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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 271 of 710

Negative / Null Result ReportMedicine

Diabetes and Performance Status Predict Severe, Persistent Radiation Proctitis: Long-Term Endoscopic Findings From STELLAR Trial.

Wang N, Xu T, Li H et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose To characterize the long-term endoscopic natural history of chronic radiation proctitis (CRP) and identify predictors of severe lesions in patients with locally advanced rectal cancer from the STELLAR study (NCT02533271) . Methods…

View details →DOI: 10.1016/j.ijrobp.2026.05.004
Negative / Null Result ReportMedicine

Effect of 5-Aminosalicylate Dose Reduction or Withdrawal on Prognosis in Patients with Ulcerative Colitis Receiving Advanced Therapy: A Multicenter Retrospective Cohort Study.

Sano Y, Yagi N, Ito Y et al. · 2026 · Digestive diseases and sciences

Background and aims The role of 5-aminosalicylates (5-ASA) in maintaining remission in patients with ulcerative colitis (UC) receiving advanced therapy remains controversial. This study evaluated the safety and feasibility of 5-ASA…

View details →DOI: 10.1007/s10620-026-09778-w
Negative / Null Result ReportMedicine

Outcomes for Labor Induction Compared With Expectant Management Among Women Receiving Hospital-Based, Midwifery-Led Care.

Smith DC, Gemkow JW, Shiferaw BA et al. · 2026 · Journal of midwifery & women's health

Introduction Use of labor induction has increased rapidly for medical and nonmedical reasons, raising questions about its impact on cesarean birth rates. With growing incidence of elective induction of labor (IOL) at 39 weeks, uncertainty…

View details →DOI: 10.1111/jmwh.70109
Negative / Null Result ReportMedicine

Dynamic tensile loading improves neotendon formation at moderate daily loading cycles, but impairs neotendon formation at high daily loading cycles.

Jenkins TL, Darden K, Pourdeyhimi B et al. · 2026 · Journal of biomechanics

Synthetic polymer scaffolds with aligned fibers permit engineered tendon development and the formation of an aligned, collagen rich matrix. However, many tissue engineered constructs cannot withstand physiologically relevant loads. Both…

View details →DOI: 10.1016/j.jbiomech.2026.113248
Negative / Null Result ReportMedicine

Addition of Preoperative Ultrasound To 4D-CT Increases Radiologist Confidence in Identifying Hyperfunctioning Parathyroid Glands.

Mohammadi S, Cunnane ME, Juliano AF et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Four-dimensional CT (4D-CT) is a key imaging modality for preoperative localization of parathyroid adenomas in primary hyperparathyroidism. Ultrasound (US) is frequently added with the assumption that it enhances…

View details →DOI: 10.3174/ajnr.a9306
Negative / Null Result ReportMedicine

Down syndrome birth rate post Dobbs decision: has it changed?

Santoro SL, Alvarado C, Tseng SY et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective In 2022, the U.S. Supreme Court decision on Dobbs v. Jackson Women's Health Organization changed abortion access. We evaluated birth rates of Down syndrome (DS) before and after the Dobbs decision hypothesizing similarity to…

View details →DOI: 10.1038/s41372-026-02560-w
Negative / Null Result ReportMedicine

Impact of additional left atrial roof ablation for persistent atrial fibrillation using cryoballoon: the ICEBERG trial.

Ukita K, Egami Y, Sugino A et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Several studies have investigated the efficacy of additional left atrial (LA) roof ablation to pulmonary vein isolation (PVI) using cryoballoon for persistent atrial fibrillation (AF). However, the evidence from randomized…

View details →DOI: 10.1007/s00392-026-02879-6
Negative / Null Result ReportMedicine

Association of Prior Antibiotic Use With Negative Surgical Bone Biopsy Cultures and Disease Recurrence in Diabetes-related Foot Osteomyelitis.

Aragón-Sánchez J, Víquez-Molina G, Aragón-Hernández J et al. · 2026 · Advances in skin & wound care

Objective The authors hypothesized that prior antibiotic treatment does not reduce culture positivity and that empirical antibiotic therapy in culture-negative cases does not increase the risk of amputation or recurrence in…

View details →DOI: 10.1097/asw.0000000000000425
Negative / Null Result ReportOpen accessMedicine

Effects of the micronutrient Sanopal® (5-hydroxymethyl-2-furfural and α-ketoglutaric acid) on oxygen affinity of hemoglobin, oxygen saturation and exercise responses at altitude.

Woyke S, Troppmair T, Mair N et al. · 2026 · Journal of the International Society of Sports Nutrition

Background With increasing altitude, the partial pressure of oxygen and oxygen saturation (SpO 2 ) decrease, reducing physical performance. This study investigates whether the nutritional supplement Sanopal® (5-hydroxymethyl-2-furfural and…

View details →DOI: 10.1080/15502783.2026.2643684
Negative / Null Result ReportMedicine

Evaluation of the clinical reasoning of GPT-4o, a multimodal generative artificial intelligence model, in 18 public gastroenterology case studies.

García-Rudolph A, Hernández-Pena E, Del Cacho N et al. · 2026 · Revista espanola de enfermedades digestivas

Introduction and aim although generative language models have been extensively studied in the field of digestive diseases, further progress requires addressing underexplored aspects such as linguistic bias, the evaluation of clinical…

View details →DOI: 10.17235/reed.2025.11369/2025
Negative / Null Result ReportOpen accessMedicine

Effect of Tranexamic Acid on Inpatient Admission and Revision Rates in Primary Rhinoplasty: A Propensity Score-Matched Analysis.

Mehdizadeh M, Smith JE, Gill J et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Tranexamic acid (TXA) is commonly used to reduce intraoperative bleeding and complications across surgical specialties. In rhinoplasty, prior studies indicate that TXA may reduce postoperative edema and ecchymosis, but its…

View details →DOI: 10.1097/gox.0000000000007659
Negative / Null Result Report

Utilizing raw rapeseed press cake in foods: A case study on sensory quality and profile of selected bitter compounds in snack bars

Thorsen JS, Bononad-Olmo A, Toft AM et al. · 2026 · Preprint

ABSTRACT Today’s canola quality rapeseed press cake (RPC) is a protein-rich co-product with potential as human food, but its application is limited due to antinutritional compounds and bitter taste. It remains, however, unknown how…

View details →DOI: 10.64898/2026.03.20.712648
Negative / Null Result ReportMedicine

Beef quality and expression of genes involved in lipid metabolism in the muscle of Nellore and Nellore × Angus steers fed whole shelled corn diets.

Teixeira PD, Casagrande DR, Rodrigues AC et al. · 2026 · Meat science

Sixteen Nellore and Sixteen Nellore × Angus steers with an initial body weight of 353 kg ±25.3 kg were randomly assigned into 2 feeding groups: whole shelled corn without forage (WSC) or WSC with sugarcane bagasse (WSCB), to evaluate…

View details →DOI: 10.1016/j.meatsci.2026.110078
Negative / Null Result ReportMedicine

Chinese Young Children Engage in Social Role-Based Sharing Behavior.

Wu X, Chai Q, He J · 2026 · Developmental science

Role ethics suggests that moral obligations arise from the duties associated with one's social roles. Yet, the influence of social roles on children's moral behavior remains unclear. This research addressed this gap by testing whether…

View details →DOI: 10.1111/desc.70140
Negative / Null Result ReportMedicine

Intraoperative 3D Fluoroscopy Reduces Revision Rates and Improves Reduction Quality in Acetabular Fracture Fixation.

Le Baron M, David G, Ward BA et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether the use of intraoperative 3D fluoroscopy during acetabular fracture fixation reduces the rate of unplanned returns to the operating room and improves radiographic quality of reduction without increasing…

View details →DOI: 10.1097/bot.0000000000003100
Negative / Null Result ReportMedicine

Poplar CLE peptides promoting ectomycorrhizal symbiosis identified through genome-wide analysis of responsive small secreted peptides.

Bonnot C, Morin E, Da Silva Machado E et al. · 2026 · Plant physiology

Plant small secreted peptides (SSPs) are involved in numerous developmental processes and adaptive plant responses. These include root development, immunity, and symbiotic relationships in herbaceous plants; three processes crucial for…

View details →DOI: 10.1093/plphys/kiag071
Negative / Null Result ReportMedicine

18-Crown-6 ether increases molecular weight of poly(3-hydroxybutyrate) synthesized in Escherichia coli.

Tanaka S, Kikukawa H, Nakai H et al. · 2026 · Journal of bioscience and bioengineering

Molecular weight of polyhydroxyalkanoate (PHA) is a critical factor governing their physical properties, particularly mechanical strength. It is empirically known that molecular weight of PHA varies depending on factors such as the…

View details →DOI: 10.1016/j.jbiosc.2026.01.008
Negative / Null Result ReportMedicine

Safety and Efficacy of Hypofractionated Preoperative Radiation Therapy in Retroperitoneal Sarcoma: A Comparative Study With Conventional Fractionation.

Baek JY, Yu JI, Lee KW et al. · 2026 · Practical radiation oncology

Purpose The role of preoperative radiation therapy (RT) in retroperitoneal sarcoma (RPS) remains controversial across histologic subtypes. Conventional fractionated RT (ConvRT) is the current standard, but hypofractionated RT (HypoRT) is…

View details →DOI: 10.1016/j.prro.2026.02.008
Negative / Null Result ReportMedicine

A randomized trial of iron- and zinc-biofortified pearl millet-based complementary feeding in children aged 12-18 months living in urban slums.

Mehta S, Huey SL, Ghugre PS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Biofortification of staple crops with higher concentrations of micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification and other interventions to target…

View details →DOI: 10.1016/j.clnu.2025.11.002
Negative / Null Result ReportMedicine

Effect of paternal resveratrol intake on mitochondria and telomere length in mouse embryos and offspring.

Teramoto N, Kobayashi N, Mitsui K et al. · 2026 · The Journal of reproduction and development

Advanced paternal age affects embryonic development and offspring phenotypes. We previously demonstrated that resveratrol prevents age-associated declines in the mitochondrial DNA copy number (mt-cn) and telomere length (TL) in embryos.…

View details →DOI: 10.1262/jrd.2026-038
Negative / Null Result ReportMedicine

Effect of white and red grape pomace on dry-cured sausages containing additives.

Carrapiso AI, Sánchez-Ordóñez M, Delgado-Adámez J et al. · 2026 · Food science and technology international = Ciencia y tecnologia de los alimentos internacional

The purpose of this study was to investigate for the first time the effect of the enrichment in white or red grape pomace stabilized by high hydrostatic pressure on the characteristics of dry-cured sausages containing additives (75 mg kg…

View details →DOI: 10.1177/10820132261461428
Negative / Null Result ReportMedicine

The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study).

Hudec J, Prokopova T, Hulkova M et al. · 2026 · Anesthesia and analgesia

Background Anesthetic agents or some pathophysiological conditions can affect transcranial motor evoked potentials (TcMEP) monitoring. However, the influence of depth of anesthesia on TcMEP reproducibility in youth remains unclear due to…

View details →DOI: 10.1213/ane.0000000000008158
Negative / Null Result ReportMedicine

Characterizing the V516M penicillin-binding protein 2 (PBP2) mutation causing zidebactam resistance in <i>Pseudomonas aeruginosa</i>.

Sastre-Femenia MÀ, Gomis-Font MA, Fernández-Muñoz A et al. · 2026 · Antimicrobial agents and chemotherapy

The triple action of the diazabicyclooctane (DBO) zidebactam (antibacterial activity [penicillin-binding protein 2 {PBP2} inhibitor], β-lactam enhancement [synergy with PBP3 inhibitors], and β-lactamase inhibition [classes A and C])…

View details →DOI: 10.1128/aac.00346-26
Negative / Null Result ReportMedicine

Brain Activity Changes During Bladder Filling in Women With Overactive Bladder After Percutaneous Tibial Neuromodulation.

Tam J, Wengler K, Yang J et al. · 2026 · Neurourology and urodynamics

Purpose Percutaneous tibial neuromodulation (PTNM) is a standard third line therapy for patients with overactive bladder (OAB). While the therapy has demonstrated efficacy, its exact mechanism of action is unclear. Functional neuroimaging…

View details →DOI: 10.1002/nau.70238