e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21247 results · page 142 of 709

Negative / Null Result ReportOpen accessMedicine

Pharmacological Treatment of Intermittent Claudication Does Not Have a Significant Effect on Gait Impairments During Claudication Pain

Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers et al. · 2012 · Journal of Applied Biomechanics

Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our…

View details →DOI: 10.1123/jab.28.2.184Cited by 11
Negative / Null Result ReportPsychology

Neuroscientific, Neuropsychological, and Psychological Evidence Comparably Impact Legal Decision Making: Implications for Experts and Legal Practitioners

Casey LaDuke, Benjamin Locklair, Kirk Heilbrun · 2018 · Journal of Forensic Psychology Research and Practice

Neuroscientific evidence is assuming an increasingly prominent role in criminal law, where it has considerable potential for affecting legal decision making. Our understanding of this effect is currently limited. Research initially…

View details →DOI: 10.1080/24732850.2018.1439142Cited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Group Decision-making: Consensus Rule Versus Majority Rule

Elizabeth Taylor, Kelsey C. Hewitt, Robert A. Reeves et al. · 2013 · Procedia Technology

Previously, in the field to solve complex problems, we had found that majority rule (MR) decision-making out-performed consensus rule (CR) by making decisions that were quicker, more practical, and of better quality. This is an important…

View details →DOI: 10.1016/j.protcy.2013.12.055Cited by 11
Negative / Null Result ReportOpen accessImmunology and Microbiology

Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RNA

Natalia Ristic, Mario P. S. Chin · 2010 · Retrovirology

BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate in human T cell lines. The replication restriction phenotype in the SL1 deletion mutant appears to be multifactorial, with defects in viral RNA dimerization and packaging in producer cells as well as in reverse transcription of the viral RNA in infected cells. In this study, we sought to characterize SL

View details →DOI: 10.1186/1742-4690-7-73Cited by 11
Negative / Null Result ReportOpen accessMedicine

Pulmonary Effects of Sustained Periods of High-G Acceleration Relevant to Suborbital Spaceflight

Ross D. Pollock, Caroline J. Jolley, N. Abid et al. · 2021 · Aerospace Medicine and Human Performance

Abstract BACKGROUND: Members of the public will soon be taking commercial suborbital spaceflights with significant G x (chest-to-back) acceleration potentially reaching up to 6 G x . Pulmonary physiology is gravity-dependent and is likely…

View details →DOI: 10.3357/amhp.5790.2021Cited by 11
Negative / Null Result Report

Funding source and primary outcome changes in clinical trials registered on ClinicalTrials.gov are associated with the reporting of a statistically significant primary outcome: a cross-sectional study

Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi et al. · 2015 · F1000Research

Background : We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study…

View details →DOI: 10.12688/f1000research.6312.1Cited by 11
Negative / Null Result Report

Can Machines Find the Bilingual Advantage? Machine Learning Algorithms Find No Evidence to Differentiate Between Lifelong Bilingual and Monolingual Cognitive Profiles

Samuel Kyle Jones, Jodie Davies-Thompson, Jeremy Tree · 2021 · Frontiers in Human Neuroscience

Bilingualism has been identified as a potential cognitive factor linked to delayed onset of dementia as well as boosting executive functions in healthy individuals. However, more recently, this claim has been called into question following…

View details →DOI: 10.3389/fnhum.2021.621772Cited by 11
Failed Experiment Report

On statistically-secure quantum homomorphic encryption

Ching-Yi Lai, Kai-Min Chung · 2018 · Quantum Information and Computation

Homomorphic encryption is an encryption scheme that allows computations to be evaluated on encrypted inputs without knowledge of their raw messages. Recently Ouyang et al. constructed a quantum homomorphic encryption (QHE) scheme for…

View details →DOI: 10.26421/qic18.9-10-4Cited by 11
Negative / Null Result ReportNeuroscience

End of the line: Line bisection, an unreliable measure of approach and avoidance motivation

Nathan Leggett, Nicole A. Thomas, Michael E. R. Nicholls · 2015 · Cognition & Emotion

Approach motivation leads to greater left hemisphere activation, whereas an avoidant motivational state activates the right hemisphere. Recent research, which served as the basis for the current experiment, suggests line bisection provides…

View details →DOI: 10.1080/02699931.2015.1053842Cited by 11
Negative / Null Result ReportNeuroscience

Does testing impair relational processing? Failed attempts to replicate the negative testing effect.

Katherine A. Rawson, Kathryn T. Wissman, Kalif E. Vaughn · 2015 · Journal of Experimental Psychology Learning Memory and Cognition

Recent research on testing effects (i.e., practice tests are more effective than restudy for enhancing subsequent memory) has focused on explaining when and why testing enhances memory. Of particular interest for present purposes, Zaromb…

View details →DOI: 10.1037/xlm0000127Cited by 11
Negative / Null Result ReportOpen accessMedicine

Interfering With DNA Decondensation as a Strategy Against Mycobacteria

Enzo M. Scutigliani, Edwin R. Scholl, Anita E. Grootemaat et al. · 2018 · Frontiers in Microbiology

Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multi-drug resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of Mycobacterium tuberculosis. We demonstrate that the DNA of M. tuberculosis can condense under stressful conditions such as starvation and antibiotic trea

View details →DOI: 10.3389/fmicb.2018.02034Cited by 11
Negative / Null Result ReportNeuroscience

Is there evidence for unaware evaluative conditioning in a valence contingency learning task?

Anne Gast, Jasmin Richter, Borys Ruszpel · 2019 · Cognition & Emotion

In three experiments we investigated whether memory-independent evaluative conditioning (EC) and other memory-independent contingency learning (CL) effects occur in the valence contingency task (VCT). In the VCT, participants respond to…

View details →DOI: 10.1080/02699931.2019.1652147Cited by 11
Negative / Null Result ReportOpen accessMedicine

Alexithymia and the Evaluation of Emotionally Valenced Scenes

Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology

Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple

View details →DOI: 10.3389/fpsyg.2020.01820Cited by 11
Negative / Null Result ReportOpen accessPsychology

Trait mindful awareness predicts inter-brain coupling but not individual brain responses during naturalistic face-to-face interactions

Yi‐Ping Phoebe Chen, Ulrich Kirk, Suzanne Dikker · 2022 · Frontiers in Psychology

In recent years, the possible benefits of mindfulness meditation have sparked much public and academic interest. Mindfulness emphasizes cultivating awareness of our immediate experience and has been associated with compassion, empathy, and various other prosocial traits. However, neurobiological evidence pertaining to the prosocial benefits of mindfulness in social settings is sparse. In this study, we investigate neural correlates of trait mindful awareness during naturalistic dyadic interactions, using both intra-brain and inter-brain measures. We used the Muse headset, a portable electroenc

View details →DOI: 10.3389/fpsyg.2022.915345Cited by 11
Negative / Null Result ReportEnvironmental Science

Temporal variation in survival and recovery rates of lesser scaup: A response

Todd W. Arnold, Alan D. Afton, Michael J. Anteau et al. · 2017 · Journal of Wildlife Management

ABSTRACT We recently analyzed long‐term (1951–2011) continental band‐recovery data from lesser scaup ( Aythya affinis ) and demonstrated that harvest rates declined through time, but annual survival rates exhibited no such trends;…

View details →DOI: 10.1002/jwmg.21315Cited by 11
Negative / Null Result ReportMedicine

Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission

Tonia C. Carter, Scott J. Hebbring, Jixia Liu et al. · 2017 · Journal of Medical Virology

Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune…

View details →DOI: 10.1002/jmv.24975Cited by 11
Negative / Null Result ReportOpen accessNeuroscience

Suppression-induced forgetting: a pre-registered replication of the think/no-think paradigm

Sera Wiechert, Leonie Hannah Shoshana Loewy, Ineke Wessel et al. · 2023 · Memory

Post-traumatic stress disorder is characterised by recurring memories of a traumatic experience despite deliberate attempts to forget (i.e., suppression). The Think/No-Think (TNT) task has been used widely in the laboratory to study…

View details →DOI: 10.1080/09658211.2023.2208791Cited by 11
Negative / Null Result ReportOpen accessMedicine

Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs

Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino et al. · 2025 · Emerging Microbes & Infections

Since the first emergence of highly pathogenic avian influenza (HPAI) H5N1 viruses in dairy cattle, the virus has continued to spread, reaching 17 states and at least 1000 dairy herds in the United States. Subsequently, spillovers of the…

View details →DOI: 10.1080/22221751.2025.2509742Cited by 11
Negative / Null Result ReportOpen accessMedicine

Kinetics of the West Nile virus induced transcripts of selected cytokines and Toll-like receptors in equine peripheral blood mononuclear cells

Muhammad Jasim Uddin, Willy W. Suen, Angela M. Bosco‐Lauth et al. · 2016 · Veterinary Research

West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcrip

View details →DOI: 10.1186/s13567-016-0347-8Cited by 11
Failed Experiment ReportOpen accessMedicine

Detection of Two Highly Diverse Peribunyaviruses in Mosquitoes from Palenque, Mexico

Anne Kopp, Alexandra Hübner, Florian Zirkel et al. · 2019 · Viruses

. Orthobunyaviruses and pacuviruses are mainly transmitted by blood-feeding insects and infect a variety of vertebrates whereas herbeviruses and shangaviruses have a host range restricted to insects. Here, we tested mosquitoes from a tropical rainforest in Mexico for infections with peribunyaviruses. We identified and characterized two previously unknown viruses, designated Baakal virus (BKAV) and Lakamha virus (LAKV). Sequencing and de novo assembly of the entire BKAV and LAKV genomes revealed that BKAV is an orthobunyavirus and LAKV is likely to belong to a new genus. LAKV was almost equidis

View details →DOI: 10.3390/v11090832Cited by 11
Negative / Null Result ReportPsychology

How literary can literariness be?

Massimo Salgaro · 2015 · Scientific Study of Literature

In literary theory, there are two common proposals about the nature of literature: that literariness is a distinctive characteristic of literary texts and that literariness is mostly characterized by highly foregrounded textual features.…

View details →DOI: 10.1075/ssol.5.2.06salCited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Robert Massey, Yu Chen, Marina Panova‐Noeva et al. · 2024 · Cardiovascular Diabetology

BACKGROUND: BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been lacking. Furthermore, it is not known whether BMI variability has an effect independent of HbA1c variability. METHODS: We investigated the association between BMI variability and 3P-MACE risk in the Harmony Outcomes trial (n = 9198), and further analysed placebo arms of REWIND (n = 4440) and EMPA-REG OUTCOME (n = 2333) trials, followed by real-world data from the Tayside Bioreso

View details →DOI: 10.1186/s12933-024-02299-8Cited by 11
Negative / Null Result ReportOpen accessMedicine

4-Aminobutyrate Aminotransferase (ABAT): Genetic and Pharmacological Evidence for an Involvement in Gastro Esophageal Reflux Disease

Johan Jirholt, Bengt Åsling, Paul Hammond et al. · 2011 · PLoS ONE

Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome microsatellite genotyping and linkage analysis. Five linked regions were identified. Two families shared a linked region (LOD 3.9 and 2.0) on chromosome 16. We used two additional independent GERD patient cohorts, one consisting of 219 trios (affected

View details →DOI: 10.1371/journal.pone.0019095Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Topological requirements of the mitochondrial heavy-strand promoters

Ornella Zollo, Neal Sondheimer · 2017 · Transcription

In vitro studies of mitochondrial transcription often use linear templates that fail to replicate key features of transcription on a circular genome. We developed a plasmid-based system for the analysis of heavy-strand promoters that…

View details →DOI: 10.1080/21541264.2017.1331156Cited by 11
Negative / Null Result ReportArts and Humanities

When “meaningless” means more: biographic resonance and audience appreciation of popular entertainment

James Alex Bonus, Judy Watts, C. Joseph Francemone · 2022 · Journal of Communication

Abstract Integrating predictions derived from the self-memory system and biographic resonance theory, the current project investigated the relationship between media-induced reminiscence and appreciation. In two experiments, undergraduates…

View details →DOI: 10.1093/joc/jqac028Cited by 11
Negative / Null Result ReportOpen accessMedicine

Data-driven profiles of attention-deficit/hyperactivity disorder using objective and ecological measures of attention, distractibility, and hyperactivity

Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Rosa Cánovas et al. · 2023 · European Child & Adolescent Psychiatry

In the past two decades, the traditional nosology of attention-deficit/hyperactivity disorder (ADHD) has been criticized for having insufficient discriminant validity. In line with current trends, in the present study, we combined a data-driven approach with the advantages of virtual reality aiming to identify novel behavioral profiles of ADHD based on ecological and performance-based measures of inattention, impulsivity, and hyperactivity. One hundred and ten Spanish-speaking participants (6-16 years) with ADHD (medication-naïve, n = 57) and typically developing participants (n = 53) complete

View details →DOI: 10.1007/s00787-023-02250-4Cited by 11
Negative / Null Result ReportOpen accessMedicine

The FGA Thr312Ala polymorphism and risk of intracerebral haemorrhage in Polish and Greek populations

Jeremiasz Jagiełła, Efthimios Dardiotis, Jerzy Gąsowski et al. · 2014 · Neurologia i Neurochirurgia Polska

BACKGROUND AND PURPOSE: Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and…

View details →DOI: 10.1016/j.pjnns.2013.12.004Cited by 11