A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21266 results · page 224 of 709
Varughese VJ, Richardson C, Pollock J et al. · 2025 · Preprint
ABSTRACT INTRODUCTION MitraClip ® (MC) placement has been extensively used as an intervention for mitral transcatheter edge-to-edge repair (mTEER) for functional mitral regurgitation (FMR). The aim of our study is to analyze the…
El-Haffaf I, Marsot A, Paillault A et al. · 2025 · Canadian journal of physiology and pharmacology
In this study, we evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. We conducted a prospective observational study in two Canadian intensive care units (ICUs) from January…
Beijer G, Swartling M, Nielsen EI et al. · 2025 · Critical care (London, England)
Background Standard dosing regimens of meropenem and piperacillin-tazobactam frequently fail to achieve targeted plasma concentrations in critically ill patients. Extended or continuous regimens are often used to improve target attainment.…
Jang S, Kim D, Kim T et al. · 2025 · Nanotechnology
In this study, a Cleaning Endpoint Evaluation Sensor (CEES) was developed and applied to improve the monitoring accuracy and uniformity control in the cleaning processes for NF 3 -based remote plasma sources in semiconductor equipment.…
Wang J · 2025 · Scandinavian journal of trauma, resuscitation and emergency medicine
This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09),…
Bacon EK, Parnell D, Muscatello G et al. · 2025 · Journal of equine veterinary science
Background The ongoing discussion surrounding the well-being of retired racehorses underscores the importance of implementing effective rehoming strategies that prioritise animal welfare. A significant knowledge gap persists regarding…
Seidel M, Barns H, Klostermann C et al. · 2025 · Journal of Nutrition Education and Behavior
Nationwide, 41% - 48% of students on college campuses are food insecure (FI). These students are more likely to do poorly in school and drop out than their food secure (FS) peers. In 2017, 30% of students at Chatham University (CU), a…
Mattiuzzi C, Lippi G · 2025 · Preprint
Background: Earlier studies suggested that coronavirus disease 2019 (COVID-19) mortality may vary by the day of the week, possibly due to healthcare system workflows or reporting delays. This study aimed to assess whether such day-of-week…
Lang A, Gabriel H, Meister TL et al. · 2026 · The Journal of hospital infection
Background Candida (Candidozyma) auris is a globally emerging multidrug-resistant fungal pathogen that causes nosocomial outbreaks in healthcare facilities. Aim To evaluate the susceptibility of different C. auris clade strains (I to V)…
Felicioni F, Nivia-Riveros JA, Caldeira-Brant AL et al. · 2026 · The Journal of nutritional biochemistry
Proper fetal development depends on maternal nutrition. We investigated the placental morphofunctional adaptations to a low-protein diet, and their impact on fetal and newborn outcomes. Swiss mice were fed either normal (NPD, 20% crude…
Metzler YA, Alyan E, Taibi Y et al. · 2025 · Preprint
Abstract Occupational psychology frequently aggregates self-reported work characteristics to higher-level units like occupations, assuming them to represent a distinct entity. However, concerns persist regarding reliability and…
Boles B, Gardner JA, Rehder CW et al. · 2025 · Archives of pathology & laboratory medicine
Context.— The joint College of American Pathologists/American College of Medical Genetics and Genomics Cytogenetics Committee works to ensure competency and proficiency of clinical cytogenetics testing laboratories through proficiency…
Tsuchie R, Hashimoto Y, Abiko M et al. · 2026 · Neurologia medico-chirurgica
Anatomical variations in the middle cerebral artery affect outcomes of mechanical thrombectomy in M1 occlusion cases. However, the relationship between middle cerebral artery branching patterns-specifically trifurcation and bifurcation-and…
Umeaghadi CF, Taylor JG, Yao S et al. · 2026 · Patient preference and adherence
Adherence surveys can be lengthy due to the high number of potential risk factors to be analyzed. As a result, researchers often reduce items into conceptual domains (eg, beliefs, economic factors) to overcome power constraints or focus…
Reiter T, Dörrler A, Hasenauer N et al. · 2025 · Preprint
ABSTRACT Background Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial investigated whether molecular imaging of…
Eckert L, Miller JS, Fitzpatrick JL et al. · 2025 · Evolution; international journal of organic evolution
Reproductive accessory glands are organs involved in reproduction that do not directly produce or release gametes but can play crucial roles in securing reproductive success. In fishes, the 2 leading hypotheses about why accessory glands…
Mo M, Xie J, Wu C et al. · 2026 · Frontiers in nutrition
Background Enteral nutrition (EN) in septic shock patients is a double-edged sword. The impact of early enteral nutrition (EEN) on mortality in septic shock patients remains uncertain, and whether this association is modified by…
Sisk BA, Antes AL, Bereitschaft C et al. · 2025 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine
Purpose United States healthcare systems have enacted varied adolescent online patient portal policies. No prior work has established whether these policies are acceptable to adolescents and parents. Methods Mixed-method Delphi approach…
Harada Y · 2026 · Cureus
Introduction Large language models are increasingly discussed as tools for patient-facing symptom assessment, but safe self-triage depends on the concrete next action recommended to the user rather than on generic urgency language alone.…
Lin CY, Liao WL, Lin HJ et al. · 2025 · Eye & contact lens
Purpose To compare the ocular comfort and tear film stability of low viscous and medium viscous lubricant eye drops in orthokeratology lens users. Method This is a prospective, two-arm, randomized, crossover trial. After a 7±2 day run-in…
Romeo DJ, Wagner CS, Ahluwalia V et al. · 2025 · The Journal of craniofacial surgery
Many people living in low-income and middle-income countries (LMICs) lack access to safe surgical and anesthetic care. The Lancet Commission on Global Surgery (LCGS) recommended that all countries track surgical volume and target 5,000…
Park SJ, Park JS, Kang DH et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Purpose To identify factors associated with failure to achieve the minimal clinically important difference (MCID) in the Scoliosis Research Society-22r (SRS-22r) despite achieving optimal global alignment in adult spinal deformity (ASD)…
Drew RH, Turner NA, Keil E et al. · 2026 · Infection control and hospital epidemiology
In a propensity-matched cohort of adult cardiac or neurosurgical procedures ( n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically…
Schmitt A, Behnes M, Bertsch T et al. · 2025 · European journal of internal medicine
Background Elevated uric acid (UA) is a recognized biomarker in patients with cardiovascular disease. However, the prognostic significance of UA levels in patients with heart failure (HF), particularly those with HF with mildly reduced…
Fortunato C, Gasperini B, Mengarelli Rinaldini D et al. · 2025 · Annali di igiene : medicina preventiva e di comunita
Background Vaccine hesitancy is considered one of the top ten threats to global health by the World Health Organization due to the potential public health consequences. Since April 1, 2021, the Italian Government has made COVID-19…
Ellis LR, O'Connor D, Khan H et al. · 2026 · European journal of nutrition
Purpose Despite equivocal human study data, anthocyanin-rich blueberries are associated with positive glycaemic effects which could benefit satiety and other cardiometabolic outcomes. The objective of this study was to examine the…
Joseph Varughese V, Richardson C, Pollock J et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : MitraClip ® (MC) placement has been extensively used as an intervention for mitral transcatheter edge-to-edge repair (mTEER) for functional mitral regurgitation (FMR). The aim of our study is to analyze the…
Chimowitz MI · 2026 · Stroke
CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials) comprised 2 parallel randomized trials in asymptomatic carotid stenosis comparing medical management alone with medical management plus…
Balakrishnan P, Saravanan S, Vignesh R et al. · 2025 · Indian journal of medical microbiology
Background Hepatitis C virus (HCV) is still a serious public health issue because it can cause cirrhosis, hepatocellular carcinoma (HCC), and chronic hepatitis. In almost 70 % of cases, HCV infection results in chronic persistence, which…
Rezaie MJ, Allahveisie A, Nikkhoo B et al. · 2025 · International journal of fertility & sterility
Background Oocyte in vitro maturation (IVM) is a valuable technology applied to acquire fully developed oocytes for several clinical purposes. Despite substantial research on optimizing culture media, the success rate of IVM remains low.…