e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 273 of 710

Negative / Null Result Report

Metabolic Dynamics During Cardiopulmonary Bypass: Oxygen Delivery, Carbon Dioxide Production, and Lactate Response Despite Preserved Global Perfusion

J D, J JA, S S et al. · 2026 · Preprint

Abstract Objective To analyze intraoperative metabolic parameters from carbon dioxide during cardiopulmonary bypass (CPB) and their association with postoperative hyperlactatemia in elective cardiac surgery. Methods This study observed 26…

View details →DOI: 10.21203/rs.3.rs-9702308/v1
Negative / Null Result ReportMedicine

Voice and Swallowing in Professional Voice Users: The Effect of Therapy Methods.

Özcan Ulubeli P, Aydoğan Z, Karakaya Gojayev E et al. · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This study aimed to evaluate pain complaints, as well as voice and swallowing functions, in professional voice users, and to compare the effectiveness of three therapeutic approaches: vocal hygiene (VH), vocal function…

View details →DOI: 10.1159/000550481
Negative / Null Result ReportMedicine

A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.

Wang X, Xu Y, Lin X et al. · 2026 · Scientific reports

Left ventricular-arterial (V-A) coupling is a key determinant of cardiovascular performance, which integrates intrinsic myocardial contractility with ventricular afterload. Septic shock frequently disrupts this coupling, and norepinephrine…

View details →DOI: 10.1038/s41598-026-56605-3
Negative / Null Result ReportMedicine

Analysis of mechanical dynamics in acoustofluidics: assessing the impact of frequency sweeping on PZT performance and acoustic phenomena.

Maisto A, Sanders RGP, de Hemptinne A et al. · 2026 · Ultrasonics

In this work, we combine acoustic streaming measurements, direct vibration measurements and the theory of wave dispersion to interpret changes in acoustic streaming. The vibration dynamics of the PZT are studied under frequency sweeping…

View details →DOI: 10.1016/j.ultras.2026.108182
Negative / Null Result Report

Redox potential in animal andrology: An experimental study on boar semen

Pintus E, Scaringi M, Engelen J et al. · 2026 · Preprint

Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…

View details →DOI: 10.64898/2026.05.21.726780
Negative / Null Result ReportMedicine

Long-Term Therapy with Eculizumab Biosimilar in Patients with Atypical Haemolytic Uraemic Syndrome: Outcomes of a Prospective Observational Study.

Kotenko O, Kozlovskaya N, Emirova K et al. · 2026 · Nephron

Background The objective of a multicentre, prospective, observational study of an eculizumab biosimilar (Elizaria®) was to analyse the efficacy and safety of long-term complement inhibitor therapy in patients with atypical haemolytic…

View details →DOI: 10.1159/000552914
Negative / Null Result ReportMedicine

Quantitative and Comparative Analysis of Dream Content in Parkinson's Disease Patients Undergoing Deep Brain Stimulation: A Pilot Study.

Joswig H, Oreizi-Esfahani S, Medack S et al. · 2026 · World neurosurgery

Background Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, resulting in motor and nonmotor symptoms including diminished sleep quality and altered dream…

View details →DOI: 10.1016/j.wneu.2026.124816
Negative / Null Result ReportOpen accessMedicine

Physical activity and glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) plasma levels in different age cohorts.

Raza GS, Jokelainen J, Stenbäck V et al. · 2026 · PloS one

Physical activity (PA) has numerous positive health effects, including improvements in cognitive function. PA stimulates the release of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) from the liver, resulting in hippocampal…

View details →DOI: 10.1371/journal.pone.0349883
Negative / Null Result ReportMedicine

Psychopathological correlates of early childhood sleep terror: associations with nutritional biomarkers, behavioral dysregulation, and sleep disturbance.

Esen Öksüzoğlu M, Kabukçu HO · 2026 · BMC psychiatry

Background Sleep terror (ST) is a common NREM parasomnia in early childhood and may be associated with broader emotional and behavioral dysregulation. However, its links with psychopathological symptoms and nutritional biomarkers remain…

View details →DOI: 10.1186/s12888-026-08298-1
Negative / Null Result ReportMedicine

Airway Mucus Occlusions in Ex-Smokers with and Without COPD.

Tcherner S, Durom E, Peters J et al. · 2026 · COPD

In patients with moderate-to-severe COPD, airway mucus-occlusions correlate with airflow limitation, exacerbation and mortality-risk. However, the clinical relevance of mucus-plugs in milder COPD is not well-understood. We evaluated…

View details →DOI: 10.1080/15412555.2026.2681969
Negative / Null Result Report

Investigating the Mediating Role of Family Support and Peer Acceptance in the Relationship Between Prosocial Behavior and Well-being of Children: A Causal Mediation Analysis

Sevahil D · 2026 · Preprint

The aim of this study was to examine the causal pathways from prosocial behavior to well-being in different grades of primary school children. We assessed for whether family support andpeer acceptance mediate this relationship, along to…

View details →DOI: 10.31234/osf.io/nyahz_v1
Negative / Null Result ReportMedicine

The Effect of Pessary Insertion on Pelvic Anatomy: A Prospective Observational Study Using Upright MRI.

Steen AV, Simmering JA, Perik M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective To determine the anatomical effect of pessaries in the upright position in women with pelvic organ prolapse (POP). Design Prospective observational cohort study. Setting Outpatient clinic of our gynaecology department. Population…

View details →DOI: 10.1111/1471-0528.70280
Negative / Null Result ReportOpen accessMedicine

Acid-base balance and respiratory mechanics during robotic-assisted surgery: an observational study.

Pitimada M, Chiumello D, Monte A et al. · 2026 · Journal of robotic surgery

To evaluate changes in acid-base equilibrium in plasma and urine according to the Stewart’s approach, in gas exchange and in respiratory mechanics during robotic-assisted surgery. Prospective observational study on patients undergoing…

View details →DOI: 10.1007/s11701-026-03392-8
Negative / Null Result ReportMedicine

Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial.

Dunseath GJ, Cheung WY, Luzio SD et al. · 2026 · Diabetes care

Objective To determine whether less invasive C-peptide tests, urine C-peptide-to-creatinine ratio (UCPCR) and dried blood spot (DBS), could replace the mixed-meal tolerance test (MMTT) in the context of an interventional clinical trial…

View details →DOI: 10.2337/dc25-2896
Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

Negative / Null Result ReportMedicine

Behavioral Adaptation to Neck Radio-Collars and Its Relations with Temperament in Two Neotropical Psittacid Species.

de Almeida GN, de Jesus LG, Branco MEC et al. · 2026 · Journal of applied animal welfare science : JAAWS

Track devices can cause behavioral, physical, and physiological adverse effects, with individuals varying in how quickly they adapt to them. We examined behavioral effects of replica radio-collars on two captive psittacid species,…

View details →DOI: 10.1080/10888705.2026.2681557
Negative / Null Result ReportMedicine

Impact of tighter glycaemic targets on pregnancy outcomes in a multi-ethnic cohort with gestational diabetes: A retrospective, single centre observational study.

Huda MS, Margari N, Islam N et al. · 2026 · Obstetric medicine

Aims To determine the impact of tighter glycaemic targets for gestational diabetes. Methods Retrospective data analysis before and after introducing tighter glucose targets. Results In 2265 pregnancies there was no change in…

View details →DOI: 10.1177/1753495x261445509
Negative / Null Result ReportMedicine

An evaluation of anatomical and functional outcomes in patients undergoing retinectomy for proliferative vitreoretinopathy.

Uzlu D, Erdöl H, Bulanık ÖB et al. · 2026 · BMC ophthalmology

Background The objective of this study was to evaluate the anatomical and functional outcomes of patients who underwent relaxing retinotomy or retinectomy for retinal detachment complicated by proliferative vitreoretinopathy. Methods The…

View details →DOI: 10.1186/s12886-026-04904-8
Negative / Null Result ReportMedicine

Mental rotation performance after acute stress.

Richardson AE, VanderKaay Tomasulo MM · 2026 · BMC psychology

Background The need to mentally rotate objects is common in everyday activities (e.g., driving, loading suitcases in a car, playing 3D video games) and in specific professions (e.g., air traffic controllers, mechanics, pilots, surgeons).…

View details →DOI: 10.1186/s40359-026-04818-6
Negative / Null Result ReportMedicine

The Importance of Objective Functional and Balance Testing in Pediatric Anterior Cruciate Ligament Reconstruction for a Safe Return-To-Sport: A Two-Year Prospective Study.

Crippa M, Turati M, Flumian C et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Pediatric anterior cruciate ligament reconstruction (ACLR) outcomes, particularly long-term functional recovery and return-to-sport (RTS), remain debated and have not been well characterized in skeletally immature…

View details →DOI: 10.1016/j.jisako.2026.101149
Negative / Null Result ReportMedicine

Antifungal susceptibility of genital yeast isolates, Auckland, 2016-2025.

Morris AJ, McKinney WP, Roberts SA · 2026 · The New Zealand medical journal

Aim Our aim was to record current susceptibility results of genital yeast isolates and to compare the results to the previous report covering the period 2001-2015. Methods Genital yeast isolates had their antifungal susceptibility…

View details →DOI: 10.26635/6965.7444
Negative / Null Result ReportMedicine

Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.

Kasai N, Ihara H, Iemitsu M et al. · 2026 · Experimental physiology

Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this…

View details →DOI: 10.1113/ep093646
Negative / Null Result ReportMedicine

Impact of lymphocyte p-glycoprotein activity on development of graft-versus-host disease after stem cell transplantation.

Nakamura S, Tajima S, Hirota T et al. · 2026 · International journal of hematology

Tacrolimus (TAC) is a pivotal immunosuppressant used to prevent graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation (HSCT). However, because lymphocytes express P-glycoprotein (P-gp), which actively effluxes…

View details →DOI: 10.1007/s12185-026-04196-0