Negative / Null Result ReportOpen accessBiochemistry
Rostami Shilan, Fathollahpour Asadollah, Abdi Mohammad et al. · 2018 · Journal of Medical Biochemistry
Background: There is a paucity of studies regarding oxidative balance and selenium (Se) status in congenital hypothyroidism. Recently, more attention has been given to the use of Se supplementation as a new treatment for thyroid disorders. Oxidative stress increases in different thyroid disorders and causes many pathological outcomes. The present study aimed to determine the serum prooxidant-antioxidant balance (PAB), Se, thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentration in congenital hypothyroidism (CH) patients and the association of their probable change with hematolo
Negative / Null Result ReportOpen accessPediatrics
Fatma Sargin, Mehmet Alçı, Büşra Kaygusuz Aydemir et al. · 2026 · BMC Pediatrics
Abstract Background Childhood epilepsy is one of the most common neurological disorders worldwide, significantly affecting cognitive, emotional, and social development. As caregivers often seek medical guidance online, the readability, understandability, and quality of internet-based patient education materials (IPEMs) are crucial for health literacy and decision-making. This study evaluates the readability, understandability, quality, and popularity of online pediatric epilepsy materials in relation to established health communication standards. Methods A Google search using the term ‘epileps
View details →DOI: 10.1186/s12887-026-06602-2 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Huanhuan Zuo, Xiaochen Xie, Jiahuan Peng et al. · 2019 · Analytical Cellular Pathology
Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the
View details →DOI: 10.1155/2019/5189165 Negative / Null Result ReportOpen accessNursing
Simone Maria Muniz da Silva Bezerra, Eduardo Tavares Gomes, Paulo César da Costa Galvão et al. · Revista Brasileira de Enfermagem
ABSTRACT Objective: To characterize relations between spiritual well-being and hope of patients in the preoperative period of cardiac surgery. Method: Exploratory cross-sectional study with quantitative approach, performed in the infirmaries of a reference hospital in cardiology. We evaluated 69 patients hospitalized in preoperative period of myocardial revascularization, valve repair or replacement. Results: We verified that patients hold relevant scores of hope and welfare in all areas, being the existential well-being significantly lower than the religious one. The average of the spiritual
View details →DOI: 10.1590/0034-7167-2016-0642 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Ovi Sofia, Muna Amalia, Herryanto Thomassawa et al. · 2024 · Interdisciplinary Perspectives on Infectious Diseases
Introduction. The imbalance of the immune response is an important factor contributing to the incidence of ocular toxoplasmosis (OT). Regulatory T cells (Treg) play a key role in maintaining the balance between Th1 and Th17 immune responses, while interleukin-27 (IL-27) levels are related to the differentiation of Th17 cells. This study analyzes the differences in the number of Treg cells and the level of IL-27 between OT patients and seropositive individuals without ocular lesions and its correlation with retinal lesion size. Methods. This analytic observational study, conducted for 8 months,
View details →DOI: 10.1155/2024/3495376 Negative / Null Result ReportOpen accessOrthopedic surgery
Neal Singleton, Vaughan Poutawera · 2017 · Journal of Orthopaedic Surgery
Aim: It has been reported in the literature that patients with poor preoperative mental health are more likely to have worse functional outcomes following primary total hip and knee arthroplasty. We could find no studies investigating whether preoperative mental health also affects length of hospital stay following surgery. The aim of this study was to determine whether preoperative mental health affects length of hospital stay and long-term functional outcomes following primary total hip and knee arthroplasty. We also aimed to determine whether mental health scores improve after arthroplasty
View details →DOI: 10.1177/2309499017718902 Negative / Null Result ReportOpen accessGynecology and obstetrics
Divya Anantharaman, Aiswaryah Radhakrishnan, Vidhyalakshmi Anantharaman · 2023 · Journal of Pregnancy
Aim. Multisystemic physiological changes in pregnancy can result in tear film and refractive changes in the eye. We report dry eye prevalence in pregnant women using Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Methods. The SPEED questionnaire was self-administered cross-sectionally to 428 pregnant women (mean age: 26.8±4.4 years) with clinically confirmed pregnancy from two obstetric clinics in Chennai, India. Subjects with predisposing risk factors for dry eye were excluded from the study. Subjects were categorized as normal, moderate, and severe dry eye based on the SPE
View details →DOI: 10.1155/2023/3421269 Negative / Null Result ReportOpen accessGeneral. Including nature conservation, geographical distribution
Jennifer L. Reidy, Lisa O'Donnell, Frank R. Thompson III · 2015 · Wildlife Society Bulletin
ABSTRACT It is critically important to determine and understand relationships between endangered species populations and landscape and habitat features to effectively manage and conserve populations and the habitats they rely on. Several recent studies focused on the golden‐cheeked warbler (Setophaga chrysoparia), an endangered songbird that breeds exclusively in central Texas, USA, have used a reproductive index to link pairing and breeding success to various factors of interest. However, no field test has evaluated the performance of a reproductive index at estimating productivity of golden‐
View details →DOI: 10.1002/wsb.576 Negative / Null Result ReportOpen accessMedicine
Fithria Aldy, Gema Nazri Yanni, Jelita Siregar · 2024 · Majalah Kedokteran Bandung
Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study ap
View details →DOI: 10.15395/mkb.v56.3281 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Filippo Mandelli, Filippo Mandelli, Filippo Mandelli et al. · 2021 · Frontiers in Neurology
Objective: Fatty infiltration of paraspinal muscle is associated with spinal disorders. It can be assessed qualitatively (i.e., Goutallier classification) and quantitatively using image processing software. The aims of this study were to compare paraspinal muscle fatty infiltration as assessed using the Goutallier classification vs. quantitative magnetic resonance images (MRI) measurements and to investigate the association between anthropometric parameters and paraspinal muscle morphology and fatty infiltration in patients with symptomatic lumbar spinal stenosis (LSS).Methods: Patients affect
View details →DOI: 10.3389/fneur.2021.656487 Negative / Null Result ReportOpen accessDentistry
Guven Kayaoglu, Mügem Gürel, Hüma Ömürlü et al. · 2009 · Journal of Applied Oral Science
OBJECTIVE: The aim of this study was to evaluate the degree of microbial contamination in packaged gutta-percha cones before and during use in clinical conditions. MATERIAL AND METHODS: Sealed packages of #15-40 gutta-percha cones were opened under aseptic laboratory conditions. Two gutta-percha cones from each size were randomly drawn and added to tubes containing glass beads and 750 µL of saline. The tubes were vortexed, serially diluted and samples of 250 µL were cultured on agar plates. The plates were incubated at 37ºC for 3 days and colonies were counted. The initially sampled packages w
View details →DOI: 10.1590/s1678-77572009000300022 Negative / Null Result ReportOpen accessMedicine
Shreya Arora, Monica Gupta, Anita Tahlan et al. · 2022 · Journal of Dr. NTR University of Health Sciences
Background: Platelet count has been widely used to evaluate the severity, guide management and predict outcome in patients with dengue fever. This sole use, however, has prevented the utility of other platelet indices like Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) from being explored. Objectives: To study the association of MPV and PDW with the disease severity in patients with dengue fever. Materials and Methods: This prospective observational study was conducted in a tertiary care centre of Northern India for a period of one year. A total of 100 patients with confirmed
View details →DOI: 10.4103/jdrntruhs.jdrntruhs_182_22 Negative / Null Result ReportOpen accessMedicine
Zuraini Mohammad Nasir, Sethu Thakachy Subha · 2021 · International Archives of Otorhinolaryngology
Introduction Foreign body aspiration is a leading cause of accidental death in children. Clinical presentation varies from non-specific respiratory symptoms to respiratory failure making diagnosis challenging. Objective To review pediatric patients who underwent bronchoscopy due to suspicion of foreign body aspiration at a tertiary center in Malaysia. Methods We retrospectively studied patients < 11 years old who underwent bronchoscopy from 2008 to 2018. Results Over the 10-year period, 20 patients underwent bronchoscopy, and 16 were found to have foreign body aspiration with equal gender dist
View details →DOI: 10.1055/s-0040-1709739 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira et al. · 2014 · Gastroenterology Research and Practice
Objectives. Small bowel capsule endoscopy (SBCE) plays a decisive role in the obscure gastrointestinal bleeding (OGIB) diagnosis. Antithrombotics may increase bleeding risk in patients with preexistent lesions or through direct mucosal aggression. We aimed to correlate antithrombotics usage with lesions with bleeding potential found in SBCE. Methods. Retrospective single-center study including 274 consecutive SBCE performed over 7 years for OGIB. The lesions were classified as P0 (no bleeding potential), P1 (uncertain bleeding potential: erosions), and P2 (high bleeding potential: angioectasia
View details →DOI: 10.1155/2014/709217 Negative / Null Result ReportOpen accessScience (General)
Xin Wang, Chen Li, Ming Li et al. · 2024 · Heliyon
Objective: Serum lactate (LA) and lactate dehydrogenase (LDH) levels have a major impact on the clinical treatment of malignant tumors and critically ill patients. Nevertheless, the assessment of disease severity in oncology patients admitted to the intensive care unit (ICU) remains incomplete when considering the serum LA and LDH levels. This study aimed to investigate the significance of serum LDH and LA levels in assessing disease severity and predicting clinical outcomes in patients with colorectal cancer (CRC) admitted to the ICU. Methods: This retrospective study included patients with C
View details →DOI: 10.1016/j.heliyon.2023.e23608 Negative / Null Result ReportOpen accessMedicine
Janan G. Hasan · 2010 · The Medical Journal of Basrah University
ABSTRACT Background: Abnormal blood lipid profiles have been associated with many malignant diseases especially in children with acute lymphoblastic leukemia on L-asparaginase therapy Objective: To investigate the frequency and clinical significance of altered lipid profiles in children with Acute lymphoblastic leukemia (ALL) on L-asparaginase therapy Patients and Methods: A prospective study was carried out between February 2008 till January 2009 on a total of 50 patients with recently diagnosed and non-treated acute lymphoblastic leukemia who were admitted to pediatric oncology unit at Basra
View details →DOI: 10.33762/mjbu.2010.49464 Negative / Null Result ReportOpen accessBiology (General)
Robert Stawski, Konrad Walczak, Ewelina Perdas et al. · 2021 · Biology
Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker. After PAD4 mediated hypercitrullination extracellular H3Cit exhibits high toxicity contributing to tissue damage which, in cases of systemic inflammation, may lead to multiorgan failure and finally to death. We tested whether circulating histones rise in response to strenuous exercise. Eleven average-trained men performed three treadmill exercise tests to exhaustion at speed correspond
View details →DOI: 10.3390/biology10030181 Negative / Null Result ReportOpen accessPsychiatry
O. Elleuch, M. Maalej, W. Guidara et al. · 2023 · European Psychiatry
Introduction The pathophysiology of bipolar disorder (BD) is complex and remains uncertain to this day. Several hypotheses have been suggested, including the involvement of inflammatory mechanisms in its pathogenesis and in eventual cognitive impairment. C-reactive protein (CRP) is one of the most commonly used inflammatory markers. High-sensitivity CRP (hs- CRP) is a more sensitive marker. Objectives We aimed to examine hs-CRP levels in patients with BD, and to investigate its relationship with cognitive functions. Methods We conducted a cross-sectional study between June 2016 and July 2018 o
View details →DOI: 10.1192/j.eurpsy.2023.1482 Negative / Null Result ReportOpen accessMedicine
Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi et al. · 2022 · PLoS ONE
Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with childhood and adult asthma in many populations including the Jordanian population. It is also known that IgE plays a crucial role in various allergic disorders, such elevated levels of total serum IgE were detected in asthma and allergic rhinitis. IgE immunoglobulin is responsible for the release of numerous inflammatory mediators, such as histamine and prostaglandins, from mast cells in asthmatic patients. Objective In this study, single nucleotide polymorphisms of GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C
View details →DOI: 10.1371/journal.pone.0274951 Negative / Null Result ReportOpen accessGeophysics. Cosmic physics
Liyu ZHANG, Donghua YOU, Rong LI et al. · 2025 · Shiyou shiyan dizhi
In recent years, multiple wells in the Sichuan Basin have produced industrial gas from the marlstone/marl-bearing limestone strata in the first member of the Middle Permian Maokou Formation (Mao 1), demonstrating promising exploration potential. Previous studies have suggested that the marlstone/marl-bearing limestone in Mao 1 exhibits self-generation and self-storage characteristics, forming low-porosity, low-permeability fracture-porosity type tight carbonate reservoirs with diverse storage spaces. Notably, diagenetic shrinkage pores and fractures formed during the transformation of sepiolit
View details →DOI: 10.11781/sysydz2025050974 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yingpu Cui, Yingpu Cui, Yaobin Lin et al. · 2022 · Frontiers in Immunology
PurposeTo develop a comprehensive PET radiomics model to predict the pathological response after neoadjuvant toripalimab with chemotherapy in resectable stage III non-small-cell lung cancer (NSCLC) patients.MethodsStage III NSCLC patients who received three cycles of neoadjuvant toripalimab with chemotherapy and underwent 18F-FDG PET/CT were enrolled. Baseline 18F-FDG PET/CT was performed before treatment, and preoperative 18F-FDG PET/CT was performed three weeks after the completion of neoadjuvant treatment. Surgical resection was performed 4–5 weeks after the completion of neoadjuvant treatm
View details →DOI: 10.3389/fimmu.2022.994917 Negative / Null Result ReportOpen accessMedicine
M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology
BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…
View details →DOI: 10.1016/j.ijcard.2016.04.064 Negative / Null Result ReportOpen accessMedicine
V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research
CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…
View details →DOI: 10.4103/0970-9290.156792 Negative / Null Result ReportOpen access
Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science
Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…
View details →DOI: 10.47836/pjtas.46.4.18 Negative / Null Result ReportOpen accessMedicine
S. Lipshultz, Paige L. Williams, B. Zeldow et al. · 2015 · AIDS (London)
Objectives:We evaluated the potential cardiac effects of in-utero exposures to antiretroviral drugs in HIV-exposed but uninfected (HEU) children. Design and methods:We compared echocardiographic parameters of left ventricular function…
View details →DOI: 10.1097/qad.0000000000000499 Negative / Null Result ReportMedicine
James K. Gabriels, M. Abdelrahman, Lakshmi Nambiar et al. · 2021 · Heart Rhythm
BACKGROUND Electrocardiographic (ECG) criteria have been proposed to localize the site of origin (SOO) of outflow region ventricular arrhythmias (VAs). Many factors influence the QRS morphology of VAs and may limit the accuracy of these…
View details →DOI: 10.1016/j.hrthm.2021.08.003 Negative / Null Result ReportMedicine
J. Stoeckle, S. Poland, H. Maynard et al. · 2024 · JCO Precision Oncology
PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New…
View details →DOI: 10.1200/po.23.00463 Negative / Null Result ReportOpen accessMedicine
Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity
This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…
View details →DOI: 10.1038/oby.2008.364 Negative / Null Result ReportMedicine
Somaye Y. Zare, Leo I. Lin, Abrar Alghamdi et al. · 2018 · American Journal of Surgical Pathology
At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an…
View details →DOI: 10.1097/pas.0000000000001106 Negative / Null Result ReportOpen accessMedicine
Guofeng Guo, Zhaoqi Huang, Shixiang Wang et al. · 2020 · Medicine
Abstract To investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and coronary artery severity in acute coronary syndrome patients of different sexes. A total of 134 patients…
View details →DOI: 10.1097/md.0000000000019653 