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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21266 results · page 225 of 709

Negative / Null Result ReportOpen accessMedicine

Register-based observational study of associations between inflammatory remission, formal treatment targets and the use of disease-modifying antirheumatic drugs among patients with early rheumatoid arthritis.

Lindqvist J, Askling J, Lampa J · 2023 · RMD open

Objective To assess associations between inflammatory remission, formal treatment targets and the likelihood of starting a new disease-modifying antirheumatic drug (DMARD), among patients with early rheumatoid arthritis (RA). Methods…

View details →DOI: 10.1136/rmdopen-2023-003111
Negative / Null Result Report

Effects of multimodal and unimodal physical training interventions on visual function in glaucoma and elderly controls – a pilot study

Moffack D, Al-Nosairy K, Beyer R et al. · 2025 · Preprint

Objective To investigate the effect of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma patients (GLA) and…

View details →DOI: 10.1101/2025.01.30.25321400
Negative / Null Result ReportMedicine

Operative Management of Perianal Crohn's Disease.

Wilkinson T, Booth K · 2025 · The Surgical clinics of North America

The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care…

View details →DOI: 10.1016/j.suc.2024.09.007
Negative / Null Result ReportOpen accessMedicine

Evaluating oral ketamine's adverse side effects in chronic pain patients.

Hom B, McIntee D, Zhang YP et al. · 2025 · Saudi journal of anaesthesia

Background Ketamine has been shown to be an effective treatment at sub-anesthetic doses for various chronic pain conditions. This study assesses the relationship between oral ketamine and the incidence of adverse side effects in patients…

View details →DOI: 10.4103/sja.sja_87_25
Negative / Null Result ReportMedicine

Standardization of Lesion Classification and Assessment by Investigators in Clinical Trials for Hidradenitis Suppurativa: A Consensus Exercise Using a Modified Delphi Approach.

Garg A, Strunk A, Midgette B et al. · 2026 · JAMA dermatology

Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective…

View details →DOI: 10.1001/jamadermatol.2025.4652
Negative / Null Result ReportOpen accessMedicine

No Association Between Face Recognition and Spatial Navigation: Evidence from Developmental Prosopagnosia and Super-Recognizers.

Estudillo AJ, Dark O, Wiener JM et al. · 2025 · Brain sciences

Background/Objectives: Previous studies have reported associations between prosopagnosia and spatial navigation, but it remains unclear whether this link is merely coincidental (i.e., observable only in prosopagnosia) or genuinely…

View details →DOI: 10.3390/brainsci15111140
Negative / Null Result ReportOpen accessMedicine

The use of cellphone based automated pupillometry to quantify opioid withdrawal in patients receiving treatment for opioid use disorder.

Evonko CJ, Vigilante KC, Leli NB et al. · 2026 · Journal of substance use and addiction treatment

Introduction Overdose deaths attributed to opioid misuse resulted in over 50,000 deaths in 2024. Opioid agonist therapies such as methadone and buprenorphine are effective for the treatment of opioid use disorder (OUD). Yet, patient…

View details →DOI: 10.1016/j.josat.2026.209927
Negative / Null Result ReportMedicine

Investigation of circulating natural autoantibodies against ANXA1 and MYC as potential biomarkers in hepatocellular carcinoma.

Wang J, Liu S, Zhang X · 2025 · Advances in medical sciences

Purpose In this study, we examined novel autoantibodies targeting tumor-associated antigens (TAAs) as biomarkers for clinical assessment of hepatocellular carcinoma (HCC) in a Chinese population. Methods and methods A total of 119 patients…

View details →DOI: 10.1016/j.advms.2025.01.004
Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

View details →DOI: 10.1038/s41598-025-33777-y
Negative / Null Result ReportOpen accessMedicine

Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults.

Li V, McClure H, Patel R et al. · 2025 · Vaccine

Background Vaccination helps prevent infections and associated sequelae, especially in older adults. Since the degree to which vaccine responses are influenced by medications is not well described, we examined the association of medication…

View details →DOI: 10.1016/j.vaccine.2025.127913
Negative / Null Result ReportOpen accessMedicine

Motives of Children for Digital Gaming and Physical Activity and Their Parents' Perceptions: Cross-Sectional Matched-Pair Study.

Wachholz F, Gamper N, Kruse S et al. · 2026 · JMIR pediatrics and parenting

Background Physical activity (PA) is essential for the healthy development of children. However, the pervasive presence of digital technologies has made digital gaming (DG) a prominent part of children's everyday lives. As children grow up…

View details →DOI: 10.2196/80129
Failed Experiment ReportMedicine

Effect of cross-head speed on the bond strength of dental resin to tooth structure - A review and re-analysis.

Hassan Elnadif H, Darvell BW · 2024 · Dental materials : official publication of the Academy of Dental Materials

Objective To review the published evidence for the role of cross-head speed on the apparent mechanical properties and bond strength of filled resins to tooth structure in order to identify the causes of inconsistency and contradictory…

View details →DOI: 10.1016/j.dental.2024.09.020
Negative / Null Result Report

Altered coagulation profile of patients with high-grade glioma: clinical study with control group.

Quispe-Pastor NJ, Gorritti-Rubio AP, Fernández-Rodríguez LJ · 2024 · Preprint

Background: Disregulation of coagulation is a common phenomenon in patients with high-grade glioma, a primary malignant brain tumor. Objective Identify if there is an alteration in the coagulation profile in patients with high-grade glioma…

View details →DOI: 10.12688/f1000research.154700.2
Negative / Null Result ReportOpen accessMedicine

Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.

Longoni M, Marmiroli A, Falkenbach F et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Introduction We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific…

View details →DOI: 10.1111/iju.70483
Negative / Null Result ReportMedicine

Evaluation of pharmacological thromboprophylaxis in critically Ill elderly patients: A multicenter cohort Study.

Alqahtani R, Sulaiman KA, Aljuhani O et al. · 2025 · Heart & lung : the journal of critical care

Background Older adults are at a higher risk of developing venous thromboembolism (VTE), particularly when admitted to the Intensive Care Units (ICUs). Parenteral anticoagulation is the primary method used for thromboprophylaxis in…

View details →DOI: 10.1016/j.hrtlng.2025.07.013
Negative / Null Result ReportOpen accessMedicine

Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.

Li J, Li A, Jiao J et al. · 2025 · Scientific reports

To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into…

View details →DOI: 10.1038/s41598-025-09304-4
Negative / Null Result ReportOpen accessMedicine

Men talk less than women during multitasking.

Szameitat AJ, Szameitat DP · 2026 · Psychological research

Contrary to the widespread stereotype that women are better at multitasking than men, no consistent sex differences in multitasking abilities between males and females have been found. We developed a novel multitasking paradigm consisting…

View details →DOI: 10.1007/s00426-026-02279-5
Negative / Null Result ReportMedicine

Plasmatic variability of direct oral anticoagulants in people with atrial fibrillation and previous gastric surgery: a pilot case series.

Romoli M, Vitiello M, Lotti EM et al. · 2025 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Data on cardioembolic prevention with direct oral anticoagulants (DOAC) in atrial fibrillation (AF) patients with previous gastric surgery are lacking. We report inter- and intra-individual differences in DOAC concentration in…

View details →DOI: 10.1007/s10072-024-07937-3
Negative / Null Result Report

Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study

El-Haffaf I, Marsot A, Paillault A et al. · 2024 · Preprint

Aim: Patients hospitalized in the intensive care units (ICU) with serious infections require rapid and optimal broad-spectrum antibiotic regimens to ensure favorable outcomes. The purpose of this study was to evaluate the exposure and…

View details →DOI: 10.22541/au.172813042.22321169/v1
Negative / Null Result ReportMedicine

Clinical risk factors associated with the need for tracheostomy in traumatic cervical and high thoracic spinal cord injury.

Konrad M, Shah B, Rady E et al. · 2025 · American journal of surgery

Background Our objective was to assess the association of completeness and level of spinal cord injury (SCI) with the need for tracheostomy and identify additional risk factors predictive of tracheostomy. Methods This was a retrospective…

View details →DOI: 10.1016/j.amjsurg.2024.116033
Negative / Null Result ReportOpen accessMedicine

Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.

Grieco T, Moliterni E, Paolino G et al. · 2024 · Dermatology practical & conceptual

Introduction Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD). Methods From 43 adult AD…

View details →DOI: 10.5826/dpc.1403a214
Negative / Null Result ReportMedicine

A qualitative study on perceptions of adolescents' sexual and reproductive health education in Yogyakarta, Indonesia.

Sikoki B, Larastiti C, Suriastini NW et al. · 2024 · International journal of adolescent medicine and health

Introduction Sexual and reproductive health (SRH) education in Yogyakarta, Indonesia, is contentious due to societal and religious taboos in the Javanese Muslim community and being misunderstood as a potential catalyst for the premarital…

View details →DOI: 10.1515/ijamh-2023-0036
Negative / Null Result ReportMedicine

Comparison of WALANT versus locoregional nerve block in staged bilateral endoscopic carpal tunnel release.

Verrewaere D, Reyniers P, Vandevivere H et al. · 2024 · Hand surgery & rehabilitation

Background Carpal tunnel release can be performed as open or endoscopic surgery. In WALANT (wide awake local anesthesia no tourniquet) a tourniquet is not used, ensuring less discomfort for the patient. In locoregional distal nerve block,…

View details →DOI: 10.1016/j.hansur.2024.101974
Negative / Null Result ReportOpen accessMedicine

Real-world effectiveness of vonoprazan-based regimen versus rabeprazole-based dual therapy for <i>Helicobacter pylori</i> eradication in a high-resistance, multi-ethnic region: a multicenter study in Guizhou, China.

Huang Y, Zheng J, Yang Z et al. · 2026 · Frontiers in medicine

Introduction While vonoprazan-amoxicillin dual therapy has achieved > 90% eradication rates for Helicobacter pylori (H. pylori) in clinical trials, its effectiveness in "real-world" regions with high primary antibiotic resistance and…

View details →DOI: 10.3389/fmed.2026.1801129
Negative / Null Result ReportOpen accessMedicine

A consensus exercise to inform the future of National Health Service General Dental Services using a modified-Delphi technique.

Chestnutt IG, Pattinson R, Brocklehurst P et al. · 2026 · British dental journal

Background Problems relating to the commissioning and delivery of National Health Service (NHS) General Dental Services (GDS) have been well-documented.Objectives This study aimed to gain consensus on issues deemed of importance to the…

View details →DOI: 10.1038/s41415-025-9100-x
Negative / Null Result ReportMedicine

Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting.

Steffens NA, Petreceli RR, Azevedo VC et al. · 2025 · Clinical biochemistry

Introduction Healthcare systems face several challenges, with microbial infections being one of the main concerns. Therapeutic drug monitoring (TDM) is a strategy that has been encouraged to optimize antimicrobial regimens, particularly…

View details →DOI: 10.1016/j.clinbiochem.2025.110874