e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 271 of 724

Negative / Null Result ReportOpen accessMedicine

Revisiting Janus Kinase Inhibitors in Hospitalized COVID-19: Evidence for Baricitinib's Superiority and the Absence of a Class Effect.

Gu L, Lin J, Yue J et al. · 2025 · Journal of inflammation research

Janus kinase (JAK) inhibitors, developed for autoimmune diseases, have been repurposed as potential therapies for severe COVID-19. Growing evidence indicates that their clinical utility is heterogeneous and cannot be generalized as a class…

View details →DOI: 10.2147/jir.s554898
Negative / Null Result ReportMedicine

Failure to correct the fractional curve in adult spinal deformity surgery is associated with rod fractures.

Jain H, Zakieh O, Chanbour H et al. · 2025 · Clinical neurology and neurosurgery

Introduction Coronal malalignment (CM) remains an understudied and challenging problem in adult spinal deformity (ASD) surgery, and the impact of the lumbosacral fractional curve (LSF) correction on postoperative outcomes remains poorly…

View details →DOI: 10.1016/j.clineuro.2025.109152
Negative / Null Result ReportMedicine

Use of a Personalised Early Warning Decision Support System for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the "Predict & Prevent" Phase III Trial.

Gkini E, Mehta RL, Tearne S et al. · 2025 · COPD

Rationale The Predict&Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDPredict™. Methods Adults with ≥1 AECOPD were randomly assigned in a 1:1 ratio…

View details →DOI: 10.1080/15412555.2025.2544719
Negative / Null Result Report

Lack of evidence for cargo release of CD63-EVs into recipient cells

Askarian-Amiri S, Weissenhorn W, Sadoul R et al. · 2025 · Preprint

Extracellular vesicles (EVs), including exosomes, are widely believed to mediate intercellular communication by delivering molecular cargo to recipient cells. However, the efficiency and mechanisms of such cargo delivery remain unclear. In…

View details →DOI: 10.1101/2025.04.01.646561
Negative / Null Result ReportMedicine

Machine Learning and Urinary Incontinence in Prostate Cancer: A Generalized Additive Model of Physical Activity and Recovery Patterns.

Manolitsis I, Feretzakis G, Tzelves L et al. · 2025 · Studies in health technology and informatics

The ASCAPE project aims to improve the health-related quality of life of prostate cancer patients using artificial intelligence-driven solutions. This study tries to unravel the complex relationships between patient data variables and…

View details →DOI: 10.3233/shti250634
Negative / Null Result ReportMedicine

Long-term Results from the LEA Randomized Trial: Extended Versus Standard Lymph Node Dissection in Patients with Bladder Cancer Undergoing Radical Cystectomy.

Heck MM, Lehmann J, Amiel T et al. · 2025 · European urology

The extent of lymph node dissection (LND) at the time of radical cystectomy (RC) for bladder cancer (BC) may affect oncologic outcomes. We present updated long-term data from a prospective, multicenter, phase 3 trial involving patients…

View details →DOI: 10.1016/j.eururo.2025.09.001
Negative / Null Result ReportOpen accessMedicine

Clinical Determinants of Urinary Podocyte Biomarkers and Their Feasibility in Paraprotein-Related Kidney Disease.

Helk O, Wagner L, Sengölge G et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Kidney injury is a frequent complication of multiple myeloma (MM) and monoclonal gammopathies. Podocyte stress markers, such as urinary nephrin and podocin, have been studied in other renal diseases but their utility…

View details →DOI: 10.3390/diagnostics16060922
Negative / Null Result ReportMedicine

[Hortitherapy and well-being in day care centres].

Zivkovic Habibi L, Zaibat M, Frenkiel J et al. · 2025 · Soins. Gerontologie

Day care centers are medical and social facilities that provide day care for people over 60 with Alzheimer's or related diseases. The main aim of the study presented here was to assess the impact of horticultural therapy sessions on the…

View details →DOI: 10.1016/j.sger.2024.10.008
Negative / Null Result ReportMedicine

Anteriorization of the inferior oblique muscle versus anteriorization and resection for asymmetrical dissociated vertical deviation.

Osama G, Elhilali H, Salah M et al. · 2025 · Strabismus

Purpose To compare the efficacy of two methods: first, bilateral symmetric anteriorization of the inferior oblique muscle and second: combined resection and anteriorization of the inferior oblique (IO) muscle for asymmetric dissociated…

View details →DOI: 10.1080/09273972.2024.2402925
Negative / Null Result ReportMedicine

Combination of short pulse and smooth modality of Er: YAG laser versus short pulse alone in treatment of striae distensae: a split-lesion study.

Sadeghinia A, Emadi SN, Jamshidi S et al. · 2025 · Lasers in medical science

Background Despite extensive research, there is still no consensus on the optimal treatment for Striae distensae (SD). Aim To evaluate the efficacy of ablative (short pulse (SP) mode) versus combined ablative and non-ablative (short pulse…

View details →DOI: 10.1007/s10103-025-04488-7
Negative / Null Result ReportMedicine

Endovascular management of carotid blowout syndrome.

Nas OF, Kandemirli SG, Korkmaz B et al. · 2025 · Neurological research

Objectives To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome. Methods Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation.…

View details →DOI: 10.1080/01616412.2024.2448635
Negative / Null Result ReportMedicine

Continuous ropivacaine wound infiltration versus epidural morphine after unplanned caesarean delivery: A noninferiority randomised controlled study.

Bruillot M, Pieper A, Sourd D et al. · 2025 · European journal of anaesthesiology

Background Treatment programs designed to enhance recovery after caesarean delivery include multimodal analgesia to ensure optimal analgesia while reducing exposure to systemic opioids. Evidence for the effectiveness of continuous wound…

View details →DOI: 10.1097/eja.0000000000002135
Negative / Null Result ReportMedicine

Comparison of post-stroke white matter assessment using disconnectome-symptom mapping versus quantitative diffusion MRI.

Domin M, Liew SL, Hordacre B et al. · 2025 · NeuroImage

Indirect structural disconnection-symptom mapping allows white matter impairment to be determined without the need for multi-directional diffusion (MDDW) imaging for each individual. Although widely used this method has not been validated.…

View details →DOI: 10.1016/j.neuroimage.2025.121347
Negative / Null Result ReportOpen accessMedicine

Multimodal Analgesia for Cardiothoracic Procedures: Nonpharmacological and Alternative Pain Management Techniques: Part 2.

Bhatt HV, Patel D, Rogando D et al. · 2025 · Annals of cardiac anaesthesia

Although thoracic epidural analgesia and paravertebral blocks have well-documented benefits in cardiac surgery, the theoretical risk of neuraxial hematoma in anticoagulated patients limits their use. Fascial plane blocks are recently…

View details →DOI: 10.4103/aca.aca_216_24
Negative / Null Result ReportOpen accessMedicine

Congee Containing Carotenoids-Enriched Functional Ingredient from Tomato Improves Cognition, Serum α-Synuclein, Monoaminergic Function, and Gut-Brain Axis Functions in the Elderly Volunteers.

Wattanathorn J, Muchimapura S, Thukham-Mee W et al. · 2025 · Life (Basel, Switzerland)

Owing to the need for a brain supplement targeting neuroprotection against age-related brain disorders and the known effect of carotenoids on brain function, we aimed to assess the effect of consuming carotenoid-rich functional congee for…

View details →DOI: 10.3390/life15071093
Negative / Null Result ReportMedicine

Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.

Lao J, Wei Y, Liu F et al. · 2025 · European journal of nutrition

Purpose Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort. Methods Women participating…

View details →DOI: 10.1007/s00394-025-03650-9
Negative / Null Result Report

Dynamic risk and protective factors in mentally disordered offenders: forensic psychiatry treatment monitoring, prison release and length of stay

Weber K, Magnenat L, Morier S et al. · 2024 · Preprint

Abstract Background The reduction of violence risk and crime recidivism is the core marker of progress in forensic psychiatry treatment for mentally disordered offenders, and commonly used to decide prison release. While dynamic risk is…

View details →DOI: 10.21203/rs.3.rs-5296154/v1
Failed Experiment ReportMedicine

Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.

Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…

View details →DOI: 10.1093/cid/ciaf038
Negative / Null Result ReportOpen accessMedicine

A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice.

Sewell KM, Oriakhi K, Ngo Tenlep SY et al. · 2026 · Ecotoxicology and environmental safety

Organophosphate flame retardants (OPFRs) are used in many consumer products, and their presence in our environment raises concerns about potential health dangers. In humans, exposure to OPFRs, such as tris(1,3-dichloro-2-propyl) phosphate…

View details →DOI: 10.1016/j.ecoenv.2026.119827
Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

View details →DOI: 10.31138/mjr.300924.ioe
Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

View details →DOI: 10.1186/s41927-025-00505-y
Negative / Null Result ReportMedicine

Robotic carotid artery stenting: a multicenter, propensity score-matched analysis of clinical outcomes and cost-effectiveness.

Patel SA, Roy JM, Musmar B et al. · 2024 · Neurosurgical focus

Objective Preclinical studies suggest that robotic carotid artery stenting (CAS) could be superior to manual CAS. However, very limited comparative data exist for patients who have undergone robotic versus manual CAS. In addition, no data…

View details →DOI: 10.3171/2024.9.focus24479
Negative / Null Result ReportMedicine

The level of agreement between the numerical rating scale and visual analogue scale for assessing pain intensity in adults with chronic pain.

Goudman L, Pilitsis JG, Billet B et al. · 2024 · Anaesthesia

The numerical rating scale and visual analogue scale are used to quantify pain intensity. However, it has not yet been explored whether these scores are interchangeable in adults with chronic pain. Data from the prospective multicentre…

View details →DOI: 10.1111/anae.16151
Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

View details →DOI: 10.5489/cuaj.9121
Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

View details →DOI: 10.3390/brainsci15111218
Negative / Null Result ReportMedicine

Sensory Stimulation and Robot-Assisted Arm Training After Stroke: A Randomized Controlled Trial.

Egger M, Bergmann J, Krewer C et al. · 2024 · Journal of neurologic physical therapy : JNPT

Background and purpose Functional recovery after stroke is often limited, despite various treatment methods such as robot-assisted therapy. Repetitive sensory stimulation (RSS) might be a promising add-on therapy that is thought to…

View details →DOI: 10.1097/npt.0000000000000486
Negative / Null Result ReportOpen accessMedicine

Neuromuscular and Neurocognitive Performance Associated with ACL Injury Risk in Youth Handball Players: A Prospective Cohort Study.

Sinka GC, Pavlik A, Mayer Á et al. · 2026 · Sports (Basel, Switzerland)

Background Anterior cruciate ligament (ACL) injuries in youth athletes are multifactorial, and the relative contributions of neuromuscular and neurocognitive variables remain inadequately comprehended. Methods In this prospective cohort…

View details →DOI: 10.3390/sports14050185