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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 198 of 661

Negative / Null Result ReportOpen accessChemistry

PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation

Tóth Štefan, Olexa Peter, Hertelyová Zdenka et al. · 2020 · Open Chemistry

The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cI

View details →DOI: 10.1515/chem-2020-0147
Negative / Null Result ReportOpen accessMedicine (General)

Correlation Between Duration of Screen Time and Method of Handling Smartphone Towards The Incidence of De Quervain’s Syndrome among The Medical Students of Diponegoro University.

Indra Hidayat, Erna Setiawati, Tanti Ajoe Kesoema et al. · 2023 · Jurnal Kedokteran Diponegoro

Background: Smartphone with all of its benefits make the majority of its users become too attached with the device that can fulfil their various needs. Due to its accessibility, an increase of daily screen time has also been observed which may have negative impacts on health, one of them being De Quervain’s Syndrome. De Quervain’s Syndrome is a type of Repetitive Strain Injury, affecting the thumb and wrist caused by a repetitious activity that puts burden or trauma to the aforementioned body parts. Objective: To assess the correlation between duration of screen time and method of handling sma

View details →DOI: 10.14710/dmj.v12i6.39048
Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities

The Effect of Robotics and Coding Education on Girls’ STEM Motivation, Attitude and Career Aspirations

Salih Gülen, İsmail Dönmez, Fatma Betül Şengönül et al. · 2025 · SAGE Open

STEM education aims to develop 21st-century skills, support economic growth and promote gender equality in STEM fields. It is known that gender stereotypes play a significant role in the formation of STEM identity. The most important factor preventing some high school-level female students from pursuing STEM careers is their lack of participation in STEM activities. Female students in high schools have limited opportunities to explore or learn about STEM careers due to the emphasis on verbal and religious courses in their curriculum. However, it is known that women can work more autonomously i

View details →DOI: 10.1177/21582440251382631
Negative / Null Result ReportOpen accessMedicine

Microperimetry – A New Tool for Assessing Retinal Sensitivity in Macular Diseases

Memota Laishram, Krishnagopal Srikanth, AR Rajalakshmi et al. · 2017 · Journal of Clinical and Diagnostic Research

Introduction: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. Aim: To study the retinal sensitivity changes in macular diseases using microperimetry. Materials and Methods: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital. This study was started from December 2014 until June 2016, in all patients with m

View details →DOI: 10.7860/jcdr/2017/25799.10213
Negative / Null Result ReportOpen accessDiseases of the respiratory system

Systemic inflammatory response to inhaled endotoxin does not correlate with airway response

Amika K. Sood, Allison J. Burbank, Michael Lawson et al. · 2019 · Respiratory Research

Abstract Background Endotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation challenge reproducibly triggers neutrophilic inflammation in the airways and in peripheral blood. Sputum induction is currently the only available method for assessing airway neutrophilia but is laborious and time-consuming. This analysis examined the correlation between systemic and airway inflammatory responses to endotoxin to determine if peripheral blood could serve as a surrogate marker for neutrophilic airway inflammation. Methods We

View details →DOI: 10.1186/s12931-019-1227-3
Negative / Null Result ReportOpen accessNuclear engineering. Atomic power

Evaluation of influence of dissolved oxygen on corrosion behaviors of FeCrW model alloys in 360 °C water

Jun Yeong Jo, Chi Bum Bahn, Hwasung Yeom · 2024 · Nuclear Engineering and Technology

The dissolved oxygen in a coolant can affect the oxidation properties of structural materials. A desirable oxide phase formation is achieved by manipulating the oxygen level in the coolant, which can mitigate structural material degradation in nuclear power plants. Therefore, the role of dissolved oxygen in the corrosion of structural materials in aqueous environments needs to be understood. In this study, a short-term corrosion test (up to 300 h) of Ferritic/Martensitic steels (F/M steels; FeCrW model alloys), namely, Fe12Cr1W, Fe9Cr1W, and Fe9Cr, in stagnant water at 360 °C was performed in

View details →DOI: 10.1016/j.net.2024.06.002
Negative / Null Result ReportOpen accessAnimal culture

Comparison of KIT patterns and infiltration of eosinophils in canine mast cell tumor

C.D. Araújo, G.S. Sanches, F. Borek et al. · 2023 · Arquivo Brasileiro de Medicina Veterinária e Zootecnia

ABSTRACT KIT protein is associated with the etiology of canine mast cell tumors (MCT); however, the expression patterns of KIT are highly variable. The aim of this study was to determine if KIT patterns are related with eosinophil count in MCT. Hematoxylin eosin and May Grünwald-Giemsa stain techniques were applied, histological grading and eosinophil counting were performed in 48 MCT samples. Immunohistochemical evaluation was performed with IL-5, VEGFr, and c-KIT antibodies. The percentage of immunolabeling with IL-5 and VEGFr was determined, and the samples incubated with c-KIT were graded

View details →DOI: 10.1590/1678-4162-12963
Negative / Null Result ReportOpen accessMedicine (General)

Plasma Level of Oxidized Low- Density Lipoprotein in Macroalbuminuric

Manoochehr Nakhjavani, Firouzeh Asgarani, Fatemeh Esfahanian et al. · 2009 · Acta Medica Iranica

Accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. To evaluate the association of oxidized low- density lipoprotein (ox-LDL) with the development of diabetic nephropathy, plasma level of ox-LDL were measured in 70 diabetic patients with macro and 63 patients with normoalbuminuria. The plasma oxidized- LDL level in patients with macroalbuminuria was higher than those in normoalbuminuric group, (85.72 ± 32.92 mu/L versus 75.07 ± 26.46 u/L, P= 0.041).

Negative / Null Result ReportOpen accessDentistry

Correlation between salivary zinc levels and salivary volume on taste disorders in elderly patients

Dewi Kania Intan Permatasari, Tenny Setiani Dewi, Dewi Marhaeni Diah Herawati · 2021 · Dental Journal

Background: Taste disorders often occur in the elderly, which can have serious consequences on their health status. Zinc and saliva volume have a role in maintaining taste acuity, especially in the elderly. Purpose: This study was to determine the correlation between salivary zinc levels, salivary volume, and taste disorders in elderly patients. Methods: This was a cross-sectional research. Elderly patients with and without taste disorders were included in this study. Salivary zinc levels were measured using the Atomic Absorption Spectrometry (AAS) method. Salivary volume was measured using th

View details →DOI: 10.20473/j.djmkg.v54.i1.p31-34
Negative / Null Result ReportOpen accessInfectious and parasitic diseases

Adherence to pre-exposure prophylaxis among men who have sex with men: A prospective cohort study

Dou Qu, Xiaoni Zhong, Guiyuan Xiao et al. · 2018 · International Journal of Infectious Diseases

Objective: To evaluate adherence to pre-exposure prophylaxis (PrEP) in a clinical trial of a population of men who have sex with men (MSM), to explore the influence of social psychology and objective factors (e.g., forgetting, too busy) on adherence, and to provide evidence for subsequent PrEP research. Methods: This study analyzed the data from the daily medication group within a PrEP study (a randomized placebo-controlled trial of oral tenofovir among MSM in Western China from April 2013 to March 2015). A total of 331 participants were analyzed. PrEP adherence was self-reported by the subjec

View details →DOI: 10.1016/j.ijid.2018.08.006
Negative / Null Result ReportOpen accessMedicine

Sensitivity of Romberg Test in Diagnosis of Peripheral Vestibular Disorders in Comparison with Caloric Test: Psychometric Study

Fatemeh Moghadasi-Boroujeni, Mansoureh Adel Ghahraman · 2020 · مجله پژوهش در علوم توانبخشی

Introduction: Romberg test is one of the balance screening tests. Since this test does not require special equipment, it is widely used in the evaluation of people suffering from balance disorders. This study aimed to determine the sensitivity of the Romberg test for the diagnosis of peripheral vestibular dysfunction compared with the caloric test that is the gold standard for the diagnosis of horizontal semicircular canal/superior vestibular nerve disorders.Materials and Methods: This study was a cross-sectional-comparative study and the sample was selected from those who referred to the audi

View details →DOI: 10.22122/jrrs.v16i0.3633
Negative / Null Result ReportOpen accessMedicine (General)

mRNA Expression and Methylation of the , , , , and Genes in Gastric Adenocarcinoma

Joel Del Bel Pádua, Carolline Fontes Alves Mariano, Alexandre Todorovic Fabro et al. · 2024 · Biomarker Insights

Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. Objective and design: This retrospective cohort study aimed to evaluate mRNA expression and promoter methylation of some homologous recombination-related genes in this neoplasm. Methods: We evaluated mRNA expression and methylation of RAD51 , ATM , ATR , BRCA1 , and BRCA2 in tumor and non-tumor frozen samples from gastrectomy specimens by RT-qPCR and MS-HRM, correlating our results with previous i

View details →DOI: 10.1177/11772719231225206
Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology

EVALUATION OF SEXUAL DYSFUNCTION IN PATIENTS WITH LUTS, RELATIONSHIP WITH TESTOSTERONE, LEPTIN AND SERUM LIPID LEVELS: RE-EVALUATION AFTER ALPHA BLOCKER TREATMENT

Aves Editorial Aves Editorial · 2019 · Urology Research and Practice

Abstract Introduction: Lower urinary tract symptoms (LUTS) associated with BPH and erectile dysfunction (ED) are common problems in aging male. In this study, we aimed to determine the causes of the relationship between LUTS and ED, and the possible effects of body mass index (BMI), serum leptin, free testosterone (fT) and lipid levels on LUTS and ED etiology. Materials and Methods: Between June 2003 and February 2004, 46 patients were recruited in this study. All patients underwent physical examination including digital rectal examination, urine analysis, uroflowmetry and residual urine volum

Negative / Null Result ReportOpen accessMedicine

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients.

M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology

BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…

View details →DOI: 10.1016/j.ijcard.2016.04.064
Negative / Null Result ReportOpen accessMedicine

Grading angiogenesis in oral squamous cell carcinoma: a histomorphometric study.

V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research

CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…

View details →DOI: 10.4103/0970-9290.156792
Negative / Null Result ReportOpen access

Microscale Dynamics of Larval Fish Assemblages in the Straits of Malacca Nearshore Coincided with Lunar Phases

Ali Md. Yeakub, Fatimah Md. Yusoff, Natrah Fatin Mohd. Ikhsan et al. · 2023 · Pertanika Journal of Tropical Agricultural Science

Marine fish larvae are an integral part of the marine environment because their abundance can become an ecological indicator. The abundance is dependent on the environmental variations that include but are not limited to lunar phases and…

View details →DOI: 10.47836/pjtas.46.4.18
Negative / Null Result ReportOpen accessMedicine

Cardiac Effects of in utero Exposure to Antiretroviral Therapy in HIV-Uninfected Children Born to HIV-Infected Mothers

S. Lipshultz, Paige L. Williams, B. Zeldow et al. · 2015 · AIDS (London)

Objectives:We evaluated the potential cardiac effects of in-utero exposures to antiretroviral drugs in HIV-exposed but uninfected (HEU) children. Design and methods:We compared echocardiographic parameters of left ventricular function…

View details →DOI: 10.1097/qad.0000000000000499
Negative / Null Result ReportMedicine

Reappraisal of Electrocardiographic Criteria for Localization of Idiopathic Outflow Region Ventricular Arrhythmias.

James K. Gabriels, M. Abdelrahman, Lakshmi Nambiar et al. · 2021 · Heart Rhythm

BACKGROUND Electrocardiographic (ECG) criteria have been proposed to localize the site of origin (SOO) of outflow region ventricular arrhythmias (VAs). Many factors influence the QRS morphology of VAs and may limit the accuracy of these…

View details →DOI: 10.1016/j.hrthm.2021.08.003
Negative / Null Result ReportMedicine

Trial of Electronic Medical Record Integrated Next-Generation Sequencing Ordering in Veterans Affairs Cancer Care

J. Stoeckle, S. Poland, H. Maynard et al. · 2024 · JCO Precision Oncology

PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New…

View details →DOI: 10.1200/po.23.00463
Negative / Null Result ReportOpen accessMedicine

Successful weight loss maintenance in relation to method of weight loss

Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity

This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…

View details →DOI: 10.1038/oby.2008.364
Negative / Null Result ReportMedicine

Comparative Pathologic Analysis of Breast Cancers Classified as HER2/neu-Amplified by FISH Using a Standard HER2/CEP17 Dual Probe and an Alternative Chromosome 17 Control Probe

Somaye Y. Zare, Leo I. Lin, Abrar Alghamdi et al. · 2018 · American Journal of Surgical Pathology

At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an…

View details →DOI: 10.1097/pas.0000000000001106
Negative / Null Result ReportOpen accessMedicine

Sex differences in uric acid and NT-pro BNP assessments during coronary severity

Guofeng Guo, Zhaoqi Huang, Shixiang Wang et al. · 2020 · Medicine

Abstract To investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and coronary artery severity in acute coronary syndrome patients of different sexes. A total of 134 patients…

View details →DOI: 10.1097/md.0000000000019653
Negative / Null Result ReportMedicine

Safety and Tolerability of GRF6019 Infusions in Severe Alzheimer’s Disease: A Phase II Double-Blind Placebo-Controlled Trial

J. Hannestad, Tiffanie Duclos, Whitney Chao et al. · 2021 · Journal of Alzheimer's Disease

Background: The plasma fraction GRF6019 shows multiple benefits on brain aging in mice, including enhanced cognition, neurogenesis, and synaptic density, as well as reduced neuroinflammation. Objective: To evaluate the safety,…

View details →DOI: 10.3233/jad-210011
Negative / Null Result ReportOpen accessComputer Science

Shaping Ability of Different Single Niti Files: A Cbct Assessment

B. Selivany, A. Yousif · 2020 · The Journal Of Duhok University

Aim : The study aimed to compare Shaping ability of WaveOne Gold, Reciproc Blue and 2Shape NiTi systems having different design and metallurgic properties. Method : Forty five extracted human single root with 10 mm root length were…

View details →DOI: 10.26682/sjuod.2020.23.2.11
Negative / Null Result ReportMedicine

Repeatability and comparability of a new swept-source optical coherence tomographer in optical biometry.

C. E. Monera Lucas, J. Escolano Serrano, C. T. Tarazona Jaimes et al. · 2022 · Archivos de la Sociedad Española de Oftalmología

PURPOSE To evaluate the reproducibility in the measurement of ocular biometric parameters using a new swept-source optical coherence tomographer and its comparability with an optical low coherence reflectometry biometer. DESIGN An…

View details →DOI: 10.1016/j.oftale.2022.04.003
Negative / Null Result ReportOpen accessMedicine

Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study

J. Ortiz, M. Fernández‐Arquero, E. Urcelay et al. · 2006 · BMC Medical Genetics

BackgroundIgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Genetic and environmental factors are suspected to be involved in the development of the disease. Interleukin-10 (IL-10) is a cytokine with…

View details →DOI: 10.1186/1471-2350-7-56
Negative / Null Result ReportOpen accessMedicine

Early stage adrenocortical carcinoma—what contributes to poor prognosis after adrenalectomy? A retrospective cohort study

Douk Kwon, C. Rah, Byung-Chang Kim et al. · 2024 · Annals of Surgical Treatment and Research

Purpose Adrenocortical carcinoma (ACC) is a rare primary carcinoma originating in the adrenal gland with a poor prognosis and a high recurrence rate. This study evaluated the risk factors associated with recurrence in patients with early…

View details →DOI: 10.4174/astr.2024.107.4.187