A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21697 results · page 156 of 724
Huanhuan Chang, Jiao Li · 2022 · Journal of Clinical Laboratory Analysis
Abstract Background At present, there is a new variant Omicron BA.2 of SARS‐CoV‐2. In some previous studies, it was found that CBC, NLR, CRP, SAA, etc. in patients with SARS‐CoV‐2 had a series of changes, which were significantly…
Haoran Zhou, Jung-Min Ji, Min Kim et al. · 2018 · Nanomaterials
The rational design of porphyrin sensitizers is always crucial for dye-sensitized solar cells (DSSCs), since the change of only a single atom can have a significant influence on the photovoltaic performance. We incorporated the…
Marlies Oostendorp, Christine H. ten Hove, Miranda van Berkel et al. · 2023 · Archives of Pathology & Laboratory Medicine
Context.— Total serum bilirubin (TSB) analysis is pivotal for diagnosing neonatal hyperbilirubinemia. Because of a routine change in laboratory equipment, our TSB assay changed from a diazo to a vanadate oxidase method. Upon…
Ping Yue, Xiaoan Zuo, Kaihui Li et al. · 2021 · Land Degradation & Development
Abstract As the third most important greenhouse gas, nitrous oxide (N 2 O) poses a significant threat to global warming and the ozone layer. However, the effects of precipitation changes on N 2 O emissions in arid areas remain unclear,…
Gamze Durhan, Ahmet Gürkan Erdemir, Sezin Yuce Sari et al. · 2020 · Breast Care
Objective: Lymphatic irradiation in breast cancer improves locoregional control and has been shown to decrease distant metastasis. However, irradiation also accelerates the formation of atherosclerosis and can cause stenosis,…
Naicheng Wu, Guohao Liu, Min Zhang et al. · 2022 · Animals
One of the key targets of community ecology and biogeography concerns revealing the variability and underlying drivers of biodiversity. Most current studies understand biodiversity based on taxonomic information alone, but few studies have…
B. WIELSTRA, J. W. ARNTZEN · 2014 · Zootaxa
We collected nuclear DNA data (52 markers) with next-generation sequencing for nine Triturus newt specimens, including the holotype and two of the paratypes of T. arntzeni, from the type locality at Vrtovać in eastern Serbia. We compare…
Seo-Ha Jeong, Yeon Gyo Nam · 2024 · Healthcare
Background/Objectives: Globally, life expectancy has been increasing with South Korea focusing on improving health to enhance quality of life. The COVID-19 pandemic further emphasized the need for digital transformation in healthcare,…
Joshua Fisher, Poonam Arora, Sophia Rhee · 2018 · Sustainability
The viability of conservation efforts, including protected areas and buffer zones, depends on finding ways to make those strategies more attractive and viable for local populations. This paper presents a pilot study utilizing a rapid rural…
Barton J. Mann, Taco Gosens, Stephen Lyman · 2012 · The American Journal of Sports Medicine
Treatment outcome researchers in orthopaedics frequently report only tests of statistical significance between group means to evaluate the effectiveness of a given intervention. Although important in establishing that mean differences are…
Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong et al. · 2020 · BMC Pulmonary Medicine
Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia…
Geoffrey L. Dickens, Laura E. O'Shea · 2017 · International Journal of Forensic Mental Health
Outcomes measures are commonly derived from post-discharge recidivism, readmission, and mortality rates but information about common outcomes across admission is scant. We determined whether reliable and clinically significant change in…
Wenhua Wan, Petra Döll, Hang Zheng · 2022 · Water Resources Research
Abstract To support the implementation of China's carbon neutrality target, this study assesses the impact of future climate change on hydroelectricity production (HP) in China. We developed a hydropower database for mainland China, which…
Xuanyu Qi, Guangzheng YANG, Zeqian Xu et al. · 2026 · Bone Research
Abstract Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear. Here, we found that neutrophil-triggered nociceptive ingrowth functioned as negative feedback regulation to inflammation during bone healing. A unique Il4ra + Ccl2 high neutrophil subset drove intense postinjury TRPV1 + nociceptive ingrowth, which in return dissipated inflammation by activating the production of pro-resolving mediator lipoxin A4 (LXA4) in osteoblasts. Mechanistically, os
Lucy R. Ivey, J. Scholtz, A. Lola Danhaive et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT A majority of JWST/NIRSpec integral field unit (IFU) studies at high redshifts to date have focused on UV-bright or massive objects, while our understanding of low-mass galaxies at early cosmic times remains limited. In this work, we present NIRSpec/IFU high-resolution observations of two low-mass ($M_*< 10^9 \ \mathrm{ M}_\odot$), low-metallicity ($[12+\log (\mathrm{O/H})]< 8$) galaxies at $z\sim 7.66$, one of which we identify as hosting a Type-II active galactic nucleus (AGN). We measure flat strong-line metallicity gradients, suggestive of interstellar medium redistribution by out
Eva Sclabassi, Sophie Peret, Chunqi Qian et al. · 2025 · Biomedicines
Background and Objectives: Autism spectrum disorder (ASD) is a heterogeneous neuro-developmental condition characterized by social communication deficits, restricted interests, and repetitive behaviors. Pharmacological management is challenging given the complex neurobiology and frequent comorbidities. This review summarizes the current evidence for pharmacological treatments in ASD, highlighting efficacy, mechanisms, limitations, and emerging therapeutic targets. Methods: A comprehensive literature review was conducted across PubMed, Cochrane Library, and Embase to identify clinical trials, s
Holly Overton, Michail Vafeiadis, Pratiti Diddi et al. · 2025 · Corporate Communications An International Journal
Purpose As companies continue to engage in CSA, they continue to struggle with determining what issues they should speak out about and how they can create compelling messages that inspire action. Guided by arguments from issue ownership theory, this study examines CSA message content effects related to two different social-political issues on advocacy behavioral intentions, megaphoning, brand preference and purchase intention. Specifically, the level of advocacy in a CSA message is examined, as well as the manner in which the message is written (narrative vs informational). Furthermore, this s
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe
Grzegorz K. Jakubiak, Natalia Pawlas, Monika Starzak et al. · 2026 · Vascular Health and Risk Management
Purpose: The purpose of this study was to analyze the relationship between resting high-sensitive serum cardiac troponin T concentration (hs-cTnT), D-dimer, and N-terminal pro–B-type natriuretic peptide (NT-proBNP), measured outside the…
Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
Ziyang Li, Huiwen Zheng, Zou Chen et al. · 2026 · Nature Communications
The family of oxiranes encompasses a variety of compounds with extensive applications across different fields. Herein, we report the development of a visible-light irradiation method using sulfinates in the presence of DABSO to form…
Anna Carolina Bruno Ferreira, Ygor Velloso Tavares, Nina Rezende Fontana et al. · 2026 · Molecules
The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into natural water bodies leads to severe ecological imbalances, affecting aquatic life and soil integrity while posing indirect risks to human health due to their mutagenic potential. Conventional physicochemical treatment methods are often hindered by prohibitive operational costs and the frequent generation of hazardous secondary pollutants.
Dunigan Parker Folk, Elizabeth Dunn · 2026 · Psychological Science
Advances in AI have enabled chatbots to provide warm, personalized support. Yet little is known about the long-term consequences of AI companionship. Across a 12-month longitudinal study with more than 2,000 adults from four Western…
Iñaki Eguren‐Santamaría, Ignacio Melero, Inmaculada Rodríguez et al. · 2025 · Journal for ImmunoTherapy of Cancer
Almost every successful anticancer treatment has been preceded by preclinical scientific breakthroughs that encouraged clinical development. However, therapeutic strategies showing promising preclinical results often fail to confirm…
Jung Ho Choi, Brandon Gipper, Shawn Shi · 2025 · Review of Accounting Studies
Early empirical evidence showed a lack of relative performance evaluation (RPE) for executive pay, a surprise given its theoretical appeal. We hypothesize that executive pay transparency can enhance the monitoring of pay practices and…
Madhur Mangalam · 2025 · European Journal of Applied Physiology
The Bayesian brain hypothesis-the idea that neural systems implement or approximate Bayesian inference-has become a dominant framework in cognitive neuroscience over the past two decades. While mathematically elegant and conceptually unifying, this paper argues that the hypothesis occupies an ambiguous territory between useful metaphor and testable, biologically plausible mechanistic explanation. We critically examine the key claims of the Bayesian brain hypothesis, highlighting issues of unfalsifiability, biological implausibility, and inconsistent empirical support. The framework's remarkabl
Robin Murray, Alice Egerton, Yueming Gao et al. · 2025 · Biological Psychiatry
Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question. TRS patients show glutamate abnormalities, and clozapine has widespread effects on glutamate. However, these actions have not been proven different to those of other antipsychotics. Immune dysfunction is also reported in TRS, and clozapine has anti-inflammatory actions, but these have not been correlated with clinical improvement. Currently, there is much i
Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang et al. · 2025 · Agronomy
Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advances in chromosome-scale genome assemblies, pan-genomics, and haplotype-resolved resequencing have greatly enhanced the capacity to identify causal variants and recover non-reference alleles linked to fibre development and environmental adaptation. Parallel progress in functional genomics and precision genome editing, particularly CRISPR/Cas
P. Abratenko, D. Andrade Aldana, Luciano Arellano et al. · 2025 · Nature
Abstract The existence of three distinct neutrino flavours, ν e , ν μ and ν τ , is a central tenet of the Standard Model of particle physics 1,2 . Quantum-mechanical interference can allow a neutrino of one initial flavour to be detected sometime later as a different flavour, a process called neutrino oscillation. Several anomalous observations inconsistent with this three-flavour picture have motivated the hypothesis that an additional neutrino state exists, which does not interact directly with matter, termed as ‘sterile’ neutrino, ν s (refs. 3–9 ). This includes anomalous observations from
Tjaša Mlinarič, Arne Van Den Kerchove, Zoe I. Barinaga et al. · 2026 · Scientific Reports
Abstract Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are two major causes of dementia, with overlapping clinical and pathophysiological characteristics. We investigated whether resting-state EEG functional connectivity could distinguish AD, FTD, and healthy controls (HC) using a stacked ensemble learning approach. A publicly available dataset (openneuro.org/datasets/ds004504) was used to extract multiple connectivity metrics across frequency bands. Base classifiers were trained using the Fisher’s Geodesic Minimum Distance to Mean (FgMDM) approach with Euclidean or Riemannian dis