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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 211 of 661

Negative / Null Result ReportOpen accessMedicine

Transspinal direct current stimulation as targeted therapy to increase motor neuron output and restore inhibition in human spinal cord injury.

Sayed Ahmad AM, Knikou M · 2026 · Frontiers in neurology

Introduction In this clinical trial, we evaluated changes in the output of motoneurons and spinal inhibitory mechanisms across multiple spinal segments before and after a series of transspinal direct current stimulation (tsDCS) sessions in…

View details →DOI: 10.3389/fneur.2026.1773679
Negative / Null Result ReportOpen accessMedicine

Preclinical Analysis of Sex-Specific Differences in the Angiogenic and Inflammatory Tissue Response to Surgical Sutures.

Wrublewsky S, Weigl J, Bickelmann C et al. · 2026 · Journal of functional biomaterials

Surgical sutures are widely used biomaterials in clinical practice. Like all other biomaterials, they induce a foreign body response after implantation that involves inflammation and angiogenesis. Although it is well known that these…

View details →DOI: 10.3390/jfb17050233
Negative / Null Result ReportOpen accessMedicine

N95 filtering facepiece respirator fit assessment outcomes by gender, age, race, and facial hair in a community population sample.

Bagheri Hosseinabadi M, Yu M, Petersen A et al. · 2026 · Annals of work exposures and health

The necessity for respiratory protection has increased due to global threats such as pandemics, industrial accidents, and extreme weather events. The effectiveness of N95 filtering facepiece respirators depends on how well they fit the…

View details →DOI: 10.1093/annweh/wxag050
Negative / Null Result ReportMedicine

Comparable survival over an extended follow-up after on-pump versus off-pump coronary artery bypass grafting: a propensity score-matched cohort.

Pikkujämsä A, Rinne P, Wistbacka JO et al. · 2026 · BMC cardiovascular disorders

Background Long-term survival following off-pump coronary artery bypass grafting (OPCAB) compared with conventional on-pump coronary artery bypass grafting (ONCAB) remains uncertain. Randomised trials and meta-analyses up to 5-10 years…

View details →DOI: 10.1186/s12872-026-06117-9
Negative / Null Result ReportMedicine

Impact of music intervention on endoscopic retrograde cholangiopancreatography patients' pain, anxiety, and vital signs: a randomized controlled trial.

Çakır E, Ciğerci Y, Yılmaz S · 2026 · Scientific reports

This study aimed to evaluate the effects of a music intervention on anxiety, pain, and vital signs in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). This randomized controlled trial included 70 patients who…

View details →DOI: 10.1038/s41598-026-50809-3
Negative / Null Result ReportMedicine

Automated Rigo Classification: An Innovative Artificial Intelligence System.

Schmidt N, Johnson G, Nencka A et al. · 2026 · Studies in health technology and informatics

Although there is variation in clinicians' application of the Rigo classification system (RCS) to adolescent idiopathic scoliosis, no artificial intelligence (AI) models have been developed to standardize the RCS specifically. This study…

View details →DOI: 10.3233/shti260751
Negative / Null Result ReportOpen accessMedicine

Effects of Combined Extreme Warming and Drought on the Physiology and Growth of <i>Quercus variabilis</i> Blume Seedlings.

Lee SH, Jang JW, Han SH et al. · 2026 · Plants (Basel, Switzerland)

Climate change is intensifying extreme climatic events such as warming and drought. This study investigated the physiological and growth responses of Quercus variabilis , a major broadleaf plantation species in South Korea, to warming and…

View details →DOI: 10.3390/plants15091354
Negative / Null Result ReportMedicine

Three-year retinal and visual outcomes after ultraviolet- and blue light-filtering intraocular lenses.

Ceylan FA, Tatar Kartaloğlu O, Yılmaz İE · 2026 · Clinical & experimental optometry

Clinical relevance Intraocular lens selection following cataract surgery has implications beyond refractive correction, with different lens chromophore compositions potentially affecting retinal light exposure and downstream visual and…

View details →DOI: 10.1080/08164622.2026.2688367
Negative / Null Result ReportMedicine

Mid-term clinical outcomes of mobile-bearing UKA: a retrospective study on the influence of patellofemoral joint disease, lower limb alignment, and implant positioning.

Chen M, Zhang C, Fan Z et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) has become an effective treatment for medial compartment osteoarthritis of the knee. However, its use in patients who also have patellofemoral joint osteoarthritis (PFOA) before surgery…

View details →DOI: 10.1186/s12891-026-10086-7
Negative / Null Result ReportOpen accessMedicine

Deficit irrigation and grafting effects on soil attributes, vegetative growth, yield components, and quality of 'Crimson Seedless' grapevines under a semiarid region.

Salama AM, Al-Obeed RS, Helmy A et al. · 2026 · Frontiers in plant science

This study evaluated the combined effects of grafting and deficit irrigation (DI) on soil attributes, vegetative growth, yield components, fruit quality, and water productivity of 'Crimson Seedless' grapevines under semiarid conditions. It…

View details →DOI: 10.3389/fpls.2026.1785340
Negative / Null Result ReportOpen accessMedicine

Fiber-to-stone distance and fragment size with holmium laser lithotripsy.

Glienke L, Hall TL, Ghani KR et al. · 2026 · Urolithiasis

Control of fragment size during laser lithotripsy has taken on increasing importance with adoption of ureteroscopic aspiration technologies. The objective of this study was to characterize the relationship between laser-fiber-to-stone…

View details →DOI: 10.1007/s00240-026-01970-x
Negative / Null Result ReportMedicine

Effect of ulnar positive variance on outcomes after arthroscopic transosseous repair of palmer 1B TFCC foveal tears.

Won JH, Shin JW, Kwon J et al. · 2026 · Journal of orthopaedic surgery and research

Purpose To determine whether ulnar positive variance (UPV) and relative ulnar positive variance (RUPV) affect clinical outcomes following arthroscopic transosseous repair of triangular fibrocartilage complex (TFCC) foveal tears. Methods…

View details →DOI: 10.1186/s13018-026-07010-z
Negative / Null Result ReportMedicine

Influence of surface treatment and cement type on the bond strength of additively manufactured permanent resin materials.

Diken Türksayar AA, Öztemel N, Yeşil Kurt İB et al. · 2026 · Odontology

This study evaluated the shear bond strength (SBS) of two dual-cure resin cements to a stereolithography-fabricated 3D-printed permanent crown material after various surface pretreatment protocols. Disc-shaped specimens were fabricated…

View details →DOI: 10.1007/s10266-026-01464-7
Negative / Null Result ReportMedicine

Comparison of the efficacy of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of double-level lumbar spondylolisthesis combined with spinal stenosis: a retrospective comparative study.

Ma Z, Luan H, Abulimiti K et al. · 2026 · BMC surgery

Objective To compare the clinical and radiographic outcomes of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of double-level lumbar spondylolisthesis combined with spinal…

View details →DOI: 10.1186/s12893-026-03917-w
Negative / Null Result ReportMedicine

Correlation between swallowing and diaphragmatic functions in stroke patients with hemiplegia: a cross-sectional observational study.

Liu X, Zhao J, Wu Y et al. · 2026 · Scientific reports

Swallowing and diaphragmatic functions share neural regulatory pathways and require synchronous assessment. Patients who have had a stroke are susceptible to many complications, of which dysphagia and diaphragmatic dysfunction are…

View details →DOI: 10.1038/s41598-026-50341-4
Negative / Null Result ReportMedicine

The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Sullivan M, Perea LL, Bradburn E et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture. Methods Design Prospective, double-blinded,…

View details →DOI: 10.1097/bot.0000000000003172
Negative / Null Result ReportOpen accessMedicine

A comparative study of clinical efficacy, electrophysiological outcomes, and perioperative parameters between endoscopic carpal tunnel release and open carpal tunnel release for carpal tunnel syndrome.

Zhang Z, Liu Y, Yang H et al. · 2026 · Frontiers in cellular neuroscience

Purpose To compare the clinical efficacy of endoscopic (ECTR) and open (OCTR) carpal tunnel release for carpal tunnel syndrome (CTS) and provide evidence-based surgical guidance. Methods A retrospective cohort study was conducted including…

View details →DOI: 10.3389/fncel.2026.1845917
Negative / Null Result ReportOpen accessMedicine

Comparison of the Bond Strength of Silane-Treated Glass Fiber Posts at Different Solvent Evaporation Times: An In Vitro Study.

Ramos-Ramos V, Dextre-Herrera S, Ramírez-Vargas G et al. · 2026 · Journal of clinical and experimental dentistry

Background Silane is used as a coupling agent on glass fiber posts to enhance chemical interaction at the post-resin cement interface. This in vitro study evaluated the bond strength of silane-treated glass fiber posts at different solvent…

View details →DOI: 10.4317/jced.63939
Negative / Null Result ReportOpen accessMedicine

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.

Hassania Y, Hassanpour S, Zendehdel M et al. · 2026 · Poultry science

This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups. In experiment 1,…

View details →DOI: 10.1016/j.psj.2026.107042
Negative / Null Result ReportMedicine

Effect of common children's beverages on surface properties of single-shade and restorative material: an in vitro study.

Almutairi M, Mousa I, Alqahtani R et al. · 2026 · Scientific reports

Single-shade composite restorations can adapt to the tooth structure, improve esthetics, and reduce reliance on shade selection. The objective of this study was to assess the effect of four different children's beverages on the color…

View details →DOI: 10.1038/s41598-026-55540-7
Negative / Null Result ReportMedicine

Face-To-Face Vs. Online Behavioral Parent Training for Young Children with ADHD: Child and Parent Outcomes.

DuPaul GJ, Kern L, Dever BV et al. · 2026 · Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Objective Behavioral parent training is a first-line psychosocial intervention for young children with Attention-Deficit/Hyperactivity Disorder. Traditional face-to-face delivery is limited by access to therapists, feasibility, and/or…

View details →DOI: 10.1080/15374416.2026.2687069
Negative / Null Result ReportOpen accessMedicine

The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding.

Wen B, Wu X, Ma X et al. · 2026 · Frontiers in immunology

The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the "triple therapy" regimen…

View details →DOI: 10.3389/fimmu.2026.1830573
Negative / Null Result ReportMedicine

[Colchicine in Cardiology Practice. Mechanisms of Influence on the Cardiovascular System, Use in the Treatment of Pericarditis and Ischemic Heart Disease].

Sukmarova ZN, Simonenko VB · 2025 · Kardiologiia

Despite significant advances in pharmacological, interventional, and surgical treatments for cardiovascular diseases (CVDs) in recent decades, it appeared that the effectiveness of standard treatments has reached a ceiling, and growing…

View details →DOI: 10.18087/cardio.2025.11.n3016
Negative / Null Result ReportMedicine

PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results.

Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews

Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…

View details →DOI: 10.1007/s10555-026-10314-5
Negative / Null Result ReportMedicine

Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: a Korean Association for the Study of Intestinal Diseases multicenter, randomized noninferiority trial.

Gweon TG, Kim SJ, Myung DS et al. · 2026 · Gastrointestinal endoscopy

Background and aims Insufficient submucosal lifting because of pretreatment with forceps biopsy frequently complicates endoscopic treatment of rectal neuroendocrine tumors (NETs) and potentially affects procedural outcomes. Despite…

View details →DOI: 10.1016/j.gie.2025.11.035
Negative / Null Result ReportMedicine

Anti-inflammatory agents for the management of COPD - Quo Vadis?

Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…

View details →DOI: 10.1016/j.rmed.2025.108396