Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →DOI: 10.1200/jco-25-01231Cited by 10 Replication FailureOpen accessMedicine
Daniel Chin, Tamara Hernández-Beeftink, Lauren J. Donoghue et al. · 2026 · European Respiratory Journal
ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease that might represent potential new drug targets, and it has been shown that drug targets with support from genetic studies are more likely to be successful in clinical development. Previous genome-wide association studies (GWAS) of IPF susceptibility have identified more than 20 signals implicating genes involved in multiple mechanisms, including telome
View details →DOI: 10.1183/13993003.00506-2026Cited by 10 Negative / Null Result ReportOpen accessMathematics
Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics
Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…
View details →DOI: 10.1214/26-aoas2230Cited by 10 Negative / Null Result ReportOpen accessMedicine
A. Giordano, Cristina Romero-Mascarell, Begoña González-Suárez et al. · 2025 · Digestive Diseases and Sciences
The integration of artificial intelligence (AI) into capsule endoscopy is transforming gastrointestinal diagnostics by enhancing lesion detection and optimizing reading efficiency. This review focuses on the clinical applications of…
View details →DOI: 10.1007/s10620-025-09099-4Cited by 10 Failed Experiment ReportOpen accessAgricultural and Biological Sciences
Irene Dini · 2026 · Molecules
Fermented foods and probiotics represent complementary yet distinct components of human nutrition. Fermented foods are shaped by biochemical transformations driven by microbial metabolism, whereas probiotics are live microorganisms that may confer health benefits to the host. In both cases, bacteria, yeasts, and filamentous fungi mediate key metabolic activities that generate bioactive compounds and modulate host-microbiota interactions. During fermentation, microbial communities synthesize organic acids, peptides, exopolysaccharides, vitamins, and other metabolites that enhance food safety, s
View details →DOI: 10.3390/molecules31081353Cited by 10 Negative / Null Result ReportOpen accessEngineering
Teevrat Garg, Ryan Hanna, Jeff Myers et al. · 2026 · Journal of Environmental Economics and Management
Aligning electric vehicle (EV) charging with periods of abundant clean energy is essential for decarbonizing transportation. In solar-dominated grids, this requires shifting charging to midday hours – when vehicles are typically parked at workplaces. Yet workplace charging networks operate under institutional constraints such as shared infrastructure, bundled parking and charging services, and limited willingness to require drivers to move vehicles, making time-of-day pricing and active management difficult to implement. In a natural field experiment (n = 629 drivers) across a large workplace
View details →DOI: 10.1016/j.jeem.2026.103383Cited by 10 Negative / Null Result ReportOpen accessMedicine
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia et al. · 2026 · Proceedings of the National Academy of Sciences
Phosphorylated-tau 217 (pTau217) is currently the most promising blood-based biomarker for accurately detecting Alzheimer’s disease (AD) pathology. However, interference from peripheral tau species in the kidneys or peripheral nerves can…
View details →DOI: 10.1073/pnas.2536792123Cited by 10 Negative / Null Result ReportOpen accessMedicine
Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs et al. · 2026 · JAMA
Importance: Digitalis glycosides may be used as additional therapy in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or HF with reduced EF (HFrEF). Objective: To assess the effect of digitalis glycosides on…
View details →DOI: 10.1001/jama.2026.7886Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ashley Rich, Ziqi Li, Alessandro De Simone et al. · 2026 · Nature Physics
Amputated salamander limbs or fish fins precisely regenerate to their pre-injury size, providing a paradigm for positional memory. Although this phenomenon has been appreciated for centuries, how position-dependent cues control tissue…
View details →DOI: 10.1038/s41567-026-03426-wCited by 10 Negative / Null Result ReportOpen accessMedicine
Van Nguyen, Sreenidhi Iyengar, Haroon Rasheed et al. · 2025 · Ophthalmology Science
Purpose Develop and test a deep learning (DL) algorithm for detecting referable glaucoma. Design Retrospective cohort study. Participants A total of 6116 patients from the Los Angeles County (LAC) Department of Health Services (DHS) were…
View details →DOI: 10.1016/j.xops.2025.100751Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Karina Gutiérrez-Moreno, Ana Isabel Olguín-Martínez, Amelia C. Montoya-Martínez et al. · 2025 · Diversity
Fungi from the genus Trichoderma have been extensively studied and used as biological control agents (BCAs) because of their versatile mechanisms of action. These include triggering systemic resistance, directly inhibiting pathogens, promoting plant growth, enhancing tolerance to abiotic stress, and producing auxins. However, the widespread application of the most studied Trichoderma strains has been limited by discrepancies between their potential results observed in controlled environments and the outcomes in greenhouses and field conditions. These differences are associated with context dep
View details →DOI: 10.3390/d17100734Cited by 10 Negative / Null Result ReportOpen accessMedicine
Joe M. Butler, Hessel Peters Sengers, Tom D. Y. Reijnders et al. · 2025 · EBioMedicine
BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-
View details →DOI: 10.1016/j.ebiom.2025.105799Cited by 10 Negative / Null Result ReportOpen accessPsychology
Isaac Davor, Francis Ohene Boateng, Franco Osei-Wusu et al. · 2026 · Cogent Education
This study examines the mediating and moderating role of metacognitive awareness in the relationship between self-regulated learning and mathematics achievement of university students in Ghana. Although self-regulated learning has attracted attention as a predictor of academic performance, few studies have examined how metacognitive awareness interacts with self-regulated learning to influence mathematics achievement in the Ghanaian context. A quantitative cross-sectional design was employed. Data were collected from 315 university students, representing a population of 3,240, using a structur
View details →DOI: 10.1080/2331186x.2026.2661434Cited by 10 Negative / Null Result ReportOpen accessMaterials Science
Ionut Iulian Lungu, Alina Ştefanache, Nicoleta Anton et al. · 2026 · Antioxidants
Copper-based nanoparticles, especially metallic copper (Cu NPs) and copper oxide (CuO NPs), have attracted increasing attention due to their redox activity, biological efficacy, and technological applications. However, conventional chemical synthesis often involves toxic reagents, limiting their biomedical applicability. In this context, plant-mediated green synthesis has evolved and has become a sustainable and cost-effective alternative. This review provides a comprehensive overview of recent advances in the biosynthesis of Cu and CuO nanoparticles using plant extracts. The main synthesis pa
View details →DOI: 10.3390/antiox15030339Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Wanting Zhang, Yuhang Xiang, Chen Lu et al. · 2026 · Molecular Biomedicine
The extracellular matrix (ECM) forms a dynamic structure around cells, providing environmental cues, mechanical support, and tissue protection. It is composed of fibrous proteins, glycosaminoglycans (GAGs), proteoglycans, and glycoproteins. The molecular, physical, and mechanical properties of the ECM regulate the motility, survival, and function of immune cells. In most cancers, inflammatory cytokines and proteases-particularly matrix metalloproteinases(MMPs)-released within the immune-infiltrated inflammatory microenvironment can remodel the ECM. Cytokines such as tumor necrosis factor-α (TN
View details →DOI: 10.1186/s43556-026-00415-6Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology
Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b
View details →DOI: 10.3389/fimmu.2025.1713426Cited by 10 Negative / Null Result ReportOpen accessMedicine
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
View details →DOI: 10.1097/j.pain.0000000000003931Cited by 10 Negative / Null Result ReportOpen accessEnergy
Ahmed M. Khalil, Samir M. Kamel, Mohamed S. Mohy Eldin · 2026 · Scientific Reports
This work used a simple technique to prepare a novel cerium titanate nano-rods embedded in a cellulose-based hydrogel with high photo catalytic degradation activity. The composite hydrogel was prepared by embedding different amounts of cerium titanate nano-rods (Ce/Ti-NRs) into a crosslinked carboxymethyl cellulose/polyacrylamide polyelectrolyte complex (CMC/PAM) as a matrix material. The physico-chemical properties of the Ce/Ti-NRs, CMC/PAM, and cerium titanate nano-rods embedded in a cellulose-based hydrogel (Ce/Ti-NRs/CMC/PAM) were investigated by FT-IR, XRD, BET, TEM, SEM, and EDX techniqu
View details →DOI: 10.1038/s41598-026-43425-8Cited by 10 Negative / Null Result ReportOpen accessHealth Professions
Ariane Ephemia Ndzignat Mouteyica, Nicholas Ngepah · 2024 · PLoS ONE
Progress in health outcomes across Africa has been uneven, marked by significant disparities among countries, which not only challenges the global health security but impede progress towards achieving the United Nations' Sustainable Development Goals 3 and 10 (SDG 3 and SDG 10) and Universal Health Coverage (UHC). This paper examines the progress of African countries in reducing intra-country health outcome disparities between 2000 and 2019. In other words, the paper investigates the convergence hypothesis in health outcome using a panel data from 40 African countries. Data were sourced from t
View details →DOI: 10.1371/journal.pone.0312089Cited by 10 Negative / Null Result ReportOpen accessMedicine
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
View details →DOI: 10.1172/jci194748Cited by 10 Negative / Null Result ReportOpen accessEngineering
Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →DOI: 10.1016/j.jclepro.2026.148153Cited by 10 Abandoned HypothesisOpen accessMedicine
Limin Liu, Qing-Qing Yu, Yulu Zhang et al. · 2026 · Cellular and Molecular Life Sciences
Renal fibrosis is a common pathological endpoint in progressive chronic kidney disease (CKD). Clinical evidence indicates that a decline in renal function is more closely associated with tubulointerstitial fibrosis (TIF) than with…
View details →DOI: 10.1007/s00018-026-06176-3Cited by 10 Negative / Null Result ReportOpen accessImmunology and Microbiology
Mariane Nunes de Nadai, Carolina Sales Vieira, Cristina Falbo Guazzelli et al. · 2026 · Revista Brasileira Ginecologia e Obstetrícia
Key points• Breast cancer is the most common type of cancer among women worldwide.• There is concern regarding the use of hormonal contraceptives and their possible relationship with the risk of breast cancer.• Several studies have evaluated the association between hormonal contraceptives and breast cancer, achieving heterogeneous results.• Some observational studies and systematic reviews suggest an association between levonorgestrel intrauterine device (LNG-IUD) use and breast cancer.However, these findings are limited by confounding factors and methodological weaknesses in the studies.• Whe
View details →DOI: 10.61622/rbgo/2026fps2Cited by 10 Negative / Null Result ReportOpen accessMedicine
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
View details →DOI: 10.1016/j.ekir.2025.10.008Cited by 10 Negative / Null Result ReportOpen accessMedicine
Giordano Fiorentù, Nicol Bernardinello, Giacomo Giulianelli et al. · 2025 · Advances in Therapy
Pulmonary hypertension (PH) is a progressive syndrome characterized by increased pulmonary artery pressure. PH often complicates chronic lung diseases, thus contributing to a substantial disease burden and poor prognosis. The WHO Group 3…
View details →DOI: 10.1007/s12325-025-03129-3Cited by 10 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Jung Ho Choi, Brandon Gipper, Shawn Shi · 2025 · Review of Accounting Studies
Early empirical evidence showed a lack of relative performance evaluation (RPE) for executive pay, a surprise given its theoretical appeal. We hypothesize that executive pay transparency can enhance the monitoring of pay practices and…
View details →DOI: 10.1007/s11142-025-09880-wCited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →DOI: 10.1093/qje/qjag044Cited by 10 Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
View details →DOI: 10.3390/jcm15155891Cited by 10 Negative / Null Result ReportOpen accessDecision Sciences
Yuan Tao, Yu Z, Tianxue Chen et al. · 2026 · iScience
Phytomedicine extraction-process optimization often relies on regression or machine learning models, but model choice is commonly judged by goodness of fit alone. Here, we assembled 1,148 structurally eligible extraction datasets from…
View details →DOI: 10.1016/j.isci.2026.116883Cited by 10 Negative / Null Result ReportOpen accessArts and Humanities
Yongliang Wang, Han Shi · 2026 · Discover Computing
Abstract The role of generative artificial intelligence (GenAI) affordance in specific task teaching, particularly the continuation writing task, remains insufficiently theorized and empirically underexplored. To bridge this research gap, a repeated-measures intervention study was conducted within the framework of Dynamic Systems Theory (DST) to investigate the implementation of GenAI-assisted continuation task instruction and its associations with the development of English as a Foreign Language (EFL) students’ writing performance. Twenty-five Chinese EFL high school students participated in
View details →DOI: 10.1007/s10791-026-10241-7Cited by 10 