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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 138 of 674

Negative / Null Result ReportOpen accessMedicine

Alexithymia and the Evaluation of Emotionally Valenced Scenes

Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology

Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple

View details →DOI: 10.3389/fpsyg.2020.01820Cited by 11
Negative / Null Result Report

Funding source and primary outcome changes in clinical trials registered on ClinicalTrials.gov are associated with the reporting of a statistically significant primary outcome: a cross-sectional study

Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi et al. · 2015 · F1000Research

Background : We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study…

View details →DOI: 10.12688/f1000research.6312.1Cited by 11
Negative / Null Result Report

Microbial Conversion of Cheese Whey to Polyhydroxybutyrate (PHB) via Statistically Optimized Cultures

Giannis Penloglou, Alexandros Pavlou, Costas Kiparissides · 2023 · Fermentation

The intended circular economy for plastics envisages that they will be partially replaced by bio-based polymers in the future. In this work, the natural polyester polyhydroxybutyrate (PHB) was produced by Azohydromonas lata using cheese…

View details →DOI: 10.3390/fermentation9070624Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Ex vivo infection model for Francisella using human lung tissue

Kristin Köppen, Diana Fatykhova, Gudrun Holland et al. · 2023 · Frontiers in Cellular and Infection Microbiology

Introduction Tularemia is mainly caused by Francisella tularensis ( Ft ) subsp. tularensis ( Ftt ) and Ft subsp. holarctica ( Ftt ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment. So far, only 2D cell culture and animal models are used to study Francisella virulence , but the gained results are transferable to human infections only to a certain extent. Method In this study, we firstly established an ex

View details →DOI: 10.3389/fcimb.2023.1224356Cited by 11
Negative / Null Result ReportOpen accessMedicine

Data-driven profiles of attention-deficit/hyperactivity disorder using objective and ecological measures of attention, distractibility, and hyperactivity

Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Rosa Cánovas et al. · 2023 · European Child & Adolescent Psychiatry

In the past two decades, the traditional nosology of attention-deficit/hyperactivity disorder (ADHD) has been criticized for having insufficient discriminant validity. In line with current trends, in the present study, we combined a data-driven approach with the advantages of virtual reality aiming to identify novel behavioral profiles of ADHD based on ecological and performance-based measures of inattention, impulsivity, and hyperactivity. One hundred and ten Spanish-speaking participants (6-16 years) with ADHD (medication-naïve, n = 57) and typically developing participants (n = 53) complete

View details →DOI: 10.1007/s00787-023-02250-4Cited by 11
Negative / Null Result ReportPsychology

Neuroscientific, Neuropsychological, and Psychological Evidence Comparably Impact Legal Decision Making: Implications for Experts and Legal Practitioners

Casey LaDuke, Benjamin Locklair, Kirk Heilbrun · 2018 · Journal of Forensic Psychology Research and Practice

Neuroscientific evidence is assuming an increasingly prominent role in criminal law, where it has considerable potential for affecting legal decision making. Our understanding of this effect is currently limited. Research initially…

View details →DOI: 10.1080/24732850.2018.1439142Cited by 11
Negative / Null Result ReportOpen accessImmunology and Microbiology

Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RNA

Natalia Ristic, Mario P. S. Chin · 2010 · Retrovirology

BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate in human T cell lines. The replication restriction phenotype in the SL1 deletion mutant appears to be multifactorial, with defects in viral RNA dimerization and packaging in producer cells as well as in reverse transcription of the viral RNA in infected cells. In this study, we sought to characterize SL

View details →DOI: 10.1186/1742-4690-7-73Cited by 11
Negative / Null Result ReportPsychology

How literary can literariness be?

Massimo Salgaro · 2015 · Scientific Study of Literature

In literary theory, there are two common proposals about the nature of literature: that literariness is a distinctive characteristic of literary texts and that literariness is mostly characterized by highly foregrounded textual features.…

View details →DOI: 10.1075/ssol.5.2.06salCited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Examining the effects of the killing of George Floyd by police in the United States on attitudes of Black Londoners: a replication

Amy Nivette, Christof Nägel, Emily Gilbert · 2023 · Police Practice and Research

High-profile incidents of police misconduct can have serious consequences for public trust in the police. A recent study in the British Journal of Political Science found that Eric Garner’s death in NYC lead to more negative attitudes towards the police in London among Black residents compared to White and Asian residents. The current study aimed to replicate this transnational effect by assessing the impact of George Floyd’s death on Londoners’ perceptions of police. Using the same data and methodological approach, we did not replicate the immediate effect on Black Londoners’ attitudes. We di

View details →DOI: 10.1080/15614263.2023.2185241Cited by 11
Negative / Null Result ReportMedicine

Should we use automated external defibrillators in hospital wards?

Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed

Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…

View details →DOI: 10.2143/acb.67.4.2062666Cited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Is there prejudice from thin air? Replicating the effect of emotion on automatic intergroup attitudes

Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology

BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su

View details →DOI: 10.1186/s40359-020-00414-4Cited by 11
Negative / Null Result ReportOpen accessNeuroscience

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Astrid Feiten, Kilian Dahm, Kai Schlepckow et al. · 2026 · Nature Communications

Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met

View details →DOI: 10.1038/s41467-026-68706-8Cited by 11
Negative / Null Result ReportOpen accessMedicine

Exercise blood pressure relative to fitness and cardiovascular outcomes: the EXERTION study

Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal

BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital

View details →DOI: 10.1093/eurheartj/ehaf1082Cited by 11
Negative / Null Result ReportOpen accessNeuroscience

Null effect of perceived drum pattern complexity on the experience of groove

Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE

There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco

View details →DOI: 10.1371/journal.pone.0311877Cited by 11
Negative / Null Result ReportOpen accessMedicine

Gut Microbiota Dysbiosis in Endometriosis: A Potential Link to Inflammation and Disease Progression

Alexandra Irma Gabriela Bauşic, Francesca Scurtu, Andrei Manu et al. · 2025 · International Journal of Molecular Sciences

Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using

View details →DOI: 10.3390/ijms26115144Cited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Evaluating the Effectiveness of Digital Marketing Campaigns through Conversion Rates and Engagement Levels Using ANOVA and Chi-Square Tests

Untung Rahardja · 2025 · Journal of Digital Market and Digital Currency.

This study investigates the effectiveness of various digital marketing campaign types—Awareness, Conversion, and Retention—on conversion rates and engagement levels. Using a dataset of 8,000 records, we conducted a comprehensive analysis through ANOVA, Chi-Square tests, and OLS regression to understand the impact of these campaign types. The ANOVA results indicated no significant differences in conversion rates across the campaign types, with an F-statistic of 0.4752 and a p-value of 0.6218. Similarly, the analysis for engagement levels, measured by website visits, yielded an F-statistic of 0.

View details →DOI: 10.47738/jdmdc.v2i1.27Cited by 11
Negative / Null Result ReportOpen accessEngineering

Short-Term Wind Power Forecast Based on STL-IAOA-iTransformer Algorithm: A Case Study in Northwest China

Zhaowei Yang, Wenqi Liu, Miwei Li et al. · 2025 · Energy Engineering

Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids. Although numerous studies have employed various methods to forecast wind power, there re... | Find, read and cite all the research you need on Tech Science Press

View details →DOI: 10.32604/ee.2025.059515Cited by 11
Negative / Null Result ReportOpen accessMaterials Science

Using Solid-State NMR to Understand the Structure of Plant Cellulose

Rosalie Cresswell, Parveen Kumar Deralia, Yoshihisa Yoshimi et al. · 2025 · Journal of the American Chemical Society

High Resolution Image Download MS PowerPoint Slide The structure of plant cellulose microfibrils remains elusive, despite the abundance of cellulose and its utility in industry. Using 2D solid-state NMR of 13 C-labeled never-dried plants, six major glucose environments are resolved, which are common to the cellulose of softwood, hardwood, and grasses. These environments are maintained in isolated holocellulose nanofibrils, allowing more detailed microfibril characterization. We show that there are only two glucose environments that reside within the microfibril core. These have the same NMR 13

View details →DOI: 10.1021/jacs.5c14452Cited by 11
Negative / Null Result ReportOpen accessPhysics and Astronomy

Non-Majorana origin of anomalous current-phase relation and Josephson diode effect in Bi 2 Se 3 /NbSe 2 Josephson junctions

Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances

Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr

View details →DOI: 10.1126/sciadv.adw6925Cited by 11
Negative / Null Result ReportOpen accessPhysics and Astronomy

X-Ray Polarization of the Magnetar 1E 1841−045

R. J. Stewart, George Younes, A. K. Harding et al. · 2025 · The Astrophysical Journal Letters

Abstract We report on IXPE and NuSTAR observations beginning 40 days after the 2024 outburst onset of magnetar 1E 1841−045, marking the first IXPE observation of a magnetar in an enhanced state. Our spectropolarimetric analysis indicates that both a blackbody (BB) plus double power-law (PL) and a double blackbody plus power-law spectral model fit the phase-averaged intensity data well, with a hard PL tail (Γ = 1.19 and 1.35, respectively) dominating above ≈5 keV. For the former model, we find the soft PL (the dominant component at soft energies) exhibits a polarization degree (PD) of ≈30% whil

View details →DOI: 10.3847/2041-8213/adbffaCited by 11
Negative / Null Result ReportPsychology

The Role of Digital Transformation and English Language Technological Self‐Efficacy in the Era of Artificial Intelligence

Muhammad Ahsan Younas, Rashid Menhas, Uzma Noor · 2026 · European Journal of Education

ABSTRACT This study investigates the multifaceted role of artificial intelligence (AI) and digital transformation (DT) in reshaping smart learning environments within the education sector. Using structural equation modelling with data…

View details →DOI: 10.1111/ejed.70536Cited by 11
Negative / Null Result ReportOpen accessMedicine

Five‐Year Unified Risk Prediction Model for Gastric and Esophageal Cancer Based on Nationwide Health Check‐Up Data in Japan: J‐GESS Score

Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology

BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…

View details →DOI: 10.1111/jgh.70409Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications

Luyuan Chang, Yang Liu, Haipeng Li et al. · 2025 · Frontiers in Cellular and Infection Microbiology

Cirrhosis remains a significant global health burden, causing approximately 1.4-1.5 million deaths each year and contributing to nearly 46 million disability-adjusted life years (DALYs) worldwide. Increasing evidence identifies the gut-liver axis as a central driver of disease progression, wherein intestinal dysbiosis, barrier disruption, and microbe-derived metabolites collectively exacerbate inflammation, fibrogenesis, and related complications. Across more than 40 recent studies, gut microbial α-diversity declined by 30-60%, and over 80% reported a marked depletion of short-chain fatty acid

View details →DOI: 10.3389/fcimb.2025.1717696Cited by 11
Negative / Null Result ReportOpen accessMathematics

The Evolution and Future Directions of PBPK Modeling in FDA Regulatory Review

Yong Li, Henry Sun, Zuoli Zhang · 2025 · Pharmaceutics

Background: Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach that integrates human physiological parameters with drug-specific characteristics (including both active pharmaceutical ingredients and excipients), and it has emerged as one of the core technologies for optimizing the efficiency and reliability of drug development. Methods: This study synthesizes applications of PBPK models in FDA-approved drugs (2020–2024), systematically analyzing model utilization frequency, indication distribution, application domains and choice of modeling platforms, to reveal th

View details →DOI: 10.3390/pharmaceutics17111413Cited by 11
Negative / Null Result ReportOpen accessMaterials Science

A 3D spheroid model for assessing nanocarrier-based drug delivery to solid tumors

Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.

3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,

View details →DOI: 10.1038/s44385-025-00041-xCited by 11
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Mechanism, Efficacy, and Safety of Natural Antibiotics

Andrei Teodor Matei, Anita Ioana Vișan · 2025 · Antibiotics

The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these molecules, leading to antibiotic-resistant bacteria that can withstand single-target synthetic drugs but are vulnerable to multiple attack pathways (e.g., cell wall disruption, protein synthesis inhibition, biofilm interference) from natural compounds. Natura

View details →DOI: 10.3390/antibiotics14100981Cited by 11
Negative / Null Result ReportOpen accessNeuroscience

Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age

Ola Ozernov‐Palchik, Amanda O’Brien, Elizabeth Jiachen Lee et al. · 2026 · Nature Communications

In adults, left hemisphere (LH) damage often leads to aphasia, but many cases of early damage leave linguistic processing intact, with a functional language system developing in the right hemisphere. To explain this early apparent equipotentiality of the two hemispheres for language, some have proposed that the language system is more bilateral during early development and becomes increasingly left-lateralized with age. We examined language lateralization using fMRI in two large developmental cohorts (total n=273 children aged 4-16 years; n=107 adults). Strong, adult-like LH lateralization (in

View details →DOI: 10.1038/s41467-026-72916-5Cited by 11
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Navigating Chinese green deals through green investment, green technology, and green energy development: a race for sustainability or greenwashing?

Buhari Doğan, Mohammad Razib Hossain, Rabeh Khalfaoui et al. · 2026 · Financial Innovation

Abstract Drawing from the recent COP28, which espouses a boom in clean energy transition through technological forwardness, and the framework of the SDG, we address critical questions related to green investment, energy investment, and environmental sustainability. We scrutinize whether green technology genuinely leads to green investment and energy investment in China and whether the causal nexus between these variables holds amid an EKC postulation. We use Chinese provincial data from 1998 to 2020 and deploy the quantile moment-based non-parametric regression technique and the newly develope

View details →DOI: 10.1186/s40854-025-00894-6Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms

Dingya Sun, Jialu Wang, Xin Li et al. · 2026 · Antioxidants

Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metab

View details →DOI: 10.3390/antiox15010109Cited by 11