Negative / Null Result ReportOpen accessMathematics
Freya Pollington, Spiros Denaxas, Kezhi Li et al. · 2025 · Journal of the American Medical Informatics Association
OBJECTIVES: Increasingly, structured longitudinal electronic health records (EHRs) are being harnessed to predict risk of having present but as yet undetected disease by analyzing "patient trajectories." Trajectory studies explore clinical event associations, characterize disease trajectories, and enhance risk prediction. This scoping review assesses study characteristics and objectives, identifies model types, and appraises model performance and reporting. MATERIALS AND METHODS: We conducted a scoping review, focused on a PubMed and Web of Science search for studies using temporal EHR sequenc
View details →DOI: 10.1093/jamia/ocaf208Cited by 9 Negative / Null Result ReportOpen accessMedicine
Xiaohua Xiao, Xueqin Yan, Chunhua Liang et al. · 2026 · Frontiers in Neurology
Alzheimer's disease (AD) is a gradual and irreversible decline in the brain's ability to function which is not only signified by amyloid-beta plaques and neurofibrillary tangles but also by and metabolic and mitochondrial changes that have a negative impact on the classical neuropathological hallmarks. It is becoming increasingly clear that the central roles in the process of synaptic dysfunction, neuronal death and cognitive decline are played by the brain's impaired glucose utilization, insulin resistance, lipid metabolism alterations, and energy homeostasis disruption. Mitochondrial dysfunc
View details →DOI: 10.3389/fneur.2026.1772036Cited by 9 Negative / Null Result ReportOpen accessMedicine
Ruxandra Oiegar, Dana Pop · 2025 · Journal of Clinical Medicine
Background/Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovium. The inflammation accelerates the development and progression of atherosclerosis, a key phenomenon in the onset of cardiovascular diseases. The aim of this review was to synthetize the traditional and RA-specific cardiovascular risk (CVR) factors and the CVR assessment guidelines in RA patients. Methods: We performed a PubMed search using specific keywords. We synthetized the main findings. Results: Although the risk factors are the traditional ones, with certain par
View details →DOI: 10.3390/jcm14186461Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Assaf Shmuel, Teddy Lazebnik, Eyal Heifetz et al. · 2025 · npj natural hazards.
Fire weather indices (FWIs) are widely used to assess wildfire risk, but are typically designed for specific regions and not adapted globally. Here, we present a systematic effort to generate country-specific FWIs that capture regional…
View details →DOI: 10.1038/s44304-025-00126-yCited by 9 Negative / Null Result ReportOpen accessPsychology
Daniel R. Espinas, Sharon Vaughn, Lynn S. Fuchs · 2025 · Pediatric Research
Interventions for individuals with specific learning disabilities (SLD) largely focus on performance within a single performance domain (e.g., reading). However, it is more the rule than the exception that individuals with SLD will experience difficulties that span multiple domains (e.g., reading and mathematics), and that co-occur with other disorders (e.g., attention-deficit/hyperactivity disorder). In this article, we discuss what has been learned about supporting children and adolescents with SLD affecting multiple performance domains (i.e., reading and mathematics), and with common co-occ
View details →DOI: 10.1038/s41390-025-04261-0Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Eric C. Schoute, Patricia A. Alexander · 2025 · Review of Educational Research
Critical thinking is praised as the hallmark of cognitive development and a raison d’être for higher education. In this review, we analyzed critical thinking interventions in higher education with regard to participant characteristics;…
View details →DOI: 10.3102/00346543251352539Cited by 9 Negative / Null Result ReportOpen accessVeterinary
Sibi Chakravathy Parivendan, Kashfia Sailunaz, Suresh Neethirajan · 2025 · Animals
This review critically analyzes recent advancements in dairy cow behavior recognition, highlighting novel methodological contributions through the integration of advanced artificial intelligence (AI) techniques such as transformer models and multi-view tracking with social network analysis (SNA). Such integration offers transformative opportunities for improving dairy cattle welfare, but current applications remain limited. We describe the transition from manual, observer-based assessments to automated, scalable methods using convolutional neural networks (CNNs), spatio-temporal models, and at
View details →DOI: 10.3390/ani15131835Cited by 9 Negative / Null Result ReportOpen accessMaterials Science
Vinicius Firmino dos Santos, Eduardo R. Almeida, Lucas Miguel Pereira Souza et al. · 2025 · Macromolecules
High Resolution Image Download MS PowerPoint Slide Polymer brushes exhibit unique structural and dynamic properties compared to free polymers due to their confined and tethered nature. While coarse-grained (CG) models for free polymers are well-established in the literature, their direct application to polymer brushes is limited. This is because brushes demonstrate distinct conformational behaviors, scaling laws, and responses to environmental stimuli that may not be accurately captured by models developed for free polymers. We have systematically evaluated chemically specific CG parameters wi
View details →DOI: 10.1021/acs.macromol.5c00273Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Tamara Evstafyeva, Nils Peter Siemonsen, William E. East · 2026 · Physical review. D/Physical review. D.
We reinvestigate the stability properties of ultracompact spinning boson stars with a stable light ring using fully nonlinear 3+1 and 2+1 numerical relativity simulations and two different formulations of the Einstein equations. We find no…
View details →DOI: 10.1103/2vz3-s39rCited by 9 Negative / Null Result ReportOpen accessChemistry
Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms
The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind
View details →DOI: 10.3390/microorganisms9040701Cited by 9 Negative / Null Result ReportOpen accessMedicine
Sandra Heskamp, Otto C. Boerman, Janneke D.M. Molkenboer‐Kuenen et al. · 2014 · Molecular Pharmaceutics
Bevacizumab and cetuximab are approved for the treatment of cancer. However, in advanced colorectal cancer, addition of cetuximab to chemotherapy with bevacizumab did not improve survival. The reason for the lack of activity remains…
View details →DOI: 10.1021/mp500460gCited by 9 Negative / Null Result Report
Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International
Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…
View details →DOI: 10.1155/2015/207534Cited by 9 Negative / Null Result Report
Jason West, Maiko Chu, Lincoln Crooks et al. · 2018 · Journal of Business Strategy
Purpose Business wargames represent an alternative approach to challenge organisations to uncover internal capabilities through competitive actions designed to counteract external threats and address strategic mismatches. Internal…
View details →DOI: 10.1108/jbs-11-2017-0154Cited by 9 Negative / Null Result Report
Dolores Ruiz-Lupión, Jordi Pascual, Nereida Melguizo-Ruiz et al. · 2019 · Insects
Soil fauna play a key role in nutrient cycling and decomposition, and in recent years, researchers have become more and more interested in this compartment of terrestrial ecosystems. In addition, soil fauna can act as ecosystem engineers…
View details →DOI: 10.3390/insects10050147Cited by 9 Negative / Null Result Report
Gengsheng L. Zeng · 2012 · International Journal of Imaging Systems and Technology
Abstract The iterative maximum‐likelihood expectation‐maximization (ML‐EM) algorithm is an excellent algorithm for image reconstruction and usually provides better images than the filtered backprojection (FBP) algorithm. However, a…
View details →DOI: 10.1002/ima.22011Cited by 9 Negative / Null Result Report
Guangming Chen, Xiaoyun Shan, Huabin Wang · 2021 · Nephrology
Abstract Aim Various studies have reported that urinary neutrophil gelatinase‐associated lipocalin (NGAL), an indicator of tubular damage, may be an effective biomarker of renal impairment in patients with diabetes. This study aimed to…
View details →DOI: 10.1111/nep.13851Cited by 9 Negative / Null Result Report
Gordon Minru Xiong, Kailash Venkatraman, Subbu Venkatraman · 2020 · Progress in Biomedical Engineering
Abstract Ever since the term ‘Magic Bullet’ was coined by Nobel laureate Paul Ehrlich to denote selective activity of a therapeutic medicine against a particular target tissue or organism, researchers have been attempting to develop the…
View details →DOI: 10.1088/2516-1091/abb008Cited by 9 Negative / Null Result Report
Nicholas Smith, Kathleen F. Hunter, Saima Rajabali et al. · 2019 · Journal of Wound, Ostomy & Continence Nursing
PURPOSE: This study aimed to determine from what sources women with urinary and dual urinary and fecal incontinence sought and received information about incontinence and absorbent products. We also evaluated source utility. DESIGN:…
View details →DOI: 10.1097/won.0000000000000494Cited by 9 Negative / Null Result Report
Yui Matsuda, Todd A. Schwartz, YunKyung Chang et al. · 2019 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Mothers’ depressive symptoms affect their children’s growth as well as physical and mental well-being. Moreover, mothers of young children with developmental delay or disability (DD) tend to have higher depressive symptoms.…
View details →DOI: 10.1177/1078390319877228Cited by 9 Negative / Null Result Report
Thomas Gerhard Wolf, Elena Baumgärtner, Burkhard Peter · 2022 · Frontiers in Psychology
Several publications with healthcare professionals, such as psychotherapists, have shown a significant difference in personality styles in practitioners using hypnosis compared to those not using hypnosis. To investigate differences in…
View details →DOI: 10.3389/fpsyg.2022.835200Cited by 9 Negative / Null Result Report
Anna Adamczak-Bugno, Aleksandra Krampikowska · 2020 · Materials
This article proposes to use the acoustic emission (AE) method to evaluate the degree of change in the mechanical parameters of fiber–cement boards. The research was undertaken after a literature review, due to the lack of a methodology…
View details →DOI: 10.3390/ma13132966Cited by 9 Negative / Null Result Report
Yuriko Adkins, Kevin D. Laugero, Bruce Mackey et al. · 2019 · Lipids
Abstract Recent studies suggest that dietary krill oil leads to higher omega‐3 polyunsaturated fatty acids (n‐3 PUFA) tissue accretion compared to fish oil because the former is rich in n‐3 PUFA esterified as phospholipids (PL), while n‐3…
View details →DOI: 10.1002/lipd.12115Cited by 9 Negative / Null Result Report
Mona Almalik, Alice Kiger, Janet Tucker · 2010 · International Journal of Qualitative Methods
Although a few researchers mention that involving interpreters can have an impact on the research process and research findings, little is published regarding methods of assessing the interpretation work's quality and impact. The impact of…
View details →DOI: 10.1177/160940691000900302Cited by 9 Negative / Null Result Report
P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity
Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…
View details →DOI: 10.1111/cob.12229Cited by 9 Negative / Null Result Report
Jack W. O’Sullivan, John P. A. Ioannidis · 2021 · Scientific Reports
Abstract With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether…
View details →DOI: 10.1038/s41598-021-97896-yCited by 9 Negative / Null Result Report
Richard A. Gallenstein, John P. Dougherty · 2024 · American Journal of Agricultural Economics
Abstract Index insurance programs in developing countries have focused almost entirely on agricultural production risk (i.e., yield) while largely avoiding output marketing risk (i.e., price). This omission may miss an important constraint…
View details →DOI: 10.1111/ajae.12445Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Surya Prakash, Aritra Das, Sidrat Tasawoor Kanth et al. · 2021 · Cerebral Cortex
Local field potentials (LFPs) in visual cortex are reliably modulated when the subject's focus of attention is cued into versus out of the receptive field of the recorded sites, similar to modulation of spikes. However, human psychophysics…
View details →DOI: 10.1093/cercor/bhab088Cited by 9 Negative / Null Result ReportOpen accessMedicine
Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research
BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi
View details →DOI: 10.2196/46934Cited by 9 Negative / Null Result ReportMedicine
William R. Cleek, Nicholas J. Johnson, Bjorn Watsjold et al. · 2019 · Shock
STUDY OBJECTIVE: The quick sequential organ failure assessment (qSOFA) was proposed to identify infected patients at risk for mortality, an indication of sepsis, in nonintensive care unit settings. This study tests whether qSOFA improves…
View details →DOI: 10.1097/shk.0000000000001496Cited by 9 Negative / Null Result ReportOpen accessMedicine
Simone Conti, Edmond Y. Lau, Victor Ovchinnikov · 2022 · Antibodies
The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms, primarily because proteins are flexible molecules, and thus, require explicit or implicit incorporation of multiple conformational states into the computational procedure. The astronomical size of the amino acid sequence space further compounds the challenge by requiring predictions to be computed
View details →DOI: 10.3390/antib11030051Cited by 9 