A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19830 results in Negative / Null Result Report · page 243 of 661
Ullah S, Subhan G, Shakir L et al. · 2026 · Preprint
Abstract Allelopathy involves the release of bioactive compounds from plants that influence the germination and growth of surrounding species. Limited evidence exists on the allelopathic effects of common weeds on wheat germination. This…
Ganeyan A, Ganesh CB · 2026 · Neuropeptides
Galanin (GAL), a neuropeptide produced in both the central and peripheral nervous systems, is implicated in various physiological processes, including reproduction in vertebrates. Yet, the role of GAL is not understood in reptilian…
Alencar TS, Santos MO, Schneider VMM et al. · 2026 · Brain research
Systemic inflammation triggers a set of physiological and behavioral changes known as sickness behavior, including fever and hypolocomotion. Previous studies demonstrated that lipopolysaccharide (LPS) induces these responses in both sexes,…
Fonseca AJM, Cabrita ARJ · 2026 · JDS communications
This study evaluated the effects of replacing soybean hulls with exhausted olive pomace (EOP) on feed intake, milk production and composition, and rumen fermentation parameters. A cyclical changeover design experiment was used with 4…
Muroi M, Fukuda S, Takahashi M et al. · 2026 · The Journal of reproduction and development
Our previous study in hamsters indicated that progesterone (P) induces enhancement of spermatozoal hyperactivation, while 17β-estradiol (Eβ) and γ-aminobutyric acid (GABA) suppress this enhancement. Since P has also been shown to enhance…
De Bruyn L, Van Beek F, Vander Perre S et al. · 2026 · Molecular and cellular endocrinology
Background Sepsis HDL- and LDL-hypocholesterolemia associate with adverse outcomes, but whether this necessitates supplementation or merely reflects disease severity remains unclear. We hypothesize that sustained hypocholesterolemia can…
Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science
This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…
Gackowska K, Krejmer-Rabalska M, Drazkowska K et al. · 2025 · Virology
Virus-like particles (VLPs) have long been utilized as immunogens to prevent infectious diseases. Particles derived from the small surface proteins of the hepatitis B virus (sHBsAg) can self-assemble into small, highly immunogenic…
Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring
Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…
Ching ASM, Kim J, Davis C · 2025 · Preprint
This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…
Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology
Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…
Alipour A, Ganjkhanlou M, Zali A et al. · 2026 · Scientific reports
The pre-weaning period is critical because early-life nutrition and management influence growth, metabolic function and Rumen development, thereby affecting subsequent productivity in dairy calves. Zinc (Zn) supplementation plays a key…
Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience
Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…
Zerlin RR, Elissetche JC, Avila-Sanchez JS et al. · 2025 · Journal of environmental management
Butterflies are important pollinators worldwide and are often sensitive indicators of ecosystem health. Prescribed fire is used in grassland to mimic historic wildfires, improve forage nutritional value, and increased forb production and…
Sarimehmetoglu N, Simsek H · 2026 · The International journal of prosthodontics
Purpose To evaluate the fracture resistance of primary tooth crowns fabricated at different thicknesses using two different 3D-printing technologies: stereolithography (SLA) and digital light processing (DLP). Materials and methods A…
Sawamoto A, Shiba M, Okuyama S et al. · 2026 · The Journal of pharmacy and pharmacology
Objectives Cynandione A (CA), a major bioactive compound isolated from Cynanchum wilfordii Radix, is a crude drug traditionally used in East Asia. We have previously demonstrated that CA induces a beige adipocyte-like phenotype in vitro.…
Stock A, Adaniya C, Gaines M et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Urethral Bulkamid is a U.S. Food and Drug Administration-approved nonsurgical treatment for stress urinary incontinence and stress-predominant mixed urinary incontinence due to intrinsic sphincter deficiency. This procedure is…
Deng SM, Chen YJ, Hung WC et al. · 2026 · Translational psychiatry
Anxiety is a common mental health disorder marked by heightened stress responses and impaired emotional regulation. While the hippocampus and the hypothalamic-pituitary-adrenal (HPA) axis play key roles in regulating anxiety, the molecular…
Ching ASM, Kim J, Davis C · 2025 · Preprint
This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…
Najafi A, Nosaka K, Javidi M et al. · 2026 · Journal of strength and conditioning research
Abstract Najafi, A, Nosaka, K, Javidi, M, Naddafha, S, Kumagawa, D, Bertochi, GFA, and Latella, C. Acute effects of accentuated eccentric loading in comparison to traditional resistance loading on velocity and other parameters in…
Goonasekera MA, Malijan GB, Sardell RJ et al. · 2026 · American journal of nephrology
Introduction Sacubitril/valsartan shows benefits in heart failure and may have kidney protective effects. Its impact on kidney tubular health in chronic kidney disease (CKD) remains unclear. We evaluated the effects of sacubitril/valsartan…
Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment
Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…
Hauptmann E MD, Whitlock R MD, Yeganeh S MD et al. · 2026 · The Journal of surgical research
Introduction Sternal-sparing left ventricular assist device (ssLVAD) insertion avoids the morbidity of median sternotomy for patients with heart failure. Obesity may present challenges in this minimal access operation. We present our…
Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma
Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…
Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…
Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research
Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…
Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports
Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…
Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science
The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…
Wang T, Liu Y, Li R et al. · 2026 · Preprint
Middle East respiratory syndrome coronavirus (MERS-CoV) is a global health concern due to a high fatality rate associated with human infections and no approved vaccines or therapeutics. While Syrian hamsters are a value animal model for…
Chambaro HM, Delhon G, Miraglia MC et al. · 2026 · Preprint
Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity, cold-chain dependence, and high-containment manufacturing. Here, we engineered a…