Negative / Null Result ReportMedicine
Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international
Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…
View details →DOI: 10.25259/sni_1424_2025 Failed Experiment ReportMedicine
Zhou, Xia, Zhao et al. · 2026 · European journal of pharmacology
This study aimed to investigate the anti-tumor effects and mechanisms of propranolol (Prop) in mice with colorectal cancer (CRC) combined with chronic stress, as well as its potential impact when used in combination with high-mobility…
View details →DOI: 10.1016/j.ejphar.2026.179065 Negative / Null Result ReportMedicine
Su, Huang, Wang · 2026 · SLAS technology
The accumulation of pathological bronchial secretions compromises ventilation and oxygenation in critically ill patients and may lead to atelectasis or secondary infection in severe cases, making timely identification and removal of…
View details →DOI: 10.1016/j.slast.2026.100443 Negative / Null Result ReportMedicine
Alomar-Dominguez, Bauer, Fries et al. · 2026 · Thrombosis research
Massive blood loss during surgery or trauma leads to dilutional coagulopathy. While fibrinogen is typically the first factor to reach critical levels, factor XIII (FXIII) also decreases proportionally, further impairing clot stability.…
View details →DOI: 10.1016/j.thromres.2026.109729 Negative / Null Result ReportMedicine
Haider, Kamran · 2026 · Cureus
Penile intraepithelial neoplasia (PeIN) is a premalignant lesion with clinical features that often overlap with benign inflammatory dermatoses. Although biopsy remains the diagnostic gold standard, topical acetic acid application producing…
View details →DOI: 10.7759/cureus.107021 Negative / Null Result ReportMedicine
Liao, Xiang, Chen et al. · 2026 · PloS one
The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…
View details →DOI: 10.1371/journal.pone.0348676 Negative / Null Result ReportMedicine
Ippoliti, Gori, Coscarella et al. · 2026 · Skin health and disease
Abrocitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in moderate-to-severe atopic dermatitis (AD), although data in patients whose AD is resistant to multiple systemic therapies remain limited. We report the…
View details →DOI: 10.1093/skinhd/vzag045 Failed Experiment ReportMedicine
Terry, Isenberg, Gomoll et al. · 2026 · Video journal of sports medicine
Multifocal cartilage defects about the knee have become increasingly prevalent. When left untreated, these injuries may progress to diffuse knee osteoarthritis. Operative management for patients with multifocal chondral defects typically…
View details →DOI: 10.1177/26350254261419144 Failed Experiment ReportMedicine
Wang, Yu · 2026 · SAGE open medical case reports
A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…
View details →DOI: 10.1177/2050313x261454853 Negative / Null Result ReportMedicine
Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics
Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…
View details →DOI: 10.1007/s43465-025-01572-6 Negative / Null Result ReportMedicine
Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders
Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…
View details →DOI: 10.1177/17562864261449515 Negative / Null Result ReportMedicine
Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports
A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…
View details →DOI: 10.1136/bcr-2026-272989 Negative / Null Result ReportMedicine
Dong, Patel, Wang et al. · 2026 · Environment international
Phthalates are pervasive endocrine-disrupting chemicals widely used in consumer products. The wide use of many phthalates results in chronic human exposure to complex mixtures rather than single compounds. Despite extensive studies on…
View details →DOI: 10.1016/j.envint.2026.110332 Replication FailureMedicine
Moses K, Kamaraj, Konda Ramachary Subramanian · 2026 · Drug delivery
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar…
View details →DOI: 10.1080/10717544.2026.2680354 Failed Experiment ReportMedicine
Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
View details →DOI: 10.1016/j.jvscit.2026.102270 Negative / Null Result ReportMedicine
Malzahn, Höft Budde, Kneißl et al. · 2026 · Innere Medizin (Heidelberg, Germany)
The German healthcare system, despite its high performance, fails to achieve the goal of needs-based service provision. Supply-induced demand, regional disparities and misaligned financial incentives lead to overuse, underuse and misuse of…
View details →DOI: 10.1007/s00108-026-02117-1 Negative / Null Result ReportMedicine
Shigemoto, Kim · 2026 · Psychology, health & medicine
Chronic pain among people of color is influenced by biological, structural, and social forces. While network models have been applied to chronic pain symptoms, research on resource disparities often isolates factors such as income, failing…
View details →DOI: 10.1080/13548506.2026.2680327 Negative / Null Result ReportMedicine
Thiede, Haris, Damjanović et al. · 2026 · Journal of mass spectrometry : JMS
In conventional native mass spectrometry (MS), one faces severe limitations when challenged with heterogeneous, high-mass samples, commonly failing to resolve clear peak distributions, and thus mass determination. Charge detection MS…
View details →DOI: 10.1002/jms.70068 Failed Experiment ReportMedicine
Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
View details →DOI: 10.1080/15476286.2026.2682069 Negative / Null Result ReportMedicine
Taylor, Roberts, Rayner · 2026 · Viruses
Chikungunya virus (CHIKV) is an alphavirus that infects dermal fibroblasts as a primary target cell during natural mosquito-borne transmission. While primary human dermal fibroblasts (hDFs) have been implicated as a key source of type I…
View details →DOI: 10.3390/v18050503 Negative / Null Result ReportMedicine
Canton, Ceballos, Canton et al. · 2026 · Pharmaceutics
Background/Objectives: Combination of antiparasitic drugs with different mechanisms of action has been suggested as an effective strategy to delay the development of parasite resistance. Considering the need to understand the…
View details →DOI: 10.3390/pharmaceutics18050630 Negative / Null Result ReportMedicine
Perez Arteaga, Yeh · 2026 · Nutrients
Surgical trauma triggers a complex metabolic and inflammatory response that can profoundly affect patient recovery and clinical outcomes. The magnitude of this stress response correlates with surgical complexity, patient comorbidities, and…
View details →DOI: 10.3390/nu18101603 Negative / Null Result ReportMedicine
Tan, Lye, Patel et al. · 2026 · International journal of molecular sciences
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this…
View details →DOI: 10.3390/ijms27104409 Negative / Null Result ReportMedicine
Ullah, Li, Aljasir et al. · 2026 · Life (Basel, Switzerland)
Background : Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with limited treatment options. Tumors harboring the BRAF V600E mutation exhibit aggressive behavior and present therapeutic challenges. Although…
View details →DOI: 10.3390/life16050772 Negative / Null Result ReportMedicine
Kuchana, Repalle, Alahari et al. · 2026 · Cancers
Artificial intelligence (AI) is reshaping oncology at every stage of the cancer care pathway, from population-level screening through molecular diagnosis, treatment planning, and post-treatment surveillance. Despite an exponential growth…
View details →DOI: 10.3390/cancers18101543 Negative / Null Result ReportMedicine
Jiang, Qi, Ma et al. · 2026 · Veterinary research
Feline calicivirus (FCV) evolves rapidly under immune pressure, yet the genetic basis of antigenic escape remains poorly understood, particularly when sequence divergence is limited. We isolated 13 FCV strains from cats in Jilin Province,…
View details →DOI: 10.1186/s13567-026-01778-y Negative / Null Result ReportMedicine
Liu, Su, Gong et al. · 2026 · BMC infectious diseases
Chlamydia abortus primarily causes abortion and stillbirth in animals and is associated with pregnancy-related complications in humans. However, it is an extremely rare cause of pneumonia in humans. While Chlamydia psittaci is a…
View details →DOI: 10.1186/s12879-026-13691-y Negative / Null Result ReportMedicine
Faurholt-Jepsen, Hammershøi, Bruun et al. · 2026 · Journal of affective disorders
Distinguishing between bipolar disorder type I and II constitutes a significant clinical challenge that relies on retrospective patient recall. Misclassification carries risks of inappropriate pharmacological management. Digital…
View details →DOI: 10.1016/j.jad.2026.122027 Negative / Null Result ReportMedicine
He, Lin, Zhang et al. · 2026 · Diabetes research and clinical practice
Cardiovascular-kidney-metabolic (CKM) syndrome defines a pathophysiological continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Stages 0-3 represent a critical subclinical window for…
View details →DOI: 10.1016/j.diabres.2026.113336 Negative / Null Result ReportMedicine
Romero-Alfano, Prats, Raldúa et al. · 2026 · The Science of the total environment
Mixture toxicity studies on neuroactive chemicals remain scarce and often rely on simplified combinations of compounds with known modes of action (MoA), despite the frequent non-monotonicity of neuroactive responses. Furthermore, real…
View details →DOI: 10.1016/j.scitotenv.2026.181901 