Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Xianglan XUAN, Changshan AN, Caicun ZHOU · 2013 · Chinese Journal of Lung Cancer
Background and objective Previous studies have reported that Met might be related to gefitinib resistance in non-small cell lung cancer (NSCLC). The present study aims to explore the mechanism of hepatocyte growth factor (HGF)-induced gefitinib resistance in different gene types of sensitive NSCLC in vitro. Methods The PC-9 and H292 cell lines were chosen and induced by HGF. The cell survival was measured using MTT assay, the cell cycle distribution was measured using PI assay, and cell apoptosis with an Annexin V-PE assay, respectively. The c-Met and p-Met protein expression was determined vi
View details →DOI: 10.3779/j.issn.1009-3419.2013.01.01 Negative / Null Result ReportOpen access
Rashad A. Mousa, Ibrahim S. Al-Sabaty · 2000
1. There is no significant effect of the sex variable on the psychological traits of the liar. 2. There is no significant effect of the father's level of education on the psychological traits of the liar. 3. There is no significant effect…
Negative / Null Result ReportOpen accessMedicine (General)
Salla Atkins, Tiia Reho, Nina Talola et al. · 2020 · Trials
Abstract Background Prolonging working careers is a key policy goal in ageing populations in Europe, but reaching this goal is complex. Occupational health services are in the best position to contribute towards prolonging working careers through preventing illnesses that cause work disability and early retirement. However, impacting on the trajectory between illness and work disability requires continuity of care and follow up, enabled through identifying patients at risk. We aimed to determine whether a combined educational and electronic reminder system in occupational health care could imp
View details →DOI: 10.1186/s13063-020-4168-8 Replication FailureOpen accessGynecology and obstetrics
Fereshteh Vaziri Nezamdoust, Hossein Hadinedoushan, Nasrin Ghasemi · 2023 · International Journal of Reproductive BioMedicine
Abstract Background: A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors. Objective: This study investigated the association between single nucleotide polymorphisms of cytotoxic T-lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women. Materials and Methods: A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood
View details →DOI: 10.18502/ijrm.v21i1.12664 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shaheen Akhtar, Sanjeev Verma, Navinder Pal Singh et al. · 2023 · National Journal of Physiology, Pharmacy and Pharmacology
Background: With improvement in living conditions in the population and the availability of treatments for various communicable and non-communicable diseases, the life expectancy and consequently the elderly population have increased. Stress leads to mental and physical problems. Aim and Objective: The aim of this study was to assess the effect of stress on muscle functions in the elderly. Materials and Methods: One hundred apparently healthy persons (50 males and 50 females) took part in the study. Perceived stress scale was used to measure their level of stress. Maximum voluntary contraction
View details →DOI: 10.5455/njppp.2023.13.11517202219122022 Negative / Null Result ReportOpen accessMedicine
Wejpisit Wongwiwattananon, Jatuporn Pakpirom, Raviwan Akarapatima · 2020 · Journal of Health Science and Medical Research (JHSMR)
Objective: This study aimed to determine the risks of propofol-based total intravenous anesthesia (TIVA) compared to local anesthesia (LA) in patients undergoing percutaneous transluminal angioplasty (PTA) in a lower extremity. Material and Methods: A retrospective cohort study was conducted in 231 patients who underwent PTA in the lower extremity using either propofol-based TIVA or LA between January 2016 and September 2018. The outcomes of interest included perioperative major adverse cardiac events (MACE) and minor perioperative complications. Risk factors analysis was performed using a uni
View details →DOI: 10.31584/jhsmr.2020747 Negative / Null Result ReportOpen accessEnglish language
Masoome Azmoode Sis Abad, Gholam-Reza Kiany, Gholam-Reza Abassian · 2024 · Journal of Modern Research in English Language Studies
The present research responds to the call for implementing diagnostic assessment through learner involvement. This study followed two aims: first, examining the distinctive effects of diagnostic self- and peer - assessments on EFL learners’ reading comprehension; second, exploring students’ diagnostic rating accuracy in various reading genres. To achieve this, a number of diagnostic reading comprehension tests and a checklist were developed, the construction of which were based on the learners’ challenging reading subskills. The participants include 60 English translation university students.
View details →DOI: 10.30479/jmrels.2023.18703.2204 Negative / Null Result ReportOpen accessPublic aspects of medicine
Ahmed M. Aman Allah, Waad M. Malibarey, Sarah S. Bin Baz et al. · 2025 · The Saudi Journal of Health Systems Research
Introduction: Telehealth is a potential method for improving the quality of care for people diagnosed with type 2 diabetes (T2D). In Saudi Arabia, there is limited research on the effectiveness of telehealth for glycemic control compared to usual care. Thus, the aim of the current study was to determine the impact of telehealth on glycemic control in individuals diagnosed with T2D, with a specific focus on the examination of hemoglobin A1c (HbA1c) values. Methods: A retrospective case-control cohort study was conducted between January and August 2024 on people diagnosed with T2D who were manag
View details →DOI: 10.1159/000544061 Negative / Null Result ReportOpen accessDentistry
Özer Alkan, Burcu Oktay Çöven, Betül Özçopur et al. · 2017 · Turkish Journal of Orthodontics
Objective:The present study aimed to evaluate the effects of ozone and prophylactic antimicrobial applications on the shear bond strengths and bond failure interfaces of orthodontic brackets.Methods:Sixty human canine teeth were randomly divided into three groups (n=20), receiving the following treatments: Group I-pumice prophylaxis (Isler Dental, Ankara, Turkey)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+Transbond XT primer and adhesive (3M Unitek, Monrovia, USA); Group II-prophylaxis paste (Topex, NJ, USA)+37% orthophosphoric acid (Dentsply, Rio de Janeiro, Brazil)+ Transbon
View details →DOI: 10.5152/turkjorthod.2017.17032 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang et al. · 2020 · BMC Cancer
Abstract Background The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margin status and locoregional recurrence (LRR). Methods Our institutional prospectively maintained database was reviewed to identify patients who were treated with NACT between January 2008 and April 2018. Results Among the main partial mastectomy specimens available for analysis (n = 161), 28 had margins 2 mm. LRR occurred in 16 patients (9.9%) and distant metastases were
View details →DOI: 10.1186/s12885-020-06955-6 Negative / Null Result ReportOpen accessMicrobiology
Yuhan Xie, Gang Peng, Hongyu Zhao et al. · 2023 · Metabolites
Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as age at blood collection, birth weight, gestational age, infant sex, parent-reported ethnicity, and maternal age at deliver
View details →DOI: 10.3390/metabo14010005 Negative / Null Result ReportOpen accessAgriculture
S. Jafari, M. Karimzadeh, A. Abdeshahi · 2021 · علوم آب و خاک
Characteristics of most soils in arid and semi-arid regions affected by carbonates. The study aimed to determine the distribution of carbonates in the size components of some soils in Khuzestan province. Upward to the bottom of Karun, Karkheh, and Jarahi rivers were studied at depths of 0-50, 50-100, and 150-100 cm. The results showed that the average amount of carbonates in the soils of the Jarahi river basin (37%) was significantly different from the amount in the soils of the other two rivers (33%). Carbonates were observed in all soil size components but the maximum was present in the clay
Negative / Null Result ReportOpen accessDentistry
Merna M. Seif, Ahmed A. Abdel Hakim, Hassan M. Abouelkheir et al. · 2025 · BMC Oral Health
Abstract Background Accurate impression registration is essential for transferring the three-dimensional (3D) implant position to the definitive cast, ensuring passivity of the final prosthesis. Various impression techniques have been developed to optimize accuracy, particularly for angulated implants. This study aimed to evaluate and compare the accuracy of open-tray impression copings, clips impression copings, and hexed implant mounts in transferring implant positions for both straight and angulated implants. Methods Five implants with different angulations (three at 0°, one at 15°, and one
View details →DOI: 10.1186/s12903-025-06304-8 Negative / Null Result ReportOpen accessMedicine
Laura Emanuelle da Rosa Carlos Monteiro, Sheila Piccoli Garcia, Leonardo Grabinski Bottino et al. · 2022 · Archives of Endocrinology and Metabolism
ABSTRACT Objective: To evaluate the precipitating factors of diabetic ketoacidosis (DKA) in patients with type 1 diabetes hospitalized through the emergency department of a tertiary hospital. Materials and methods: Individuals with type 1 diabetes hospitalized for DKA from January 2005 to March 2010 (first period [P1], n = 75) and from April 2010 to January 2017 (second period [P2], n = 97) were identified through a query of electronic medical records. Data were collected by reviewing medical records. Only the first hospitalization of each participant in each period was included. Results: In P
View details →DOI: 10.20945/2359-3997000000480 Negative / Null Result Report
Xiang Zheng, Yingying He, Minmin Cao et al. · 2025 · Canadian Journal of Forest Research
Chinese fir ( Cunninghamia lanceolata (Lamb.) Hook) is one of the most dominant tree species in southern China. However, the effect of different nitrogen (N) levels on soil respiration in subtropical Chinese fir plantations remains…
View details →DOI: 10.1139/cjfr-2025-0011 Negative / Null Result ReportOpen accessSports medicine
Mario Hevesi MD, PhD, Alexander M. Boos, Allen Wang et al. · 2024 · Orthopaedic Journal of Sports Medicine
Objectives: Medial meniscus posterior root tears (MMPRTs) render the meniscus essentially non-functional, resulting in increased peak contact pressures, reduced forced dissipation, and increased risk of early osteoarthritis. Transtibial root repair has shown promise at restoring meniscus function and improving clinical outcomes; however, a paucity of literature exists evaluating the prognostic clinical and radiographic factors for poor outcomes following isolated meniscus root repair. The purpose of this study was to 1) describe the patient reported clinical outcomes after isolated MMPRT repai
View details →DOI: 10.1177/2325967124s00200 Negative / Null Result ReportOpen accessMedicine
Matthias Huber, Till Treutler, Peter Martus et al. · 2013 · PLoS ONE
Unlabelled Treatment of hypertension in hemodialysis (HD) patients is characterised by lack of evidence for both the blood pressure (BP) target goal and the recommended drug class to use. Telmisartan, an Angiotensin receptor blocker (ARB) that is metabolised in the liver and not excreted via HD extracorporeal circuit might be particularly suitable for HD patients. We designed and conducted a randomised, placebo-controlled, double-blind and cross-over trial for treatment of dialysis-associated hypertension with telmisartan 80 mg once daily or placebo on top of standard antihypertensive treatmen
View details →DOI: 10.1371/journal.pone.0079322 Negative / Null Result ReportOpen accessOrthopedic surgery
Taeko Fukuda, Shinobu Imai, Shunji Simoda et al. · 2020 · Journal of Orthopaedic Surgery
Purpose: It is unclear whether perioperative analgesic techniques affect the functional outcome of total knee replacement (TKR). We investigated the effects of peripheral nerve block (PNB) and local infiltration (LI) on walking ability after TKR. Methods: The medical records of 7143 patients who underwent TKR using general anesthesia with PNB or LI techniques were reviewed. Factors affecting independence and/or improvement of walking after surgery were investigated using multivariate regression analysis. To adjust for baseline differences and minimize selection bias for the chosen analgesic te
View details →DOI: 10.1177/2309499020931656 Negative / Null Result ReportOpen accessMedicine
Thaiz Ferraz Borin, Debora A P C Zuccari, Bruna V Jardim-Perassi et al. · 2014 · PLoS ONE
A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-231 tumor cells were implanted in animals' right flank and randomly assigned to early (1 and 2), starting treatments on day 0, or delayed groups (3 and 4) on day 8 after implantation of tumor. Animals received HET0016 (10 mg/kg) treatment via intraperitoneal injection for 5 days/week for either 3 or 4
View details →DOI: 10.1371/journal.pone.0116247 Negative / Null Result ReportOpen accessNursing
Tarek Mahmoud Shaker Mohamed, Hala Mohamed Abdelhamed Ali, Asmaa Sayed Abd-Almageed et al. · 2022 · International Egyptian Journal of Nursing Sciences and Research
Background: COVID-19 represents a major threat to hemodialysis health life, due to their low immunity, it is essential to wear a face mask to protect them against the outbreak of the COVID-19 pandemic. Aim: To evaluate the effect of wearing a face mask on oxygen saturation among hemodialysis patients versus healthy staff members.Methods: Research design: a quasi-experimental research design Setting: dialysis units at Mansoura University and New General Mansoura hospital. Subjects: A purposive sample with a total of 190 patients was classified into two equal groups, entitled hemodialysis patien
View details →DOI: 10.21608/ejnsr.2022.247067 Negative / Null Result ReportOpen accessSports medicine
Nurtekin Erkmen, Yağmur Kocaoğlu, Ahmet Kaan Aslan et al. · 2023 · Türk Spor ve Egzersiz Dergisi
The aim of this study was to investigate the effect of warm-up activity on the visual response time of the dominant and non-dominant hand and foot in basketball players. A total of 13 male basketball athletes with an age of 14.38 ± .506 years, height 180.15 ± 8.07 cm, body weight 66.54 ± 13.73 and sports experience 4.69 ± 13.73 years were voluntarily included in the study. Visual response time of the dominant and non-dominant hand and foot were measured before and after the warm-up protocol. The warm-up protocol consisted of a 20-minute warm-up activity including basketball-specific movements
View details →DOI: 10.15314/tsed.1380623 Negative / Null Result ReportOpen accessOphthalmology
Shunsuke Nakakura, Ryo Asaoka · 2022 · Eye and Vision
Abstract Background To evaluate the postoperative outcomes of initial trabeculectomy (Trab) and Ex-PRESS (EX) in terms of achieving an intraocular pressure (IOP) below 15 and 18 mmHg. Methods This study retrospectively analyzed 64 and 54 cases of Trab and EX, respectively, performed by the same surgeon with uniform management from April 2018 to March 2019. Surgical success was defined as 5 < IOP < 15 mmHg (criterion 1) and 5 < IOP < 18 mmHg (criterion 2) without additional glaucoma medication, needling, and bleb reconstruction 2 months after surgery. Survival analysis with Cox regression was p
View details →DOI: 10.1186/s40662-022-00279-1 Negative / Null Result ReportOpen accessMedicine (General)
Yuli Lusiana Sari, Desi Dwi Wisudanti, Muhammad Ali Shodikin · 2018 · Journal of Agromedicine and Medical Sciences (AMS)
Cocoa (Theobroma cacao L) is an industrial material that often used in chocolates production, but the part that used is cocoa bean, so that cocoa husk accumulate as waste. This study aimed to determine effectiveness of cocoa husk extracts to first and second phase of licking time of mice induced formalin. This study used 28 mices that divided into seven groups. NaCMC 1% to group K(-), 0.0048 mg/gBW sodium diclofenac to K(+), extracts dose variations, ie 0.25 mg/gBW, 0.5 mg/gBW, 1 mg/gBW, 2mg/gBW and 4 mg/gBW to group K1, K2, K3, K4, and K5 administered orally 30 minutes before subcutaneous inj
View details →DOI: 10.19184/ams.v4i2.6328 Negative / Null Result ReportOpen accessOrthopedic surgery
Akhil A. Chandra, Filippo Romanelli, Alex Tang et al. · 2022 · Knee Surgery & Related Research
Abstract Background Flap reconstruction with perforator, fasciocutaneous, muscular, and/or free microvascular flaps is utilized to cover wound defects and improve vascularization and antibiotic/nutrient delivery. Flap use in revision procedures for total knee arthroplasty has been explored previously; however, current data are limited and studies comparing healing and complication rates between different flap types are lacking. Methods A literature review was performed using PubMed on 13 January 2022. Studies were included if they reported healing and complication rates for either gastrocnemiu
View details →DOI: 10.1186/s43019-022-00145-3 Negative / Null Result ReportOpen accessMedical technology
Carlo Calabrese, Carlo Calabrese, Dania Gelli et al. · 2022 · Frontiers in Medical Technology
BackgroundCrohn's disease (CD) is a potentially debilitating condition that burdens Italian healthcare substantially. The symptomatic management relies on prompt therapy adjustment to reduce flares and follow-up diagnostic inputs to maximise remission. Capsule endoscopy (CE) has introduced advantages in CD diagnostics, allowing the direct inspection of the entire gastrointestinal mucosa. The diagnostic procedure is comparable in effort to standard ileocolonoscopy (IC) but requires no anaesthesia. Whether CE follow-up improves clinical outcomes remains to be defined.ObjectivesTo provide a preli
View details →DOI: 10.3389/fmedt.2022.1038087 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yuan-yuan LU, Xu-tong ZHAO, Qing-qing WANG et al. · 2018 · Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the mitochondrial DNA (mtDNA) mutation load in hair follicles from different scalp regions of patients with mitochondrial, encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), compare the mutation load in different scalp regions, and analyze the difference in mutation load between scalp regions with lesion site in the brain and scalp regions without lesion site in the brain. Methods Seven MELAS patients with m.3243A > G mutations were studied. Hair follicles were obtained from 8 scalp regions (bilateral frontal, temporal, parietal and occipital lobe
View details →DOI: 10.3969/j.issn.1672-6731.2018.08.004 Negative / Null Result ReportOpen accessDentistry
Anum Tanwir, Shahbaz Ahmed, Hira Akhtar et al. · 2022 · European Endodontic Journal
Objective: The objective of this study was to compare the effectiveness of premedication drugs including single dose Piroxicam and Prednisolone in regard to post endodontic pain at different time intervals (24, 48, 72 and 96 hours) after single visit root canal treatment. Methods: This randomized clinical trial (registration no. NCT04124822) was performed in operative dentistry department of a private clinical institute. One hundred twenty patients identified with symptomatic irreversible pulpitis were included in the study. The pain intensity levels were marked through the use of visual analo
View details →DOI: 10.14744/eej.2022.24119 Negative / Null Result ReportOpen accessMedicine
Wishyar Jamal Al-Bazzaz, Nihad Rifaat Jawad2 Ali W. AlKhayat · 2020 · Zanco Journal of Medical Sciences
Background and objective: Prostate Thulium laser vaporization is a novel treatment option for a bladder outlet obstruction caused by benign prostate enlargement. However, this surgical technique has not yet been standardized. We present our finding of using Tm vaporesection of the prostate. This study aimed to assess the efficacy and safety of thulium laser versus bipolar transurethral resection of the prostate for treating patients with benign prostatic obstruction. Methods: Sixty three consecutive patients with benign prostatic hyperplasia attending public and private clinics in Erbil city w
View details →DOI: 10.15218/zjms.2020.027 Negative / Null Result ReportOpen accessSocial Sciences
Richie Bayuran · 2019 · JPAIR
Brown seaweed is one of the algal species that has been used as food, a source of nutritional supplements, and formulated for therapeutic and cosmetic purposes. This study evaluated the antioxidant and antistaphylococcal activities of topical fucoidan gel (TFG) from the Sargassum oligocystum. A completely randomized design was used, and the experimental protocol includes extraction, lyophilization, and characterization, quality testing, and biological assay. Physicochemical tests suggested that the lyophilized fucoidan is comparable with the properties of pharmaceutical-grade fucoidan. FTIR ch
View details →DOI: 10.7719/jpair.v38i1.731 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Cristiana Mateus, Cláudio J. Maia, Fernanda Domingues et al. · 2023 · Antibiotics
Aliarcobacter butzleri is a Gram-negative bacterium associated with infections of the gastrointestinal tract and widely distributed in various environments. For successful infection, A. butzleri should be able to tolerate various stresses during gastrointestinal passage, such as bile. Bile represents an antimicrobial host barrier that acts against external noxious agents and consists of a variety of bile salts. The intestinal bile salts act as detergents involved in the antimicrobial host defense; although, on the bacterial side, they could also serve as a signal to activate virulence mechanis
View details →DOI: 10.3390/antibiotics12091387 