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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 272 of 710

Negative / Null Result ReportMedicine

Long-term outcomes of tacrolimus conversion to sirolimus in kidney transplant recipients: an eight-year follow-up.

Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology

Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…

View details →DOI: 10.3389/fneph.2026.1813146
Negative / Null Result ReportMedicine

Chronic Mild Unpredictable Stress Selectively Downregulates Exon I Bdnf mRNA in the Rat Frontal Cortex Independently of Anhedonia.

Stepanichev M, Peregud D, Manolova A et al. · 2026 · Cell biochemistry and function

Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild…

View details →DOI: 10.1002/cbf.70225
Negative / Null Result ReportMedicine

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI

Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…

View details →DOI: 10.1002/jmri.70356
Negative / Null Result ReportMedicine

Achilles tendon rupture does not significantly reduce career longevity in professional soccer players compared with matched controls.

Khan HA, Khan A, Rosenberg A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort. Methods A retrospective analysis of ATR cases in professional male athletes from…

View details →DOI: 10.1002/ksa.70420
Negative / Null Result ReportMedicine

Does a Brochure Reduce Dental Anxiety in Patients Undergoing Third Molar Extraction? A Randomized Clinical Trial.

Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…

View details →DOI: 10.1016/j.joms.2026.05.063
Negative / Null Result ReportMedicine

Supervised Machine Learning Models for Ocular Sagittal Height Prediction Incorporating Corneoscleral Profile Data.

González-Cruces T, Carrillo-Pulido M, Aguilar-Salazar FJ et al. · 2026 · Eye & contact lens

Objective This study aimed to develop supervised machine learning (ML) models to predict ocular sagittal height (OC-SAG), using anterior eye data derived from topography and tomography. Method ology: A retrospective cohort of 100 eyes…

View details →DOI: 10.1097/icl.0000000000001277
Negative / Null Result ReportMedicine

Effect of additive manufacturing technology and print orientation on the accuracy of static guided implant surgery: An in vitro study.

Amini S, Alshammari M, Abdulhameed N et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

Purpose The aim of this in vitro study was to investigate the effect of print orientation and printing technology on the accuracy of static computer-aided implant surgery (s-CAIS). Materials and methods A cone beam computed tomography…

View details →DOI: 10.1111/jopr.70152
Negative / Null Result ReportMedicine

Exploring a Single Music Therapy Session to Reduce 22q11.2 Deletion Syndrome Child and Adolescent's Outpatient Clinic-Related Anxiety.

Broughton MC, Bunzli E, Pagel S et al. · 2026 · Journal of paediatrics and child health

Aim This study explored whether a single music therapy session could reduce 22q11.2 deletion syndrome (DS) children and adolescents' clinic-related anxiety when visiting the hospital outpatient clinic for health appointments. Methods The…

View details →DOI: 10.1111/jpc.70397
Negative / Null Result ReportMedicine

Mediating effects of depression, stigma, and self-efficacy on self-management improvement in an evidence-based epilepsy self-management program.

Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B

Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…

View details →DOI: 10.1016/j.yebeh.2026.111117
Negative / Null Result Report

Comparative chemical characterisation of chitosans and their impact on growth, faecal consistency and microbiota composition in weaned piglets

Blasio SD, Middelkoop A, Molist F et al. · 2026 · Preprint

Managing post-weaning diarrhoea (PWD) in piglets is difficult due to limits on antibiotics and zinc. Chitosan is emerging as a potential feed additive. We analysed a chito-oligosaccharide hydrochloride (COS-HCl), a low molecular weight…

View details →DOI: 10.64898/2026.03.26.714014
Negative / Null Result ReportMedicine

Relationship Between Mental Health and Protective Health Behaviors in Adolescents: A Secondary Data Analysis.

Mahat G, Zha P · 2026 · Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

Evidence highlights rising mental health concerns among youth. This study investigated the relationship between protective behaviors, including physical activity, regular breakfast, sleep, and parental monitoring, and adolescent mental…

View details →DOI: 10.1016/j.pedhc.2026.05.012
Negative / Null Result ReportMedicine

Impact of oral glucocorticoids on the effectiveness of romosozumab: the multicenter OASIS cohort study.

Yukishima T, Kobayakawa T, Hirano Y et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

This multicenter retrospective cohort compared romosozumab outcomes between oral glucocorticoid users and non-users. Bone turnover marker responses and lumbar spine bone mineral density gains were similar, whereas total hip bone mineral…

View details →DOI: 10.1007/s00198-026-08051-0
Negative / Null Result ReportMedicine

Attention Networks and Speech Disfluencies among Monolingual Dutch and Bilingual Dutch-Turkish Speaking Children: A Pilot Study.

Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…

View details →DOI: 10.1159/000551501
Negative / Null Result ReportMedicine

Influence of the correct placement of external ventricular drainage on puncture channel bleeding in patients with aneurysmal subarachnoid hemorrhage.

Marschal V, Ziebart A, Abdoullahi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

While ventriculostomy-associated hemorrhages are well-documented in spontaneous subarachnoid hemorrhage (SAH), the impact of external ventricular drainage (EVD) placement accuracy on puncture channel bleeding (PCB) remains underexplored.…

View details →DOI: 10.1016/j.jocn.2026.112077
Negative / Null Result Report

Relative Hemodynamic Timing in Human White Matter

Li M, Ding Z, Gore JC · 2026 · Preprint

ABSTRACT Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health. We developed Local Propagation Mapping to quantify the spatiotemporal architecture of relative hemodynamic timing within…

View details →DOI: 10.64898/2026.05.29.728865
Negative / Null Result ReportMedicine

Effects of glucose ingestion on blood flow in the small intestine and exercising limbs during endurance exercise.

Endo MY, Kashima H, Miura A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Performance during endurance exercise depends on the balance between the blood flow (BF) to active muscles and their energy use. We compared the acute cardiovascular regulation after the ingestion of a 300-mL drink containing 50 g glucose…

View details →DOI: 10.1152/japplphysiol.00954.2025
Negative / Null Result ReportMedicine

Clinical Characteristics and Management for Flares in Patients With Rheumatoid Arthritis Treated With Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs.

Kim YE, Ahn SM, Oh JS et al. · 2026 · International journal of rheumatic diseases

Objective To evaluate the frequency and management of flares in rheumatoid arthritis (RA) patients treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). Methods Data were analyzed from the KOrean…

View details →DOI: 10.1111/1756-185x.70631
Negative / Null Result ReportOpen accessMedicine

[Corrigendum] Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.

Niu P, Sun Y, Wang S et al. · 2026 · Molecular medicine reports

Following the publication of the above article, an interested reader drew to the authors' attention that, concerning the TUNEL assay data shown in Fig. 5A on p. 6, the images shown for the H 2 O 2 and PU+H 2 O 2 groups were remarkably…

View details →DOI: 10.3892/mmr.2026.13849
Negative / Null Result ReportMedicine

A polymorphism and expression levels of SCD and their relationships to production traits in a Japanese farmed emu population.

Koshiishi Y, Moriya S, Ishida Y et al. · 2026 · PloS one

The emu is a novel poultry species producing meat, eggs, and fat. In particular, emu oil derived from the fat is considered the most important product of the emu owing to its anti-inflammatory and anti-melanin production. Meanwhile, there…

View details →DOI: 10.1371/journal.pone.0352695
Negative / Null Result ReportMedicine

Factors influencing time to speech processor upgrades.

Hung C, Spitzer ER, Waltzman SB · 2026 · Cochlear implants international

Objective Cochlear implant (CI) speech processors have undergone technological advancements. Therefore, patients upgrade speech processors when new features are available or when their previous device becomes broken and is no longer…

View details →DOI: 10.1080/14670100.2026.2635191
Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

View details →DOI: 10.1038/s41598-026-58855-7
Negative / Null Result ReportMedicine

Pharmacokinetics of polyethylene glycol (PEG)-capped gold nanoparticles in rats: impact of free PEG pre-administration.

Darweesh RS, Alnuaimi TM, Zayed AL et al. · 2026 · Nanotechnology

Polyethylene glycol (PEG)-capped gold nanoparticles (PEG-AuNPs) are of great interest for targeted drug delivery and targeted delivery of chemotherapy due to their biocompatibility and ability to evade detection by the immune system.…

View details →DOI: 10.1088/1361-6528/ae4fc9
Negative / Null Result ReportMedicine

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Ifrah-Tsruya H, Lev M, Polat U · 2026 · Vision research

Attention-Deficit/Hyperactivity Disorder (ADHD) is typically conceptualized as a disorder of executive control; however, accumulating evidence suggests that early sensory processing may also be atypical. The present study examined contrast…

View details →DOI: 10.1016/j.visres.2026.108867