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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19814 results in Negative / Null Result Report · page 132 of 661

Negative / Null Result ReportNeuroscience

How does Stroop interference change with practice? A reappraisal from the musical Stroop paradigm.

Laurent Grégoire, Pierre Perruchet, Bénédicte Poulin-Charronnat · 2014 · Journal of Experimental Psychology Learning Memory and Cognition

Most earlier studies investigating the evolution of the Stroop effect with the amount of reading practice have reported data consistent with an inverted U-shaped curve, whereby the Stroop effect appears early during reading acquisition,…

View details →DOI: 10.1037/xlm0000044Cited by 12
Negative / Null Result ReportOpen accessMedicine

Kinetics of the West Nile virus induced transcripts of selected cytokines and Toll-like receptors in equine peripheral blood mononuclear cells

Muhammad Jasim Uddin, Willy W. Suen, Angela M. Bosco‐Lauth et al. · 2016 · Veterinary Research

West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcrip

View details →DOI: 10.1186/s13567-016-0347-8Cited by 11
Negative / Null Result ReportOpen accessMedicine

The FGA Thr312Ala polymorphism and risk of intracerebral haemorrhage in Polish and Greek populations

Jeremiasz Jagiełła, Efthimios Dardiotis, Jerzy Gąsowski et al. · 2014 · Neurologia i Neurochirurgia Polska

BACKGROUND AND PURPOSE: Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and…

View details →DOI: 10.1016/j.pjnns.2013.12.004Cited by 11
Negative / Null Result ReportOpen accessMedicine

Customized Prediction of Short Length of Stay Following Elective Cardiac Surgery in Elderly Patients Using a Genetic Algorithm

Joon Lee, Sapna Govindan, Leo Anthony Celi et al. · 2013 · World Journal of Cardiovascular Surgery

OBJECTIVE: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. DESIGN: Utilization of a machine learning algorithm in a prospectively collected STS database consisting of patients who received cardiac surgery between January 2002 and June 2011. SETTING: Urban tertiary-care center. PARTICIPANTS: Geriatric patients aged 70 years or older at the time of cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Predefined morbidity and mortality events were collec

View details →DOI: 10.4236/wjcs.2013.35034Cited by 11
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Harnessing genotype-by-environment interaction to determine adaptability of advanced cowpea lines to multiple environments in Uganda

Abiriga Francis, O. Ongom Patrick, Rubaihayo Patrick et al. · 2020 · Journal of Plant Breeding and Crop Science

This study was conducted to determine the yield stability of advanced cowpea lines in diverse agro-ecological zones of Uganda in order to facilitate documentation requirements for national performance trials (NPT). Thirty cowpea genotypes were evaluated against six checks in three localities, over three growing seasons, making a total of 9 unique environments. The trials were laid in a 6x6 alpha lattice design with three replications and grain yield was the principal trait measured. Single-site and multi-location data were summarized using analysis of variance. Further analysis of stability wa

View details →DOI: 10.5897/jpbcs2020.0891Cited by 11
Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Investigating the quadrupedal abilities of Scutellosaurus lawleri and its implications for locomotor behavior evolution among dinosaurs

Lilian Anderson, Charlotte Brassey, Stuart Pond et al. · 2023 · The Anatomical Record

A reversion to secondary quadrupedality is exceptionally rare in nature, yet the convergent re-evolution of this locomotor style occurred at least four separate times within Dinosauria. Facultative quadrupedality, an intermediate state between obligate bipedality and obligate quadrupedality, may have been an important transitional step in this locomotor shift, and is proposed for a range of basal ornithischians and sauropodomorphs. Advances in virtual biomechanical modeling and simulation have allowed for the investigation of limb anatomy and function in a range of extinct dinosaurian species,

View details →DOI: 10.1002/ar.25189Cited by 11
Negative / Null Result ReportOpen accessComputer Science

Improving SAT-solving with Machine Learning

Haoze Wu · 2017

In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…

View details →DOI: 10.1145/3017680.3022464Cited by 11
Negative / Null Result ReportEngineering

Implication of anchor placement on performance of UWB real-time locating system

Charuwalee Suwatthikul, Witsarawat Chantaweesomboon, Supatra Manatrinon et al. · 2017

Recently, real-time locating system (RTLS) with centimeter accuracy using radio frequency signal is available for commercial deployment with the use of ultra-wideband (UWB) technology. One of the commercial UWB real time locating systems…

View details →DOI: 10.1109/ictemsys.2017.7958760Cited by 11
Negative / Null Result ReportOpen accessMedicine

Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs

Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino et al. · 2025 · Emerging Microbes & Infections

Since the first emergence of highly pathogenic avian influenza (HPAI) H5N1 viruses in dairy cattle, the virus has continued to spread, reaching 17 states and at least 1000 dairy herds in the United States. Subsequently, spillovers of the…

View details →DOI: 10.1080/22221751.2025.2509742Cited by 11
Negative / Null Result ReportOpen accessArts and Humanities

There’s More to the Story: Both Individual and Collective Policy Narratives Can Increase Support for Community-Level Action

Chris Skurka, Jeff Niederdeppe, Liana B. Winett · 2020 · DOAJ (DOAJ: Directory of Open Access Journals)

Narratives can convey the need or community-level action to address social problems. Yet narratives often tell stories about specific individuals rather than the broader collectives these problems affect. Some theorists argue that individualizing collective problems inhibits audiences from recognizing upstream causes and solutions. This study tested how narrative individualization (whether a story focuses on an individual case or a larger collective) might produce trade-offs when mobilizing support for community-level policies to address childhood obesity. We also investigated whether narrativ

View details →Cited by 11
Negative / Null Result ReportOpen accessPsychology

Communicating Evidence about the Causes of Obesity and Support for Obesity Policies: Two Population-Based Survey Experiments

James P. Reynolds, Milica Vasiljevic, Mark Pilling et al. · 2020 · International Journal of Environmental Research and Public Health

Public support for numerous obesity policies is low, which is one barrier to their implementation. One reason for this low support is the tendency to ascribe obesity to failings of willpower as opposed to the environment. Correlational evidence supports this position. However, the experimental evidence is mixed. In two experimental studies, participants were randomised to receive no message, messages about the environment’s influence on obesity (Study 1 &amp; 2), or messages about the environment’s influence on human behaviour (Study 1). We investigated whether communicating these messages cha

View details →DOI: 10.3390/ijerph17186539Cited by 11
Negative / Null Result ReportOpen accessMedicine

Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice

Allyson L. Anding, Sofia Kinton, Kaitlyn Baranowski et al. · 2023 · Journal of Pharmacology and Experimental Therapeutics

Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidase, which leads to muscle weakness, cardiac and respiratory failure, and early mortality. Alglucosidase alfa, a recombinant…

View details →DOI: 10.1124/jpet.123.001593Cited by 11
Negative / Null Result ReportOpen accessMedicine

Alexithymia and the Evaluation of Emotionally Valenced Scenes

Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology

Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple

View details →DOI: 10.3389/fpsyg.2020.01820Cited by 11
Negative / Null Result ReportOpen accessMedicine

4-Aminobutyrate Aminotransferase (ABAT): Genetic and Pharmacological Evidence for an Involvement in Gastro Esophageal Reflux Disease

Johan Jirholt, Bengt Åsling, Paul Hammond et al. · 2011 · PLoS ONE

Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome microsatellite genotyping and linkage analysis. Five linked regions were identified. Two families shared a linked region (LOD 3.9 and 2.0) on chromosome 16. We used two additional independent GERD patient cohorts, one consisting of 219 trios (affected

View details →DOI: 10.1371/journal.pone.0019095Cited by 11
Negative / Null Result ReportMedicine

Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission

Tonia C. Carter, Scott J. Hebbring, Jixia Liu et al. · 2017 · Journal of Medical Virology

Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune…

View details →DOI: 10.1002/jmv.24975Cited by 11
Negative / Null Result ReportOpen accessMedicine

Devimistat plus chemotherapy vs chemotherapy alone for older relapsed or refractory patients with AML: results of the ARMADA trial

Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia

Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…

View details →DOI: 10.1016/j.bneo.2024.100009Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Anticancer efficacy of the hypoxia‐activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

Vasilios Liapis, Aneta Zysk, Mark DeNichilo et al. · 2017 · Cancer Medicine

Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death. This study assessed the anticancer efficacy of evofosfamide in

View details →DOI: 10.1002/cam4.1115Cited by 11
Negative / Null Result ReportArts and Humanities

When “meaningless” means more: biographic resonance and audience appreciation of popular entertainment

James Alex Bonus, Judy Watts, C. Joseph Francemone · 2022 · Journal of Communication

Abstract Integrating predictions derived from the self-memory system and biographic resonance theory, the current project investigated the relationship between media-induced reminiscence and appreciation. In two experiments, undergraduates…

View details →DOI: 10.1093/joc/jqac028Cited by 11
Negative / Null Result ReportOpen accessNeuroscience

Suppression-induced forgetting: a pre-registered replication of the think/no-think paradigm

Sera Wiechert, Leonie Hannah Shoshana Loewy, Ineke Wessel et al. · 2023 · Memory

Post-traumatic stress disorder is characterised by recurring memories of a traumatic experience despite deliberate attempts to forget (i.e., suppression). The Think/No-Think (TNT) task has been used widely in the laboratory to study…

View details →DOI: 10.1080/09658211.2023.2208791Cited by 11
Negative / Null Result ReportOpen accessMedicine

Still a Place for Metoclopramide as a Prokinetic Drug in Critically Ill Patients?

Arthur R. H. van Zanten, Y. G. Van Der Meer, Willem A. Venhuizen et al. · 2015 · Journal of Parenteral and Enteral Nutrition

Neurologic adverse reactions, including extrapyramidal disorders, dyskinesia, dystonia, convulsions, hypertonia, and tremors.4 The reported occurrence of tardive dyskinesia ranges from <0.01%–23%.5 High occurrence is attributed to chronic…

View details →DOI: 10.1177/0148607114567711Cited by 11
Negative / Null Result ReportOpen accessEngineering

Gas Chromatography–Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn’s from Ulcerative Colitis, in Children

Rachael Slater, Kukatharmini Tharmaratnam, Salma Belnour et al. · 2024 · Sensors

The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn's disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography-sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a

View details →DOI: 10.3390/s24155079Cited by 11
Negative / Null Result Report

Did medical doctors who order abdominal CT scans during on-call hours truly become worse at clinical reasoning? Yes, they did

Selin Ersoydan, Derya Yakar, Ömer Kasalak et al. · 2022 · European Radiology

Abstract Objective To investigate temporal changes in clinical reasoning quality of physicians who requested abdominal CT scans at a tertiary care center during on-call hours within a 15-year period. Methods This retrospective study…

View details →DOI: 10.1007/s00330-022-09121-7Cited by 11
Negative / Null Result ReportNeuroscience

The grain-size lineup: A test of a novel eyewitness identification procedure.

Ruth Horry, Neil Brewer, Nathan Weber · 2015 · Law and Human Behavior

When making a memorial judgment, respondents can regulate their accuracy by adjusting the precision, or grain size, of their responses. In many circumstances, coarse-grained responses are less informative, but more likely to be accurate,…

View details →DOI: 10.1037/lhb0000166Cited by 11
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Tetanus in the Elderly: The Management of Intensive Care and Prolonged Hospitalization

Hiroki Isono, Taiju Miyagami, Kohta Katayama et al. · 2016 · Internal Medicine

Tetanus is a potentially fatal infection. Approximately 100 cases are reported in Japan each year; however, little is known about its clinical course and outcomes in the current era of treatment. We herein report three cases of tetanus in…

View details →DOI: 10.2169/internalmedicine.55.7131Cited by 11
Negative / Null Result ReportOpen accessMedicine

Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: results from a multicenter study in China

Danfeng Xu, Rong Na, Da Huang et al. · 2020 · Asian Journal of Andrology

To evaluate whether prostate volume (PV) would provide additional predictive utility to the prostate health index (phi) for predicting prostate cancer (PCa) or clinically significant prostate cancer, we designed a prospective,…

View details →DOI: 10.4103/aja.aja_136_19Cited by 11
Negative / Null Result Report

Can Machines Find the Bilingual Advantage? Machine Learning Algorithms Find No Evidence to Differentiate Between Lifelong Bilingual and Monolingual Cognitive Profiles

Samuel Kyle Jones, Jodie Davies-Thompson, Jeremy Tree · 2021 · Frontiers in Human Neuroscience

Bilingualism has been identified as a potential cognitive factor linked to delayed onset of dementia as well as boosting executive functions in healthy individuals. However, more recently, this claim has been called into question following…

View details →DOI: 10.3389/fnhum.2021.621772Cited by 11
Negative / Null Result ReportOpen accessMedicine

Ulinastatin did not reduce mortality in elderly multiple organ failure patients: a retrospective observational study in a single center ICU

Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono et al. · 2017 · Acute Medicine & Surgery

Aim Our aim was to evaluate the effect of ulinastatin on 28‐day mortality in patients who developed multiple organ failure ( MOF ) related to their acute illness and were admitted to the intensive care unit ( ICU ). Methods We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28‐day all‐cause mortality. Secondary outcomes were ventilator‐free days, ICU ‐free days, and vasopressor‐free days at day 28. We investigated the association between ulinastatin treatment and ou

View details →DOI: 10.1002/ams2.304Cited by 11
Negative / Null Result ReportOpen accessSocial Sciences

Bidirectional Associations of Adolescents’ Momentary Social Media Use and Negative Emotions

Tyler Colasante, Katie Faulkner, Dana Kharbotli et al. · 2024 · Affective Science

Abstract Public discourse and empirical studies have predominantly focused on the negative repercussions of social media on adolescents’ mental health. However, pervasive social media use is a relatively new phenomenon—its apparent harms have been widely accepted before sufficient longitudinal and experimental research has been conducted. The present study used an intensive longitudinal design (four assessments/day × 14 days; N = 154 12- to 15-year-olds ( M age = 13.47, SD = 0.58); N = 6,240 valid measurement occasions) to test the directionality of social media–negative emotion links in early

View details →DOI: 10.1007/s42761-024-00244-2Cited by 11