A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21252 results · page 156 of 709
Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology
PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…
Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research
AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…
Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open
STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research
The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…
Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…
Sha Sha, Lina Ren, Xiaona Xing et al. · 2025 · Neural Regeneration Research
Alzheimer's disease, a devastating neurodegenerative disorder, is characterized by progressive cognitive decline, primarily due to amyloid-beta protein deposition and tau protein phosphorylation. Effectively reducing the cytotoxicity of…
Lucy Plumb, Anna Casula, Manish D. Sinha et al. · 2023 · Clinical Kidney Journal
ABSTRACT Background Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study…
Jwa Hoon Kim, Jae Ho Jeong, Baek‐Yeol Ryoo et al. · 2020 · Cancer Research and Treatment
PURPOSE: This study evaluated the efficacy of adjuvant chemotherapy (AC) in patients with resected ampulla of Vater (AoV) carcinoma. MATERIALS AND METHODS: Data from 646 patients who underwent surgical resection at Asan Medical Center…
Lujun Shen, Fei Cao, Ying Liu et al. · 2025 · BMC Medicine
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) stage C…
Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science
We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…
Peter Beckwith, Mpho Tlali, Salome Charalambous et al. · 2021 · American Journal of Tropical Medicine and Hygiene
Tuberculosis (TB) remains the leading cause of hospitalization and in-hospital mortality in HIV-positive adults. Using data from hospital and clinic files, research databases, and autopsy, we describe causes and outcomes of admissions, and…
Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences
Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention
Amira Soliman, Björn Agvall, Kobra Etminani et al. · 2023 · Journal of Medical Internet Research
BACKGROUND: Sensitive and interpretable machine learning (ML) models can provide valuable assistance to clinicians in managing patients with heart failure (HF) at discharge by identifying individual factors associated with a high risk of readmission. In this cohort study, we delve into the factors driving the potential utility of classification models as decision support tools for predicting readmissions in patients with HF. OBJECTIVE: The primary objective of this study is to assess the trade-off between using deep learning (DL) and traditional ML models to identify the risk of 100-day readmi
Iván Chérrez-Ojeda, Marcus Maurer, Miguel Félix et al. · 2021 · World Allergy Organization Journal
BackgroundFew studies have explored the association between obstructive sleep apnea (OSA) and chronic urticaria (CU). Our study aims to fill this gap by determining the frequency of the risk categories for OSA and how they might correlate…
LI-HSIOU CHEN, Kuo-Liang Chiu, Te‐Chun Hsia et al. · 2020 · In Vivo
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among…
Maryam Karimi, Mazaher Khodabandehloo, Bahram Nikkhoo et al. · 2016 · PubMed
Background and Objective: Any role of human papillomavirus (HPV) in the development of breast cancer is conjectural. The aim of this study was to investigate possible links between HPV and breast cancer in women, Sanandaj, Iran. Methods:…
Federico de Gregorio, Kasey Windels · 2020 · Journal of Advertising
This exploratory research tests two competing general predictions: the expert-performance literature predicting creatives will demonstrate greater creativity than others while the process-performance paradox literature predicting they will…
J. Robert McCorkle, Rebecca Ahn, Connie D. Cao et al. · 2024 · Cancers
) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate efficacy in ovarian cancer cells. Artesunate and navitoclax both demonstrated antiproliferative effects on 2D and 3D ovarian cancer cell models as single
Surya Prakash, Aritra Das, Sidrat Tasawoor Kanth et al. · 2021 · Cerebral Cortex
Local field potentials (LFPs) in visual cortex are reliably modulated when the subject's focus of attention is cued into versus out of the receptive field of the recorded sites, similar to modulation of spikes. However, human psychophysics…
Matthew S W Rassette, Elizabeth I. Pierpont, Tina Wahl et al. · 2011 · PubMed
Treatment of Northern fowl mite (Ornithonyssus sylviarum) infestation on poultry in research facilities can be challenging. The mite has a rapid reproductive cycle (egg to adult in 5 to 7 d), and chemical treatments can be toxic to birds,…
Eisha Hassan, Fazila‐Tun‐Nesa Malik, Qazi Waqas Khan et al. · 2025 · IEEE Access
Document Clustering has attracted the interest of many researchers who have created several solutions to this problem by combining different techniques, models, and algorithms. While famous for its simplicity, the most commonly used algorithm, K-Means, suffers from issues such as finding the optimal value for k and random initialization of the centroids. In this paper, we propose a hybrid methodology combining K-Means++ with the metaheuristic algorithm PSO to overcome the challenges of both these algorithms. K-Means++ is a smart initialization technique that selects clusters based on probabili
Urszula Smyczyńska, Szymon Grabia, Zuzanna Nowicka et al. · 2021 · Cancers
State-of-art normal tissue complication probability (NTCP) models do not take into account more complex individual anatomical variations, which can be objectively quantitated and compared in radiomic analysis. The goal of this project was development of radiomic NTCP model for radiation-induced hypothyroidism (RIHT) using imaging biomarkers (radiomics). We gathered CT images and clinical data from 98 patients, who underwent intensity-modulated radiation therapy (IMRT) for head and neck cancers with a planned total dose of 70.0 Gy (33–35 fractions). During the 28-month (median) follow-up 27 pat
Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ
Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)
Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science
In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al
Hailey Miller, Sandy Askew, Miriam B. Berger et al. · 2024 · Hypertension
BACKGROUND: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with…
Simone Conti, Edmond Y. Lau, Victor Ovchinnikov · 2022 · Antibodies
The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms, primarily because proteins are flexible molecules, and thus, require explicit or implicit incorporation of multiple conformational states into the computational procedure. The astronomical size of the amino acid sequence space further compounds the challenge by requiring predictions to be computed
William R. Cleek, Nicholas J. Johnson, Bjorn Watsjold et al. · 2019 · Shock
STUDY OBJECTIVE: The quick sequential organ failure assessment (qSOFA) was proposed to identify infected patients at risk for mortality, an indication of sepsis, in nonintensive care unit settings. This study tests whether qSOFA improves…
Mohammed Abdallah, Ke Zhang, Lijun Chao et al. · 2024 · Hydrology and earth system sciences
Abstract. Precipitation is a vital key element in various studies of hydrology, flood prediction, drought monitoring, and water resource management. The main challenge in conducting studies over remote regions with rugged topography is that weather stations are usually scarce and unevenly distributed. However, open-source satellite-based precipitation products (SPPs) with a suitable resolution provide alternative options in these data-scarce regions, which are typically associated with high uncertainty. To reduce the uncertainty of individual satellite products, we have proposed a D-vine copul
Janet Quint, Pei Zhu, Rekha Balu et al. · 2015 · SSRN Electronic Journal
Success for All (SFA) combines a challenging elementary reading program, whole-school reform elements, and an emphasis on continuous improvement. In 2010, the Success for All Foundation (SFAF) received a scale-up grant under the U.S.…