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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20217 results in Negative / Null Result Report · page 144 of 674

Negative / Null Result ReportOpen accessMedicine

Results of the Kigali Imbereheza Project: A 2-Arm Individually Randomized Trial of TI-CBT Enhanced to Address ART Adherence and Mental Health for Rwandan Youth Living With HIV.

Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed

BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…

View details →DOI: 10.1097/qai.0000000000002911Cited by 10
Negative / Null Result ReportOpen accessNeuroscience

Majority language skill, not measures of bilingualism, predicts executive attention in bilingual children

David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology

Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.

View details →DOI: 10.1016/j.jecp.2021.105256Cited by 10
Negative / Null Result Report

No clinically significant difference in postoperative pain and side effects comparing conventional and enhanced recovery total hip arthroplasty with early mobilization

Jan Reinhard, Melanie Schindler, Franziska Leiss et al. · 2023 · Archives of Orthopaedic and Trauma Surgery

Abstract Introduction Enhanced recovery after surgery (ERAS) leads to less morbidity, faster recovery, and, therefore, shorter hospital stays. The expected increment of primary total hip arthroplasty (THA) in the U.S. highlights the need…

View details →DOI: 10.1007/s00402-023-04858-2Cited by 10
Negative / Null Result Report

Single-ion induced surface modifications on hydrogen-covered Si(001) surfaces—significant difference between slow highly charged and swift heavy ions

C Länger, P Ernst, M Bender et al. · 2021 · New Journal of Physics

Abstract Hydrogen-covered Si(001) surfaces were exposed to swift heavy ions (SHI) and slow highly charged ions (HCI). Using scanning tunneling microscopy as analysis tool, the ion-induced modifications on the surface were resolved on the…

View details →DOI: 10.1088/1367-2630/ac254dCited by 10
Negative / Null Result Report

Combination of Lactobacillus plantarum HAC03 and Garcinia cambogia Has a Significant Anti-Obesity Effect in Diet-Induced Obesity Mice

Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients

Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…

View details →DOI: 10.3390/nu15081859Cited by 10
Negative / Null Result Report

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis

Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology

Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…

View details →DOI: 10.3389/fcimb.2022.1005392Cited by 10
Negative / Null Result Report

HEATING EFFECT OF THERMALLY SIGNIFICANT BLOOD VESSELS IN PERFUSED TUMOR TISSUE DURING CRYOSURGERY

Z. F. LIU, G. ZHAO, Y. H. CHENG et al. · 2012 · Journal of Mechanics in Medicine and Biology

The purpose of this work is to evaluate the heating effect of thermally significant blood vessels (TSBVs) during cryosurgery process. A theoretical model is developed to describe the heat transfer of perfused tissue containing a 6…

View details →DOI: 10.1142/s0219519411004575Cited by 10
Negative / Null Result Report

Observational study of the implementation of telephone advice nursing in Sweden: did callers follow recommendations and did the rate of healthcare visits change?

Amanda Sundberg, Anna Carin Wahlberg, Niklas Zethraeus et al. · 2021 · BMJ Open

Objectives Telephone advice nursing is introduced in many countries with one key aim being a reduction of avoidable healthcare visits. The aim of this study was to explore whether callers to a telephone advice nursing service followed the…

View details →DOI: 10.1136/bmjopen-2021-051233Cited by 10
Negative / Null Result Report

Repairing "Failed" Questions in Foreign Language Classrooms

Yusuke Okada · 2010 · JALT Journal

While the pedagogical value of teachers’ questioning in classrooms has been well studied, what exactly teachers do if a question fails to obtain an adequate response has not yet been sufficiently addressed from an interactional…

View details →DOI: 10.37546/jaltjj32.1-3Cited by 10
Negative / Null Result ReportOpen accessComputer Science

Noise Reduction in EEG Signals using Convolutional Autoencoding Techniques

Conor Hanrahan · 2019 · ARROW@Dublin Institute of Technology (Dublin Institute of Technology)

The presence of noise in electroencephalography (EEG) signals can significantly reduce the accuracy of the analysis of the signal. This study assesses to what extent stacked autoencoders designed using one-dimensional convolutional neural…

View details →Cited by 10
Negative / Null Result Report

Development of a ground-based sensorimotor disorientation analog to replicate astronaut postflight experience

Sarah C. Moudy, Brian T. Peters, Torin K. Clark et al. · 2024 · Frontiers in Physiology

The perceptual and motor coordination problems experienced following return from spaceflight reflect the sensory adaptation to altered gravity. The purpose of this study was to develop a ground-based analog that replicates similar…

View details →DOI: 10.3389/fphys.2024.1369788Cited by 10
Negative / Null Result Report

“I Have Failed Them and Failed My Duties”: Experiences of Hospital Social Workers Discharging Patients into Homelessness

Rae Morris, Fiona Lewis, Nancy Baker et al. · 2021 · Health & Social Work

Abstract Homelessness is a long-standing issue at the forefront of healthcare globally, and discharge of homeless patients from hospital settings can exacerbate gaps and burdens in healthcare systems. In hospitals, social workers often…

View details →DOI: 10.1093/hsw/hlab039Cited by 10
Negative / Null Result ReportOpen accessMedicine

“Fast track” rehabilitation after gastric cancer resection: experience with 80 consecutive cases

Jingxiang Song, Xiaohuang Tu, Bing Wang et al. · 2014 · BMC Gastroenterology

BACKGROUND: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. RESULTS: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%)

View details →DOI: 10.1186/1471-230x-14-147Cited by 10
Negative / Null Result ReportOpen accessMedicine

Use of Automated Insulin Delivery in Pregnancies Complicated by Type 1 Diabetes

Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology

AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.

View details →DOI: 10.17925/ee.2024.20.2.14Cited by 10
Negative / Null Result ReportOpen accessMedicine

Physicians’ knowledge, attitude, and prescribing behavior regarding stress ulcer prophylaxis in China: a multi-center study

Xiao Xuan Xing, Chen Zhu, Yan Chu et al. · 2021 · BMC Gastroenterology

BACKGROUND: Perioperative patients are at risk of developing stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU) as well as the general ward, so it may lead to overmedication. However, there have been no surveys regarding SUP knowledge or prescribing habits. OBJECTIVE: Our study assessed the knowledge, attitudes, and prescribing behavior of the surgeons toward perioperative patients regarding SUP and determined factors associated with low knowledge and high level of prescribing behavior

View details →DOI: 10.1186/s12876-021-01979-zCited by 10
Negative / Null Result ReportOpen accessImmunology and Microbiology

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial

Shih-Hong Chen, Wing-Sum Chan, Chih‐Min Liu et al. · 2020 · Annals of Intensive Care

Abstract Background Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and…

View details →DOI: 10.1186/s13613-020-00699-zCited by 10
Negative / Null Result ReportOpen accessEngineering

Nomogram for Predicting In-Hospital Mortality in Patients with Acute ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock after Primary Percutaneous Coronary Intervention

Yudan Wang, Litian Liu, Xinning Li et al. · 2022 · Journal of Interventional Cardiology

Background: Mortality after percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients with cardiogenic shock (CS) remains high. However, the real-world risk factors for mortality in these patients are poorly defined. Objective: The aim of this study is to establish a clinical prognostic nomogram for predicting in-hospital mortality after primary PCI in STEMI patients with CS. Methods: This retrospective, multicenter, observational study included STEMI patients with CS who underwent PCI at 39 hospitals in Hebei Province from January 2018 to December 2019. A

View details →DOI: 10.1155/2022/8994106Cited by 10
Negative / Null Result ReportOpen accessMedicine

Pharmacological Treatment of Heart Failure with Preserved Ejection Fraction

Kazuhiro Yamamoto · 2017 · Yonago acta medica

Heart failure with preserved ejection fraction is a socioeconomic burden in Japan as well as other developed countries. Diuretics are widely used to attenuate symptoms and signs of congestion in both heart failure with preserved and…

View details →DOI: 10.33160/yam.2017.06.001Cited by 10
Negative / Null Result ReportMedicine

First-line immune checkpoint inhibitors alone or in combination with chemotherapy in real-life elderly patients with advanced non-small cell lung cancer (NEJ057).

Mao Uematsu, Yoko Tsukita, Takehiro Tozuka et al. · 2023 · Journal of Clinical Oncology

9012 Background: Immune checkpoint inhibitor (ICI) plus chemotherapy is now a standard treatment for non-small cell lung cancer (NSCLC) without targetable oncogene alternations. However, the efficacy and safety of ICI plus chemotherapy…

View details →DOI: 10.1200/jco.2023.41.16_suppl.9012Cited by 10
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Modulation of autophagy: A phase II study of vorinostat (VOR) plus hydroxychloroquine (HCQ) vs regorafenib (RGF) in chemo-refractory metastatic colorectal cancer (mCRC).

Sukeshi Patel Arora, Laura Tenner, John Sarantopoulos et al. · 2019 · Journal of Clinical Oncology

3551 Background: Agents targeting the angiogenic pathway have been a cornerstone therapy in mCRC. In chemo-refractory mCRC, RGF, an oral multikinase inhibitor with considerable angiogenic inhibition, has shown modest effects on survival.…

View details →DOI: 10.1200/jco.2019.37.15_suppl.3551Cited by 10
Negative / Null Result ReportOpen accessMedicine

Effectiveness of early awake self proning strategy in non-intubated patients with COVID-19 hypoxemia: An open-labelled randomized clinical trial from Jodhpur, India

Maya Gopalakrishnan, Satyendra Khichar, Suman Saurabh et al. · 2022 · Monaldi Archives for Chest Disease

Awake self-proning is being used widely as respiratory support in COVID-19 hypoxemia, in resource-limited settings. We aimed to investigate the effectiveness of early awake self-proning in preventing mortality and the need for intubation…

View details →DOI: 10.4081/monaldi.2022.2431Cited by 10
Negative / Null Result ReportOpen accessMedicine

Mucosal Melanoma of the Oral Cavity: What is the Role of Elective Neck Dissection?

Sean Haimowitz, David Cohen, Aatin K. Dhanda et al. · 2022 · The Laryngoscope

OBJECTIVES: Mucosal melanoma (MM) is a rare malignancy that can present in the head and neck (H&N). The Oral cavity is the second most common primary site in the H&N after sinonasal mucosa. This study investigates the impact of demographic…

View details →DOI: 10.1002/lary.30152Cited by 10
Negative / Null Result ReportMedicine

Effect of Warfarin on Survival in Patients with Concomitant Left Ventricular Systolic Dysfunction and Pulmonary Hypertension: A Population Cohort Study

Andrew Goudie, Douglas H.J. Elder, Harshal Deshmukh et al. · 2014 · European Journal of Heart Failure

BACKGROUND: The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among…

View details →DOI: 10.1002/ejhf.199Cited by 10
Negative / Null Result ReportMedicine

Real-world data on melanoma brain metastases and survival outcome

Sidsel Pedersen, Søren Møller, Marco Donia et al. · 2022 · Melanoma Research

Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical…

View details →DOI: 10.1097/cmr.0000000000000816Cited by 10
Negative / Null Result ReportOpen accessMedicine

Addition of chemotherapy to intensity-modulated radiotherapy does not improve survival in stage II nasopharyngeal carcinoma patients

Fangzheng Wang, Jiang Chuner, Quanquan Sun et al. · 2018 · Journal of Cancer

In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients. At the last follow-up, 18 patients had experien

View details →DOI: 10.7150/jca.25042Cited by 10
Negative / Null Result ReportMedicine

Impact of prenatal diagnosis on the outcome of patients with a transposition of great arteries: A 24‐year population‐based study

Anne Debost‐Legrand, Lemlih Ouchchane, Christine Francannet et al. · 2015 · Birth Defects Research Part A Clinical and Molecular Teratology

BACKGROUND: Transposition of great arteries (TGA) defined as the combination of concordant atrioventricular and discordant ventriculo-arterial connections is one of the most common congenital heart defects. Prenatal diagnosis of TGA…

View details →DOI: 10.1002/bdra.23474Cited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The copepod Acartia tonsa as live feed for fat snook (Centropomus parallelus) larvae from notochord flexion to advanced metamorphosis

Márcia Vanacor Barroso, Cristina Vaz Avelar de Carvalho, Rosemar Antoniassi et al. · 2017 · Latin American Journal of Aquatic Research

From early development until the completion of metamorphosis, fat snook (Centropomus parallelus) larvae are commonly fed the rotifers Brachionus spp. and Artemia spp. nauplii. In this study, cultivated copepods Acartia tonsa were evaluated…

View details →DOI: 10.3856/vol45-issue1-fulltext-15Cited by 10
Negative / Null Result ReportNeuroscience

Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine.

Brent A Bushey, Victor H Auld, John E Volk et al. · 2011 · PubMed

This study examined whether combining lipid emulsion and advanced cardiac life support (ACLS) improves survival in an unanesthetized swine model of bupivacaine- and hypoxia-induced cardiovascular collapse. Arterial and venous catheters and…

View details →Cited by 10