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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19814 results in Negative / Null Result Report · page 141 of 661

Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Increasing imputation and prediction accuracy for Chinese Holsteins using joint Chinese–Nordic reference population

Peipei Ma, Mogens Sandø Lund, Xiangdong Ding et al. · 2014 · Journal of Animal Breeding and Genetics

This study investigated the effect of including Nordic Holsteins in the reference population on the imputation accuracy and prediction accuracy for Chinese Holsteins. The data used in this study include 85 Chinese Holstein bulls genotyped…

View details →DOI: 10.1111/jbg.12111Cited by 10
Negative / Null Result Report

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis

Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology

Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…

View details →DOI: 10.3389/fcimb.2022.1005392Cited by 10
Negative / Null Result Report

Combination of Lactobacillus plantarum HAC03 and Garcinia cambogia Has a Significant Anti-Obesity Effect in Diet-Induced Obesity Mice

Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients

Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…

View details →DOI: 10.3390/nu15081859Cited by 10
Negative / Null Result Report

Reliable and Clinically Significant Change in Outcomes for Forensic Mental Health Inpatients: Use of the HoNOS-Secure

Geoffrey L. Dickens, Laura E. O'Shea · 2017 · International Journal of Forensic Mental Health

Outcomes measures are commonly derived from post-discharge recidivism, readmission, and mortality rates but information about common outcomes across admission is scant. We determined whether reliable and clinically significant change in…

View details →DOI: 10.1080/14999013.2017.1286415Cited by 10
Negative / Null Result Report

Kicking Triturus arntzeni when it’s down: large-scale nuclear genetic data confirm that newts from the type locality are genetically admixed

B. WIELSTRA, J. W. ARNTZEN · 2014 · Zootaxa

We collected nuclear DNA data (52 markers) with next-generation sequencing for nine Triturus newt specimens, including the holotype and two of the paratypes of T. arntzeni, from the type locality at Vrtovać in eastern Serbia. We compare…

View details →DOI: 10.11646/zootaxa.3802.3.7Cited by 10
Negative / Null Result ReportOpen accessChemistry

Net Analyte Signal-based Quantitative Determination of Fusel Oil in Korean Alcoholic Beverage Using FT-NIR Spectroscopy

Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering

Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…

View details →DOI: 10.5307/jbe.2016.41.3.208Cited by 10
Negative / Null Result Report

Quantifying Clinically Significant Change

Barton J. Mann, Taco Gosens, Stephen Lyman · 2012 · The American Journal of Sports Medicine

Treatment outcome researchers in orthopaedics frequently report only tests of statistical significance between group means to evaluate the effectiveness of a given intervention. Although important in establishing that mean differences are…

View details →DOI: 10.1177/0363546512457346Cited by 10
Negative / Null Result ReportOpen accessEngineering

The relevance of preferential flow in catchment scale simulations: Calibrating a 3D dual‐permeability model using DREAM

Luisa Hopp, Barbara Glaser, Julian Klaus et al. · 2019 · Hydrological Processes

Abstract The occurrence of preferential flow in the subsurface has often been shown in field experiments. However, preferential flow is rarely included in models simulating the hydrological response at the catchment scale. If it is…

View details →DOI: 10.1002/hyp.13672Cited by 10
Negative / Null Result Report

HEATING EFFECT OF THERMALLY SIGNIFICANT BLOOD VESSELS IN PERFUSED TUMOR TISSUE DURING CRYOSURGERY

Z. F. LIU, G. ZHAO, Y. H. CHENG et al. · 2012 · Journal of Mechanics in Medicine and Biology

The purpose of this work is to evaluate the heating effect of thermally significant blood vessels (TSBVs) during cryosurgery process. A theoretical model is developed to describe the heat transfer of perfused tissue containing a 6…

View details →DOI: 10.1142/s0219519411004575Cited by 10
Negative / Null Result ReportOpen accessMedicine

Histogram analysis from stretched exponential model on diffusion-weighted imaging: evaluation of clinically significant prostate cancer

Eun-Ju Kim, Chan Kyo Kim, Hyun Soo Kim et al. · 2020 · British Journal of Radiology

Objective: To evaluate the usefulness of histogram analysis of stretched exponential model (SEM) on diffusion-weighted imaging in evaluating clinically significant prostate cancer (CSC). Methods: A total of 85 patients with prostate cancer…

View details →DOI: 10.1259/bjr.20190757Cited by 10
Negative / Null Result ReportOpen accessEnvironmental Science

Both species richness and growth forms affect nutrient removal in constructed wetlands: A mesocosm experiment

Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution

Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la

View details →DOI: 10.3389/fevo.2023.1139053Cited by 10
Negative / Null Result Report

Development of a ground-based sensorimotor disorientation analog to replicate astronaut postflight experience

Sarah C. Moudy, Brian T. Peters, Torin K. Clark et al. · 2024 · Frontiers in Physiology

The perceptual and motor coordination problems experienced following return from spaceflight reflect the sensory adaptation to altered gravity. The purpose of this study was to develop a ground-based analog that replicates similar…

View details →DOI: 10.3389/fphys.2024.1369788Cited by 10
Negative / Null Result ReportOpen accessNeuroscience

Majority language skill, not measures of bilingualism, predicts executive attention in bilingual children

David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology

Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.

View details →DOI: 10.1016/j.jecp.2021.105256Cited by 10
Negative / Null Result ReportMedicine

Estimated glomerular filtration rate by formulas in patients with cirrhosis: An unreliable procedure

Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International

BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…

View details →DOI: 10.1111/liv.15134Cited by 10
Negative / Null Result Report

“I Have Failed Them and Failed My Duties”: Experiences of Hospital Social Workers Discharging Patients into Homelessness

Rae Morris, Fiona Lewis, Nancy Baker et al. · 2021 · Health & Social Work

Abstract Homelessness is a long-standing issue at the forefront of healthcare globally, and discharge of homeless patients from hospital settings can exacerbate gaps and burdens in healthcare systems. In hospitals, social workers often…

View details →DOI: 10.1093/hsw/hlab039Cited by 10
Negative / Null Result ReportOpen accessDecision Sciences

No relationship between researcher impact and replication effect: an analysis of five studies with 100 replications

John Protzko, Jonathan W. Schooler · 2020 · PeerJ

What explanation is there when teams of researchers are unable to successfully replicate already established ‘canonical’ findings? One suggestion that has been put forward, but left largely untested, is that those researchers who fail to replicate prior studies are of low ‘expertise and diligence’ and lack the skill necessary to successfully replicate the conditions of the original experiment. Here we examine the replication success of 100 scientists of differing ‘expertise and diligence’ who attempted to replicate five different studies. Using a bibliometric tool ( h -index) as our indicator

View details →DOI: 10.7717/peerj.8014Cited by 10
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells

Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal

The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…

View details →DOI: 10.1536/ihj.17-625Cited by 10
Negative / Null Result ReportOpen accessMedicine

Can early measles vaccination control both measles and respiratory syncytial virus infections?

Lien Anh Ha Do, Zheng Quan Toh, Paul Vincent Licciardi et al. · 2021 · The Lancet Global Health

Measles virus and respiratory syncytial virus (RSV) are two important global health pathogens causing substantial morbidity and mortality worldwide. The current measles vaccination schedule has the first dose given at 9-12 months of age…

View details →DOI: 10.1016/s2214-109x(21)00464-2Cited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group

Michal Mego, Barbora Judita Kasperová, Jozef Chovanec et al. · 2024 · Frontiers in Oncology

Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we

View details →DOI: 10.3389/fonc.2024.1438657Cited by 10
Negative / Null Result ReportOpen accessMedicine

Use of Automated Insulin Delivery in Pregnancies Complicated by Type 1 Diabetes

Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology

AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.

View details →DOI: 10.17925/ee.2024.20.2.14Cited by 10
Negative / Null Result ReportOpen accessMedicine

Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic

Martin S. Weber, Jacqueline Nicholas, Michael R. Yeaman · 2021 · Neurology Neuroimmunology & Neuroinflammation

Bruton tyrosine kinase inhibitors (BTKis) encompass a new class of therapeutics currently being evaluated for the treatment of multiple sclerosis (MS). Whether BTKis affect COVID-19 risk or severity or reduce vaccine efficacy are important…

View details →DOI: 10.1212/nxi.0000000000001067Cited by 10
Negative / Null Result ReportOpen accessMedicine

Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection

Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology

Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level

View details →DOI: 10.1155/2017/5238402Cited by 10
Negative / Null Result ReportOpen accessMedicine

The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning

Mohammad Reza Beyranvand, Soleyman Farrokhi, Hassan Peyvandi et al. · 2019 · Archives of Industrial Hygiene and Toxicology

Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. They were divided in two groups of 23: one receiving amiodarone and the other not (control). The treatment group received amiodarone prophylaxis in the initial intravenous bolus dose of 150 mg, followed by a drip of 1 mg/min for six hours and then of 0.5 mg/min for eight

View details →DOI: 10.2478/aiht-2019-70-3162Cited by 10
Negative / Null Result ReportOpen accessMedicine

“Fast track” rehabilitation after gastric cancer resection: experience with 80 consecutive cases

Jingxiang Song, Xiaohuang Tu, Bing Wang et al. · 2014 · BMC Gastroenterology

BACKGROUND: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. RESULTS: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%)

View details →DOI: 10.1186/1471-230x-14-147Cited by 10
Negative / Null Result ReportOpen accessMedicine

Thought-provoking Molecules for Drug Discovery: antioxidants

İpek Komşuoğlu Çelikyurt · 2011 · Pharmaceutica Analytica Acta

Affirmative influence of antioxidant vitamins may be observed in atherosclerosis and endothelial dysfunction, male infertility, Parkinson's disease (especially via lipoic acid), diabetes, brain tumors and skin maturation There is not yet…

View details →DOI: 10.4172/2153-2435.s3-001Cited by 10
Negative / Null Result ReportOpen accessMedicine

A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

Qiang Tang, Yanwei Liu, Yingfeng Fu et al. · 2021 · Scientific Reports

The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that adv

View details →DOI: 10.1038/s41598-021-87413-6Cited by 10
Negative / Null Result ReportNeuroscience

Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine.

Brent A Bushey, Victor H Auld, John E Volk et al. · 2011 · PubMed

This study examined whether combining lipid emulsion and advanced cardiac life support (ACLS) improves survival in an unanesthetized swine model of bupivacaine- and hypoxia-induced cardiovascular collapse. Arterial and venous catheters and…

View details →Cited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The copepod Acartia tonsa as live feed for fat snook (Centropomus parallelus) larvae from notochord flexion to advanced metamorphosis

Márcia Vanacor Barroso, Cristina Vaz Avelar de Carvalho, Rosemar Antoniassi et al. · 2017 · Latin American Journal of Aquatic Research

From early development until the completion of metamorphosis, fat snook (Centropomus parallelus) larvae are commonly fed the rotifers Brachionus spp. and Artemia spp. nauplii. In this study, cultivated copepods Acartia tonsa were evaluated…

View details →DOI: 10.3856/vol45-issue1-fulltext-15Cited by 10
Negative / Null Result ReportEconomics, Econometrics and Finance

Does the SARB respond to oil price movements? Historical evidence from the frequency domain

Goodness C. Aye, Olorato Gadinabokao, Rangan Gupta · 2016 · Energy Sources Part B Economics Planning and Policy

Causality testing procedures in the frequency domain and the time domain are employed to analyses the relationship between oil prices and interest rate in South Africa, covering the time period January 1936–November 2013 . Results show…

View details →DOI: 10.1080/15567249.2014.966927Cited by 10