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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21697 results · page 212 of 724

Negative / Null Result ReportMedicine

Elevated serum calprotectin levels in major depressive disorder: no evidence of association with S100A9 rs3014866 polymorphism.

Akbas F, Baykan O, Avcikurt AS et al. · 2026 · BMC psychiatry

Background Major depressive disorder (MDD) has been increasingly associated with low-grade inflammation, with neutrophils playing a central role. Calprotectin is a mainly neutrophil-derived inflammatory mediator. We investigated whether…

View details →DOI: 10.1186/s12888-026-08161-3
Negative / Null Result ReportMedicine

Perinatal outcomes in normotensive versus hypertensive HELLP syndrome.

Anteby M, Wertheimer KO, Dominsky O et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a…

View details →DOI: 10.1002/ijgo.71073
Negative / Null Result ReportMedicine

Chronological age does not predict poor outcomes after neoadjuvant chemoradiotherapy for rectal cancer: a retrospective study.

Otowa Y, Matsuda T, Ando M et al. · 2026 · Surgery today

Background The benefit of neoadjuvant chemoradiotherapy (NACRT) for elderly patients with locally advanced rectal cancer (LARC) remains unclear because these patients are often excluded from trials. We evaluated the safety and oncologic…

View details →DOI: 10.1007/s00595-026-03306-z
Negative / Null Result ReportMedicine

Feasibility of a Noninvasive Core Temperature Sensor and the Effects of Combined Cooling on Thermal Strain and Performance in Beach Volleyball.

Hu X, Murakami G, Hasegawa H · 2026 · International journal of sports physiology and performance

Purpose This study evaluated the practical feasibility of the CORE sensor for noninvasive tracking of changes in estimated core body temperature (Est-Tcore) during simulated beach volleyball match-play in the heat and examined the effects…

View details →DOI: 10.1123/ijspp.2025-0588
Negative / Null Result ReportMedicine

Randomized controlled trial investigating the efficacy of oral azithromycin in preventing perinatal infections in pregnant women undergoing labor induction.

Cao H, Zhou Y, Gu N et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objectives This study evaluates oral azithromycin's effectiveness in reducing intrapartum and puerperal infection rates in term pregnant women undergoing labor induction to guide antibiotic prophylaxis. Methods This single-center…

View details →DOI: 10.1002/ijgo.71083
Negative / Null Result Report

The Value of Cervical Length Changes for the Prediction of Preterm Birth with Normal Mid-Trimester Cervical Length; a Prospective Longitudinal Study

Cekic SG, Unal C, Benlioglu C et al. · 2026 · Preprint

Abstract Background The purpose of the study is to evaluate whether the change in cervical length (ΔCx) between the first and second trimesters can predict spontaneous preterm birth (sPTB) in women with a normal mid-trimester cervical…

View details →DOI: 10.21203/rs.3.rs-8827201/v1
Negative / Null Result ReportMedicine

Association between CT-evaluated Poststenotic Dilatation in Human Renal Artery Stenosis and Kidney Release of MCP-1.

Al Saeedi M, Abdurakhimova DA, Arabi T et al. · 2026 · Radiology

Background Renal artery stenosis (RAS) can trigger the development of renal damage and poststenotic dilatation (PSD). However, the clinical relevance and mechanisms are ill-characterized. Purpose To characterize the mechanisms underlying…

View details →DOI: 10.1148/radiol.252637
Negative / Null Result ReportMedicine

Therapeutic effects of selumetinib on diffuse neurofibroma and optic pathway glioma in neurofibromatosis type 1.

Hwang S, Kim PH, Kim H et al. · 2026 · Journal of neuro-oncology

Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic pathway…

View details →DOI: 10.1007/s11060-026-05643-y
Negative / Null Result ReportMedicine

Serum but not cerebrospinal fluid biomarkers are associated with domain-specific cognitive performance in PWH.

Vuaran E, Trunfio M, Russo M et al. · 2026 · Journal of neurovirology

INTRODUCTION: Blood biomarkers would be the ideal tool in routine practice in early identifying People With HIV (PWH) with low cognitive performance (LNP). We aimed to assess the diagnostic performance of neurodegeneration and brain injury…

View details →DOI: 10.1007/s13365-025-01288-1
Negative / Null Result ReportMedicine

Effectiveness and safety of treatment for heterozygous familial hypercholesterolaemia and multifactorial dyslipidaemia in children: an overview of systematic reviews.

Le Thi TG, Geist M, Novosad Y et al. · 2026 · European journal of preventive cardiology

Aims This overview of systematic reviews (SRs) summarizes evidence on effectiveness and safety of treatment for paediatric heterozygous familial hypercholesterolaemia (heFH) and multifactorial dyslipidaemia (MFD). Methods and results…

View details →DOI: 10.1093/eurjpc/zwag125
Negative / Null Result ReportMedicine

Clinical and microbiological characteristics of multidrug-resistant acute bacterial endophthalmitis after cataract surgery. Endophthalmitis Management Study Report # 8.

Das T, Belenje A, Joseph J et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose Report the clinico-microbiological characteristics of multidrug-resistant acute postcataract bacterial endophthalmitis. Methods Consecutive 32 cases from a prospective multicenter study in India were analyzed for the clinical…

View details →DOI: 10.1097/iae.0000000000004696
Negative / Null Result ReportMedicine

Supervised exercise and pelvic floor muscle training eases current pelvic and genital pain but not worst pelvic and genital pain in women with endometriosis: a randomised trial.

Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy

Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…

View details →DOI: 10.1016/j.jphys.2025.09.012
Negative / Null Result ReportMedicine

Does Auditory Stimulation Matter? A Single-Subject Design Examining the Active Ingredients Within a Modified Cycles Approach.

Redman N, Brumbaugh K, Farquharson K · 2025 · Seminars in speech and language

This investigation compared the effectiveness of the Cycles Approach with and without auditory stimulation. Using an alternating treatment design (AATD), three preschool-aged children with severe phonological disorders received a modified…

View details →DOI: 10.1055/a-2719-4944
Negative / Null Result Report

Perineural Invasion as a High-Risk Feature Is Not a Predictive Biomarker for Postoperative Adjuvant Radiotherapy in Stage II Low Rectal Cancer: A Retrospective Analysis of a Real-World Cohort

Li X, Yan M, Li T et al. · 2025 · Preprint

Abstract Background Perineural invasion (PNI), though reported with varying incidence in rectal cancer, is a recognized marker of adverse prognosis. While postoperative adjuvant radiotherapy is a cornerstone of multidisciplinary management…

View details →DOI: 10.21203/rs.3.rs-8387361/v1
Negative / Null Result ReportMedicine

The utility of global versus domain-specific neuropsychological test score dispersion as markers of cognitive impairment.

Fatima H, Schaffert J, Carlew AR et al. · 2025 · The Clinical neuropsychologist

Objective Cognitive dispersion (CD) or neuropsychological test score variability has been associated with more rapid cognitive decline, and the development of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The predictive…

View details →DOI: 10.1080/13854046.2025.2577149
Negative / Null Result ReportMedicine

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir-ritonavir in patients with COVID-19.

Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology

Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…

View details →DOI: 10.1002/bcp.70507
Negative / Null Result ReportMedicine

Vocal Fundamental Frequency and Generalized Anxiety Disorder: Insights from a Large Multi-Country Cohort in Africa.

Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…

View details →DOI: 10.1016/j.jvoice.2026.03.014
Negative / Null Result ReportMedicine

Impact of Bariatric Surgery on Gout Medication: a Nationwide Cohort Study.

Kwon Y, Park J, Kim D et al. · 2026 · Obesity surgery

Background While bariatric surgery (BS) is an effective treatment for gout in patients with morbid obesity, little is known about how BS influences subsequent use of gout medications. We investigated the impact of BS on gout medication…

View details →DOI: 10.1007/s11695-025-08445-9
Negative / Null Result ReportMedicine

Inter-joint coordination and coordination variability during gait differentiate copers from noncopers in males with anterior cruciate ligament deficiency.

Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics

Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…

View details →DOI: 10.1016/j.jbiomech.2026.113416
Negative / Null Result ReportMedicine

Relationship Between Changes in Intestinal Desulfovibrio Levels and Oxygen Desaturation in Patients With Obstructive Sleep Apnea Syndrome.

Sınır B, Ortan P, Sayin SS et al. · 2026 · Respiratory medicine

Purpose Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and sleep fragmentation, which may alter gut microbiota composition. We primarily aimed to compare intestinal Desulfovibrio detection/abundance between patients…

View details →DOI: 10.1016/j.rmed.2026.108986
Negative / Null Result Report

Behavioral and Physiological Welfare Responses of Rhode Island Red Hens Reared in Individual Cage, Colony Cage and Deep-Litter Systems

Kumar A, Sinha RRK, Sahu SP et al. · 2026 · Preprint

Abstract The present experiment was conducted to compare three housing systems Individual cages, Colony cages and Deep litter on welfare, behaviour, and physiological traits in Rhode Island Red laying hens under tropical conditions. A…

View details →DOI: 10.21203/rs.3.rs-9950223/v1
Negative / Null Result ReportMedicine

Impact of application repetition on Joule heating and lesion formation using a circular-shaped pulsed field catheter.

Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…

View details →DOI: 10.1007/s10840-026-02379-7
Negative / Null Result ReportMedicine

Clinical study of the superthin anterolateral thigh flap for reconstruction of post-traumatic ankle joint soft-tissue defects.

Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…

View details →DOI: 10.1053/j.jfas.2026.06.019
Negative / Null Result ReportMedicine

Efficacy and Safety of an Innovative Intraoral Cleaning Device-A Randomized Controlled Clinical Trial.

Steuber T, Graetz C, Springer C et al. · 2026 · International journal of dental hygiene

Objective This two-centre, double-blind, randomized, parallel-group study compared the efficacy and safety of a novel powered full-mouth cleaning device system (FMCD) with habitual toothbrushing (CG) in patients with generalized gingivitis…

View details →DOI: 10.1111/idh.70116
Negative / Null Result ReportMedicine

Comparing Clinical and Radiological Outcomes for a Three-Dimensional Printed Highly-Porous Cup and a Hydroxyapatite-Coated Non-Highly-Porous Cup in Total Hip Arthroplasty Using Propensity Score Matching.

Okazaki T, Imagama T, Matsuki Y et al. · 2026 · The Journal of arthroplasty

Background The use of highly-porous acetabular components in total hip arthroplasty (THA) has gained popularity. To elucidate the clinical and radiological outcomes of three-dimensional (3D)-printing highly porous cups, we compared…

View details →DOI: 10.1016/j.arth.2026.06.011
Negative / Null Result ReportMedicine

Determining the Impact of Race and Ethnicity on Diagnosis and Management of Vestibular Schwannoma.

Patel AA, Levi JR, Weber PC · 2026 · The Annals of otology, rhinology, and laryngology

Objective While prior literature has demonstrated that patients of lower socioeconomic groups may have larger tumors on presentation and poorer outcomes, there is limited literature on the impact of race and ethnicity on management of…

View details →DOI: 10.1177/00034894261453716