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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 261 of 710

Negative / Null Result ReportMedicine

MD-DGNN: A Metadata-Driven Dual Graph Neural Network based on Brain Functional Connectivity for ASD Classification.

Li, Zhang, Leng et al. · 2026 · IEEE journal of biomedical and health informatics

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires early and efficient diagnosis. Functional magnetic resonance imaging (fMRI), with high temporal and spatial resolution, is a powerful tool for…

View details →DOI: 10.1109/jbhi.2026.3702096
Negative / Null Result ReportMedicine

The Indian Smell Identification Test for Parkinson's Disease: Limitations of Binary Scoring and Proposal of a Modified Graded Approach.

Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology

Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…

View details →DOI: 10.4103/aian.aian_1319_25
Negative / Null Result ReportMedicine

Clinical and radiological outcomes of a cartilage-preserving pinhole transtibial technique versus standard pull-out repair for traumatic posterior meniscal root tears.

Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…

View details →DOI: 10.14744/tjtes.2026.68654
Negative / Null Result ReportMedicine

Role of Angiotensin II as a Vasoactive Agent to Treat Distributive Shock With a Focus on Preliminary Data in Pediatric-Aged Patients.

Ito, Spellman, Khan et al. · 2026 · Paediatric anaesthesia

In pediatric-aged patients, distributive (vasoplegic) shock is commonly caused by sepsis, anaphylaxis, or the humoral/immunologic response following cardiopulmonary bypass. In general, the first-line vasoactive agent for children is…

View details →DOI: 10.1002/pan.70237
Failed Experiment ReportMedicine

Endovascular management of a ruptured pancreaticoduodenal artery pseudoaneurysm using a stent-graft: a case report and literature review.

Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports

Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…

View details →DOI: 10.1097/rc9.0000000000000525
Negative / Null Result ReportMedicine

Constructing a biomimetic ECM protective barrier: a strategic interface design for urethral repair to mitigate foreign body reaction.

Niu, Liu, Sun et al. · 2026 · Journal of nanobiotechnology

Urethral reconstruction often fails due to the foreign body reaction (FBR) triggered by the graft, leading to chronic inflammation, fibrosis, and lumen obstruction. To address this challenge, we developed an innovative strategy: a…

View details →DOI: 10.1186/s12951-026-04649-y
Negative / Null Result ReportMedicine

Peripherally located type I vestibular hair cells are required for several motor behaviors and stimulus-evoked brainstem neural responses in adult mice.

Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…

View details →DOI: 10.1523/jneurosci.0005-26.2026
Negative / Null Result ReportMedicine

Cellular respiration toxicity: A novel comprehensive water quality index based on universal biological processes.

Chen, Yang, Liu et al. · 2026 · Journal of hazardous materials

Assessing water quality comprehensively is crucial for predicting environmental risks. However, existing toxicity assessments are limited to specific physiological processes or reference organisms, failing to capture holistic hazards. Here…

View details →DOI: 10.1016/j.jhazmat.2026.142596
Negative / Null Result ReportMedicine

Finite-size effects and energy alignment in molecular XANES under periodic boundary conditions: A systematic comparison of core-hole treatments.

Fujikata, Muramatsu, Mizoguchi · 2026 · The Journal of chemical physics

X-ray absorption near-edge structure (XANES) provides element-specific insights into local electronic and structural environments, but quantitative interpretation of molecular XANES under periodic boundary conditions (PBC) remains…

View details →DOI: 10.1063/5.0329032
Negative / Null Result ReportMedicine

Decreased posterior tibial slope is not a risk factor for posterior cruciate ligament reconstruction failure: A multicentric analysis of 173 cases.

Pizza, Perelli, Grassi et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To investigate whether posterior tibial slope (PTS) is associated with failure after posterior cruciate ligament reconstruction (PCLR) in a cohort of patients undergoing isolated PCLR and PCL-based multiligament knee injuries (MLKI)…

View details →DOI: 10.1002/ksa.70472
Negative / Null Result ReportMedicine

Diaphragmatic ultrasound to guide ventilator weaning and early tracheostomy in high cervical spinal cord injury: A case report.

Vivanco-Aravena, Leiva, Hidalgo · 2026 · The journal of spinal cord medicine

Ventilator dependence is a major cause of morbidity and mortality in patients with high cervical spinal cord injury (CSCI), largely due to diaphragmatic dysfunction. Conventional assessment of inspiratory muscle strength, such as maximal…

View details →DOI: 10.1080/10790268.2026.2667039
Negative / Null Result ReportMedicine

A prediction nomogram for faltering catch-up growth in full-term small-for-gestational-age infants: a retrospective cohort study.

Hu, Yang, Li et al. · 2026 · Frontiers in pediatrics

Catch-up growth (CUG) before two years of age in small-for-gestational-age (SGA) infants is a key predictor of adult short stature. We aimed to establish and temporally validate a prediction nomogram for faltering CUG (FCUG) in full-term…

View details →DOI: 10.3389/fped.2026.1792285
Negative / Null Result ReportMedicine

Bedside transcranial Doppler as a diagnostic bridge for suspected intracranial hypertension after traumatic brain injury surgery: A case report.

Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international

Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…

View details →DOI: 10.25259/sni_1424_2025
Failed Experiment ReportMedicine

Investigating the efficacy of propranolol in treating chronic stress combined with colorectal cancer in mice and its antitumor potential.

Zhou, Xia, Zhao et al. · 2026 · European journal of pharmacology

This study aimed to investigate the anti-tumor effects and mechanisms of propranolol (Prop) in mice with colorectal cancer (CRC) combined with chronic stress, as well as its potential impact when used in combination with high-mobility…

View details →DOI: 10.1016/j.ejphar.2026.179065
Negative / Null Result ReportMedicine

The prognostic value of the early neutrophil-to-lymphocyte ratio for 28-day mortality in sepsis patients: A machine learning-based investigation of the MIMIC database.

Liao, Xiang, Chen et al. · 2026 · PloS one

The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…

View details →DOI: 10.1371/journal.pone.0348676
Failed Experiment ReportMedicine

Failed air enema reduction leading to the diagnosis of small-bowel intussusception secondary to Meckel's diverticulum with ectopic gastric mucosa in a 5-month-old infant: A case report.

Wang, Yu · 2026 · SAGE open medical case reports

A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…

View details →DOI: 10.1177/2050313x261454853
Negative / Null Result ReportMedicine

Impaction Injury of the Femoral Head After Traumatic Posterior Hip Dislocation: A Literature Review and Case Study.

Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics

Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…

View details →DOI: 10.1007/s43465-025-01572-6
Negative / Null Result ReportMedicine

Complement C5 inhibitors as add-on rescue treatment in severe AQP4-antibody neuromyelitis optica spectrum disorder attacks: a case series and literature review.

Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders

Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…

View details →DOI: 10.1177/17562864261449515
Negative / Null Result ReportMedicine

Posterior circulation stroke secondary to atlantoaxial instability-induced vertebral artery dissection and pseudoaneurysm in a paediatric patient.

Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports

A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…

View details →DOI: 10.1136/bcr-2026-272989