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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21277 results · page 244 of 710

Negative / Null Result ReportMedicine

Comparison between drug-eluting bead transarterial chemoembolization versus conventional TACE in elderly patients with colorectal cancer liver metastases: a cohort study.

Tian L, Hu B, Song M et al. · 2026 · Frontiers in oncology

Background Drug-eluting bead (DEB) transarterial chemoembolization (TACE) possesses several advantages over conventional TACE (cTACE) such as higher intratumor drug concentration and lower systemic toxicity, which has been widely applied…

View details →DOI: 10.3389/fonc.2026.1785622
Negative / Null Result ReportMedicine

Lineage-specific selection signals in the Growth arrest-specific protein 8 (GAS8) domain protein of Trypanosoma melophagium.

Das A, Ghosh A, Pal S et al. · 2026 · Scientific reports

The Growth arrest-specific protein 8 (GAS8) domain-containing gene family (Orthogroup 6127at5690) is a highly conserved, single-copy orthologous group in the Trypanosoma taxa retained for codon-based evolutionary analysis (10 validated…

View details →DOI: 10.1038/s41598-026-56233-x
Negative / Null Result Report

HCC within LR-M on CEUS LI-RADS: Analysis of Washout Timing & Intensity

Samuel AS, Qiao A, Merrill CD et al. · 2026 · Preprint

Abstract Purpose: LR-M nodules > 1cm, are probably or definitely malignant, but not specific for hepatocellular carcinoma (HCC). HCC is found within LR-M category in 44%. We identify CEUS imaging features within the LR-M category…

View details →DOI: 10.21203/rs.3.rs-9596403/v1
Negative / Null Result ReportOpen accessMedicine

Thyroid Function Tests and Serum Amylase Levels in Chronic Kidney Disease: A Cross-Sectional Study Correlating Biochemical Changes With Disease Severity at a Tertiary Care Centre in India.

Sharma P, Samaria A, Tak H et al. · 2026 · Cureus

Background Chronic kidney disease (CKD) represents a major and growing health concern in both global and Indian populations. In addition to progressive renal dysfunction, CKD is frequently accompanied by metabolic and endocrine…

View details →DOI: 10.7759/cureus.104974
Negative / Null Result ReportMedicine

Association between body mass index and high grade cervical intraepithelial neoplasia (CIN 2/3) in a dysplasia referral population.

F G, J H, L SJ et al. · 2026 · Cancer treatment and research communications

Background Obesity is increasingly recognized as a risk factor for several malignancies, including cervical cancer. Women with obesity participate less frequently in screening and may have higher rates of unsatisfactory cytology,…

View details →DOI: 10.1016/j.ctarc.2026.101279
Negative / Null Result ReportMedicine

Aqueous Humor Angiotensin-Converting Enzyme and TGF-β1 Levels in Proliferative Vitreoretinopathy: A Prospective Clinical Study.

Koçak N, Özdemir A, Esenkaya M et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To evaluate plasma and aqueous humor angiotensin-converting enzyme (ACE) and transforming growth factor-β1 (TGFβ1) levels in patients with proliferative vitreoretinopathy (PVR) secondary to rhegmatogenous retinal detachment (RRD).…

View details →DOI: 10.1097/iae.0000000000004885
Negative / Null Result ReportMedicine

Cardiac Computed Tomography-Guided Procedural Planning for Percutaneous Mitral Paravalvular Leak Closure: Impact on Crossing Time.

Vella C, Romano V, Ricchetti G et al. · 2026 · The Canadian journal of cardiology

Mitral paravalvular leaks (PVLs) are a recognized complication of prosthetic valve implantation and may cause heart failure or hemolysis, often requiring percutaneous closure in patients at high surgical risk. Although transesophageal…

View details →DOI: 10.1016/j.cjca.2026.06.021
Negative / Null Result ReportMedicine

Skeletal muscle status and malnutrition as predictors of short-term radiotherapy response and oral mucositis in head and neck cancer.

Zhang H, Hu X, Zhao J et al. · 2026 · Precision radiation oncology

Objective This study aimed to investigate whether baseline skeletal muscle status and malnutrition in patients with locally advanced head and neck cancer (HNC) are associated with short-term treatment outcomes and acute radiation oral…

View details →DOI: 10.1002/pro6.70072
Negative / Null Result Report

Comparative Analysis of Lesion Detection and Uptake Characteristics of 68Ga-FAPI PET/CT versus 18F-FDG PET/CT in Gastric Cancer: A Preliminary Translational Study

KALENDER E, YILDIRIM EE, YERDEŞ E et al. · 2026 · Preprint

Abstract Purpose This study aimed to compare lesion detection and uptake characteristics of 68 Ga-FAPI PET/CT and 18 F-FDG PET/CT in patients undergoing imaging for gastric cancer (GC) staging. Methods A total of 24 patients with…

View details →DOI: 10.21203/rs.3.rs-9357738/v1
Negative / Null Result ReportMedicine

Clinical course after cardiac resynchronization therapy in transthyretin amyloid cardiomyopathy receiving disease-modifying therapy.

Yamauchi S, Kondo H, Mitarai K et al. · 2026 · Heart and vessels

Background The clinical course of patients with transthyretin amyloid cardiomyopathy (ATTR-CM) undergoing cardiac resynchronization therapy (CRT) remains insufficiently characterized, particularly in the era of disease-modifying therapy…

View details →DOI: 10.1007/s00380-026-02710-2
Negative / Null Result ReportOpen accessMedicine

Comparison of Hook Fixation and Vertebroplasty for Prevention of Proximal Junctional Failure: A Retrospective Cohort Study.

Cho ST, Cho JH, Lee DH et al. · 2026 · Global spine journal

Study DesignRetrospective cohort study.ObjectiveTo compare the association of vertebroplasty and hook fixation at the uppermost instrumented vertebra (UIV) with proximal junctional failure (PJF) after long-segment fusion for degenerative…

View details →DOI: 10.1177/21925682261449174
Negative / Null Result ReportMedicine

Grower or Shower: Is It Even a Thing? Penile Growth Patterns and Erectile Dysfunction Aetiology in Growers and Showers.

García-Gómez B, Jarillo-Ochoa M, García-Rojo E et al. · 2026 · Andrology

Introduction Penile elongation patterns lack objective scientific validation, and their association with vascular mechanisms of erectile dysfunction (ED) remains unclear. The objective is to define objective grower and shower profiles…

View details →DOI: 10.1111/andr.70284
Negative / Null Result ReportMedicine

A community-based exercise intervention to reduce functional risk factors for injury among stroke survivors in South Korea: a pilot randomized controlled trial.

Kang D, Eun SD, Park J · 2026 · Scientific reports

Stroke survivors living in the community often experience persistent impairments in muscle strength, balance, mobility, and cardiorespiratory fitness after hospital discharge, which increase vulnerability during daily activities. This…

View details →DOI: 10.1038/s41598-026-50927-y
Negative / Null Result ReportMedicine

Association between lactation number and quality traits of milk from individual cows with a focus on plasmin activity.

Johansson M, Lindberg M, Lundh Å · 2026 · The Journal of dairy research

This study investigated the hypothesis that milk quality traits and milk proteolytic activity vary with lactation number in dairy cows. Milk was collected from 109 individual cows, 20 Swedish Holstein and 89 Swedish Red, from 12 commercial…

View details →DOI: 10.1017/s002202992610226x
Negative / Null Result ReportMedicine

No Effect of Menstrual Cycle Phase on Wingate Power Outputs or Perceived Exertion in Eumenorrheic Women.

Lambright KR, Bunn JA, Newmire DE · 2026 · Journal of strength and conditioning research

Abstract Lambright, KR, Bunn, JA, and Newmire, DE. No effect of menstrual cycle phase on Wingate power outputs or perceived exertion in eumenorrheic women. J Strength Cond Res XX(X): 000-000, 2026-This study examined whether anaerobic…

View details →DOI: 10.1519/jsc.0000000000005503
Negative / Null Result ReportMedicine

Real-world predictors of severe chemotherapy-induced neutropenia in non-Hodgkin lymphoma: Evaluation of biosimilar and reference rituximab.

Andriyanto DB, Syafhan NF, Nurhayati F · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

BackgroundThe adoption of rituximab biosimilars offers a cost-effective alternative for treating Non-Hodgkin Lymphoma (NHL). However, real-world safety data regarding severe hematological toxicities in the Indonesian clinical setting…

View details →DOI: 10.1177/10781552261450088
Negative / Null Result Report

Urban environment and socio-economic inequalities in childhood excess weight: a cross-sectional study in Geneva, Switzerland

Richard V, De Ridder D, Héritier H et al. · 2026 · Preprint

ABSTRACT Background Childhood overweight and obesity represent major public health challenges, shaped by socio-economic and environmental factors. This study investigates the mediating and moderating role of urban environmental exposures…

View details →DOI: 10.64898/2026.05.26.26354079
Negative / Null Result ReportMedicine

Three-year results of a prospective, controlled clinical study evaluating treatment of intra-bony defects with PRF or EMD- a randomized control trial.

Dőri F, Németh F, Arweiler N et al. · 2026 · BMC oral health

Background Periodontal regenerative surgery is a well-established treatment modality for intrabony periodontal defects. Enamel matrix derivative (EMD) is one of the most extensively documented biologic agents, whereas platelet-rich fibrin…

View details →DOI: 10.1186/s12903-026-08845-y
Negative / Null Result ReportMedicine

Next-generation sequencing (NGS) analysis and age-based survival comparison among glioblastoma (GBM) patients: a two-center cohort study.

Lee CO, Park SY, Yun Y et al. · 2026 · Acta neurochirurgica

Objective Glioblastoma (GBM) incidence increases with age, and its etiologies may differ between young and elderly patients. This study aimed to investigate genetic differences between young and elderly GBM patients using next-generation…

View details →DOI: 10.1007/s00701-026-06924-1
Negative / Null Result Report

36–Month Prospective Multicenter Comparison of Endoscopic Facet Denervation and Cryoneurolysis for Chronic Lumbar Facet Joint Pain

Rapčan R, Kočan L, Witkovsky V et al. · 2026 · Preprint

Abstract Objective Endoscopic facet denervation (ED) and percutaneous cryoneurolysis (Cryo) have emerged as alternative interventional treatments for lumbar facet joint–mediated pain; however, comparative long-term outcome data remain…

View details →DOI: 10.21203/rs.3.rs-8688458/v1
Negative / Null Result ReportMedicine

Muscle-dominant ANCA-associated vasculitis: a single-center cohort study.

Yahata A, Nakamoto N, Oiwa H · 2026 · Rheumatology international

To investigate the clinical characteristics of muscle-dominant ANCA-associated vasculitis (muscle-dominant AAV) in a consecutive single-center cohort. We retrospectively analyzed consecutive patients newly diagnosed with microscopic…

View details →DOI: 10.1007/s00296-026-06151-y
Negative / Null Result Report

Effect of Delayed Initiation of Mepolizumab on Exacto Scale Scores, Clinical Remission Separ-Remas Criteria, and Functional Outcomes in Uncontrolled Severe Asthma: A Real-World Study

León-Lloreda A, Muñoz-Sánchez B, Polonio-González M et al. · 2026 · Preprint

INTRODUCTION: Delayed initiation of mepolizumab may influence long-term disease control and the achievement of clinical and functional outcomes in patients with uncontrolled severe asthma (SUA), but no definitive conclusions have yet been…

View details →DOI: 10.20944/preprints202606.0712.v1
Negative / Null Result ReportMedicine

Combined anterior cruciate ligament and anterolateral ligament reconstruction using an adjustable-loop device provides similar short-term clinical outcomes compared with isolated reconstruction.

Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…

View details →DOI: 10.1016/j.jisako.2026.101073