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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 269 of 724

Negative / Null Result Report

Effect of Intravenous Lipid Emulsion Therapy on Xenobiotic Plasma Partitioning and Short-Term Neurological Outcome in Companion Animals with Suspected Neurotoxicosis: A Case Series

Voorhorst A, Pouzot-Nevoret C, Vernooij JC et al. · 2026 · Preprint

Intravenous lipid therapy (ILE) is used to treat neurotoxicosis in companion animals, but clinical evidence for in vivo xenobiotic partitioning and benefit remains limited. This study evaluated associations between the log n-octanol/water…

View details →DOI: 10.20944/preprints202602.1330.v1
Negative / Null Result ReportMedicine

The HBA-3 score: a simple bedside tool to predict cage subsidence after TLIF.

Najjar E, Khan S, Quraishi NA et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Background Cage subsidence is a common radiographic finding following transforaminal lumbar interbody fusion (TLIF), but its clinical relevance remains uncertain. Hounsfield Unit (HU) values from preoperative CT scans have emerged as…

View details →DOI: 10.1007/s00586-026-09906-0
Negative / Null Result ReportMedicine

Impact of patient-reported taxane-induced peripheral neuropathy on dose reductions or worsening quality of life in Black women with breast cancer: Analysis from ECOG-ACRIN EAZ171.

Ballinger TJ, Zhao F, Jiang G et al. · 2026 · Cancer

Background Black patients with breast cancer experience higher rates of taxane-induced peripheral neuropathy (TIPN), which may compromise chemotherapy dose delivery and health-related quality of life (HRQOL). Using the prospective…

View details →DOI: 10.1002/cncr.70466
Negative / Null Result ReportMedicine

Impact of adherence to six-month home-based HIIT on cardiorespiratory fitness in older adults.

Fosstveit SH, Feron J, Lohne-Seiler H et al. · 2026 · BMC sports science, medicine & rehabilitation

Background High-intensity interval training (HIIT) was originally designed to improve athletic performance, but a growing body of research over the past decade has highlighted its positive impact on various other health outcomes. However,…

View details →DOI: 10.1186/s13102-026-01750-5
Negative / Null Result ReportMedicine

The Association Between Social Determinants of Health, Race, and Sex on Risk for Readmission After Heart Transplantation.

Lemos C, Vargas F, Donald EM et al. · 2026 · Journal of cardiac failure

Background Women, racial and ethnic minority groups, and patients of low socioeconomic status (SES) face barriers linked to adverse outcomes after heart transplantation (HT). Data are lacking regarding the association of these demographics…

View details →DOI: 10.1016/j.cardfail.2026.04.016
Negative / Null Result ReportMedicine

Longitudinal Associations Among Avoidant/Restrictive Food Intake Disorder Symptoms, Body Dissatisfaction, Restriction, and Suicide Ideation Among Adolescents.

Sahlan RN, Frietchen R, Billman Miller MG et al. · 2025 · Suicide & life-threatening behavior

Objective Although previous research has established bidirectional links between many eating disorder (ED) symptoms and suicidal ideation (SI), no research has examined how symptoms of avoidant/restrictive food intake disorder (ARFID)…

View details →DOI: 10.1111/sltb.70033
Negative / Null Result ReportMedicine

Feasibility of the pre-operative measurement of fractional exhaled nitric oxide and respiratory mechanics to predict respiratory outcomes in children undergoing general anaesthesia.

Hauser N, Sommerfield D, Nguyen J et al. · 2026 · Anaesthesia

Introduction Peri-operative respiratory adverse events remain a major cause of morbidity and mortality in children undergoing general anaesthesia; those with asthma are at higher risk. The aim of this feasibility study was to determine…

View details →DOI: 10.1111/anae.70056
Negative / Null Result Report

Moderating Effects of Intention to Screen on the Relationship Between Attitude Towards Screening and Cancer and High Blood Pressure Screening Uptake Among Nigerians

Fasanu O, Oloruntola FP · 2026 · Preprint

Abstract Background Why is there low behavioural response towards cancer and high blood pressure (HBP) screening uptake among Nigerians? The present study addressed this question by using the theory of planned behaviour (TPB) to…

View details →DOI: 10.21203/rs.3.rs-8836769/v1
Negative / Null Result ReportMedicine

Trajectories and predictors of psycho-social adjustment in patients post hepatocellular carcinoma surgery: A longitudinal study.

Li M, He H, Dong L et al. · 2026 · Journal of psychosomatic research

Background Patients post hepatocellular carcinoma (HCC) surgery encounter physiological challenges as well as psychological and social adaptation problems,yet the trajectory and predictors of their psychosocial adjustment (PSA) remain…

View details →DOI: 10.1016/j.jpsychores.2026.112691
Negative / Null Result ReportMedicine

Death Conceptualizations: How do Youth Presenting to a Pediatric Psychiatric Emergency Department View the End of their Lives?

Tezanos KM, Simeone A, Gerson R et al. · 2026 · Child psychiatry and human development

Youth are presenting to Emergency Departments (EDs) following a suicide-related crisis at higher rates and younger ages. Clinicians lack tools to effectively discern suicide risk in younger patients. The present investigation examines how…

View details →DOI: 10.1007/s10578-026-02006-6
Negative / Null Result ReportMedicine

Prenatal echocardiographic diagnosis and outcomes of fetal sustained supraventricular tachycardia: a ten-year single-center experience.

Ciriello GD, Colonna D, Morelli C et al. · 2026 · Indian pacing and electrophysiology journal

Fetal echocardiography plays a pivotal role in the diagnosis and management of fetal arrhythmias, allowing evaluation of the electrophysiological mechanism and guiding appropriate medical therapy. Herein, we describe our ten-year…

View details →DOI: 10.1016/j.ipej.2026.03.015
Negative / Null Result ReportMedicine

The interdependence of health and grandparenting intensity: A dyadic perspective from grandparent couples in the Health and Retirement Study.

Chan ACY, Stephan AT, Sneed RS · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives While the intensity of grandparent caregiving has been linked to older adults' health, limited research has examined the bidirectional associations between grandparenting intensity and health, particularly within grandparent…

View details →DOI: 10.1093/geronb/gbag022
Negative / Null Result ReportMedicine

Prediction of Anthracycline Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early-Stage Breast Cancer by the MammaPrint 70-Gene Signature for Patients Enrolled in the FLEX Study.

O'Shaughnessy J, Brufsky AM, Layeequr Rahman R et al. · 2026 · JCO precision oncology

Purpose Randomized trials have not demonstrated clear benefit from anthracyclines for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC). The MammaPrint 70-gene…

View details →DOI: 10.1200/po-25-01285
Negative / Null Result ReportMedicine

Longitudinal associations of cardiorespiratory fitness and physical activity with changes in cognitive function in breast cancer patients undergoing chemotherapy: a prospective matched-control study.

Xiao H, Warner E, Ryan J et al. · 2026 · Cancer causes & control : CCC

Purpose Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline…

View details →DOI: 10.1007/s10552-026-02165-w
Negative / Null Result ReportMedicine

Impact of Left Atrial Dilatation on Catheter Ablation Outcomes for Persistent Atrial Fibrillation: Does Size Matter?

William JB, Chieng D, Crowley R et al. · 2026 · JACC. Clinical electrophysiology

Background Left atrial (LA) enlargement is commonly used in patient selection for catheter ablation. However, its role in predicting postablation outcomes in persistent atrial fibrillation (AF) remains uncertain. Objectives The study goal…

View details →DOI: 10.1016/j.jacep.2026.04.019
Negative / Null Result ReportMedicine

Trauma-focused or non-trauma-focused? Treatment preferences and expectancies among veterans with co-occurring posttraumatic stress disorder and substance use disorder.

Alpert E, Kaplan A, Nelson D et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective Among patients with co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUDs), little is known about early PTSD treatment processes, including treatment preference and outcome expectancy. This study…

View details →DOI: 10.1037/tra0002161
Negative / Null Result ReportMedicine

Kidney Transplantation for Lithium Nephrotoxicity is Associated With Noninferior Graft and Patient Survival: A National Donor-Stratified Registry Analysis.

Cohen H, Toro D, Zuluaga D et al. · 2026 · Clinical transplantation

Introduction To evaluate donor-stratified graft and patient survival following kidney transplantation (KT) for lithium-associated end-stage kidney disease (ESKD). Methods This retrospective analysis utilized the Organ Procurement and…

View details →DOI: 10.1111/ctr.70563
Negative / Null Result ReportMedicine

Somatic Mutations and Mutation Burden Predict Treatment Response and Survival in Adult Acquired Pure Red Cell Aplasia.

Yang L, Zhang H, Wei Y et al. · 2026 · American journal of hematology

Immunosuppressive therapy (IST) is the standard treatment for acquired pure red cell aplasia (aPRCA), but predictors of treatment response and long-term prognosis remain unclear. The clinical significance of somatic mutations in aPRCA is…

View details →DOI: 10.1002/ajh.70311
Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Augmented Reality-Based Clinical Task Performance Among Novice Users: Cross-Sectional Quantitative Study.

Vellore AJ, Bhatia S, Kann MR et al. · 2026 · JMIR XR and spatial computing

Background Augmented reality (AR) can provide risk-free training for medical trainees, yet little is known about which learner characteristics facilitate adoption or inform training design. Objective We aimed to identify which learner…

View details →DOI: 10.2196/81236
Negative / Null Result ReportMedicine

Physical Frailty, Self-Care Behaviors, and 6-Month Clinical Outcomes Among Adults With Heart Failure.

Denfeld QE, Hiatt SO, Dieckmann NF et al. · 2026 · The Journal of cardiovascular nursing

Many adults with heart failure (HF) are physically frail, and HF self-care behaviors, especially symptom monitoring and management (SMM), may affect physical frailty; however, the association between SMM behaviors and physical frailty has…

View details →DOI: 10.1097/jcn.0000000000001342
Negative / Null Result ReportMedicine

Introduction of a modified surgical approach for ProACT balloon placement: a retrospective cohort study.

Axelsen JK, Boesen L, Bisbjerg R et al. · 2026 · Scandinavian journal of urology

Objective To compare adjustable continence balloons (ProACT) implanted above the pelvic floor with or without subsequent placement of a third balloon (AP) with a modified technique placing balloons below the pelvic floor (BP). Materials…

View details →DOI: 10.2340/sju.v61.45579
Negative / Null Result ReportMedicine

Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.

Koch M, Mostert J, Strijbis EM et al. · 2026 · Journal of neurology, neurosurgery, and psychiatry

Background Phase 2 clinical trials in primary progressive multiple sclerosis (PPMS) often use MRI brain volume measures as their primary endpoint. Here, we investigate the longitudinal association between change in MRI outcomes and change…

View details →DOI: 10.1136/jnnp-2025-337940
Negative / Null Result ReportMedicine

High-frequency Ultrasound Evaluation of Midline Crossing-over Vessel: Correlation with Perfusion of Deep Inferior Epigastric Perforator Flap.

Lee SJ, Han HH, Eom JS et al. · 2026 · Plastic and reconstructive surgery

Background The deep inferior epigastric perforator (DIEP) flap is widely used in autologous breast reconstruction, with its success heavily reliant on the vascular anatomy, particularly midline crossing-over vessels that facilitate…

View details →DOI: 10.1097/prs.0000000000012864
Negative / Null Result ReportMedicine

Investigating the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Executive Errors Scale in Adults With Schizophrenia Spectrum Disorders.

Raudeberg R, Iverson GL · 2026 · Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Objective The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief neuropsychological screening battery that measures aspects of attention, immediate and delayed memory, and verbal and…

View details →DOI: 10.1093/arclin/acaf104