Replication FailureOpen accessMedicine
Zehua Dong, Lianlian Wu, Hongliu Du et al. · 2026 · Gastroenterology
BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. METHODS: Participants from 24 hospitals in China from December 21, 2021, to November 11, 2023, were randomized to AI-assisted or nonassisted esophagogastroduodenoscopy. Primary outcome was detection rate of gastric neoplasms after pathologic review. Secondary outcomes included detection rate of gastric neoplasms before review, relative early gastric cancer detection ratio,
View details →DOI: 10.1053/j.gastro.2025.12.020Cited by 9 Negative / Null Result ReportOpen accessMedicine
Michael Harrison Storandt, Frank A. Sinicrope · 2026 · BMJ Oncology
The treatment paradigm for deficient mismatch repair (dMMR) colorectal cancer (CRC) has evolved substantially in recent years. Universal mismatch repair testing and broad use of next-generation sequencing have increased the detection of…
View details →DOI: 10.1136/bmjonc-2025-000980Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yang Fu, Jie Liu, Zeming Mo et al. · 2026 · MedComm
ABSTRACT Melanoma is the most aggressive skin malignant tumor, typically exhibiting a high mutation burden and potentially harboring mutations in NRAS, BRAF, or NF1. To enhance survival rates, these driver alterations can achieve significant antitumor activity through targeted therapy. In the past decade, BRAF inhibitors combined with MEK inhibitors significantly improved the prognosis of BRAF mutation melanoma. Nevertheless, researchers have attempted various strategies to block the NRAS signaling pathway, NRAS mutation in melanoma is still considered to be untargetable. In recent years, MEK
View details →DOI: 10.1002/mco2.70566Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sarah Ancheta, Leah C. Dorman, Guillaume Le Treut et al. · 2026 · PLoS Computational Biology
Single-cell RNA sequencing is revolutionizing our understanding of cell state dynamics, allowing researchers to capture and quantify the transcriptomic profile of a single cell at a specific timepoint. Among the computational techniques used to predict cellular trajectories, RNA velocity has emerged as a predominant tool for modeling transcriptional dynamics. RNA velocity leverages the mRNA maturation process to generate velocity vectors that predict the likely future state of a cell, offering insights into cellular differentiation, aging, and disease progression. Although this technique has s
View details →DOI: 10.1371/journal.pcbi.1014303Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Batist Geldhof, Jolien Pattyn, Sam Noppen et al. · 2026 · Plant Stress
Abstract Developing leaves undergo a vast array of age-related changes as they mature. These include physiological, hormonal and morphological changes that determine their adaptation plasticity towards adverse conditions. Waterlogging…
View details →DOI: 10.1016/j.stress.2026.101423Cited by 9 Negative / Null Result ReportOpen accessPsychology
Chang Hu, Wenying Huang, W. W. Zhang et al. · 2026 · BMC Psychiatry
BACKGROUND: Suicidal ideation is an emerging issue among athletes, posing significant risks to their mental health. The mechanisms linking psychological strain to suicidal ideation remain unclear. This study addresses this gap by examining…
View details →DOI: 10.1186/s12888-026-08099-6Cited by 9 Negative / Null Result ReportOpen accessMaterials Science
HASAN F. SHABBIR, Yanwen Chen, Jing Sun et al. · 2026 · International Journal of Molecular Sciences
Since their initial discovery in 2003, carbon quantum dots (CDs) have attracted significant attention due to their unique optical properties and potential biomedical applications. This review critically examines the past 20 years of research on CDs, with a particular focus on cytotoxicity studies from the last decade. CDs, typically less than 10 nm in size, have been synthesized from various organic and inorganic precursors using multiple methods, including hydrothermal, microwave, and chemical reduction techniques. Their properties can be finely tuned by modifying synthesis parameters and inc
View details →DOI: 10.3390/ijms27093782Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Nic Glewwe, Evan M. Dastin-van Rijn, Cathy S. Chen et al. · 2026 · Neuropsychopharmacology
Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback. Flexibility is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility may reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex. While previous research has identified sex differences in value based decision making in mice, whether sex reflects a major source of variation in cognitive f
View details →DOI: 10.1038/s41386-026-02397-zCited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ariadna Tibau, Edward R. Scheffer Cliff, Alejandra Romano et al. · 2025 · EClinicalMedicine
Background: The accelerated approval pathway allows the FDA to approve drugs for serious conditions based on promising surrogate measures, with confirmatory studies required later. If subsequent testing shows an unfavorable benefit-risk profile, the indication may be withdrawn. This study aimed to identify factors associated with the withdrawal of drug indications following accelerated approval. Methods: In this retrospective cohort study, we identified FDA-approved drugs for solid and hematologic cancers from 1992 to 2022 and extracted factors present at the time of accelerated approval, incl
View details →DOI: 10.1016/j.eclinm.2025.103088Cited by 9 Negative / Null Result ReportOpen accessMedicine
Lene Bjerke Laborie, Jennifer Lee, Edward Antram et al. · 2026 · European Radiology
OBJECTIVES: This scoping review aims to evaluate the performance of artificial intelligence (AI) models designed for adults when applied to paediatric imaging datasets without additional adaptations, and to quantify performance degradation across different modalities, use-cases and age groups. MATERIALS AND METHODS: A literature search was conducted covering 10 years (1/01/2014-23/06/2025) using terms relating to "child", "adult", "artificial intelligence", "radiology" and "validation/performance". Two reviewers independently extracted data using standardised templates and conducted a narrativ
View details →DOI: 10.1007/s00330-026-12354-5Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Lalitwadee Kawinwanichakij, Karl Glazebrook, Themiya Nanayakkara et al. · 2026 · The Astrophysical Journal
Abstract We present the morphological properties of 17 spectroscopically confirmed massive quiescent galaxies ( 10.2 < log ( M * / M ⊙ ) < 11.2 ) at 3.0 < z < 4.3, observed with JWST/NIRSpec and NIRCam. Using Sérsic profile fits to F277W and F444W imaging, we derive the size–mass relation and find typical sizes of ∼0.6–0.8 kpc at M * = 5 × 10 10 M ⊙ , consistent with ∼7× growth from z ∼ 4 to the present, including ∼2× by z ∼ 2. We find tentative evidence that formation history and morphology jointly influence galaxy sizes: late-forming bulge-dominated galaxies appear more compact by ∼0.2–0.3 d
View details →DOI: 10.3847/1538-4357/ae0a18Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jorinde van de Vis, Jordy de Vries, Marieke Postma · 2026 · Progress in Particle and Nuclear Physics
The origin of the universal asymmetry between matter and antimatter remains a mystery. Electroweak baryogenesis is a well-motivated mechanism for generating the asymmetry dynamically, using interesting features of the Standard Model. In addition, it relies on beyond-the-Standard Model physics active around the electroweak scale: new physics coupling to the Higgs to make the electroweak phase transition first order, and a new mechanism of CP violation. The relatively low energy scale at which electroweak baryogenesis occurs makes certain aspects of the mechanism testable through collider experi
View details →DOI: 10.1016/j.ppnp.2026.104244Cited by 9 Replication FailureOpen accessMedicine
Gavin Giovannoni, Gavin Giovannoni, Laura M. Airas et al. · 2026 · The Lancet
BACKGROUND: The ORATORIO trial showed that ocrelizumab reduced the risk of disability progression versus placebo in patients with primary progressive multiple sclerosis (PPMS). We aimed to elucidate the effect of ocrelizumab in older and more disabled patients with PPMS, particularly regarding hand function preservation. METHODS: ORATORIO-HAND was a multicentre, double-blind, randomised, placebo-controlled, phase 3b study with 138 sites across 22 countries. Patients with PPMS aged 18-65 years and Expanded Disability Status Scale (EDSS) score of 3·0-8·0 were randomly assigned 1:1 to intravenous
View details →DOI: 10.1016/s0140-6736(26)00617-3Cited by 9 Negative / Null Result ReportOpen accessMedicine
Приходько Вероника Александровна, Sergey V. Okovityi · 2026 · Biomedicines
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an exceptionally high global prevalence that is projected to continue rising in the near future. MASLD is strongly associated with a spectrum of cardiometabolic risk factors, and may itself, in turn, contribute to cardiovascular morbidity and mortality. This interconnection warrants the development of integrated treatment strategies targeting shared pathophysiological processes and addressing both hepatic, metabolic, and cardiovascular outcomes. In this work, we review the modern MASLD clinical development pip
View details →DOI: 10.3390/biomedicines14040909Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lidia Bakota, Kerli Tulva, Nataliya I. Trushina et al. · 2026 · Translational Psychiatry
The neuronal microtubule-associated protein tau is involved in several neurodegenerative diseases, collectively referred to as tauopathies. In these diseases, it aggregates and plays a central role in triggering cell death. Tau was…
View details →DOI: 10.1038/s41398-026-03947-1Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Wolfgang Wüster · 2025 · Vertebrate Zoology
The advent of molecular methods has revolutionised the field of species delimitation and description, one of the key tasks of systematic biology. In animal taxonomy, one marker, the mitochondrial DNA (mtDNA) molecule, has acquired and retained disproportionate influence. This is despite its uniparental, clonal mode of inheritance, as a result of which the entire molecule acts as a single locus, and that precludes its use as a test for admixture between putative lineages, a key consideration in species delimitation. To establish the extent to which the limitations of mtDNA affect present-day ta
View details →DOI: 10.3897/vz.75.e161536Cited by 9 Negative / Null Result ReportOpen accessMedicine
Shangkai Gao, Léa Décarie-Spain, Cindy Gu et al. · 2026 · Comprehensive physiology
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governing complex cognitive processes. Here, we synthesize emerging evidence from preclinical models and human studies demonstrating that GLP-1 receptor (GLP-1R) signaling modulates multiple cognitive domains, including reward and motivational processes relevant to obesity and substance use disorder, affective-related behaviors, and learning and memory. We propose a
View details →DOI: 10.1002/cph4.70129Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kamel Mouloudj, Tiziana Amoriello, Eeman Almokdad et al. · 2026 · Sustainability
Product waste in grocery supply chains remains a major concern for multiple stakeholders, particularly retailers, due to the direct financial losses it generates and the potential risks it poses to customer health and safety. In this context, digital technologies—especially artificial intelligence (AI)—offer promising opportunities to improve retail performance and reduce waste. Accordingly, this study aims to investigate the factors influencing retailers’ intentions to adopt AI-based solutions for product waste reduction. To achieve this objective, the Technology Acceptance Model (TAM) was ex
View details →DOI: 10.3390/su18062768Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Erlei Zhi, Haowei Bai, Chuan Ren et al. · 2025 · Nature Communications
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we…
View details →DOI: 10.1038/s41467-025-63280-xCited by 9 Negative / Null Result ReportOpen accessMedicine
Xinyu Li, Tao Huang · 2025 · Breast Cancer
Hormone receptor-positive (HR +) and HER2-positive (HER2+) breast cancers represent a biologically unique subset of breast malignancies characterized by the co-expression of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2). These cancers exhibit distinct molecular features, often leading to aggressive growth and higher recurrence rates. HR+/HER2+ breast cancer cells can utilize estrogen and HER2-driven signaling pathways to promote proliferation, survival, and metastatic potential, presenting unique challenges and opportunities for treat
View details →DOI: 10.1007/s12282-025-01779-3Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruairidh Macleod, Frederik Valeur Seersholm, Bianca De Sanctis et al. · 2026 · Nature
Abstract Plague is among the most devastating diseases in human history 1 . However, early strains of the plague-causing bacterium Yersinia pestis lacked virulence factors that are required for the bubonic form until around 3,800 years ago 2,3 . Consequently, the morbidity and mortality of early plague strains remain unclear. Here we describe early plague strains that are associated with two phases of outbreaks among mid-Holocene hunter-gatherers near Lake Baikal in southeast Siberia, beginning from about 5,500 years ago. These outbreaks occur across four hunter-gatherer cemeteries, with a 39%
View details →DOI: 10.1038/s41586-026-10540-5Cited by 9 Negative / Null Result ReportOpen accessPsychology
Kimmo Sorjonen, Gustav Nilsonne, Ata Ghaderi et al. · 2026 · PLoS ONE
The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the RI-CLPM is susceptible to spurious findings when observed scores on the two variables are affected by common auto-correlated state factors. In reanalyses of empirical data, we found contradictory decreasing, increasing, and null prospective effects between within-individual levels of self-esteem and problematic eating behaviors among Dutch teenagers (N = 1856)
View details →DOI: 10.1371/journal.pone.0351302Cited by 9 Negative / Null Result ReportOpen accessMedicine
Yüksel Erkin, Erkan Özduran, İlhan Celil Özbek et al. · 2026 · PLoS ONE
Patients seeking information about Myofascial Pain Syndrome (MPS), which affects a large segment of the population, are increasingly turning to AI-based chatbots as an alternative to traditional methods. However, the medical accuracy of the content offered by these digital platforms, as well as its suitability to the "grade 6 reading level" standard, which determines its comprehensibility by patients, is a critical point of uncertainty. This study aims to fill this significant gap in the literature by systematically comparing MPS content generated by different AI models using readability indic
View details →DOI: 10.1371/journal.pone.0350402Cited by 9 Negative / Null Result ReportOpen accessMedicine
Michael J. Corley, Varun B. Dwaraka, Alina P.S. Pang et al. · 2026 · Nature Communications
Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biological aging is lacking. We report a post hoc exploratory epigenetic age analysis of a 32-week, randomized, double-blind, placebo-controlled phase 2b trial (NCT04019197) of semaglutide in adults with human immunodeficiency virus (HIV)-associated lipohypertrophy (semaglutide n = 45; placebo n = 39). The parent trial's primary endpoint was change in visceral adipose tissue, with secondary cardiometabolic and body-composition endpoints; epigenetic agi
View details →DOI: 10.1038/s41467-026-72861-3Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Da Cui · 2025 · Frontiers in Sustainable Food Systems
Under the dual challenges of intensifying global food security crises and pressing demands for sustainable agricultural development, investigating the mechanisms through which large-scale agricultural operations affect the grain production resilience carries significant strategic importance. Using a quasi-natural experiment based on land transfer policy, this study assesses these mechanisms. The findings indicate that large-scale agricultural operations significantly enhances grain production resilience. This positive effect is mediated by increased income levels among rural residents and grea
View details →DOI: 10.3389/fsufs.2025.1596449Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Zhuoming Zhang, Tengpeng Xu, Yun Chen · 2026 · The Astrophysical Journal
Abstract We present a Bayesian comparative analysis of five cosmological models: ΛCDM, w CDM, w 0 w a CDM, ϕ CDM (with scalar-field dark energy), and an interacting dark energy scenario (the ξ -index model), to investigate dark energy evolution and the Hubble tension. Utilizing the latest data from the second data release of the Dark Energy Spectroscopic Instrument (Baryon Acoustic Oscillations, BAO), Pantheon+ (type Ia supernovae, SNIa), and cosmic microwave background (CMB) data (including lensing) from Planck and the Atacama Cosmology Telescope, we report three key findings. First, the Hubb
View details →DOI: 10.3847/1538-4357/ae4738Cited by 9 Negative / Null Result ReportOpen accessMedicine
Gerti Dajti, Maria Chiara Vaccaro, Giuliana Germinario et al. · 2025 · Clinical Transplantation
BACKGROUND: The role of machine perfusion after kidney transplantation (KT) in extended criteria donors (ECD) is unclear, and the current evidence in the literature remains controversial. METHODS: We present an open-label single center…
View details →DOI: 10.1111/ctr.70166Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Joss Bland‐Hawthorn, Thor Tepper-García, Oscar Agertz et al. · 2025 · The Astrophysical Journal
Abstract In response to recent observations from JWST and Atacama Large Millimeter Array, we explore a new class of dynamically self-consistent models that mimics a plausible progenitor of the Milky Way over a wide range of disk gas fractions, f gas . The high gas surface densities encourage vigorous star formation, which in turn couples with the gas to drive turbulence. We show that this coupling through momentum recoil drives a random walk of the baryonic potential minimum with respect to total gravitational potential, Φ tot ( R , ϕ , z ). The amplitude of the bulk motion depends on the feed
View details →DOI: 10.3847/1538-4357/ae0931Cited by 9 Failed Experiment ReportOpen accessPhysics and Astronomy
Rafael Navarro-Carrera, K. I. Caputi, Edoardo Iani et al. · 2025 · The Astrophysical Journal
Abstract Making use of JWST NIRSpec and NIRCam data, we conduct a detailed analysis of GN- z 8-LAE, a strong Ly α emitter at z = 8.279. We investigate the interstellar medium (ISM) conditions that enable the Ly α detection in this source at the Epoch of Reionization (EoR) and scrutinize GN- z 8-LAE as an early reionizer. In agreement with previous results, we find that GN- z 8-LAE is a young galaxy (age ∼10 Myr) with a lower stellar mass ( M ⋆ ∼ 10 7.66 M ⊙ ) than most Ly α emitters (LAEs) at similar redshifts. The derived stellar-mass and star formation rate surface densities are Σ M ⋆ ∼ 355
View details →DOI: 10.3847/1538-4357/adca35Cited by 9 Negative / Null Result ReportOpen accessMedicine
Hyunmin Yu, Jacqueline Margo Brooks Carthon, Linda H. Aiken et al. · 2026 · Research in Nursing & Health
The Pathway to Excellence (Pathway) program administered by the American Nurses Credentialing Center, recognizes organizations that foster positive nursing practice environments. However, evidence linking Pathway designation to nurse-reported outcomes remains limited. This cross-sectional study integrated data from the Penn 2024 Nurses4All Study and the American Hospital Association Annual Survey. The sample included 16,979 direct care nurses from 1672 hospitals in 10 US states (866 nurses in 63 Pathway hospitals and 16,113 nurses in 1609 non-Pathway, non-Magnet hospitals). The independent var
View details →DOI: 10.1002/nur.70052Cited by 9 