A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Yui Matsuda, Todd A. Schwartz, YunKyung Chang et al. · 2019 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Mothers’ depressive symptoms affect their children’s growth as well as physical and mental well-being. Moreover, mothers of young children with developmental delay or disability (DD) tend to have higher depressive symptoms.…
Mona Almalik, Alice Kiger, Janet Tucker · 2010 · International Journal of Qualitative Methods
Although a few researchers mention that involving interpreters can have an impact on the research process and research findings, little is published regarding methods of assessing the interpretation work's quality and impact. The impact of…
Peter N. Chalmers · 2019 · Arthroscopy
Abstract The optimal surgical technique for arthroscopic rotator cuff repair remains controversial, with advantages and disadvantages to each of the most commonly used methods. The pattern as well as number of suture anchors relative to…
Gordon Minru Xiong, Kailash Venkatraman, Subbu Venkatraman · 2020 · Progress in Biomedical Engineering
Abstract Ever since the term ‘Magic Bullet’ was coined by Nobel laureate Paul Ehrlich to denote selective activity of a therapeutic medicine against a particular target tissue or organism, researchers have been attempting to develop the…
Nicholas Smith, Kathleen F. Hunter, Saima Rajabali et al. · 2019 · Journal of Wound, Ostomy & Continence Nursing
PURPOSE: This study aimed to determine from what sources women with urinary and dual urinary and fecal incontinence sought and received information about incontinence and absorbent products. We also evaluated source utility. DESIGN:…
Yuriko Adkins, Kevin D. Laugero, Bruce Mackey et al. · 2019 · Lipids
Abstract Recent studies suggest that dietary krill oil leads to higher omega‐3 polyunsaturated fatty acids (n‐3 PUFA) tissue accretion compared to fish oil because the former is rich in n‐3 PUFA esterified as phospholipids (PL), while n‐3…
Thomas Gerhard Wolf, Elena Baumgärtner, Burkhard Peter · 2022 · Frontiers in Psychology
Several publications with healthcare professionals, such as psychotherapists, have shown a significant difference in personality styles in practitioners using hypnosis compared to those not using hypnosis. To investigate differences in…
Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International
Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…
Hisayuki Katsuyama, Hidekatsu Yanai, Hiroki Adachi et al. · 2023 · Gastroenterology Research
Background: We previously reported that the selective peroxisome proliferator-activated receptor alpha modulator, pemafibrate, significantly reduced serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and…
Mattias Ekre, Jakob Tytor, Mogens Bove et al. · 2020 · Diseases of the Esophagus
Summary Eosinophilic esophagitis (EoE) is a chronic inflammatory condition with eosinophilic infiltration of the esophageal mucosa. The most prominent symptom is dysphagia, which may result in esophageal bolus impaction in need of surgical…
Joao Gabriel Ostrowski, József Menyhárt · 2020 · Acta Polytechnica Hungarica
Based particularly on data technologies, information is rapidly evolving in engineering. In mechanical engineering, maintenance is benefiting the most from data innovations, the reduction of maintenance costs, and the improvement of system…
Magdalena Sabat, Bartosz Haładus, Michał Klincewicz et al. · 2022 · Scientific Reports
The perceived duration of an interval depends on numerous aspects of the passed event both endogenous, including physiological arousal, level of wakefulness, attention, and surprise, as well as exogenous such as valence, salience, or context in the environment. There is some evidence that "time-giving" cues from the environment (zeitgebers) are coupled with time perception. The movement of the sun on the horizon was demonstrated to affect interval perception in a study conducted by Schatzschneider et al. (2016) claiming that the sun's motion is a zeitgeber that influences time perception. In t
Shailesh D. Pawar, Sadhana S. Kode, Sachin S. Keng et al. · 2022 · The Indian Journal of Medical Research
Background & objectives Polio, measles, rubella, influenza and rotavirus surveillance programmes are of great public health importance globally. Virus isolation using cell culture is an integral part of such programmes. Possibility of…
Elizabeth Bartlett, Ashley Yttredahl, Maura Boldrini et al. · 2023 · European Psychiatry
Abstract Background Reported childhood adversity (CA) is associated with development of depression in adulthood and predicts a more severe course of illness. Although elevated serotonin 1A receptor (5-HT 1A R) binding potential, especially…
Bahru M. Gebeyehu, Asie k. Jabir, Getachew Tegegne et al. · 2023 · Remote Sensing
Quantification of hydrologic model prediction uncertainty for various flow quantiles is of great importance for water resource planning and management. Thus, this study is designed to assess the effect of subbasin spatial scale on the hydrological model prediction uncertainty for different flow quantiles. The Soil Water Assessment Tool (SWAT), a geographic information system (GIS) interfaced hydrological model, was used in this study. Here, the spatial variations within the sub-basins of the Omo Gibe River basin in Ethiopia’s Abelti, Wabi, and Gecha watersheds from 1989 to 2020 were examined.
Pamela J. Kaisaki, Georg Otto, Karène Argoud et al. · 2016 · G3 Genes Genomes Genetics
Abstract To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (BN) controls, which contain well-defined blocks (1–183 Mb) of genetic polymorphisms, and in 123 genetically heterogeneous rats of an (GK × BN)F2 offspring. Within each congenic we identified 73–1351 differentially expressed genes (DEGs), only 7.7% of which mapped within the congenic blocks, and which may be regulated in cis. The remai
Diane Pecher, Heleen van Mierlo, Rouwen Cañal‐Bruland et al. · 2015 · Journal of Experimental Psychology General
Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that…
Gautam Das, Malayendu Saha, Abhijit Kundu · 2016 · Vision The Journal of Business Perspective
The anomalies in respect to initial public offering (IPO) performance in literature have stimulated multitude of research works in explaining critical issues, such as under-pricing during short-run and underperformance phenomena in the…
Andrew J. Steward, Daniel J. Kelly, Diane R. Wagner · 2016 · Tissue Engineering Part A
Although hydrostatic pressure (HP) is known to regulate chondrogenic differentiation of mesenchymal stromal/stem cells (MSCs), improved insight into the mechanotransduction of HP may form the basis for novel tissue engineering strategies.…
Won Fy Lee, Clea McNeely, Janet E. Rosenbaum et al. · 2020 · Journal of Research on Educational Effectiveness
We examined the effect on attendance of a truancy court-diversion program for elementary students. Truancy court-diversion programs represent a shift from a law-and-order approach toward a public health model to address school absenteeism.…
Mojun Zhu, Brian A. Costello, Jun Yin et al. · 2021 · Pancreas
OBJECTIVES: Systemic therapies for pancreatic neuroendocrine tumors (PNETs) are limited. The combination of bevacizumab and temsirolimus showed significant antitumor activity, but the single-agent activity of bevacizumab was unknown. We…
Sherry Towers, Anuj Mubayi, Carlos Castillo‐Chávez · 2018 · PLoS ONE
BACKGROUND: When attempting to statistically distinguish between a null and an alternative hypothesis, many researchers in the life and social sciences turn to binned statistical analysis methods, or methods that are simply based on the moments of a distribution (such as the mean, and variance). These methods have the advantage of simplicity of implementation, and simplicity of explanation. However, when null and alternative hypotheses manifest themselves in subtle differences in patterns in the data, binned analysis methods may be insensitive to these differences, and researchers may erroneou
Kawthar Al-Salmi, Farook S Wali, Ahmed Sameer Nadeem et al. · 2019 · Journal of Neurology & Stroke
Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and…
Peter Doshi · 2024 · BMJ
A top selling antiplatelet drug has never quite shaken off doubts about its advantage over cheaper rivals. With generic versions of ticagrelor about to launch, Peter Doshi takes a fresh look at the evidence
Pooja Advani, Kathryn J. Ruddy, Joerg Herrmann et al. · 2023 · Frontiers in Oncology
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum
Mariela E. Jaffé, Rainer Greifeneder · 2019 · Journal of Language and Social Psychology
This article investigates the negativity bias in truth judgments, which holds that negatively (vs. positively) framed statements are more likely to be judged true. Throughout four studies we find that expectations moderate the negativity…
Yi-Lun Ge, Pu-Zhi Wang, Jia-Hui Yan et al. · 2022 · Advanced Neurology
Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists
Mohammad R. Jahan‐Parvar, Filip Žikeš · 2023 · Review of Financial Studies
Abstract We present evidence that several popular low-frequency measures of effective spread suffer from a volatility-induced bias and that volatility is the primary driver of the variation of these liquidity proxies. Using data for U.S. equities and major foreign exchange rates, we show that the bias arises when the effective spread is small relative to volatility. We document that the bias has become more acute over time and show that volatility-biased measures fail to replicate some well-known results in empirical finance. We conclude by providing guidance on the choice of low-frequency mea
Zengyou He, Hao Liang, Zheng Chen et al. · 2020 · IEEE Transactions on Knowledge and Data Engineering
Community detection is a key data analysis problem across different fields. During the past decades, numerous algorithms have been proposed to address this issue. However, most work on community detection does not address the issue of…
Zerrin Önder, İbrahim Çanak, Ümit Totur · 2017 · Open Mathematics
Abstract In this paper, we prove that a bounded double sequence of fuzzy numbers which is statistically convergent is also statistically ( C , 1, 1) summable to the same number. We construct an example that the converse of this statement…