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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 269 of 710

Negative / Null Result ReportMedicine

Comparison of prehospital tidal volume delivery performance between automated transport ventilators and bag-valve devices in out-of-hospital cardiac arrest patients: does the pressure limit matter?

Chen CH, Yu PH, Fan CY et al. · 2026 · Frontiers in medicine

Background Automatic transport ventilators (ATVs) are a potential option for ventilating patients experiencing out-of-hospital cardiac arrest (OHCA); however, their tidal volume delivery performance at different pressure limits compared…

View details →DOI: 10.3389/fmed.2026.1826906
Negative / Null Result ReportMedicine

Analyzing the association between age-related macular degeneration, retinal vascular occlusions, and dementia.

Alshaikhsalama A, Thompson K, Hashim H et al. · 2026 · European journal of ophthalmology

PurposeTo investigate the association between age-related macular degeneration (AMD), retinal artery occlusion (RAO), and retinal vein occlusion (RVO) and the future development of Alzheimer's disease (AD), vascular dementia (VaD), and…

View details →DOI: 10.1177/11206721261438587
Negative / Null Result ReportMedicine

Effects of a home-based exercise and physical activity intervention after inpatient rehabilitation on real-world mobility in older adults with cognitive impairment: a secondary analysis of a randomised controlled trial.

Werner C, Ullrich P, Degli Angeli L et al. · 2026 · Age and ageing

Persistent mobility limitations after inpatient rehabilitation are common in older adults with cognitive impairment (CI). Home-based exercise interventions can improve locomotor capacity during this vulnerable period; however, evidence…

View details →DOI: 10.1093/ageing/afag189
Negative / Null Result ReportMedicine

Transient pH film model for in vitro powder dissolution of weakly basic drugs into buffer and comparison to conventional film model.

Patel RP, Polli JE · 2026 · Journal of pharmaceutical sciences

The dissolution of ionizable drugs is critically influenced by the pH of the microenvironment at the solid-liquid interface, which in part can be impacted by the dissolving drug itself. For weak bases, dissolution may increase surface pH,…

View details →DOI: 10.1016/j.xphs.2026.104265
Negative / Null Result Report

Intensive Versus Standard Statin Therapy in Acute Ischemic Stroke: A Comparative Study on the Risk of Pneumonia and Multidrug-Resistant Bacterial Infections

Wen Z, Yang Z, Cheng J et al. · 2026 · Preprint

Abstract Background The use of intensive statin therapy in acute ischemic stroke (AIS) is common; however, its association with post-stroke pneumonia (PSP) remains uncertain. This study aimed to determine whether intensive-dose…

View details →DOI: 10.21203/rs.3.rs-8842936/v1
Negative / Null Result ReportMedicine

Work-related Well-Being, Turnover Intention, and Completed Turnover in a Cohort of U.S. Patient Care Workers.

Boden LI, Peters SE, McTernan M et al. · 2026 · Journal of occupational and environmental medicine

Objective To determine whether burnout and thriving from work affect turnover intention and actual turnover. Methods This study used multivariable logistic regression to estimate the impact of burnout and thriving from work on turnover…

View details →DOI: 10.1097/jom.0000000000003713
Failed Experiment ReportMedicine

Pre-post implementation study of a medication-focused order set for management of acute agitation in a pediatric emergency department.

Mills KP, Kemper M, Hoganson GM et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose To assess changes in prescribing practice after implementation of a medication-focused order set for acute agitation management in a pediatric emergency department (ED). Methods Patients 5 to 18 years of age who presented to the…

View details →DOI: 10.1093/ajhp/zxaf117
Failed Experiment ReportMedicine

Real World Treatment Patterns Among Patients with Painful Diabetic Peripheral Neuropathy in the United States.

Schuster NM, Jeyakumar S, Menzie AM et al. · 2026 · Pain medicine (Malden, Mass.)

Objective This study analyzes real-world treatment patterns among patients newly initiating treatment for painful diabetic peripheral neuropathy using a contemporary dataset in the United States. Methods A retrospective study using the…

View details →DOI: 10.1093/pm/pnag055
Failed Experiment ReportMedicine

Field evaluation in the Eastern United States of a biological control Blossom Protect for fire blight suppression efficacy, potential to cause fruit russeting, and compatibility with fungicides.

Zeng Q, Cox K, Jung J et al. · 2026 · Plant disease

Fire blight is a destructive disease of apple and pear, and its severity is intensified under humid conditions. Biological controls are important components of the integrated management of plant diseases; however, field trials in the…

View details →DOI: 10.1094/pdis-02-26-0264-re
Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

View details →DOI: 10.1016/j.ctarc.2026.101262
Negative / Null Result ReportMedicine

Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.

Marian M, Rosu M, Tarta C et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Post-thyroidectomy hypoparathyroidism (hypoPTH) is the most common complication of total thyroidectomy. Transient hypoPTH was defined as postoperative day 1 (POD1) intact parathyroid hormone (PTH) Materials and…

View details →DOI: 10.3390/medicina62061137
Negative / Null Result ReportMedicine

DNAemia Thresholds to Discontinue Antivirals in Preemptive Management for Cytomegalovirus Seropositive Recipients After Kidney Transplantation.

Miehrig AH, Foresto RD, Tedesco-Silva H et al. · 2026 · Transplantation

Background Treatment of cytomegalovirus (CMV) after kidney transplantation aims to achieve cessation of viral replication; however, the use of highly sensitive DNA assays creates uncertainty regarding the optimal DNAemia threshold for…

View details →DOI: 10.1097/tp.0000000000005695
Negative / Null Result ReportMedicine

Patient factors outweigh procedure extent in infection risk after cervical disc arthroplasty.

Mastrokostas PG, Said M, Mastrokostas LE et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To determine the 90-day incidence of surgical site infection (SSI) after cervical disc arthroplasty (CDA), compare single versus multilevel procedures, and identify independent predictors of SSI. Methods We identified adult…

View details →DOI: 10.1007/s00586-026-10012-4
Negative / Null Result ReportMedicine

Adrenocorticotropin hormone regulates sphingosine-1-phosphate synthesis via cortisol in bovine adrenocortical cells.

Medina-Moctezuma ZB, Guzmán-Sánchez A, González-Aretia D et al. · 2026 · Biochemical and biophysical research communications

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) stimulate the synthesis of sphingosine-1 phosphate (S1P) in Gs-coupled receptors dependent manner, enabling S1P to mediate specific bioactivities of FSH and LH. Because…

View details →DOI: 10.1016/j.bbrc.2026.153994
Negative / Null Result ReportMedicine

Clinical and laboratory characteristics of critically ill COVID-19 patients with chronic lung disease.

Yavuz T, Sarac O, Alpdogan O et al. · 2026 · Journal of infection in developing countries

Introduction Chronic lung diseases (CLD) are associated with increased susceptibility to respiratory infections and may influence COVID-19 outcomes. This research aims to assess the clinical, laboratory findings, and prognostic outcomes in…

View details →DOI: 10.3855/jidc.21431
Negative / Null Result Report

0.1% ropivacaine combined with a lower sufentanil concentration for epidural analgesia does not increase breakthrough pain in the latent phase of labor: a double-blind, randomized, controlled, non-inferiority trial

Zhang X, Shen T, Ye S et al. · 2026 · Preprint

Objective: : To investigate the effect of 0.1% ropivacaine with a lower concentration sufentanil for epidural analgesia during the latent phase of labor. Design: : Double-blind, randomized, controlled, non-inferiority trial. Setting: : A…

View details →DOI: 10.22541/au.177305981.18200091/v1
Negative / Null Result ReportMedicine

Do congenital heart diseases or chromosomal anomalies influence the surgical outcomes of esophagocoloplasty in esophageal atresia patients?

Tannuri ACA, Abe Takahasi BN, de Almeida Estrambk G et al. · 2026 · Journal of pediatric surgery

Background Esophageal atresia (EA) is frequently associated with congenital heart disease (CHD) and chromosomal anomalies, mainly Down syndrome (DS). While these conditions affect outcomes following primary repair, their specific impact on…

View details →DOI: 10.1016/j.jpedsurg.2026.163202
Negative / Null Result ReportMedicine

Application of quinoa oil emulsions in fresh goat cheese: effects on lipid profile, technological properties and microstructure.

Muñoz-Tebar N, Lucas-González R, Muñoz-Bas C et al. · 2026 · Food chemistry

This study investigates the use of quinoa oil emulsion as a novel plant-based ingredient to improve the nutritional quality of fresh goat cheese. Quinoa oil emulsions (3 and 6 g/L) were characterized and incorporated in fresh cheese. The…

View details →DOI: 10.1016/j.foodchem.2026.149384
Negative / Null Result ReportMedicine

GnRH Administration Increases Synchronisation of Ovulation in Mares.

Cui B, Liu Y, Wu X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The objective of this study was to evaluate the effects of exogenous GnRH administration at the beginning of estrus synchronisation in mares during the spring transitional period. Estrus was synchronised using a progesterone releasing…

View details →DOI: 10.1111/rda.70165
Negative / Null Result ReportMedicine

Physiologic, Psychological, Nutritional, and Rest-Activity Observations During 120 Days of Low-Tech Off-Grid Living in the Baja California Desert: A 2-Participant Field Case Study.

Mauvieux B, Montardy Q, Remilly M et al. · 2026 · Wilderness & environmental medicine

Off-grid low-tech living is increasingly proposed for arid environments, yet longitudinal field data documenting health, nutrition, and rest-activity organization under real-world conditions remain scarce. Our objective was to describe…

View details →DOI: 10.1177/10806032261436382
Negative / Null Result ReportMedicine

A description of self-selected treatments and self-reported improvement following treatment among post-9/11 veterans experiencing disruptive dizziness following a comprehensive traumatic brain injury evaluation.

Cheever K, Kalvesmaki A, Swan AA et al. · 2026 · Brain injury

Background This study aimed to explore what treatments were sought by post-9/11 Veterans with and without a formal diagnosis related to their long-term dizziness following completion of a Comprehensive Traumatic Brain Injury Evaluation…

View details →DOI: 10.1080/02699052.2026.2673984