Negative / Null Result ReportOpen accessVeterinary medicine
Luana D. Felizari, Luke K. Fuerniss, Jonathan L. Beckett et al. · 2025 · Veterinary Sciences
This study evaluates the effects of a proprietary tannin blend (BX), supplemented with or without sodium monensin (MON), on beef cattle performance, carcass traits, and health. Steers ( n = 2986; initial shrunk body weight (SBW) 254 ± 9.2 kg) were allocated into 48 pens (61–62 steers/pen; 12 pens/treatment) fed for 230 d. Treatments included: (1) no feed additives (CTL); (2) BX (7.95 g/animal daily); (3) MON + Tylosin phosphate (TYL; 437.52 mg MON/animal daily + 80 mg TYL/animal daily); or (4) MON + BX (437.52 mg MON/animal daily + 7.95 g BX/animal daily). Data were analyzed in R 4.2.1 using a
View details →DOI: 10.3390/vetsci12050446 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Kyle Hayes, Elizabeth Warner, Chris Bollinger et al. · 2020 · BMC Nephrology
Abstract Background Focal segmental glomerulosclerosis (FSGS) causes renal fibrosis and may lead to kidney failure. FSGS and its common complication, proteinuria, are challenging to treat. Corticosteroids are ineffective in many patients with FSGS, and alternative treatments often yield suboptimal responses. Repository corticotropin injection (RCI; Acthar® Gel), a naturally sourced complex mixture of purified adrenocorticotropic hormone analogs and other pituitary peptides, may have beneficial effects on idiopathic FSGS via melanocortin receptor activation. Methods Two studies in a preclinical
View details →DOI: 10.1186/s12882-020-01879-6 Replication FailureOpen accessGeriatrics
Anum Zahra, Maarten van Smeden, Petra J. M. Elders et al. · 2025 · BMC Geriatrics
Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerability in this frail population. However, the prognostic value of these cumulative comorbidity scores like the Charlson comorbidity index (CCI) remained unclear in this population. We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods
View details →DOI: 10.1186/s12877-025-05721-2 Negative / Null Result ReportOpen accessMedicine
Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
View details →DOI: 10.2196/33488 Negative / Null Result ReportOpen accessVeterinary medicine
Pei-Chih Lee, Yuqing Yang, Kaywalee Chatdarong et al. · 2026 · Frontiers in Veterinary Science
IntroductionDry-preservation of gametes offers a promising alternative to cryobanking by potentially storing cells at ambient temperatures; however, successful preservation of whole oocytes remains limited by dehydration-induced cellular damages. This study evaluated whether intracellular delivery of trehalose via a membrane-permeable derivative, trehalose hexaacetate (6-O-Ac-Tre), could enhance dehydration tolerance of domestic cat cumulus–oocyte complexes (COCs), a relevant model for mammalian fertility preservation.MethodsCat COCs were incubated with 0, 3, 10, or 30 mM of 6-O-Ac-Tre to asse
View details →DOI: 10.3389/fvets.2026.1805930 Negative / Null Result ReportOpen access
Nurfitri Iriani Utami, Abd. Karman, Moh Syarifudin · 2022 · OIKONOMIKA : Jurnal Kajian Ekonomi dan Keuangan Syariah
The massive digital transformation was escalating due to the emergence of the Covid-19 Pandemic occurred in almost all industrial sectors including the banking sector. To respond to this challenge, banking presents an innovation that is…
View details →DOI: 10.53491/oikonomika.v3i1.353 Replication FailureOpen accessDiseases of the genitourinary system. Urology
Wanqing Huang, Jiuxu Bai, Yanping Zhang et al. · 2024 · Renal Failure
Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data o
View details →DOI: 10.1080/0886022x.2024.2338217 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yuka Nadai, Yuka Nadai, Kathrin Held et al. · 2019 · Frontiers in Immunology
Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o
View details →DOI: 10.3389/fimmu.2019.00717 Failed Experiment ReportOpen accessMedicine (General)
Andrew J. Klein, Mark Berlacher, Jesse A. Doran et al. · 2020 · MedEdPORTAL
Introduction The interpretation of electrocardiograms (ECGs) is a critical competency for internal medicine trainees, yet time and resources to foster proficiency are limited. Methods This resident-authored ECG email curriculum for first-year residents involved 129 first-year internal medicine residents at three major academic university hospitals. Residents either received the resident-authored ECG email curriculum (intervention group) or continued standard training (control group). The curriculum involved 10 multiple-choice ECG cases emailed biweekly over the 6-month study period. All partic
View details →DOI: 10.15766/mep_2374-8265.10927 Failed Experiment ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Nenonen Arja, Rinne Marjo, Groundstroem Kaj et al. · 2007 · Cardiovascular Ultrasound
Abstract Background Myocardial diastolic tissue velocities are reduced already in newly onset Type 2 diabetes mellitus (T2D). Poor disease control may lead to left ventricular (LV) systolic dysfunction and heart failure. The aim of this study was to assess the effects of exercise training on myocardial diastolic function in T2D patients without ischemic heart disease. Methods 48 men (52.3 ± 5.6 yrs) with T2D were randomized to supervised training four times a week and standard therapy (E), or standard treatment alone (C) for 12 months. Glycated hemoglobin (HbA 1c ), oxygen consumption (VO 2max
View details →DOI: 10.1186/1476-7120-5-32 Failed Experiment ReportOpen accessOrthopedic surgery
Karthikeyan Chinnakkannu MD, John E Femino MD, Natalie Glass PhD et al. · 2019 · Foot & Ankle Orthopaedics
Category: Ankle, Arthroscopy, Hindfoot, Sports Introduction/Purpose: Posterior ankle/hindfoot arthroscopy (PAHA) is an established surgical option for treating pathologies, of posterior ankle and subtalar joints, which otherwise would require open incisions. Arthroscopic procedures are less invasive, provide magnified visualization and allow earlier rehabilitation and return to activity. Many studies have reported outcomes after PAHA, however only two studies have reported complications in larger cohorts. Although posterior ankle impingement (PAI) is a common indication for PAHA, it is a non-s
View details →DOI: 10.1177/2473011419s00018 Methods Dead-EndOpen accessMedicine (General)
Xiaochun Zhang, Xiaoying Tang, Thomas M. Daly · 2020 · Practical Laboratory Medicine
Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the final metabolite 4-pyridoxic acid (PA) can provide additional information regarding supplement intake and hypophosphatasia. The aim of this study is to develop a simple method traceable to the NIST standard reference material 3950 for simultaneous detection of PLP and PA. Design & methods: A one-step reverse phase HPLC method with fluorescence
View details →DOI: 10.1016/j.plabm.2020.e00160 Negative / Null Result ReportOpen accessBotany
R. mawar, S. Lodha · 2002 · Phytopathologia Mediterranea
The combined effect of Brassica amendments (mustard oil–cake or mustard residue at 2.5 tons ha-1) and summer irrigation was tested for survival of Macrophomina phaseolina and Fusarium oxysporum f. sp. cumini and on the severity of dry root rot on clusterbean in the rainy season and on wilt of cumin in the subsequent winter season in the same field. Seed coating with a Bacillus sp., an antagonist bacterium against M. phaseolina, was also integrated with pod residues to improve control of dry root rot. The soil temperature of amended soil after one summer irrigation in June ranged from 38–44°C a
View details →DOI: 10.14601/phytopathol_mediterr-1649 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Bela Scapec, Jozo Grgic, Dorian Varovic et al. · 2024 · Journal of the International Society of Sports Nutrition
Background Caffeine is one of the most popular ergogenic aids consumed by athletes. Caffeine’s ergogenic effect has been generally explained by its ability to bind to adenosine receptors, thus modulating pain and reducing perceived exertion. Another pharmacological agent that may improve performance due to its analgesic proprieties is paracetamol. This study aimed to explore the effects of caffeine, paracetamol, and caffeine + paracetamol consumption on muscular endurance, strength, power, anaerobic endurance, and jumping performance.Methods In this randomized, crossover, double-blind study, 2
View details →DOI: 10.1080/15502783.2024.2400513 Methods Dead-EndOpen accessDairy processing. Dairy products
R.B. Standish, A.D. Wright, N.L. Whitehouse et al. · 2024 · Journal of Dairy Science
ABSTRACT: The purpose of this experiment was to determine if nicotinic acid (NA) effects on dairy cows and rumen microbial characteristics are forage-type dependent (corn silage, CS; grass silage, GS). Four late-lactation (DIM = 225 ± 12 d) Holstein cows were used in a 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments. The main effects were a CS (66.10% CS) based diet or a GS (79.59%) based diet with or without 12 g/d NA. Each experimental period lasted for 28 d. Milk production and milk components, blood metabolites, apparent total-tract nutrient digestibilities, minu
View details →DOI: 10.3168/jds.2023-24483 Methods Dead-EndOpen accessSports
Marcus Vinicius Machado, Alexandre Rosas Batista, Leandro Ricardo Altimari et al. · 2010 · Revista Brasileira de Cineantropometria e Desempenho Humano
The aim of this study was to evaluate the effect of caffeine intake on critical power model parameters determined on a cycle ergometer. Eight male subjects participated in this study. A double-blind protocol consisting of the intake of pure caffeine (6 mg/kg) or placebo (maltodextrin) 60 min before testing was used. Subjects were submitted to four constant-load tests on a cycle ergometer. These tests were conducted randomly in the caffeine and placebo groups [checar] at intensities of 80, 90, 100 and 110% maximum power at a rate of 70 rpm until exhaustion to determine the critical power. As a
Methods Dead-EndOpen accessMedical emergencies. Critical care. Intensive care. First aid
Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong et al. · 2020 · Critical Care
Abstract Background The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock. Methods We performed a prospective, multicenter study in 11 French ICUs. Patients presenting septic shock, with the development of AKI within the first 6 h, were included. Urine [TIMP-2]*[IGFBP7] was determined at inclusion (0 h), 6 h, 12 h, an
View details →DOI: 10.1186/s13054-020-02984-6 Failed Experiment ReportOpen accessMedicine
A. J. Oswald, R. L. Hollis, M. Churchman et al. · 2026 · Scientific Reports
Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective detection methods are desirable. This study assessed quantitative PCR (qPCR) as a method of BRCA1/2 CNL detection in HGSOC, in two patient cohorts (cohort 1 n = 355, cohort 2 n = 86) and a cell line panel (n = 10) using sequencing-based copy number (CN) assessment as a comparator (panel-based sequenci
View details →DOI: 10.1038/s41598-025-34516-z Failed Experiment ReportOpen accessPsychology
Christian Nawroth, Zoe M. Martin, Alan G. McElligott et al. · 2020 · Frontiers in Psychology
Dogs (Canis lupus familiaris) are extremely adept in interpreting human-given cues, such as the pointing gesture. However, the underlying mechanisms on how domestic non-companion species use these cues are not well understood. We investigated the use of human-given pointing gestures by goats (Capra hircus) in an object choice task, where an experimenter surreptitiously hid food in one of two buckets. Subjects first had to pass a pre-test where the experimenter indicated the location of the food to the subject by a proximal pointing gesture. Subjects that succeeded in the use of this gesture we
View details →DOI: 10.3389/fpsyg.2020.00915 Negative / Null Result ReportOpen access
Ananda Krisma Delya, Tri Naimah, U. Wibowo et al. · 2023 · AL-TANZIM : JURNAL MANAJEMEN PENDIDIKAN ISLAM
This study aims to determine the organizational climate's effect on work happiness with Islamic religiosity as a moderator variable for Islamic-based school teachers in the Banyumas Regency. A correlational quantitative approach was used…
View details →DOI: 10.33650/al-tanzim.v7i3.3999 Failed Experiment ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Diana Jansen, Annemijn H. Jonkman, Lisanne Roesthuis et al. · 2018 · Critical Care
Abstract Background Diaphragm dysfunction develops frequently in ventilated intensive care unit (ICU) patients. Both disuse atrophy (ventilator over-assist) and high respiratory muscle effort (ventilator under-assist) seem to be involved. A strong rationale exists to monitor diaphragm effort and titrate support to maintain respiratory muscle activity within physiological limits. Diaphragm electromyography is used to quantify breathing effort and has been correlated with transdiaphragmatic pressure and esophageal pressure. The neuromuscular efficiency index (NME) can be used to estimate inspira
View details →DOI: 10.1186/s13054-018-2172-0 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Christopher J. Kirwan, Barbara J. Philips, Iain A. M. MacPhee · 2013 · Critical Care Research and Practice
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI. Aim. This study t
View details →DOI: 10.1155/2013/406075 Negative / Null Result ReportOpen accessPsychology
Phietica R. R. Silva, Phietica R. R. Silva, Regina H. Silva et al. · 2020 · Frontiers in Psychology
Empathy is the ability to (a) be affected by and share the emotional state of another; (b) assess the reasons for the other’s state; and (c) identify with the other, adopting their perspective. This phenomenon has been shown to exist in several species and is proposed as a motivator for prosocial behavior. The experimental study of this feature in laboratory rodents is a more viable alternative in comparison to wild animals. A recent report showed that rats opened a door to free their cage mate from a restraint box. Although this behavior has been suggested to be motivated by empathy, this fac
View details →DOI: 10.3389/fpsyg.2020.01795 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
View details →DOI: 10.3390/antiox12050987 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal
Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group
View details →DOI: 10.1016/j.ehj.2012.10.002 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p
View details →DOI: 10.1002/jcsm.12428 Replication FailureOpen accessMedicine
A. Bühler, Johannes Thrul, Evelin Strüber et al. · 2015 · Health Promotion International
Because of scarce research, the effectiveness of substance abuse prevention in leisure settings remains unclear. In this study, we evaluated the effectiveness of a peer-led educational prevention measure with adolescent groups in…
View details →DOI: 10.1093/heapro/dav007 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Solberg Peter, Were Willy, Downing Robert S et al. · 2007 · AIDS Research and Therapy
Abstract Background CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. Methods We conducted a cross-sectional study of HIV-infected adults in Uganda, who presented for assessment for ART-eligibility with WHO clinical stages I, II or
View details →DOI: 10.1186/1742-6405-4-1 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Colleen M. Badke, Matthew L. Friedman, Z. Leah Harris et al. · 2020 · Resuscitation Plus
Aim: To determine if an untrained cardiopulmonary resuscitation (CPR) Coach, with no access to real-time CPR feedback technology, improves CPR quality. Methods: This was a prospective randomized pilot study at a tertiary care children's hospital that aimed to integrate an untrained CPR Coach into resuscitation teams during simulated pediatric cardiac arrest. Simulation events were randomized to two arms: control (no CPR Coach) or intervention (CPR Coach). Simulations were run by pediatric intensive care unit (PICU) providers and video recorded. Scenarios focused on full cardiopulmonary arrest;
View details →DOI: 10.1016/j.resplu.2020.100035 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Cassandra A. A. Locatelli, My-Anh Nguyen, Nadya M. Morrow et al. · 2026 · Cardiovascular Diabetology
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by inflammation and dysregulated lipid metabolism. Moreover, whereas KD has shown mixed, sometimes detrimental, effects on circulating cholesterol levels in humans, it is currently unclear the whole-body balance of risk and benefit across hepatic, atherosclerotic, and pancreatic effects. Methods We use
View details →DOI: 10.1186/s12933-025-03046-3 