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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 221 of 724

Negative / Null Result ReportMedicine

The relationship between distal lumbar lordosis correction and early postoperative L1-pelvic angle changes in adult spinal deformity surgery.

de Oliveira RG, Fujii T, Younus I et al. · 2026 · Spine deformity

Purpose To evaluate the early postoperative relationship between changes in distal and proximal lumbar lordosis and the L1-pelvic angle in adult spinal deformity surgery. Methods A retrospective review was performed of 120 adult spinal…

View details →DOI: 10.1007/s43390-026-01482-z
Negative / Null Result ReportOpen accessMedicine

Three-Dimensional Speckle-Tracking Echocardiography-Derived Left Ventricular Volumes Show No Associations with Mitral Annular Plane Systolic Excursion in Healthy Adults (Findings from the MAGYAR-Healthy Study).

Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine

Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…

View details →DOI: 10.3390/jcm15103589
Negative / Null Result Report

Target Amplicon Deep Sequencing of Pfk13 gene in patients with Plasmodium falciparum malaria during the therapeutic efficacy study trials from 2020 to 2022 in Senegal

Tine A, Diallo MA, Gaye A et al. · 2026 · Preprint

Abstract Background: Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment in Africa. However, the emergence of Plasmodium falciparum artemisinin partial resistance associated with mutations in the…

View details →DOI: 10.21203/rs.3.rs-9272508/v1
Negative / Null Result ReportMedicine

Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level.

Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…

View details →DOI: 10.1002/smi.70167
Negative / Null Result ReportMedicine

Lack of association between Helicobacter pylori and pediatric atopy: Evidence from a Latin American multicenter cohort.

Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…

View details →DOI: 10.1002/jpn3.70237
Negative / Null Result ReportMedicine

Spatial Association between Air Pollution and Non-communicable Diseases and their Distribution in India.

Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…

View details →DOI: 10.4103/ijcm.ijcm_209_25
Negative / Null Result Report

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · Preprint

Abstract Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy, and to determine whether therapeutic…

View details →DOI: 10.21203/rs.3.rs-8673450/v1
Negative / Null Result ReportMedicine

The lack of association between cumulative MTX dose and liver fibrosis in PsA: a cohort study.

Kharouf F, Mehta P, Carrizo Abarza V et al. · 2025 · Rheumatology (Oxford, England)

Objectives Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic…

View details →DOI: 10.1093/rheumatology/keaf282
Negative / Null Result ReportMedicine

Quantitative assessments of ultrasound-based rotator cuff muscle quality.

Nasr AJ, Wang H, Khazzam M et al. · 2026 · PM & R : the journal of injury, function, and rehabilitation

Background Fatty infiltration and muscle atrophy strongly influence clinical outcomes in patients with rotator cuff tears. Emerging quantitative techniques integrated with brightness-mode ultrasound and shear wave elastography (SWE) have…

View details →DOI: 10.1002/pmrj.70097
Negative / Null Result ReportOpen accessMedicine

Lack of association between G6PD variants and Parkinson disease.

Chifamba LV, Parlar SC, Liu L et al. · 2026 · HGG advances

Oxidative stress has been implicated in Parkinson disease (PD). Genes involved in PD, such as PRKN, PINK1, and PARK7, contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase,…

View details →DOI: 10.1016/j.xhgg.2025.100555
Negative / Null Result ReportMedicine

Association of Psychotropic and Opioid Medication Use With Physical Function in Hospitalized Older Adults With Dementia.

Kim N, Resnick B, Galik E et al. · 2026 · Journal of gerontological nursing

Purpose To examine whether psychotropic medications (antipsychotics, sedatives, antiseizures, antidepressants, and anxiolytics) and opioids were associated with physical function in hospitalized older adults with dementia. Method A…

View details →DOI: 10.3928/00989134-20251104-01
Negative / Null Result ReportMedicine

Impact of Selective Serotonin Reuptake Inhibitors on Bleeding Rates in HeartMate 3 Left Ventricular Assist Device Patients Not Taking Aspirin.

Ganter M, Bowyer M, Relic E et al. · 2026 · Artificial organs

Background Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) therapy have been associated with increased bleeding risk in left ventricular assist device (LVAD) patients receiving warfarin…

View details →DOI: 10.1111/aor.70078
Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

View details →DOI: 10.1053/j.jrn.2025.06.003
Negative / Null Result ReportMedicine

Postoperative Fever Following Pelvic and Acetabular Fixation: Incidence, Risk Factors, and Lack of Association With Surgical Site Infection.

Ayoub M, Curtis E, Vue Y et al. · 2025 · Orthopedics

Background Despite numerous studies showing postoperative fever can be a common and benign occurrence, there is still a significant and costly workup when fevers occur after surgery, including for orthopedic patients with pelvic ring and…

View details →DOI: 10.3928/01477447-20250506-01
Negative / Null Result Report

CD44v6 Promotes Proliferation, Migration, and Invasion in Cholangiocarcinoma Cells, but Lacks Independent Prognostic Significance

Myint KZ, Rattanasinganchan P, Moolthiya P et al. · 2025 · Preprint

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile duct epithelium. Alt-hough the CD44v6 splice variant is implicated in the progression of numerous cancers, its functional role and clinical relevance in CCA remain poorly…

View details →DOI: 10.20944/preprints202509.1220.v1
Negative / Null Result ReportMedicine

SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study.

Velez MP, Treacy K, Shellenberger J et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18-44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from…

View details →DOI: 10.1016/j.jogc.2025.103159
Negative / Null Result ReportMedicine

25-Hydroxyvitamin D levels are associated with mortality and cardiovascular events in systemic lupus erythematosus.

Assawasaksakul T, Fava A, Goldman D et al. · 2026 · Annals of the rheumatic diseases

Objectives We assessed the association between 25-hydroxyvitamin D (25(OH)D) levels and rates of mortality and cardiovascular events (stroke, myocardial infarction, angina/bypass) in patients with systemic lupus erythematosus (SLE).…

View details →DOI: 10.1016/j.ard.2025.10.013
Negative / Null Result ReportMedicine

The role of susceptibility weighted imaging as a substitute to post-contrast T1-weighed images in detection of active multiple sclerosis lesions.

Rashad Ali F, Teiba MK, Sheha AS et al. · 2026 · Clinical radiology

Background and purpose Magnetic susceptibility levels of multiple sclerosis plaques increase as they convert from the active enhancing stage to the chronic or inactive nonenhancing stages. The purpose of our study was to discern whether a…

View details →DOI: 10.1016/j.crad.2025.107127
Negative / Null Result ReportOpen accessMedicine

Evaluation of the therapeutic value of conventional transpedal lymphography for the treatment of inguinal lymphatic fistulas after lymphadenectomy.

Wolfram C, Vogl TJ, Eichler K et al. · 2026 · CVIR endovascular

Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy and to determine whether therapeutic success is…

View details →DOI: 10.1186/s42155-026-00713-8
Negative / Null Result ReportMedicine

Ultrafine particles and black carbon concentrations and determinants in aircraft cabins of a French airline: Paris-aircraft study.

Laporte MC, Mullot JU, Hlal R et al. · 2025 · Environment international

People are spending increasing amounts of time on airplanes. Nevertheless, few studies have characterized the concentrations of ultrafine particles (UFP) and black carbon (BC) in aircraft cabins, which are particulate pollutants known to…

View details →DOI: 10.1016/j.envint.2025.109905
Negative / Null Result ReportMedicine

Chymotrypsin B2 (CTRB2) Deletion Variant Induces Endoplasmic Reticulum Stress but does not Increase Risk for Chronic Pancreatitis.

Demcsák A, Hegyi E, Hegyi P et al. · 2025 · Pancreas

Objectives CTRB2-del, a commonly occurring loss-of-function deletion variant in the CTRB2 gene encoding chymotrypsinogen B2 was shown to induce endoplasmic reticulum (ER) stress and increase risk for pancreatic cancer but not for chronic…

View details →DOI: 10.1097/mpa.0000000000002538
Negative / Null Result ReportMedicine

The Relationships Between Cochlear Nerve Health and AzBio Sentence Scores in Quiet and Noise in Postlingually Deafened Adult Cochlear Implant Users.

Gao Z, Yuan Y, Oleson JJ et al. · 2026 · Ear and hearing

Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users. Design Study…

View details →DOI: 10.1097/aud.0000000000001779
Negative / Null Result ReportMedicine

The association between body mass index and treatment outcomes in major depressive disorder: a CAN-BIND-1 study.

Kim HK, Jones BDM, Hahn MK et al. · 2026 · Journal of psychiatric research

Being overweight is commonly observed in patients with major depressive disorder (MDD). However, the relationship between body weight and treatment outcomes in MDD is less clear. In this context, we examined the association between BMI and…

View details →DOI: 10.1016/j.jpsychires.2026.03.036
Negative / Null Result ReportMedicine

Beyond appearance: Cultural and psychometric validation of the Thai broad conceptualization of beauty scale using bifactor ESEM.

Jinchang K, Jarunratanakul P · 2025 · Body image

Expanding conceptualizations of beauty can promote positive body image and reduce appearance-related concerns. In collectivist cultures, beauty is often perceived through both appearance and inner or social qualities. This study examined…

View details →DOI: 10.1016/j.bodyim.2025.101964
Negative / Null Result ReportMedicine

Lack of association between chronological age and fisher group and poor outcomes in older patients with severe-grade aneurysmal subarachnoid hemorrhage: a nationwide registry study in Japan.

Suzuki K, Sato H, Sorimachi T et al. · 2025 · Neurosurgical review

Older age and Fisher group scores predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, among aging societies, treatment indications and decisions in older patients with severe-grade aSAH (World…

View details →DOI: 10.1007/s10143-025-03638-3