e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 141 of 674

Negative / Null Result ReportOpen accessArts and Humanities

Exploring GenAI affordance in EFL continuation task instruction for developing Chinese high school students’ writing complexity, accuracy and fluency

Yongliang Wang, Han Shi · 2026 · Discover Computing

Abstract The role of generative artificial intelligence (GenAI) affordance in specific task teaching, particularly the continuation writing task, remains insufficiently theorized and empirically underexplored. To bridge this research gap, a repeated-measures intervention study was conducted within the framework of Dynamic Systems Theory (DST) to investigate the implementation of GenAI-assisted continuation task instruction and its associations with the development of English as a Foreign Language (EFL) students’ writing performance. Twenty-five Chinese EFL high school students participated in

View details →DOI: 10.1007/s10791-026-10241-7Cited by 10
Negative / Null Result ReportOpen accessDecision Sciences

Large-scale assessment of regression modeling practices in phytomedicine extraction process optimization

Yuan Tao, Yu Z, Tianxue Chen et al. · 2026 · iScience

Phytomedicine extraction-process optimization often relies on regression or machine learning models, but model choice is commonly judged by goodness of fit alone. Here, we assembled 1,148 structurally eligible extraction datasets from…

View details →DOI: 10.1016/j.isci.2026.116883Cited by 10
Negative / Null Result ReportOpen accessMedicine

Neonatal Respiratory Outcomes in Placenta Previa with Histopathologically Confirmed Placenta Accreta Spectrum

Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine

Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc

View details →DOI: 10.3390/jcm15155891Cited by 10
Negative / Null Result ReportOpen accessSocial Sciences

Fairness Across the World

Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics

Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather

View details →DOI: 10.1093/qje/qjag044Cited by 10
Negative / Null Result ReportOpen accessEnvironmental Science

Dynamic oxygen vacancy engineering on CuO via refreshable catalytic surface for high-efficient water decontamination

Xinyi Zhang, Liangjie Wang, Jian Wei et al. · 2026 · Nature Communications

Oxygen vacancies (Ov) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully…

View details →DOI: 10.1038/s41467-025-68180-8Cited by 10
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration

Ashley Rich, Ziqi Li, Alessandro De Simone et al. · 2026 · Nature Physics

Amputated salamander limbs or fish fins precisely regenerate to their pre-injury size, providing a paradigm for positional memory. Although this phenomenon has been appreciated for centuries, how position-dependent cues control tissue…

View details →DOI: 10.1038/s41567-026-03426-wCited by 10
Negative / Null Result ReportOpen accessMedicine

Risk stratification and scoring systems in upper and lower gastrointestinal bleeding: review of performance and limitations in the emergency department

Fatemeh Mohammadyari, Amirreza Aflak, Mahta ZareDini et al. · 2025 · Frontiers in Medicine

Background: Gastrointestinal bleeding (GIB), which includes both upper GIB (variceal and non-variceal) and lower GIB, represents a significant cause of emergency department referrals. Main body: Given the potential risks of blood transfusion, re-bleeding, and mortality in these patients, it is essential to establish a system for prioritizing critical patients. Several risk stratification scoring systems have been developed based on patients' clinical characteristics and/or endoscopic findings. However, the optimal scoring system for each clinical scenario remains uncertain. Conclusion: In this

View details →DOI: 10.3389/fmed.2025.1564015Cited by 10
Negative / Null Result ReportOpen accessPsychology

The role of metacognitive awareness as mediator and moderator in the nexus between self-regulated learning and mathematics achievement

Isaac Davor, Francis Ohene Boateng, Franco Osei-Wusu et al. · 2026 · Cogent Education

This study examines the mediating and moderating role of metacognitive awareness in the relationship between self-regulated learning and mathematics achievement of university students in Ghana. Although self-regulated learning has attracted attention as a predictor of academic performance, few studies have examined how metacognitive awareness interacts with self-regulated learning to influence mathematics achievement in the Ghanaian context. A quantitative cross-sectional design was employed. Data were collected from 315 university students, representing a population of 3,240, using a structur

View details →DOI: 10.1080/2331186x.2026.2661434Cited by 10
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review

Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology

Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b

View details →DOI: 10.3389/fimmu.2025.1713426Cited by 10
Negative / Null Result ReportOpen accessMedicine

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons with differential pain etiology

Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain

ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…

View details →DOI: 10.1097/j.pain.0000000000003931Cited by 10
Negative / Null Result ReportOpen accessEngineering

Optimization of binary binder blends for aqueous-based slurries of SiOx/C for next-generation lithium-ion batteries

Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production

The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…

View details →DOI: 10.1016/j.jclepro.2026.148153Cited by 10
Negative / Null Result ReportOpen accessNursing

Association of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011–2012

Hengying Chen, Jue Wang, Baohua Zheng et al. · 2024 · Lipids in Health and Disease

BACKGROUND: Exposure to different concentration levels of fatty acids (FAs) may have an impact on depression. However, previous studies using individual FAs may not reflect the performance of mixtures of various FAs, and the associations of FA patterns with depression remain unclear. METHODS: We conducted the cross-sectional analysis in 792 adults aged 18 and older with available serum FAs and depression screening data in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The serum concentrations of thirty FAs were measured using gas chromatography-mass spectrometry and t

View details →DOI: 10.1186/s12944-024-02142-9Cited by 10
Negative / Null Result ReportOpen accessMedicine

GLP-1 and the cardiovascular system

Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation

The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA

View details →DOI: 10.1172/jci194748Cited by 10
Negative / Null Result ReportOpen accessNeuroscience

Control your emotions: evidence for a shared mechanism of cognitive and emotional control

Eldad Keha, Hadar Naftalovich, Ariel Shahaf et al. · 2024 · Cognition & Emotion

The current investigation examined the bidirectional effects of cognitive control and emotional control and the overlap between these two systems in regulating emotions. Based on recent neural and cognitive findings, we hypothesised that…

View details →DOI: 10.1080/02699931.2024.2326902Cited by 10
Negative / Null Result ReportOpen accessEnergy

Photocatalytic degradation of Congo red dye using innovative cerium titanate nanorods embedded in a cellulose-based hydrogel

Ahmed M. Khalil, Samir M. Kamel, Mohamed S. Mohy Eldin · 2026 · Scientific Reports

This work used a simple technique to prepare a novel cerium titanate nano-rods embedded in a cellulose-based hydrogel with high photo catalytic degradation activity. The composite hydrogel was prepared by embedding different amounts of cerium titanate nano-rods (Ce/Ti-NRs) into a crosslinked carboxymethyl cellulose/polyacrylamide polyelectrolyte complex (CMC/PAM) as a matrix material. The physico-chemical properties of the Ce/Ti-NRs, CMC/PAM, and cerium titanate nano-rods embedded in a cellulose-based hydrogel (Ce/Ti-NRs/CMC/PAM) were investigated by FT-IR, XRD, BET, TEM, SEM, and EDX techniqu

View details →DOI: 10.1038/s41598-026-43425-8Cited by 10
Negative / Null Result ReportOpen accessMedicine

Bicistronic-CD19/22 Chimeric Antigen Receptor T-Cell Therapy for Childhood Refractory Lupus Nephritis

Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…

View details →DOI: 10.1016/j.ekir.2025.10.008Cited by 10
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial

Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine

Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom

View details →DOI: 10.1038/s41591-026-04440-4Cited by 10
Negative / Null Result ReportOpen accessPhysics and Astronomy

The Velocity Field Olympics: assessing velocity field reconstructions with direct distance tracers

Richard Stiskalek, Harry Desmond, Julien Devriendt et al. · 2025 · Monthly Notices of the Royal Astronomical Society

ABSTRACT The peculiar velocity field of the local Universe provides direct insights into its matter distribution and the underlying theory of gravity, and is essential in cosmological analyses for modelling deviations from the Hubble flow. Numerous methods have been developed to reconstruct the density and velocity fields at $z \lesssim 0.05$, typically constrained by redshift-space galaxy positions or by direct distance tracers such as the Tully–Fisher relation, the Fundamental Plane, or Type Ia supernovae. We introduce a validation framework to evaluate the accuracy of these reconstructions

View details →DOI: 10.1093/mnras/staf1960Cited by 10
Negative / Null Result ReportOpen accessSocial Sciences

SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0)

Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)

This record provides SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0). SΔϕ-65 defines Slop not by whether it is produced by AI or humans, but by whether low execution or production cost externalizes high verification, rebuttal, correction, interpretation, cleanup, and restabilization cost onto others. The central proposition of this document is: Slop is not defined by the producer. Slop is defined by a cost asymmetry: low execution TCC on the producer side, high restabilization TCC on the receiver, platform, expert, p

View details →DOI: 10.5281/zenodo.20127428Cited by 10
Negative / Null Result ReportOpen accessImmunology and Microbiology

Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy

Koen H.M. Prange, Gemma Bel-Bordes, MAC Depuydt et al. · 2026 · European Heart Journal

BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot

View details →DOI: 10.1093/eurheartj/ehag117Cited by 10
Negative / Null Result ReportOpen accessMedicine

Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer’s disease

Francesco Nonino, Silvia Minozzi, L. Sambati et al. · 2026 · Cochrane Database of Systematic Reviews

RATIONALE: Alzheimer's disease is a neurodegenerative disorder and the most common cause of dementia. Aggregated amyloid-beta protein deposits are implicated in its pathogenesis. Amyloid-beta-targeting monoclonal antibodies (sometimes represented as Aβ-mAbs) are potentially disease-modifying for Alzheimer's disease: through the clearance of amyloid in the brain, they may slow cognitive and functional decline. OBJECTIVES: To assess the clinical benefits and harms of amyloid-beta-targeting monoclonal antibodies aducanumab, bapineuzumab, crenezumab, donanemab, gantenerumab, lecanemab, ponezumab,

View details →DOI: 10.1002/14651858.cd016297Cited by 10
Negative / Null Result ReportOpen accessComputer Science

Not all cognitive offloading is equal: distinguishing dependent and autonomous offloading to generative AI

Qiuhan Zhu, Xiangnan Li, Yiang Dong et al. · 2026 · Frontiers in Psychology

Generative AI tools such as ChatGPT now perform core cognitive operations—reasoning, synthesis, evaluation, and creative generation—on users' behalf, raising urgent questions for educational psychology about how AI use relates to cognitive development. Yet research on cognitive offloading has largely treated AI use as a unidimensional phenomenon, obscuring a theoretically consequential distinction: whether AI substitutes for the user's own thinking or scaffolds it. Drawing on the autonomous–dependent help typology and self-determination theory, the present study introduces and examines a disti

View details →DOI: 10.3389/fpsyg.2026.1878629Cited by 10
Negative / Null Result ReportOpen accessSocial Sciences

Unpacking EFL teachers’ perceived opportunities and challenges of multimodal AI-driven language testing

Ali Derakhshan, Gurpinder Singh Lalli, Yujong Park · 2026 · Language Testing in Asia

While Artificial Intelligence (AI) has significantly transformed L2 testing and assessment, empirical research into how EFL practitioners perceive the specific opportunities and challenges of these tools remains limited. To address this…

View details →DOI: 10.1186/s40468-026-00445-5Cited by 10
Negative / Null Result ReportOpen accessMedicine

Mapping intratumor heterogeneity across layers for advancing immunotherapy

Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell

Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…

View details →DOI: 10.1016/j.cell.2026.03.025Cited by 10
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Chengjiao Yang, Ruici Yang, Binbin Zheng et al. · 2026 · Cell Death and Disease

Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pathways (AARS1/2, KATs, HDACs) and non-enzymatic mechanisms (MGO/LGSH), alongside their critical structural underpinnings. Furthermore, we delineate how lactylation signals are interpreted by specific readers (e.g., TRIM33), directly reprogram non-histone protein function through s

View details →DOI: 10.1038/s41419-026-08494-7Cited by 10
Negative / Null Result ReportOpen accessSocial Sciences

Pedagogical partnerships with generative AI in higher education: how dual cognitive pathways paradoxically enable transformative learning

Shaofeng Wang, Hao Zhang · 2026 · International Journal of Educational Technology in Higher Education

Abstract The rapid integration of generative artificial intelligence (GenAI) into higher education has precipitated a critical tension between the pursuit of efficiency and the imperative for deep, transformative learning. While GenAI offers unprecedented speed in knowledge processing, it raises concerns that efficiency-driven motivations may erode the cognitive struggle essential for intellectual growth. This study investigates how Human-GenAI pedagogical partnerships influence transformative learning through the dual cognitive pathways of vigilance and offloading, moderated by efficiency ori

View details →DOI: 10.1186/s41239-026-00585-xCited by 10
Negative / Null Result ReportOpen accessPsychology

Within-Person Association Between Daily Screen Use and Sleep in Youth

Matthew Bourke, Claudia I. Maddren, Franziska Sippel et al. · 2026 · Archives of Pediatrics and Adolescent Medicine

Importance: Understanding the within-person association between daily screen use and sleep can help clarify whether this association reflects potentially causal effects or confounding factors. Objective: To synthesize evidence on the…

View details →DOI: 10.1001/jamapediatrics.2025.6490Cited by 10
Negative / Null Result ReportOpen accessMedicine

Cell Migration–Proliferation Dichotomy in Cancer: Biological Fact or Experimental Artefact?

Abdulaziz Alfahed · 2024 · Biology

The migration-proliferation dichotomy (MPD) has long been observed in cultured cancer cells. This phenomenon is not only relevant to tumour progression but may also have therapeutic significance in clinical cancer. However, MPD has rarely been investigated in primary cancer. This study aimed to either confirm or disprove the existence of MPD in primary cancer. Using primary gastric, colorectal and prostate cancer (GC, CRC and PCa) cohorts from the Cancer Genome Atlas and Memorial Sloan Kettering Cancer Center, this study interrogated the MPD phenomenon by utilising RNA-Seq-based proliferation

View details →DOI: 10.3390/biology13100753Cited by 10
Negative / Null Result ReportOpen accessMedicine

Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer’s disease continuum

Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications

To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species

View details →DOI: 10.1038/s41467-026-71732-1Cited by 10
Negative / Null Result ReportOpen accessMathematics

Scale reliant inference

Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics

Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…

View details →DOI: 10.1214/26-aoas2230Cited by 10