Negative / Null Result ReportOpen accessMedicine
András Komócsi, Dániel Aradi, Tibor Szük et al. · 2018 · The American Journal of Cardiology
Evidence is conflicting regarding the clinical benefits of selecting P2Y12 inhibitors based on platelet function testing (PFT). Between March 1, 2013 and March 1, 2014, we collected clinical characteristics and platelet function data in a…
View details →DOI: 10.1016/j.amjcard.2018.01.032Cited by 12 Negative / Null Result ReportOpen accessMedicine
Helen L. Reeves, John Reicher, Georgia Priona et al. · 2022 · Frontline Gastroenterology
Objective: Hepatocellular carcinoma (HCC) deaths are rising alarmingly. Many patients are unsuitable for available therapies. Poor response rates further hamper outcomes for those that are. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. Design/method: As a quality/service improvement, we audited consecutive patients treated with SIRT (2015-2020) by the Newcastle upon Tyne Hospitals National Health Service Foundation Trust HCC multidisciplinary team. Indications, Barcelona clinic liver cancer (BCLC) stage, treat
View details →DOI: 10.1136/flgastro-2022-102137Cited by 12 Negative / Null Result ReportOpen accessNursing
Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients
Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.
View details →DOI: 10.3390/nu14204395Cited by 12 Negative / Null Result ReportOpen accessNeuroscience
Susanne Clinch, Stacie Hudgens, Elizabeth Gibbons et al. · 2023 · Patient Related Outcome Measures
Purpose: Adaptive Behavior Scale is often used in autism spectrum disorder (ASD) trials. The Adaptive Behavior Composite Score (VABS-ABC) is the standardized overall score (the average of the Socialization, Communication and Daily Living…
View details →DOI: 10.2147/prom.s385542Cited by 12 Negative / Null Result Report
Oleh V. Lushchak, Dmytro V. Gospodaryov, Ihor S. Yurkevych et al. · 2015 · Archives of Insect Biochemistry and Physiology
Aging is often associated with accumulation of oxidative damage in proteins and lipids. However, some studies do not support this view, raising the question of whether high levels of oxidative damage are associated with lifespan. In the…
View details →DOI: 10.1002/arch.21308Cited by 12 Negative / Null Result ReportOpen accessEngineering
Christoph Leo, Maria C. Rizzi, N M Bos et al. · 2021 · Frontiers in Bioengineering and Biotechnology
This study has analyzed sex-specific differences in pedestrian and cyclist accidents involving passenger cars. The most frequently injured body regions, types of injuries, which show sex-specific differences and the general accident parameters of females and males were compared. Accident data from three different European countries (Austria, Netherlands, Sweden) were analyzed. The current analysis shows that for both, females and males, pedestrian and cyclist injuries are sustained mainly to the body regions head, thorax, upper extremities and lower extremities. The results show that the odds
View details →DOI: 10.3389/fbioe.2021.677952Cited by 12 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Alexander A. Rashin, Marcin J. Domagalski, Michael T. Zimmermann et al. · 2014 · Acta Crystallographica Section D Biological Crystallography
Validation of general ideas about the origins of conformational differences in proteins is critical in order to arrive at meaningful functional insights. Here, principal component analysis (PCA) and distance difference matrices are used to…
View details →DOI: 10.1107/s1399004713028812Cited by 12 Negative / Null Result ReportOpen accessMedicine
Yang� Yang, Shengru Liang, Yuqian Li et al. · 2019 · Neuropsychiatric Disease and Treatment
BACKGROUND: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear. MATERIALS AND METHODS:…
View details →DOI: 10.2147/ndt.s190845Cited by 12 Negative / Null Result Report
Stephen F. Hall, Rebecca J. Griffiths, Brian O'Sullivan et al. · 2019 · Head & Neck
Abstract Background Distant metastases (DM) are a leading cause of death for patients with oropharyngeal cancer (OPSCC). The objective of this study was to compare the rates of DM after chemoradiotherapy (CRT) and radiotherapy alone (RT)…
View details →DOI: 10.1002/hed.25679Cited by 12 Negative / Null Result ReportOpen accessMedicine
Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter et al. · 2025 · Acta Neuropathologica Communications
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. Utilizing these properties, seed amplification assays (SAA) enable the detection of aSyn pathology in living patients. We hypothesized that structurally distinct aSyn aggregates, or strains, may underlie the clinical heterogeneity of PD. To t
View details →DOI: 10.1186/s40478-024-01923-8Cited by 12 Negative / Null Result ReportOpen accessMedicine
Shih-Chun Chang, Chi-Ming Tang, Puo‐Hsien Le et al. · 2021 · Cancers
Whether gastric adenocarcinoma (GC) patients with adjacent organ invasion (T4b) benefit from aggressive surgery involving pancreatic resection (PR) remains unclear. This study aimed to clarify the impact of PR on survival in patients with locally advanced resectable GC. Between 1995 and 2017, patients with locally advanced GC undergoing radical-intent gastrectomy with and without PR were enrolled and stratified into four groups: group 1 (G1), pT4b without pancreatic resection (PR); group 2 (G2), pT4b with PR; group 3 (G3), positive duodenal margins without Whipple’s operation; and group 4 (G4)
View details →DOI: 10.3390/cancers13061289Cited by 12 Negative / Null Result ReportOpen accessPsychology
Christian Greiner, Vincent Besch, Marissa Bouchard-Boivin et al. · 2025 · PLoS ONE
The concept of epistemic trust is gaining traction in the mental health field. Epistemic trust is thought to play a foundational role as a resilience factor against the development and maintenance of psychopathology by fostering social learning. The primary aim of this study was to validate the French-language version of the Epistemic Trust, Mistrust and Credulity Questionnaire (ETMCQ). We further sought to replicate previously reported associations with key developmental and psychological factors (childhood trauma, mentalizing and attachment) and test for epistemic trust's potential mediating
View details →DOI: 10.1371/journal.pone.0303918Cited by 12 Negative / Null Result ReportOpen accessMaterials Science
Luis E. Castro-Anaya, Eduardo Marese, Jaime A. Lozano et al. · 2025 · Journal of Chemical Information and Modeling
High Resolution Image Download MS PowerPoint Slide Traditionally, designing novel materials involves exploring new compositions guided by insights from previous work, relying on a trial-and-error approach, where continuous synthesis and characterization proceed until the properties meet the improvements. This method is inefficient due to the challenges of exploring vast chemical spaces. In this study, a machine-learning-based methodology is developed to assist the design from available data in the literature, allowing us to test in silico more than 1.2 million compositions. Two databases with
View details →DOI: 10.1021/acs.jcim.4c01944Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Marcel Garz, Märt Ots · 2025 · Journal of Communication
Abstract News organizations have been under financial pressure to streamline their activities for decades. Critics argue that this pressure undermines the quality of news, posing a severe threat to democracy. However, the effects of media consolidation on news quality are theoretically ambiguous and empirical evidence is scarce. To address this gap, we study the case of the Swedish newspaper industry between 2014 and 2022, a period where more than half of the country’s newspapers changed their owners. We collect over 2 million articles from 108 newspapers and apply state-of-the-art computation
View details →DOI: 10.1093/joc/jqae053Cited by 12 Negative / Null Result ReportOpen accessImmunology and Microbiology
Yuliya Semenova, Ademi Yergaliyeva, Ainur Aimurziyeva et al. · 2024 · Antibiotics
BACKGROUND/OBJECTIVES: There has been a lack of a holistic approach to evaluating antibiotic consumption in Kazakhstan over the past few years using an internationally recognized methodology. Therefore, this study aimed to provide a nationwide evaluation of antibiotic consumption in Kazakhstan during the period 2019-2023. METHODS: Defined daily doses per 1000 inhabitants per day (DIDs) were calculated for systemic antibiotics (J01 code of the Anatomical Therapeutic Chemical Classification System (ATC)) following the methodology established by the Global Antimicrobial Resistance and Use Surveil
View details →DOI: 10.3390/antibiotics13121123Cited by 12 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shanwen Gu, Adil Javed · 2025 · Sustainability
The E-7 nations face significant challenges in harmonizing artificial intelligence (AI) adoption with sustainable economic and environmental goals. While AI holds transformative potential to revolutionize energy structures, modernize infrastructure, broaden financial inclusion, and reduce carbon emissions, its effective integration is frequently hindered by policy inertia, economic limitations, and long-standing institutional barriers. Using the multi-level perspective (MLP), this study employs the method of moments quantile regression (MMQREG) on panel data from 2004 to 2024 to investigate th
View details →DOI: 10.3390/su17135920Cited by 12 Negative / Null Result ReportOpen accessSocial Sciences
Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review
Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon
View details →DOI: 10.1017/s0003055424001394Cited by 12 Negative / Null Result ReportOpen accessPhysics and Astronomy
Callum T. Donnan, Mark Dickinson, Anthony J. Taylor et al. · 2025 · The Astrophysical Journal
Abstract We present JWST/NIRSpec PRISM observations of three luminous ( M UV < −20) galaxies at z ∼ 10 observed with the CANDELS-Area Prism Epoch of Reionization Survey (CAPERS) Cycle 3 program. These galaxies exhibit extreme UV slopes compared to typical galaxies at z = 10. Of the three sources, two of them are a close pair (0 . ″ 22) of blue galaxies at z = 9.800 ± 0.003 and z = 9.808 ± 0.002 with UV slopes of β = −2.87 ± 0.15 and β = −2.46 ± 0.10, respectively, selected from PRIMER COSMOS NIRCam imaging. We perform spectrophotometric modeling of the galaxies, which suggests extre
View details →DOI: 10.3847/1538-4357/ae0a1fCited by 12 Negative / Null Result ReportOpen accessMedicine
Jia-Jie Guo, Qi-Qi Hang, Ting Xu et al. · 2025 · Lipids in Health and Disease
BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using
View details →DOI: 10.1186/s12944-025-02619-1Cited by 12 Negative / Null Result ReportOpen accessEngineering
Yue Cheng, Jian Wang, Mingwang Shao et al. · 2025 · Advanced Composites and Hybrid Materials
Hybrid polymer composites with carbon fillers are of great interest for applications requiring specific mechanical, electrical, and thermal properties. However, studies on hybrid polymer composite fiber (HPCF) with multiple carbon fillers…
View details →DOI: 10.1007/s42114-025-01341-xCited by 12 Negative / Null Result ReportOpen accessMedicine
Edoardo Cipolletta, Tatiana Zverkova Sandström, D. Rozza et al. · 2026 · JAMA Internal Medicine
Importance: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in patients with gout is unknown. Objectives: To evaluate the association between achieving a serum urate treatment target lower than 6 mg/dL and cardiovascular events among patients with gout who were newly prescribed ULT. Design, Setting, and Participants: This new-user cohort study using emulated target trial framework with up to 5-year follow-up was performed using primary care data from the C
View details →DOI: 10.1001/jamainternmed.2025.7453Cited by 12 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Amina Hamdouni · 2025 · International Journal of Financial Studies
This study examines the association between Saudi banks’ internal adoption of AI-enabled FinTech-related digital tools and their financial performance, sustainability performance, and financial stability over the period 2015–2024. Using a panel dataset of 10 banks, the analysis investigates how the adoption of AI-driven technologies—such as machine-learning credit assessment, robo-advisory systems, and automated compliance tools—is related to market performance (Tobin’s Q), accounting performance (ROA and ROE), financial stability (Z-Score), and sustainability outcomes measured by both Bloombe
View details →DOI: 10.3390/ijfs13040234Cited by 12 Negative / Null Result ReportOpen accessImmunology and Microbiology
Ali Ghasemi, Amaia Martínez-Usatorre, Yang Liu et al. · 2025 · Nature Communications
Cancer immunotherapy using dendritic cells (DC) pulsed ex vivo with tumour antigens is considered safe, but its clinical efficacy is generally modest. Here we engineer DC progenitors (DCP), which can replenish conventional type 1 DCs…
View details →DOI: 10.1038/s41467-025-64172-wCited by 12 Negative / Null Result ReportOpen accessEnvironmental Science
Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications
Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…
View details →DOI: 10.1038/s41467-025-64175-7Cited by 12 Negative / Null Result ReportOpen accessMedicine
M.a Cruces Souto-Gallardo, Arturo Jiménez–Cruz, Montserrat Bacardí‐Gascón · 2026 · Archivos Latinoamericanos de Nutrición
The aim of this study was to evaluate the ability of parents to estimate the weight status of preschool children attending the Instituto Mexicano del Seguro Social (IMSS) day-care centers using three different tools. A total of 100…
View details →DOI: 10.37527/2011.61.4.007Cited by 12 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Sadek Ahmed, Khaled M. Attallah, Marwa Eid Sayyed · 2026 · AAPS PharmSciTech
Abstract This research focuses on creating a novel Brijaluronic-based terpesomal system capable of transporting quercetin (QER) efficiently to the brain. The vesicles were fabricated through an ethanol-injection method and then refined using a structured optimization approach in Design-Expert® software. The influence of three main formulation parameters: terpene-to-drug ratio, surfactant type, and hyaluronic acid amount were evaluated. The optimization process was designed to maximize EE%, minimize VS, and maintain ZP within an acceptable stability range. The optimal formula hit a desirability
View details →DOI: 10.1208/s12249-026-03366-xCited by 12 Negative / Null Result ReportOpen accessEnvironmental Science
Anwar Zahid, Md. Aminur Rahman, M. Rashidul Hassan et al. · 2026 · BRAC University Journal
The study area lies on the coastal belt of the Bengal Delta, southern Bangladesh. This study bas been condocted to deteonine salinity sources in the multi-layered aquifers of the Bengal Delta. Dissolved major ions including chloride (Cr) and brontide (Br) were measured in groundwater of the coastal areas of Bangladesh to assess the source(s) of salinity. Ionic concentrations of 48 groundwater samples were analyzed for this study; samples were collected from observation wells installed at different depths down to 336 m. The major ion trends of the upper (<200 m deep) Sodium (Na')-Chloride (C
View details →DOI: 10.64501/tg9bbj82Cited by 12 Negative / Null Result ReportOpen accessMedicine
Shivani Baisiwala, Elisa Fazzari, Matthew Li et al. · 2026 · Cell Reports
A major obstacle to identifying effective therapies for the aggressive brain tumor glioblastoma is the lack of human-specific, immunocompetent models that reflect the human tumor microenvironment. To address this, we developed the…
View details →DOI: 10.1016/j.celrep.2025.116790Cited by 12 Negative / Null Result ReportOpen accessEngineering
Lianpeng Dai, Xin Zhao, Yishan Pan et al. · 2026 · Journal of Rock Mechanics and Geotechnical Engineering
Strainburst is a type of severe dynamic hazard frequently encountered in underground excavation, involving violent rock ejection. It is caused by the release of elastic strain energy stored in the surrounding rocks. Hence, the burst energy…
View details →DOI: 10.1016/j.jrmge.2026.02.003Cited by 12 Negative / Null Result ReportOpen accessMedicine
Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine
Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…
View details →DOI: 10.1038/s41591-025-04071-1Cited by 12 