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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21283 results · page 260 of 710

Negative / Null Result Report

Developmental Relationship Between Home Literacy Environment and Emergent Literacy in a Transparent Orthography: A Two-Year Longitudinal Study in Japanese Preschoolers

Tanji T, Takahashi K, Matsushita H et al. · 2025 · Preprint

Abstract We examined the relationship between home literacy environment and early literacy acquisition in Japanese syllabic Hiragana and whether this relationship changes during the preschool years. One hundred five Japanese-speaking young…

View details →DOI: 10.21203/rs.3.rs-7583467/v1
Negative / Null Result ReportMedicine

Value of carbohydrate antigen 125 in pleural effusion from acute heart failure and its relationship with atrial fibrillation.

Pérez Pisón E, Llàcer P, Croset F et al. · 2026 · Medicina clinica

Introduction Pleural effusion (PE) is a frequent complication in acute heart failure (AHF), driven by hydrostatic pressure, impaired lymphatic drainage, and systemic inflammation. This study aimed to evaluate the association between…

View details →DOI: 10.1016/j.medcli.2025.107316
Negative / Null Result ReportMedicine

Association of QTc Dispersion with Mortality, Intensive Care Unit Admission, Intubation, and Hospital Stay Duration in Acute Methadone Poisoning.

Taherkhani A, Yeganegi H, Tavasol A et al. · 2026 · Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

Objective The objective of this study is to investigate the prognostic significance of QTc dispersion (QTcd) in patients with acute methadone poisoning and its association with critical clinical outcomes, including mortality, Intensive…

View details →DOI: 10.5543/tkda.2025.69048
Negative / Null Result ReportMedicine

Serum zinc-α2-glycoprotein and renal dysfunction in the general population: evidence from a 13-year cohort study.

Enomoto M, Fukami A, Adachi H et al. · 2026 · Clinical and experimental nephrology

Background Zinc-α2-glycoprotein (ZAG) is an adipokine, which may act locally to regulate adipocyte metabolism. Downregulation of ZAG expression in obesity has been reported in obesity in both mice and humans. In contrast, other studies…

View details →DOI: 10.1007/s10157-025-02813-6
Negative / Null Result ReportMedicine

Systematic reexamination of early verb dominance: Verbal and nonverbal characteristics of caregiver input and their contribution to long-term language outcomes.

Kim M, Mun J, Kim G et al. · 2026 · Developmental psychology

Early language input to infants varies in lexical composition across languages and contexts. For instance, American-English input emphasizes nouns more than verbs, while Mandarin Chinese and Korean inputs provide more verbs than nouns, the…

View details →DOI: 10.1037/dev0002089
Negative / Null Result ReportMedicine

Testing Sentence-in-Noise Recognition With Synthetic Speech and Automatic Speech Recognition.

Calandruccio L, Weidman D, Leatherwood A et al. · 2025 · Journal of speech, language, and hearing research : JSLHR

Purpose Characterizing speech-in-noise recognition is fundamental to both clinical audiology and hearing research. Current methods rely on human speech recordings and human testers. However, modern artificial intelligence tools could…

View details →DOI: 10.1044/2025_jslhr-24-00893
Negative / Null Result ReportMedicine

Young athletes' social goals during the children-to-youth sport transition: A latent profile and latent transition analysis.

Jørgensen TM, Abrahamsen FE, Gjesdal S · 2026 · Journal of sports sciences

While the social aspect of sports is considered crucial for participation, the influence of social goals in motivating young athletes remains relatively unexplored. This study examined social goal profiles and their stability during…

View details →DOI: 10.1080/02640414.2025.2575416
Negative / Null Result ReportMedicine

Social attunement and alcohol use: The role of age and gender.

Romein C, Colyer-Patel K, Kroon E et al. · 2026 · Addictive behaviors

Background Alcohol use typically peaks during adolescence and early adulthood, when its social reinforcement value is high, and then decreases as individuals take on more adult-like responsibilities. The present study investigates whether…

View details →DOI: 10.1016/j.addbeh.2025.108587
Negative / Null Result ReportMedicine

Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes.

Gregoire N, Klukas E, Kaseweter K et al. · 2025 · Psychopharmacology

Rationale Ketamine-assisted therapy is emerging as a fast-acting intervention for treatment-resistant depression and anxiety. However, individual response to treatment varies, and little is known about how personality traits and trauma…

View details →DOI: 10.1007/s00213-025-06948-y
Negative / Null Result ReportMedicine

Can higher guy's scores predict increased complications? exploring the link with clavien-dindo classification.

Gul L, Ullah S, Yousuf SB et al. · 2025 · JPMA. The Journal of the Pakistan Medical Association

Objectives To determine the role of guy's stone score in predicting the complications rate for percutaneous nephrolithotomy. Methods The descriptive study was conducted at the Sindh Institute of Urology and Transplantation, Karachi, from…

View details →DOI: 10.47391/jpma.20571
Negative / Null Result ReportMedicine

Intravenous Bolus Fluid Therapy Versus No Fluid Therapy Prior to Pericardiocentesis in Dogs: A Randomized Controlled Trial in 30 Dogs.

Jones N, Humm K, Tinson EW · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To determine the cardiovascular and respiratory effects of bolus IV isotonic crystalloid fluid therapy before pericardiocentesis in dogs with pericardial effusion. Design Prospective, randomized, nonblinded clinical trial…

View details →DOI: 10.1111/vec.70073
Negative / Null Result ReportMedicine

Hemolysis and Acute Kidney Injury Following Cardiac Surgery With Cardiopulmonary Bypass in Patients With Preexisting Renal Dysfunction.

Volleman C, Phelp PG, Dubelaar DPC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Acute kidney injury (AKI) is a common complication following cardiac surgery with cardiopulmonary bypass (CPB). This study investigated whether cell-free hemoglobin (CFHb) levels after CPB are associated with endothelial damage…

View details →DOI: 10.1053/j.jvca.2026.02.039
Negative / Null Result ReportMedicine

How Do Sex and Family SES Influence the Relation Between School Well-Being and Academic Domains? A Multi-Group Cross-Lagged Panel Analysis from Fifth To Eighth Grade.

Rémeau M, Raffy G, Borst G · 2026 · Journal of youth and adolescence

Although the association between academic achievement and well-being has been widely studied in cross-sectional and correlational studies, prior research has rarely clarified the directionality of these links by adopting a longitudinal…

View details →DOI: 10.1007/s10964-025-02281-x
Negative / Null Result ReportMedicine

Relative influence of paraspinal muscularity and underlying bone quality on proximal junctional kyphosis and failure mode in patients undergoing thoracolumbar instrumented fusion.

Pennington Z, Mikula AL, Hamouda A et al. · 2026 · Clinical neurology and neurosurgery

Objective To assess paraspinal muscularity and bone quality contribution to PJK risk. Methods Defining PJK as ≥ 10° increase in proximal junctional angle from first upright radiograph, thoracolumbopelvic fusion patients experiencing PJK…

View details →DOI: 10.1016/j.clineuro.2025.109286
Negative / Null Result ReportMedicine

MASLD in the oldest-old: lack of association with cognition or functional autonomy and poor predictive utility of the hepatic steatosis index.

Brol MJ, Groth M, Uschner FE et al. · 2025 · GeroScience

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition increasingly recognized in aging populations. However, its clinical relevance in older adults-particularly in relation to sarcopenia, cognitive…

View details →DOI: 10.1007/s11357-025-02060-3
Negative / Null Result ReportMedicine

Baseline electrophysiological markers of reward and error processing are associated with improved outcomes in prize-based contingency management.

Forster SE, Forman SD, Dickey MW et al. · 2026 · Drug and alcohol dependence

Background Veterans are disproportionately affected by cocaine use disorder (CUD), a condition without approved pharmacotherapies, marked by high return to use rates. Prize-Based Contingency Management (PBCM) is an effective behavioral…

View details →DOI: 10.1016/j.drugalcdep.2025.113003
Negative / Null Result ReportMedicine

Longitudinal Associations between Mattering Dimensions and Loneliness in Adolescents: Bidirectional Effects at between- and Within-Person Levels.

Li HM, Flett GL, Cao CH et al. · 2026 · Journal of youth and adolescence

Although cross-sectional research links mattering to reduced adolescent loneliness, longitudinal studies examining temporal dynamics and distinctions between analytical levels or mattering dimensions are scarce. Without understanding…

View details →DOI: 10.1007/s10964-025-02286-6
Negative / Null Result Report

Waiting Time from Referral to Intake and Its Clinical Implications: Routine Outcome Monitoring Data from a Large Dutch Outpatient Clinic

Menéndez SM, Stehouwer K, Abikenari MA et al. · 2025 · Preprint

Background: Long waiting times remain a key barrier to accessing outpatient mental health care in the Netherlands and worldwide. Little is known about patterns of symptom change during waiting times and whether certain individuals are at…

View details →DOI: 10.31234/osf.io/ej4z7_v1
Negative / Null Result Report

Waiting Time from Referral to Intake and Its Clinical Implications: Routine Outcome Monitoring Data from a Large Dutch Outpatient Clinic

Menéndez SM, Stehouwer K, Abikenari MA et al. · 2025 · Preprint

Background: Long waiting times remain a key barrier to accessing outpatient mental health care in the Netherlands and worldwide. Little is known about patterns of symptom change during waiting times and whether certain individuals are at…

View details →DOI: 10.31234/osf.io/ej4z7_v2
Negative / Null Result ReportMedicine

Harnessing Fear and Promoting Self-Efficacy in Response to Mass Casualty Scenarios: Evaluating Stop the Bleed at an Urban University.

Tong ST, Phillips K, Gomez J et al. · 2026 · Journal of prevention (2022)

Emergency situations range from everyday traffic accidents to incidents of mass gun violence and require individuals to be prepared and willing to act in times of crisis. To encourage people to help one another during such emergencies, the…

View details →DOI: 10.1007/s10935-025-00878-3
Negative / Null Result ReportMedicine

Different effects of guilt and shame on grief among naturally bereaved Chinese adults: A three-wave cross-lagged panel analysis.

Yu X, Huang J, Jiang W et al. · 2026 · Journal of psychiatric research

Background Bereavement, i.e., the death of significant others, generally arouses grief reactions and may be accompanied by feelings of guilt and shame. However, it remains unclear whether guilt and shame can influence grief adaptation…

View details →DOI: 10.1016/j.jpsychires.2025.12.005
Negative / Null Result ReportMedicine

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Wakisaka Y, Inai K, Harada G et al. · 2025 · Cardiology in the young

Background Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been…

View details →DOI: 10.1017/s1047951125110159