains unclear. We aimed to investigate this…

View details →DOI: 10.20944/preprints202606.0136.v1
Negative / Null Result ReportMedicine

Tibial-Sided Suspension Fixation increases Risk of Cyclops Lesion following Anterior Cruciate Ligament Reconstruction.

Hansen BK, Sandefur EP, Garcia AR et al. · 2026 · The journal of knee surgery

Abstract Cyclops lesions are a common postoperative complication that occurs in up to 47% of patients after anterior cruciate ligament reconstruction (ACLR), often resulting in painful extension loss. While risk factors for cyclops lesions…

View details →DOI: 10.1055/a-2886-8022
Negative / Null Result ReportMedicine

Independent and joint associations of chronotype and sleep quality with psychoactive substance use in adolescents.

Espinoza-Abad R, Gogeascoechea-Trejo MDC, García-García F · 2026 · Sleep medicine

Objective To examine the associations of chronotype and sleep quality with psychoactive substance use among adolescents attending schools with different schedules and patterns associated with chronotype-school schedule combinations.…

View details →DOI: 10.1016/j.sleep.2026.109095
Negative / Null Result ReportMedicine

A randomized controlled trial to evaluate the efficacy and safety of a double-walled incubator compared to a radiant warmer in the care of extremely low-birth-weight infants.

Kabra NS, Umate SS, Halder P et al. · 2026 · Journal of tropical pediatrics

This study compared the safety and efficacy of double-walled incubators versus radiant warmers in extremely low-birth weight (ELBW: birth weight < 1000 g) preterm infants, hypothesizing that incubator care would reduce the time to regain…

View details →DOI: 10.1093/tropej/fmag040
Negative / Null Result ReportMedicine

Macromolecular crowding and ionic strength diminish the energetic severity of the Arrhenius break point of thermolysin: Implications for biological significance.

Miller JJ, Duggal M, Bahnson BJ · 2026 · Protein science : a publication of the Protein Society

A growing number of enzymes demonstrate deviations from typical linear kinetic temperature dependencies as modeled by the Arrhenius and Eyring equations. These deviations may manifest as biphasic temperature dependencies consisting of two…

View details →DOI: 10.1002/pro.70632
Negative / Null Result ReportMedicine

Perioperative Outcomes of Robot-Assisted Partial Nephrectomy Using Hinotori Compared With da Vinci Xi: A Propensity Score-matched Analysis.

Kanehira M, Nozaki Y, Ogasawara K et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Introduction Robot-assisted partial nephrectomy (RAPN) using the da Vinci Surgical System (DVSS) is broadly performed globally. In Japan, the Hinotori Surgical Robot System (HSRS) has recently been developed. However, few studies have…

View details →DOI: 10.1002/rcs.70173
Negative / Null Result ReportMedicine

Species-level reporting of Coagulase-negative staphylococci with MALDI-TOF does not impact clinical outcomes.

Cebulla C, Hamdan A, Poonawala H et al. · 2026 · Diagnostic microbiology and infectious disease

Background Coagulase-negative Staphylococci (CoNS) are common blood culture contaminants, yet distinguishing true infection from contamination remains challenging. In January 2023, we implemented routine species-level CoNS reporting. This…

View details →DOI: 10.1016/j.diagmicrobio.2026.117479
Negative / Null Result ReportMedicine

Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.

Askarian F, Karimizadeh Z, Kalantari A et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Acute kidney injury (AKI) is an understudied complication in pediatric Fanconi anemia (FA) patients undergoing hematopoietic stem cell transplantation (HSCT). This study evaluates AKI incidence, risk factors, renal trajectories,…

View details →DOI: 10.1007/s00467-026-07390-8
Negative / Null Result ReportMedicine

Should nintedanib be continued after acute exacerbation of idiopathic pulmonary fibrosis? A retrospective observational study using a nationwide database in Japan.

Shuto H, Hagiwara A, Kudoh R et al. · 2026 · Respiratory medicine and research

Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) carries a high risk of short-term mortality, and optimal management strategies remain unclear. Although recent studies have suggested that antifibrotic therapy…

View details →DOI: 10.1016/j.resmer.2026.101293
Negative / Null Result ReportMedicine

<i>Staphylococcus aureus</i> inhibits the NLRP3 inflammasome in macrophages to varying degrees during early and late stages of infection.

Bhagat S, Kaur K, Petronglo JR et al. · 2026 · Infection and immunity

Staphylococcus aureus ( S. aureus ) is a highly virulent pathogen responsible for chronic infections such as osteomyelitis. Although its interaction with the host immune system has been widely studied, the specific role of inflammasomes in…

View details →DOI: 10.1128/iai.00200-26
Negative / Null Result ReportMedicine

Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.

He CZ, Qiu Q, Lai H et al. · 2026 · BMC ophthalmology

This study aimed to evaluate whether a combination of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters could improve the discrimination between clinically diagnosed normal-tension glaucoma (NTG) and non-glaucomatous…

View details →DOI: 10.1186/s12886-026-05065-4
Negative / Null Result ReportMedicine

Long-term outcomes of tacrolimus conversion to sirolimus in kidney transplant recipients: an eight-year follow-up.

Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology

Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…

View details →DOI: 10.3389/fneph.2026.1813146
Negative / Null Result ReportMedicine

Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia.

Stepanichev M, Peregud D, Manolova A et al. · 2026 · Cell biochemistry and function

Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild…

View details →DOI: 10.1002/cbf.70225
Negative / Null Result ReportMedicine

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI

Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…

View details →DOI: 10.1002/jmri.70356
Negative / Null Result ReportMedicine

Achilles tendon rupture does not significantly reduce career longevity in professional soccer players compared with matched controls.

Khan HA, Khan A, Rosenberg A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort. Methods A retrospective analysis of ATR cases in professional male athletes from…

View details →DOI: 10.1002/ksa.70420
Negative / Null Result ReportMedicine

Does a Brochure Reduce Dental Anxiety in Patients Undergoing Third Molar Extraction? A Randomized Clinical Trial.

Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…

View details →DOI: 10.1016/j.joms.2026.05.063