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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 260 of 724

Negative / Null Result ReportMedicine

Assessing the Impact of Visualizations of Quantitative and Qualitative Risk Information on the Comprehension of Hypothetical Risk-Based Breast Cancer Screening Results.

van Strien-Knippenberg IS, Timmermans DRM, Weber M et al. · 2025 · Health communication

This study aimed to assess whether, in the context of communicating risk-based breast cancer screening results, visualizations of risk information consisting of an icon array depicting quantified breast cancer risk and simplified drawings…

View details →DOI: 10.1080/10410236.2025.2582779
Negative / Null Result Report

Vibratory stimulation and not action observation or mirror therapy reduces paralyzed hand spasticity in chronic stroke survivors

Nakano H, Nakagawa K, Ikuno T et al. · 2024 · Preprint

Objective Post-stroke spasticity prevalence increases with time from stroke onset, and negatively impacts the patient’s quality of life. Vibratory stimulation (VS) to the spastic muscles can reduce spasticity, whereas action observation…

View details →DOI: 10.1101/2024.12.03.24318436
Negative / Null Result ReportMedicine

Unveiling the linkage between low-carbon energy and energy sources diversification.

Kuziboev B, Pícha K, Nazif Çatık A et al. · 2025 · Journal of environmental management

This research is the first to investigate the effect of low-carbon energy risk on the diversification of energy sources. To this end, a sample of 64 countries from 2000 to 2018 is analysed. For empirical estimations, we employ the Method…

View details →DOI: 10.1016/j.jenvman.2025.127544
Negative / Null Result Report

Effects of Two Different Intraoperative Fluid Rates on Tissue Oxygenation and Haemodynamic Stability in Anaesthetised Horses

Moura RA, Bisiau A, Freeman D et al. · 2025 · Preprint

Background: Perioperative fluid therapy can influence oxygen delivery and tissue oxygenation, but its effects in horses are poorly understood. Objectives: To compare two intraoperative fluid administration strategies on peripheral tissue…

View details →DOI: 10.22541/au.176131103.35539940/v1
Negative / Null Result Report

Multimodal Approach to Intraventricular Hemorrhage Using Echocardiography, Near-Infrared Spectroscopy, and Electrical Cardiometry in Preterm Infants

Hibner A, Tong MK, Liu L et al. · 2025 · Preprint

Abstract OBJECTIVE: To investigate single versus combination hemodynamic parameters on intraventricular hemorrhage (IVH) or mortality in preterm infants. STUDY DESIGN: Data from 482 infants under 32 weeks gestational age were analyzed,…

View details →DOI: 10.21203/rs.3.rs-7376716/v1
Negative / Null Result Report

Optimizing Biomass and Phycobilin Production in Arthrospira platensis Through Carbon Source Variation and Developing a Cost-Effective Purification Method

Far ZS, Nematollahi MA, Hosseini SV et al. · 2025 · Preprint

Abstract Arthrospira platensis, commonly known as Spirulina , is an industrially cultivated cyanobacterium due to its high content of phycobiliproteins, mainly phycoerythrin, phycocyanin, and allophycocyanin. In this work, a low-cost…

View details →DOI: 10.21203/rs.3.rs-7284160/v1
Negative / Null Result ReportMedicine

Mental Fatigue Impairs Motor Performance but Not Motor Learning in Fatigued or Non-Fatigued Conditions.

Godoi Filho JRM, Abreu TFO, Vieira QR et al. · 2026 · Journal of motor behavior

We investigated the influence of mental fatigue on motor performance and learning. Additionally, we examined whether practicing under mental fatigue induces resilience in future performance under similar fatigue conditions. Ninety-two…

View details →DOI: 10.1080/00222895.2025.2585181
Negative / Null Result Report

MdLRR-RLK1-MdGRP1-LIKE module improved biotic resistance in apple

Chen W, Zhang C, Guo W et al. · 2025 · Preprint

Apple is an important economic species, and it always suffered by biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apples. Besides, the LRR-RLKs…

View details →DOI: 10.22541/au.175022852.28343178/v1
Negative / Null Result Report

Preliminary results of a randomized controlled trail: Effects of remotely supervised physical activity on health profile in frail older adults

Zhang X, Li F, Li J et al. · 2025 · Preprint

Introduction Supervised physical activity (PA) interventions have demonstrated efficacy and safety in improving health outcomes among frail populations. However, the growing disparity between limited healthcare resources and the rapidly…

View details →DOI: 10.1101/2025.06.26.25330386
Negative / Null Result ReportMedicine

Mitomycin C in Non-endoscopic Endonasal Dacryocystorhinostomy: A Randomized Clinical Trial Involving 442 Cases.

Mohapatra S, Rath S, Kapoor AG et al. · 2026 · American journal of ophthalmology

Purpose To evaluate whether 0.04% mitomycin C (MMC) application at the ostium enhances the outcome of non-endoscopic endonasal dacryocystorhinostomy (NEED) in individuals with primary acquired nasolacrimal duct obstruction (PANDO). Design…

View details →DOI: 10.1016/j.ajo.2025.10.005
Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

Negative / Null Result ReportMedicine

Enhanced recruitment methods for a dietary intervention trial aimed at reducing risk of colorectal cancer.

Harvin S, Guetterman TC, Hirko KA et al. · 2026 · Contemporary clinical trials

This study developed and evaluated strategies to optimize recruitment and retention to a mobile health-supported dietary intervention trial, the MyBestGI Study. This included instituting a Personal Technology Assistant and enhancing the…

View details →DOI: 10.1016/j.cct.2026.108322
Negative / Null Result Report

Respiratory Biofeedback Training as an Adjunct Intervention in Pulmonary Rehabilitation for Late-Stage COPD: A Pilot Trial

Lagravinese G, Castellana G, Genco M et al. · 2025 · Preprint

Abstract Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and…

View details →DOI: 10.21203/rs.3.rs-6974767/v1
Negative / Null Result ReportMedicine

Reevaluating diagnostic confidence: the impact of delayed excretory phase imaging in CT urography on detecting renal and urinary tract abnormalities.

Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)

Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…

View details →DOI: 10.1007/s00261-025-05145-x
Negative / Null Result ReportMedicine

Commercial cytokine assay on equine cerebrospinal fluid does not distinguish equine degenerative myeloencephalopathy from cervical vertebral stenotic myelopathy.

Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research

Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…

View details →DOI: 10.2460/ajvr.25.06.0212
Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

View details →DOI: 10.1152/ajpregu.00160.2025
Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

View details →DOI: 10.1055/a-2621-0465
Negative / Null Result ReportMedicine

Perceptual, Thermoregulatory, and Performance Effects of Menthol Gel Application in Trained Triathletes Exercising in Hot Conditions.

Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance

Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…

View details →DOI: 10.1123/ijspp.2025-0038
Negative / Null Result ReportMedicine

Reduction of Enteric Pathogens in Bottled Water Using Residual Ozone.

Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection

Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…

View details →DOI: 10.1016/j.jfp.2025.100585
Negative / Null Result ReportOpen accessMedicine

Evaluating Dermal Bioactivity of Metal Additive Manufacturing Powders Using Human <i>In Vitro</i> and <i>Ex Vivo</i> Skin Models.

Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology

Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…

View details →DOI: 10.1021/acs.chemrestox.6c00100
Negative / Null Result ReportMedicine

Understanding the effects of recent atmospheric heatwaves on seagrass-inhabited intertidal shellfish beds: a mesocosm experiment.

Román S, Vázquez E, Román M et al. · 2025 · Marine environmental research

Shellfish beds are key estuarine habitats coinhabited by commercial species and ecosystem engineers such as the seagrass Zostera noltei. Organisms inhabiting the intertidal areas of these beds are threatened by marine and atmospheric…

View details →DOI: 10.1016/j.marenvres.2025.107547
Negative / Null Result ReportMedicine

Design and optimization of an automatic deep learning-based cerebral reperfusion scoring (TICI) using thrombus localization.

Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie

Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…

View details →DOI: 10.1016/j.neurad.2025.101366
Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…

Negative / Null Result ReportOpen accessMedicine

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects.

Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity

Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…

View details →DOI: 10.1177/17534259261455983
Negative / Null Result ReportMedicine

Improving the accuracy of screening for large-for-gestational-age fetuses: a multicenter observational study.

Birene B, Ferreira A, Raimond E et al. · 2025 · Journal of perinatal medicine

Objectives Large-for-gestational-age (LGA) fetuses present significant maternal and neonatal risks. However, prenatal screening is prone to inaccuracies, leading to potentially unnecessary interventions. This study aims to evaluate the…

View details →DOI: 10.1515/jpm-2025-0015
Negative / Null Result ReportMedicine

Will a co-created program enhance implementation of injury prevention training in youth handball in Sweden? A cluster-randomized controlled trial.

Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport

Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…

View details →DOI: 10.1016/j.jsams.2025.06.011
Negative / Null Result ReportMedicine

The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis.

Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…

View details →DOI: 10.1016/j.biopha.2025.118519