Failed Experiment ReportOpen accessNeuroscience
Min Li, Min Li, Shuang Chen et al. · 2025 · Signal Transduction and Targeted Therapy
Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preceding β-amyloid accumulation and driving disease progression. However, therapeutic autophagy modulation is severely restricted by the blood-brain barrier (BBB). To overcome this, we developed Microglia-Liposome Fusion Extrusion (MiLi-FE), a method to engineer microglia-derived nanovesicles (AR@ENV) for the codelivery of AR7 (a CMA inducer) and rapamycin (a mac
View details →DOI: 10.1038/s41392-025-02453-yCited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luyuan Chang, Yang Liu, Haipeng Li et al. · 2025 · Frontiers in Cellular and Infection Microbiology
Cirrhosis remains a significant global health burden, causing approximately 1.4-1.5 million deaths each year and contributing to nearly 46 million disability-adjusted life years (DALYs) worldwide. Increasing evidence identifies the gut-liver axis as a central driver of disease progression, wherein intestinal dysbiosis, barrier disruption, and microbe-derived metabolites collectively exacerbate inflammation, fibrogenesis, and related complications. Across more than 40 recent studies, gut microbial α-diversity declined by 30-60%, and over 80% reported a marked depletion of short-chain fatty acid
View details →DOI: 10.3389/fcimb.2025.1717696Cited by 11 Negative / Null Result ReportOpen accessMathematics
Yong Li, Henry Sun, Zuoli Zhang · 2025 · Pharmaceutics
Background: Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach that integrates human physiological parameters with drug-specific characteristics (including both active pharmaceutical ingredients and excipients), and it has emerged as one of the core technologies for optimizing the efficiency and reliability of drug development. Methods: This study synthesizes applications of PBPK models in FDA-approved drugs (2020–2024), systematically analyzing model utilization frequency, indication distribution, application domains and choice of modeling platforms, to reveal th
View details →DOI: 10.3390/pharmaceutics17111413Cited by 11 Negative / Null Result ReportOpen accessMaterials Science
Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.
3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,
View details →DOI: 10.1038/s44385-025-00041-xCited by 11 Negative / Null Result ReportOpen accessNeuroscience
Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →DOI: 10.3390/brainsci14050516Cited by 10 Negative / Null Result ReportOpen accessMedicine
Tara L. Alvarez, Mitchell Scheiman, Farzin Hajebrahimi et al. · 2025 · British Journal of Sports Medicine
OBJECTIVE: The CONCUSS randomised clinical trial compared the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed therapy for the treatment of concussion-related convergence insufficiency…
View details →DOI: 10.1136/bjsports-2025-109807Cited by 10 Negative / Null Result ReportOpen accessNursing
Hengying Chen, Jue Wang, Baohua Zheng et al. · 2024 · Lipids in Health and Disease
BACKGROUND: Exposure to different concentration levels of fatty acids (FAs) may have an impact on depression. However, previous studies using individual FAs may not reflect the performance of mixtures of various FAs, and the associations of FA patterns with depression remain unclear. METHODS: We conducted the cross-sectional analysis in 792 adults aged 18 and older with available serum FAs and depression screening data in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The serum concentrations of thirty FAs were measured using gas chromatography-mass spectrometry and t
View details →DOI: 10.1186/s12944-024-02142-9Cited by 10 Negative / Null Result ReportOpen accessMedicine
Yu Jun Wong, Laurent Lam, Pierre‐Antoine Soret et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis (PBC). However, the frequency and clinical relevance of discordant biochemical and LSM changes remain unclear. We aim to determine the performance of the most recent or current LSM (LSMc) in predicting first hepatic decompensation (HD) in the setting of discordant biochemical and LSM responses. METHODS: In this international, multicenter study, we included patients with at least two reliable LSM performed at least 6 months apart. Patients
View details →DOI: 10.1016/j.jhep.2025.09.024Cited by 10 Negative / Null Result ReportOpen accessHealth Professions
Shanti Prasad Khanal, Chitra Bahadur Budhathoki, Orkan Okan · 2025 · BMC Public Health
BACKGROUND: There is a gap in theory-based interventions targeting adolescent health literacy. This study evaluated the impact of a school-based health literacy intervention on self-efficacy, health literacy awareness, situation, and…
View details →DOI: 10.1186/s12889-025-24827-1Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Eldad Keha, Hadar Naftalovich, Ariel Shahaf et al. · 2024 · Cognition & Emotion
The current investigation examined the bidirectional effects of cognitive control and emotional control and the overlap between these two systems in regulating emotions. Based on recent neural and cognitive findings, we hypothesised that…
View details →DOI: 10.1080/02699931.2024.2326902Cited by 10 Negative / Null Result ReportOpen accessMedicine
Calvin Trieu, Argonde C. van Harten, Mardou S. S. A. van Leeuwenstijn et al. · 2025 · JAMA Network Open
Importance: Blood-based biomarkers identify Alzheimer disease and hold promise for monitoring disease progression, even in the preclinical disease stages. Objective: To investigate longitudinal trajectories of blood-based biomarkers and association with cognitive decline and risk of progression in individuals with subjective cognitive decline (SCD). Design, Setting, and Participants: This prospective cohort study (Subjective Cognitive Impairment Cohort) of individuals with SCD evaluated at a memory clinic underwent biennial biomarker collection and annual cognitive assessment and diagnostic ev
View details →DOI: 10.1001/jamanetworkopen.2025.45862Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sami Alobaidi · 2025 · Frontiers in Medicine
Chronic kidney disease (CKD) remains a major global health issue, affecting millions and presenting persistent diagnostic and therapeutic challenges. Conventional biomarkers such as serum creatinine and estimated glomerular filtration rate have well-recognized limitations, underscoring the need for novel diagnostic tools and interventions. Emerging evidence highlights the gut-kidney axis as a central contributor to CKD pathogenesis, shaped by microbial dysbiosis and altered metabolite production. Harmful metabolites such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide promote
View details →DOI: 10.3389/fmed.2025.1675458Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This record provides SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0). SΔϕ-65 defines Slop not by whether it is produced by AI or humans, but by whether low execution or production cost externalizes high verification, rebuttal, correction, interpretation, cleanup, and restabilization cost onto others. The central proposition of this document is: Slop is not defined by the producer. Slop is defined by a cost asymmetry: low execution TCC on the producer side, high restabilization TCC on the receiver, platform, expert, p
View details →DOI: 10.5281/zenodo.20127428Cited by 10 Negative / Null Result ReportOpen accessMedicine
Francesco Nonino, Silvia Minozzi, L. Sambati et al. · 2026 · Cochrane Database of Systematic Reviews
RATIONALE: Alzheimer's disease is a neurodegenerative disorder and the most common cause of dementia. Aggregated amyloid-beta protein deposits are implicated in its pathogenesis. Amyloid-beta-targeting monoclonal antibodies (sometimes represented as Aβ-mAbs) are potentially disease-modifying for Alzheimer's disease: through the clearance of amyloid in the brain, they may slow cognitive and functional decline. OBJECTIVES: To assess the clinical benefits and harms of amyloid-beta-targeting monoclonal antibodies aducanumab, bapineuzumab, crenezumab, donanemab, gantenerumab, lecanemab, ponezumab,
View details →DOI: 10.1002/14651858.cd016297Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Ali Derakhshan, Gurpinder Singh Lalli, Yujong Park · 2026 · Language Testing in Asia
While Artificial Intelligence (AI) has significantly transformed L2 testing and assessment, empirical research into how EFL practitioners perceive the specific opportunities and challenges of these tools remains limited. To address this…
View details →DOI: 10.1186/s40468-026-00445-5Cited by 10 Negative / Null Result ReportOpen accessSocial Sciences
Shaofeng Wang, Hao Zhang · 2026 · International Journal of Educational Technology in Higher Education
Abstract The rapid integration of generative artificial intelligence (GenAI) into higher education has precipitated a critical tension between the pursuit of efficiency and the imperative for deep, transformative learning. While GenAI offers unprecedented speed in knowledge processing, it raises concerns that efficiency-driven motivations may erode the cognitive struggle essential for intellectual growth. This study investigates how Human-GenAI pedagogical partnerships influence transformative learning through the dual cognitive pathways of vigilance and offloading, moderated by efficiency ori
View details →DOI: 10.1186/s41239-026-00585-xCited by 10 Negative / Null Result ReportOpen accessDentistry
Gilliana Rozenblum, Karima Ait‐Aissa, G. E. D. Zahran et al. · 2025 · Alzheimer s & Dementia
Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and Neisseria spp. impairs anti-inflammatory protection, worsening neuronal damage. P. gingivalis is strongly linked to an increased risk of AD, especially in individuals with systemic conditions like diabetes, hypertension, and chronic kidney disease. Its presence
View details →DOI: 10.1002/alz.71011Cited by 10 Negative / Null Result ReportOpen accessMedicine
Mónika Fekete, Tamás Jarecsny, Andrea Ceglédi et al. · 2025 · Nutrients
Background: Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are among the leading causes of disability and mortality worldwide. Dietary patterns have emerged as modifiable risk factors that may influence disease onset and progression. The Mediterranean diet (MedDiet), rich in fruits, vegetables, whole grains, legumes, fish, and extra virgin olive oil, has been consistently associated with better cognitive outcomes and reduced risk of neurodegeneration. Aim: This narrative review summarizes current evidence on the role of the MedDiet in slowing the progression
View details →DOI: 10.3390/nu17243929Cited by 10 Negative / Null Result ReportOpen accessEngineering
Angela Stefania Bergantino, Giulio Fusco, Mario Intini et al. · 2025 · The Annals of Regional Science
Abstract The digital economy can function either as a catalyst to stimulate economic growth or else as a driver of socioeconomic inequality when its benefits are unevenly distributed. This study investigates the effect of rural digital connectivity on income inequality in Italy. Utilizing NUTS 3 panel data spanning 2014–2022, we conduct a counterfactual Difference-in-Differences approach with continuous treatment intensity to estimate the impact of introducing rural broadband coverage at speeds of 30 and 100 Mbps on multiple measures of income distribution, including the Gini, Theil, and Atkin
View details →DOI: 10.1007/s00168-025-01440-zCited by 10 Negative / Null Result ReportOpen accessMedicine
Fanjing Kong, Yanru Zhao, Weiming Zhang et al. · 2026 · Nature Communications
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially approved for type 2 diabetes mellitus. Recent evidence suggests their therapeutic potential in various diseases, though their efficacy and safety remain incompletely…
View details →DOI: 10.1038/s41467-025-67701-9Cited by 10 Negative / Null Result ReportOpen accessNeuroscience
Jacob A. Westerberg, Pieter R. Roelfsema · 2025 · Trends in Cognitive Sciences
Perceptual experience depends on recurrent interactions between lower and higher cortices. One theory, predictive coding, posits that feedback from higher to lower brain regions decreases neuronal activity predicted by higher-level representations. Despite the widespread adoption of predictive coding in neuroscience, the correspondence to neurophysiological findings in sensory cortices remains elusive. Here, we review how the canonical patterns of intra- and inter-cortical interactions that occur during perception and shifts of attention deviate from those predicted by predictive coding. We ar
View details →DOI: 10.1016/j.tics.2025.09.018Cited by 10 Negative / Null Result ReportOpen accessMedicine
Jörg Matthes, Anne Reinhardt, Selma Hodzic et al. · 2026 · Journal of Medical Internet Research
Background: The rise of generative artificial intelligence (AI) tools such as ChatGPT is rapidly transforming how people access information online. In the health context, generative AI is seen as a potentially disruptive information source due to its low entry barriers, conversational style, and ability to tailor content to users' needs. However, little is known about whether and how individuals use generative AI for health purposes, and which groups may benefit or be left behind, raising important questions of digital health equity. Objective: This study aimed to assess the current relevance
View details →DOI: 10.2196/75648Cited by 10 Negative / Null Result ReportOpen accessMedicine
Sherry S. Y. Nyeo, Erin M. Cumming, Oliver S. Burren et al. · 2026 · Nature
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
View details →DOI: 10.1038/s41586-025-10020-2Cited by 10 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang et al. · 2025 · Agronomy
Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advances in chromosome-scale genome assemblies, pan-genomics, and haplotype-resolved resequencing have greatly enhanced the capacity to identify causal variants and recover non-reference alleles linked to fibre development and environmental adaptation. Parallel progress in functional genomics and precision genome editing, particularly CRISPR/Cas
View details →DOI: 10.3390/agronomy15102393Cited by 10 Negative / Null Result ReportOpen accessEngineering
Rui Zhao, Qiushi Feng, Yangyang Xia et al. · 2025 · Pharmaceuticals
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses and advancing precision oncology, with established correlations to clinical outcomes in patient-derived models. These systems have transformed preclinical drug screening by bridging the gap between conventional two-dimensional (2D) cultures and in vivo models, preserving tumor histopathology, cellular heterogeneity, and patient-specific molecular
View details →DOI: 10.3390/ph18101540Cited by 10 Negative / Null Result ReportOpen accessEngineering
Yawen Zhu, Wanqi Yang, Zhong‐Xia Wang et al. · 2025 · Journal of Nanobiotechnology
Liver regeneration is a sophisticated biological process influenced by a complex microenvironment that becomes profoundly altered in various pathological conditions. Current therapeutic approaches, including liver transplantation and…
View details →DOI: 10.1186/s12951-025-03729-9Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras et al. · 2026 · Nature Medicine
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome. In multivariable confounder-adjusted regression models, antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant asso
View details →DOI: 10.1038/s41591-026-04284-yCited by 10 Replication FailureOpen accessMedicine
Kang Wang, Jinkai Feng, Hongming Yu et al. · 2025 · Signal Transduction and Targeted Therapy
Transarterial chemoembolization (TACE) is the standard treatment for intermediate-stage hepatocellular carcinoma (HCC), yet its efficacy as a standalone therapy remains suboptimal. This phase 2 trial (ChiCTR2100049829) evaluated the feasibility and safety of TACE combined with atezolizumab and bevacizumab in patients with intermediate-stage HCC. Participants received TACE followed by atezolizumab and bevacizumab until disease progression, unacceptable toxicity, or death. The primary endpoint was objective response rate (ORR) assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1
View details →DOI: 10.1038/s41392-025-02427-0Cited by 10 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Borbála Turcsán, Dorottya Júlia Ujfalussy, Andrea Kerepesi et al. · 2025 · Scientific Reports
Most dog owners in Western countries regard their dogs as companions or family members, prompting extensive research on the human-animal bond. However, many studies rely on broad categories or single dimensions, such as satisfaction or attachment, which can oversimplify the complexity of these relationships. In contrast, our study employed a multifaceted approach, examining the dog-owner bond across 13 relationship scales and comparing these scales to four different types of human relationships to reveal the human-like roles of dogs within a family. Participants (N = 717) characterized their r
View details →DOI: 10.1038/s41598-025-95515-8Cited by 10 Replication FailureOpen accessPsychology
Lea J. Mertens, Michael Koslowski, Felix Betzler et al. · 2026 · JAMA Psychiatry
Importance: Psilocybin shows promise in treating depression, although limitations of previous research warrant further research. Objective: To investigate the efficacy and safety of oral psilocybin, 25 mg, with adjunct psychotherapy in…
View details →DOI: 10.1001/jamapsychiatry.2026.0132Cited by 10 