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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21697 results · page 143 of 724

Negative / Null Result ReportOpen accessSocial Sciences

Is there prejudice from thin air? Replicating the effect of emotion on automatic intergroup attitudes

Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology

BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su

View details →DOI: 10.1186/s40359-020-00414-4Cited by 11
Failed Experiment ReportOpen accessEconomics, Econometrics and Finance

Optimal Markowitz portfolio using returns forecasted with time series and machine learning models

Damian Ślusarczyk, Robert Ślepaczuk · 2025 · Journal Of Big Data

We aim to answer whether using forecasted stock returns based on machine learning and time series models in a mean-variance portfolio framework yields better results than relying on historical returns. Nevertheless, the problem of…

View details →DOI: 10.1186/s40537-025-01164-zCited by 11
Negative / Null Result ReportOpen accessNeuroscience

Sexual dimorphism in the complete Drosophila male central nervous system connectome

Stuart Berg, Isabella R. Beckett, Marta Costa et al. · 2026 · Cell

Sex differences in behavior exist across all animals, typically under strong genetic regulation. In Drosophila, fruitless/doublesex transcription factors identify dimorphic neurons, but their organization into functional circuits remains unclear. We present the connectome of the entire Drosophila male central nervous system. This contains 166,700 neurons spanning the brain and nerve cord, fully proofread and annotated, including fruitless/doublesex expression and 11,710 neuron types. We provide the first comprehensive comparison between male and female brain connectomes to synaptic resolution,

View details →DOI: 10.1016/j.cell.2026.08.015Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Research advances in the study of traditional Chinese medicine formula granules on signaling pathway-mediated disease mechanisms

Zhuoxu Gu, Zhonghao Wang, Xianquan Zhang et al. · 2025 · Frontiers in Pharmacology

As a modern dosage form of traditional Chinese medicine, Traditional Chinese Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as a critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential of TCMFG in treating complex diseases, such as inflammation, tumors, metabolic disorders, fibrosis, and orthopedic conditions like osteoarthritis and osteoporosis, by modulati

View details →DOI: 10.3389/fphar.2025.1609211Cited by 11
Negative / Null Result ReportOpen accessEngineering

Towards a more realistic evaluation of machine learning models for bearing fault diagnosis

João Paulo Vieira, Victor Afonso Bauler, Rodrigo Kobashikawa Rosa et al. · 2026 · Mechanical Systems and Signal Processing

Reliable detection of bearing faults is essential for maintaining the safety and operational efficiency of rotating machinery. While recent advances in machine learning (ML), particularly deep learning, have shown strong performance in controlled settings, many studies fail to generalize to real-world applications due to methodological flaws, most notably data leakage. This paper investigates the issue of data leakage in vibration-based bearing fault diagnosis and its impact on model evaluation. We demonstrate that common dataset partitioning strategies, such as segment-wise and condition-wise

View details →DOI: 10.1016/j.ymssp.2026.114640Cited by 11
Negative / Null Result ReportOpen accessEngineering

Two-terminal β-Ga2O3 photo-synapse for diversified in-sensor computing via self-trapped holes engineering

Yiyin Nie, Shujie Jiao, Xing Yang et al. · 2026 · Light Science & Applications

Abstract The rapid advancement of artificial intelligence has propelled the development of β-Ga 2 O 3 photo-synapses for solar-blind ultraviolet neuromorphic machine vision systems. However, existing β-Ga 2 O 3 photo-synapses not only exhibit reduced stability but also display high weight update nonlinearity. Herein, we propose a novel strategy to construct β-Ga 2 O 3 photo-synapses with low weight update nonlinearity based on self-trapped holes, aiming to achieve multi-level in-sensor computing tasks. Theoretical and experimental investigations revealed that the interaction between the larger

View details →DOI: 10.1038/s41377-026-02298-2Cited by 11
Negative / Null Result ReportOpen accessMedicine

Transnasal spread of bupivacaine into the pterygopalatine fossa following endoscopically assisted cotton swab placement: a cadaveric study

Simon Istenič, Anže Jerman, Luka Pušnik et al. · 2025 · Regional Anesthesia & Pain Medicine

BACKGROUND: There are conflicting data on the efficacy of transnasal topical anesthetic approaches intended to achieve a pterygopalatine ganglion block, specifically regarding the extent to which local anesthetics reach the pterygopalatine…

View details →DOI: 10.1136/rapm-2025-106553Cited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Efficacy of an appropriate point-of-use water treatment intervention for low-income communities in India utilizing Moringa oleifera, sari-cloth filtration and solar UV disinfection

Syed Imran Ali, Morgan C. MacDonald, J. Jincy et al. · 2011 · Journal of Water Sanitation and Hygiene for Development

This study investigated the efficacy of a POU water treatment system featuring sari-cloth filtration and/or Moringa oleifera coagulation as pre-treatments for solar disinfection (SODIS). Surface water from a peri-urban slum in Chennai,…

View details →DOI: 10.2166/washdev.2011.043Cited by 11
Negative / Null Result ReportOpen accessMedicine

Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation

Jing Cheng, Carl Gao, Reeta Ala‐Jaakkola et al. · 2024 · JAMA Network Open

Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking. Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation,…

View details →DOI: 10.1001/jamanetworkopen.2024.36888Cited by 11
Negative / Null Result ReportOpen accessArts and Humanities

There’s More to the Story: Both Individual and Collective Policy Narratives Can Increase Support for Community-Level Action

Chris Skurka, Jeff Niederdeppe, Liana B. Winett · 2020 · DOAJ (DOAJ: Directory of Open Access Journals)

Narratives can convey the need or community-level action to address social problems. Yet narratives often tell stories about specific individuals rather than the broader collectives these problems affect. Some theorists argue that individualizing collective problems inhibits audiences from recognizing upstream causes and solutions. This study tested how narrative individualization (whether a story focuses on an individual case or a larger collective) might produce trade-offs when mobilizing support for community-level policies to address childhood obesity. We also investigated whether narrativ

View details →Cited by 11
Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Investigating the quadrupedal abilities of Scutellosaurus lawleri and its implications for locomotor behavior evolution among dinosaurs

Lilian Anderson, Charlotte Brassey, Stuart Pond et al. · 2023 · The Anatomical Record

A reversion to secondary quadrupedality is exceptionally rare in nature, yet the convergent re-evolution of this locomotor style occurred at least four separate times within Dinosauria. Facultative quadrupedality, an intermediate state between obligate bipedality and obligate quadrupedality, may have been an important transitional step in this locomotor shift, and is proposed for a range of basal ornithischians and sauropodomorphs. Advances in virtual biomechanical modeling and simulation have allowed for the investigation of limb anatomy and function in a range of extinct dinosaurian species,

View details →DOI: 10.1002/ar.25189Cited by 11
Negative / Null Result ReportOpen accessMedicine

Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: results from a multicenter study in China

Danfeng Xu, Rong Na, Da Huang et al. · 2020 · Asian Journal of Andrology

To evaluate whether prostate volume (PV) would provide additional predictive utility to the prostate health index (phi) for predicting prostate cancer (PCa) or clinically significant prostate cancer, we designed a prospective,…

View details →DOI: 10.4103/aja.aja_136_19Cited by 11
Negative / Null Result ReportOpen accessMedicine

Nonopioid vs opioid analgesics after impacted third-molar extractions

Cecile A. Feldman, Janine Fredericks-Younger, Paul J. Desjardins et al. · 2025 · The Journal of the American Dental Association

BACKGROUND: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted. METHODS: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery. Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioi

View details →DOI: 10.1016/j.adaj.2024.10.014Cited by 11
Negative / Null Result Report

WHERE DOES AVICENNA DEMONSTRATE THE EXISTENCE OF GOD?

Daniel D. De Haan · 2016 · Arabic Sciences and Philosophy

Abstract This study examines a number of different answers to the question: where does Avicenna demonstrate the existence of God within the Metaphysics of the Healing ? Many interpreters have contended that there is an argument for God's…

View details →DOI: 10.1017/s0957423915000132Cited by 11
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Harnessing genotype-by-environment interaction to determine adaptability of advanced cowpea lines to multiple environments in Uganda

Abiriga Francis, O. Ongom Patrick, Rubaihayo Patrick et al. · 2020 · Journal of Plant Breeding and Crop Science

This study was conducted to determine the yield stability of advanced cowpea lines in diverse agro-ecological zones of Uganda in order to facilitate documentation requirements for national performance trials (NPT). Thirty cowpea genotypes were evaluated against six checks in three localities, over three growing seasons, making a total of 9 unique environments. The trials were laid in a 6x6 alpha lattice design with three replications and grain yield was the principal trait measured. Single-site and multi-location data were summarized using analysis of variance. Further analysis of stability wa

View details →DOI: 10.5897/jpbcs2020.0891Cited by 11
Negative / Null Result ReportOpen accessComputer Science

Improving SAT-solving with Machine Learning

Haoze Wu · 2017

In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…

View details →DOI: 10.1145/3017680.3022464Cited by 11
Negative / Null Result Report

Effect of methionine hydroxy analog feed supplements: Significant alteration and enrichment of rumen microbiota and metabolome in Hu sheep

Shujie Li, Hanfang Zeng, Changjian Wang et al. · 2022 · Frontiers in Veterinary Science

Methionine hydroxy analogs (MHA) are widely used as the main sources of methionine in ruminant feed production. The purpose of this study was to explore the effect of using MHA supplements such as MHA as a salt of calcium (MHA-Ca) and…

View details →DOI: 10.3389/fvets.2022.999726Cited by 11
Negative / Null Result ReportNeuroscience

The grain-size lineup: A test of a novel eyewitness identification procedure.

Ruth Horry, Neil Brewer, Nathan Weber · 2015 · Law and Human Behavior

When making a memorial judgment, respondents can regulate their accuracy by adjusting the precision, or grain size, of their responses. In many circumstances, coarse-grained responses are less informative, but more likely to be accurate,…

View details →DOI: 10.1037/lhb0000166Cited by 11
Negative / Null Result ReportOpen accessEngineering

Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children

Rachael Slater, Kukatharmini Tharmaratnam, Salma Belnour et al. · 2024 · Sensors

The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn's disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography-sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a

View details →DOI: 10.3390/s24155079Cited by 11
Negative / Null Result ReportOpen accessHealth Professions

Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND

Pieter M. R. Herings, Adam H. Dyer, Seán Kennelly et al. · 2022 · Sensors

Type 2 Diabetes Mellitus (T2DM) in midlife is associated with a greater risk of dementia in later life. Both gait speed and spatiotemporal gait characteristics have been associated with later cognitive decline in community-dwelling older adults. Thus, the assessment of gait characteristics in uncomplicated midlife T2DM may be important in selecting-out those with T2DM at greatest risk of later cognitive decline. We assessed the relationship between Inertial Motion Unit (IMUs)-derived gait characteristics and cognitive function assessed via Montreal Cognitive Assessment (MoCA)/detailed neuropsy

View details →DOI: 10.3390/s22155710Cited by 11
Negative / Null Result ReportOpen accessMedicine

Significant association factors of bone mineral density in Taiwan adults

Yuh‐Feng Wang, Tzyy‐Ling Chuang, Mei‐Hua Chuang et al. · 2019 · Tzu Chi Medical Journal

OBJECTIVE: To examine the biofactors associated with bone mineral density (BMD) in southern Taiwanese adults. MATERIALS AND METHODS: The medical records of 3242 adults who underwent health examinations between June 2014 and February 2018…

View details →DOI: 10.4103/tcmj.tcmj_113_19Cited by 11
Negative / Null Result ReportEngineering

Implication of anchor placement on performance of UWB real-time locating system

Charuwalee Suwatthikul, Witsarawat Chantaweesomboon, Supatra Manatrinon et al. · 2017

Recently, real-time locating system (RTLS) with centimeter accuracy using radio frequency signal is available for commercial deployment with the use of ultra-wideband (UWB) technology. One of the commercial UWB real time locating systems…

View details →DOI: 10.1109/ictemsys.2017.7958760Cited by 11
Negative / Null Result ReportOpen accessMedicine

Customized Prediction of Short Length of Stay Following Elective Cardiac Surgery in Elderly Patients Using a Genetic Algorithm

Joon Lee, Sapna Govindan, Leo Anthony Celi et al. · 2013 · World Journal of Cardiovascular Surgery

OBJECTIVE: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. DESIGN: Utilization of a machine learning algorithm in a prospectively collected STS database consisting of patients who received cardiac surgery between January 2002 and June 2011. SETTING: Urban tertiary-care center. PARTICIPANTS: Geriatric patients aged 70 years or older at the time of cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Predefined morbidity and mortality events were collec

View details →DOI: 10.4236/wjcs.2013.35034Cited by 11
Negative / Null Result ReportComputer Science

The Effect of 360-Degree Video Authentic Materials on EFL Learners' Listening Comprehension

Suhe Ji, Ke Li, Linfeng Zou · 2019 · 2019 International Joint Conference on Information, Media and Engineering (IJCIME)

Although the increased use of authentic materials in listening comprehension teaching has become general practice, it is crucial to find out whether or not the new technology-supported authentic material could be beneficial to English as a…

View details →DOI: 10.1109/ijcime49369.2019.00065Cited by 11
Negative / Null Result ReportMedicine

Differential susceptibility to effects of the home environment on motor developmental outcomes of preschool children: low birthweight status as a susceptibility factor

Jennifer Chun-Li Wu, Tung‐liang Chiang · 2015 · Early Child Development and Care

Low birthweight (LBW) children tend to have higher risks of developmental problems. According to differential susceptibility hypothesis, these putatively vulnerable children may also disproportionately benefit from positive environmental…

View details →DOI: 10.1080/03004430.2015.1085862Cited by 11
Negative / Null Result Report

Orthognathic Surgery Has a Significant Positive Effect on Perceived Personality Traits and Perceived Emotional Facial Expressions in Subjects with Primary Maxillary Deficiency

Jeffrey C. Posnick, Brian E. Kinard · 2019 · Plastic and Reconstructive Surgery - Global Open

Background: Crowdsourcing is increasingly being used in medical research to obtain the opinion of laypeople. The investigators hypothesized that a layperson’s perception of a primary maxillary deficiency (PMD) dentofacial deformity (DFD)…

View details →DOI: 10.1097/gox.0000000000002198Cited by 11
Negative / Null Result Report

Did medical doctors who order abdominal CT scans during on-call hours truly become worse at clinical reasoning? Yes, they did

Selin Ersoydan, Derya Yakar, Ömer Kasalak et al. · 2022 · European Radiology

Abstract Objective To investigate temporal changes in clinical reasoning quality of physicians who requested abdominal CT scans at a tertiary care center during on-call hours within a 15-year period. Methods This retrospective study…

View details →DOI: 10.1007/s00330-022-09121-7Cited by 11